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Tumor Promotion

MedGen UID:
274320
•Concept ID:
C1519689
•
Neoplastic Process

Definition

The second step in two-stage carcinogenesis: the conversion of an initiated (premalignant) cell to malignancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTumor Promotion

Professional guidelines

PubMed

Mathematical Modeling and Analysis of CD200-CD200R in Cancer Treatment.
Liao KL, Watt KD
Bull Math Biol 2022 Jul 6;84(8):82. doi: 10.1007/s11538-022-01039-x. PMID: 35792958
Oxy-PAHs: occurrence in the environment and potential genotoxic/mutagenic risk assessment for human health.
Clergé A, Le Goff J, Lopez C, Ledauphin J, Delépée R
Crit Rev Toxicol 2019 Apr;49(4):302-328. Epub 2019 Sep 12 doi: 10.1080/10408444.2019.1605333. PMID: 31512557
Perspectives on the risk assessment for nongenotoxic carcinogens and tumor promoters.
Perera FP
Environ Health Perspect 1991 Aug;94:231-5. doi: 10.1289/ehp.94-1567969. PMID: 1954932Free PMC Article

Recent clinical studies

Etiology

Thresholds for carcinogens.
Calabrese EJ, Priest ND, Kozumbo WJ
Chem Biol Interact 2021 May 25;341:109464. Epub 2021 Apr 3 doi: 10.1016/j.cbi.2021.109464. PMID: 33823170
ROS in cancer therapy: the bright side of the moon.
Perillo B, Di Donato M, Pezone A, Di Zazzo E, Giovannelli P, Galasso G, Castoria G, Migliaccio A
Exp Mol Med 2020 Feb;52(2):192-203. Epub 2020 Feb 14 doi: 10.1038/s12276-020-0384-2. PMID: 32060354Free PMC Article
Mechanistic Evidence for Red Meat and Processed Meat Intake and Cancer Risk: A Follow-up on the International Agency for Research on Cancer Evaluation of 2015.
Turesky RJ
Chimia (Aarau) 2018 Oct 31;72(10):718-724. doi: 10.2533/chimia.2018.718. PMID: 30376922Free PMC Article
The Intestinal Microbiota in Colorectal Cancer.
Tilg H, Adolph TE, Gerner RR, Moschen AR
Cancer Cell 2018 Jun 11;33(6):954-964. Epub 2018 Apr 12 doi: 10.1016/j.ccell.2018.03.004. PMID: 29657127
Safety Aspects of the Use of Quercetin as a Dietary Supplement.
Andres S, Pevny S, Ziegenhagen R, Bakhiya N, Schäfer B, Hirsch-Ernst KI, Lampen A
Mol Nutr Food Res 2018 Jan;62(1) Epub 2017 Dec 19 doi: 10.1002/mnfr.201700447. PMID: 29127724

Diagnosis

Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling.
Lin SC, Liao YC, Chen PM, Yang YY, Wang YH, Tung SL, Chuang CM, Sung YW, Jang TH, Chuang SE, Wang LH
J Biomed Sci 2022 Dec 22;29(1):109. doi: 10.1186/s12929-022-00888-x. PMID: 36550569Free PMC Article
MicroRNAs and Efferocytosis: Implications for Diagnosis and Therapy.
Mahmoudi A, Moadab F, Safdarian E, Navashenaq JG, Rezaee M, Gheibihayat SM
Mini Rev Med Chem 2022;22(20):2641-2660. doi: 10.2174/1389557522666220330150937. PMID: 35362375
Hepatocellular Carcinoma Immune Landscape and the Potential of Immunotherapies.
Giraud J, Chalopin D, Blanc JF, Saleh M
Front Immunol 2021;12:655697. Epub 2021 Mar 18 doi: 10.3389/fimmu.2021.655697. PMID: 33815418Free PMC Article
Autophagy and Hallmarks of Cancer.
Huang T, Song X, Yang Y, Wan X, Alvarez AA, Sastry N, Feng H, Hu B, Cheng SY
Crit Rev Oncog 2018;23(5-6):247-267. doi: 10.1615/CritRevOncog.2018027913. PMID: 30311559Free PMC Article
Emerging roles of long non-coding RNA in cancer.
Sanchez Calle A, Kawamura Y, Yamamoto Y, Takeshita F, Ochiya T
Cancer Sci 2018 Jul;109(7):2093-2100. Epub 2018 Jun 28 doi: 10.1111/cas.13642. PMID: 29774630Free PMC Article

