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Hard Palate Mucoepidermoid Carcinoma

MedGen UID:
272699
•Concept ID:
C1333938
•
Neoplastic Process
Synonyms: Mucoepidermoid Carcinoma of Hard Palate; Mucoepidermoid Carcinoma of the Hard Palate

Definition

A mucoepidermoid carcinoma arising from the minor salivary glands in the hard palate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHard Palate Mucoepidermoid Carcinoma

Professional guidelines

PubMed

Review of 109 cases of primary malignant orofacial lesions seen at a Nigerian Tertiary Hospital.
Adesina OM, Soyele OO, Oyetola EO, Fatusi OA
Niger Postgrad Med J 2018 Oct-Dec;25(4):246-251. doi: 10.4103/npmj.npmj_115_18. PMID: 30588946
Long-term treatment outcome of minor salivary gland carcinoma of the hard palate.
Li Q, Zhang XR, Liu XK, Liu ZM, Liu WW, Li H, Guo ZM
Oral Oncol 2012 May;48(5):456-62. Epub 2012 Jan 16 doi: 10.1016/j.oraloncology.2011.12.005. PMID: 22248739

Recent clinical studies

Etiology

Mucoepidermoid carcinoma of hard palate.
Gill S, Mohan A, Aggarwal S, Varshney A
Indian J Pathol Microbiol 2018 Jul-Sep;61(3):397-398. doi: 10.4103/IJPM.IJPM_617_17. PMID: 30004063
Mucoepidermoid carcinoma diagnosed in orthodontic patients.
Rocha LA, Brasil Moreira AE, Pereira Neto JS, Vargas PA, Lopes MA
Am J Orthod Dentofacial Orthop 2010 Sep;138(3):349-51. doi: 10.1016/j.ajodo.2008.08.038. PMID: 20816306
Calcifications in clear cell mucoepidermoid carcinomas.
Yang S, Chen X
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010 Feb;109(2):274-5. Epub 2009 Oct 31 doi: 10.1016/j.tripleo.2009.08.012. PMID: 19880334
Intraoral minor salivary gland neoplasm: a single institution experience of 80 cases.
Jansisyanont P, Blanchaert RH Jr, Ord RA
Int J Oral Maxillofac Surg 2002 Jun;31(3):257-61. doi: 10.1054/ijom.2002.0223. PMID: 12190130
Mucoepidermoid carcinoma of the oral cavity.
Olsen KD, Devine KD, Weiland LH
Otolaryngol Head Neck Surg 1981 Sep-Oct;89(5):783-91. doi: 10.1177/019459988108900518. PMID: 6799909

Diagnosis

Mucoepidermoid carcinoma. An update and review of the literature.
Peraza A, Gómez R, Beltran J, Amarista FJ
J Stomatol Oral Maxillofac Surg 2020 Dec;121(6):713-720. Epub 2020 Jun 18 doi: 10.1016/j.jormas.2020.06.003. PMID: 32565266
Mucoepidermoid Carcinoma in a 33-Year-Old White Man.
Behring CM, Lazzari MA
Lab Med 2015 Fall;46(4):327-31. doi: 10.1309/LMD9RI33QNRSXNMM. PMID: 26489678
CT and MR imaging findings of palatal tumors.
Kato H, Kanematsu M, Makita H, Kato K, Hatakeyama D, Shibata T, Mizuta K, Aoki M
Eur J Radiol 2014 Mar;83(3):e137-46. Epub 2013 Dec 12 doi: 10.1016/j.ejrad.2013.11.028. PMID: 24377674
Mucoepidermoid carcinoma diagnosed in orthodontic patients.
Rocha LA, Brasil Moreira AE, Pereira Neto JS, Vargas PA, Lopes MA
Am J Orthod Dentofacial Orthop 2010 Sep;138(3):349-51. doi: 10.1016/j.ajodo.2008.08.038. PMID: 20816306
Calcifications in clear cell mucoepidermoid carcinomas.
Yang S, Chen X
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010 Feb;109(2):274-5. Epub 2009 Oct 31 doi: 10.1016/j.tripleo.2009.08.012. PMID: 19880334

