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Testicular yolk sac tumor, glandular-alveolar pattern

MedGen UID:
273637
•Concept ID:
C1515305
•
Neoplastic Process
Synonyms: glandular-alveolar pattern testicular yolk sac tumor; glandular-alveolar pattern testicular yolk sac tumour; Testicular Yolk Sac Tumor, Glandular-Alveolar Pattern; testicular yolk sac tumor, glandular-alveolar pattern
 
Monarch Initiative: MONDO:0004402

Definition

A yolk sac tumor that arises from the testis and is characterized by the presence of gland-like spaces, irregular alveoli, and tubular structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular yolk sac tumor, glandular-alveolar pattern

Recent clinical studies

Diagnosis

FoxA2 is a reliable marker for the diagnosis of yolk sac tumour postpubertal-type.
Ricci C, Ambrosi F, Franceschini T, Giunchi F, Di Filippo G, Franchini E, Massari F, Mollica V, Tateo V, Bianchi FM, Colecchia M, Acosta AM, Fiorentino M
Histopathology 2023 Sep;83(3):465-476. Epub 2023 Jun 14 doi: 10.1111/his.14968. PMID: 37317674
Glypican 3 has a higher sensitivity than alpha-fetoprotein for testicular and ovarian yolk sac tumour: immunohistochemical investigation with analysis of histological growth patterns.
Zynger DL, McCallum JC, Luan C, Chou PM, Yang XJ
Histopathology 2010 May;56(6):750-7. doi: 10.1111/j.1365-2559.2010.03553.x. PMID: 20546340

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