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Signet ring cell variant cervical mucinous adenocarcinoma

MedGen UID:
273126
•Concept ID:
C1516424
•
Neoplastic Process
Synonyms: Cervical Mucinous Adenocarcinoma, Signet Ring Cell Type; cervical mucinous adenocarcinoma, signet Ring cell type; Cervical Mucinous Adenocarcinoma, Signet Ring Cell Variant; cervical mucinous adenocarcinoma, signet Ring cell variant; Cervical Mucinous Adenocarcinoma, Signet Ring Cell-Type; Cervical Mucinous Adenocarcinoma, Signet-Ring Cell Type; signet ring cell variant cervical mucinous adenocarcinoma; signet ring mucinous carcinoma
 
Monarch Initiative: MONDO:0003768

Definition

A rare cervical mucinous adenocarcinoma characterized by the presence of signet ring cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSignet ring cell variant cervical mucinous adenocarcinoma

Recent clinical studies

Etiology

NKX3.1 Expression and Molecular Characterization of Secretory Myoepithelial Carcinoma (SMCA): Advancing the Case for a Salivary Mucous Acinar Phenotype.
Patel S, Wald AI, Bastaki JM, Chiosea SI, Singhi AD, Seethala RR
Head Neck Pathol 2023 Jun;17(2):467-478. Epub 2023 Feb 6 doi: 10.1007/s12105-023-01524-2. PMID: 36746884Free PMC Article
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article
Newly Described Entities in Salivary Gland Pathology.
Skálová A, Gnepp DR, Lewis JS Jr, Hunt JL, Bishop JA, Hellquist H, Rinaldo A, Vander Poorten V, Ferlito A
Am J Surg Pathol 2017 Aug;41(8):e33-e47. doi: 10.1097/PAS.0000000000000883. PMID: 28614209
From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II.
Young RH
Adv Anat Pathol 2007 May;14(3):149-77. doi: 10.1097/PAP.0b013e3180504abf. PMID: 17452813

Diagnosis

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article
Newly Described Entities in Salivary Gland Pathology.
Skálová A, Gnepp DR, Lewis JS Jr, Hunt JL, Bishop JA, Hellquist H, Rinaldo A, Vander Poorten V, Ferlito A
Am J Surg Pathol 2017 Aug;41(8):e33-e47. doi: 10.1097/PAS.0000000000000883. PMID: 28614209
Fine-needle aspiration of mucin-producing thyroid tumors.
Yang GC, Scognamiglio T, Kuhel WI
Acta Cytol 2011;55(6):549-55. Epub 2011 Dec 9 doi: 10.1159/000333228. PMID: 22156465
From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II.
Young RH
Adv Anat Pathol 2007 May;14(3):149-77. doi: 10.1097/PAP.0b013e3180504abf. PMID: 17452813

Prognosis

Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article
Newly Described Entities in Salivary Gland Pathology.
Skálová A, Gnepp DR, Lewis JS Jr, Hunt JL, Bishop JA, Hellquist H, Rinaldo A, Vander Poorten V, Ferlito A
Am J Surg Pathol 2017 Aug;41(8):e33-e47. doi: 10.1097/PAS.0000000000000883. PMID: 28614209

Clinical prediction guides

NKX3.1 Expression and Molecular Characterization of Secretory Myoepithelial Carcinoma (SMCA): Advancing the Case for a Salivary Mucous Acinar Phenotype.
Patel S, Wald AI, Bastaki JM, Chiosea SI, Singhi AD, Seethala RR
Head Neck Pathol 2023 Jun;17(2):467-478. Epub 2023 Feb 6 doi: 10.1007/s12105-023-01524-2. PMID: 36746884Free PMC Article
A variant of early gastric carcinoma. Histologic and histochemical studies of early signet ring cell carcinomas discovered beneath preserved surface epithelium.
Yamashina M
Cancer 1986 Sep 15;58(6):1333-9. doi: 10.1002/1097-0142(19860915)58:6<1333::aid-cncr2820580625>3.0.co;2-b. PMID: 3017536

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