Therapy

Bilateral necrotizing sialometaplasia of the hard palate in a patient with bulimia: a case report and review of the literature.
Janner SF, Suter VG, Altermatt HJ, Reichart PA, Bornstein MM
Quintessence Int 2014 May;45(5):431-7. doi: 10.3290/j.qi.a31543. PMID: 24634907
Relapsing high grade mucoepidermoid carcinoma. Long-lasting complete response following reirradiation and EGFR blockade.
Milanovic D, Jeremic B, Kayser G, Rischke HC, Pfeiffer J, Henke A
Strahlenther Onkol 2012 Jun;188(6):518-22. Epub 2012 Apr 12 doi: 10.1007/s00066-012-0096-1. PMID: 22526230
Autonomization of free flaps in the oral cavity: A prospective clinical study.
Mücke T, Wolff KD, Rau A, Kehl V, Mitchell DA, Steiner T
Microsurgery 2012 Mar;32(3):201-6. Epub 2012 Jan 20 doi: 10.1002/micr.20984. PMID: 22262645
Atypical clinical manifestation of mucoepidermoid carcinoma in the palate.
Munhoz Ede A, Cardoso CL, Tjioe KC, Sant'ana E, Consolaro A, Damante JH, Rurira-Bullen IR
Gen Dent 2009 Nov-Dec;57(6):e51-3. PMID: 21467005
Improvement in quality of life of an oncological patient by laser phototherapy.
Campos L, Simões A, Sá PH, Eduardo Cde P
Photomed Laser Surg 2009 Apr;27(2):371-4. doi: 10.1089/pho.2008.2300. PMID: 18800946

Prognosis

Mucoepidermoid carcinoma: Evaluating the prognostic impact of primary tumor site.
Mimica X, Yuan A, Hay A, Katabi N, Zanoni DK, Valero C, Shah JP, Wong RJ, Cohen MA, Patel SG, Ganly I
Oral Oncol 2021 Dec;123:105602. Epub 2021 Nov 9 doi: 10.1016/j.oraloncology.2021.105602. PMID: 34768210Free PMC Article
Mucoepidermoid carcinoma diagnosed in orthodontic patients.
Rocha LA, Brasil Moreira AE, Pereira Neto JS, Vargas PA, Lopes MA
Am J Orthod Dentofacial Orthop 2010 Sep;138(3):349-51. doi: 10.1016/j.ajodo.2008.08.038. PMID: 20816306
Mucoepidermoid carcinoma of minor salivary glands: a clinical study of 16 cases and review of the literature.
Triantafillidou K, Dimitrakopoulos J, Iordanidis F, Koufogiannis D
Oral Dis 2006 Jul;12(4):364-70. doi: 10.1111/j.1601-0825.2005.01166.x. PMID: 16792720
Red-blue lesion of the hard palate.
Manganaro AM, Will MJ, Ragno JR Jr, Holton JB
J Oral Maxillofac Surg 1997 Feb;55(2):159-65. doi: 10.1016/s0278-2391(97)90235-4. PMID: 9024353
Mucoepidermoid carcinoma of the oral cavity.
Olsen KD, Devine KD, Weiland LH
Otolaryngol Head Neck Surg 1981 Sep-Oct;89(5):783-91. doi: 10.1177/019459988108900518. PMID: 6799909

Clinical prediction guides

Mucoepidermoid carcinoma: Evaluating the prognostic impact of primary tumor site.
Mimica X, Yuan A, Hay A, Katabi N, Zanoni DK, Valero C, Shah JP, Wong RJ, Cohen MA, Patel SG, Ganly I
Oral Oncol 2021 Dec;123:105602. Epub 2021 Nov 9 doi: 10.1016/j.oraloncology.2021.105602. PMID: 34768210Free PMC Article
Mucoepidermoid carcinoma misdiagnosed as palatal odontogenic infection: an overview on the differential diagnosis of palatal lesions.
Brajdić D, Virag M, Manojlović S, Luksić I, Franćeski D, Biocić J, Bosan-Kilibarda I, Zajc I, Macan D
Coll Antropol 2010 Dec;34(4):1473-9. PMID: 21874742
Survival in oral cavity minor salivary gland carcinoma.
Kakarala K, Bhattacharyya N
Otolaryngol Head Neck Surg 2010 Jul;143(1):122-6. doi: 10.1016/j.otohns.2010.02.033. PMID: 20620630
Improvement in quality of life of an oncological patient by laser phototherapy.
Campos L, Simões A, Sá PH, Eduardo Cde P
Photomed Laser Surg 2009 Apr;27(2):371-4. doi: 10.1089/pho.2008.2300. PMID: 18800946
Mucoepidermoid carcinoma of the hard palate: a rare cause of hypervascular tumor.
Lee WH, Yoon JH
Yonsei Med J 2003 Aug 30;44(4):723-6. doi: 10.3349/ymj.2003.44.4.723. PMID: 12950132

Recent systematic reviews

Why is the histomorphological diagnosis of tumours of minor salivary glands much more difficult?
Ihrler S, Agaimy A, Guntinas-Lichius O, Haas CJ, Mollenhauer M, Sandison A, Greber L
Histopathology 2021 Nov;79(5):779-790. Epub 2021 Aug 18 doi: 10.1111/his.14421. PMID: 34042205

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