Therapy

Thresholds for carcinogens.
Calabrese EJ, Priest ND, Kozumbo WJ
Chem Biol Interact 2021 May 25;341:109464. Epub 2021 Apr 3 doi: 10.1016/j.cbi.2021.109464. PMID: 33823170
Role of autophagy in tumorigenesis, metastasis, targeted therapy and drug resistance of hepatocellular carcinoma.
Huang F, Wang BR, Wang YG
World J Gastroenterol 2018 Nov 7;24(41):4643-4651. doi: 10.3748/wjg.v24.i41.4643. PMID: 30416312Free PMC Article
Mechanistic Evidence for Red Meat and Processed Meat Intake and Cancer Risk: A Follow-up on the International Agency for Research on Cancer Evaluation of 2015.
Turesky RJ
Chimia (Aarau) 2018 Oct 31;72(10):718-724. doi: 10.2533/chimia.2018.718. PMID: 30376922Free PMC Article
Safety Aspects of the Use of Quercetin as a Dietary Supplement.
Andres S, Pevny S, Ziegenhagen R, Bakhiya N, Schäfer B, Hirsch-Ernst KI, Lampen A
Mol Nutr Food Res 2018 Jan;62(1) Epub 2017 Dec 19 doi: 10.1002/mnfr.201700447. PMID: 29127724
Antioxidant and anti-inflammatory properties of curcumin.
Menon VP, Sudheer AR
Adv Exp Med Biol 2007;595:105-25. doi: 10.1007/978-0-387-46401-5_3. PMID: 17569207

Prognosis

Tumor Microenvironment and Immune Escape in the Time Course of Glioblastoma.
Virtuoso A, De Luca C, Cirillo G, Riva M, Romano G, Bentivegna A, Lavitrano M, Papa M, Giovannoni R
Mol Neurobiol 2022 Nov;59(11):6857-6873. Epub 2022 Sep 1 doi: 10.1007/s12035-022-02996-z. PMID: 36048342Free PMC Article
Thresholds for carcinogens.
Calabrese EJ, Priest ND, Kozumbo WJ
Chem Biol Interact 2021 May 25;341:109464. Epub 2021 Apr 3 doi: 10.1016/j.cbi.2021.109464. PMID: 33823170
Tumor-associated neutrophils as new players in immunosuppressive process of the tumor microenvironment in breast cancer.
Hajizadeh F, Aghebati Maleki L, Alexander M, Mikhailova MV, Masjedi A, Ahmadpour M, Hashemi V, Jadidi-Niaragh F
Life Sci 2021 Jan 1;264:118699. Epub 2020 Oct 31 doi: 10.1016/j.lfs.2020.118699. PMID: 33137368
CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis.
Yang H, Zhang Q, Xu M, Wang L, Chen X, Feng Y, Li Y, Zhang X, Cui W, Jia X
Mol Cancer 2020 Feb 27;19(1):41. doi: 10.1186/s12943-020-01165-x. PMID: 32103760Free PMC Article
Final report of the safety assessment of niacinamide and niacin.
Cosmetic Ingredient Review Expert Panel
Int J Toxicol 2005;24 Suppl 5:1-31. doi: 10.1080/10915810500434183. PMID: 16596767

Clinical prediction guides

Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling.
Lin SC, Liao YC, Chen PM, Yang YY, Wang YH, Tung SL, Chuang CM, Sung YW, Jang TH, Chuang SE, Wang LH
J Biomed Sci 2022 Dec 22;29(1):109. doi: 10.1186/s12929-022-00888-x. PMID: 36550569Free PMC Article
Thresholds for carcinogens.
Calabrese EJ, Priest ND, Kozumbo WJ
Chem Biol Interact 2021 May 25;341:109464. Epub 2021 Apr 3 doi: 10.1016/j.cbi.2021.109464. PMID: 33823170
CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis.
Yang H, Zhang Q, Xu M, Wang L, Chen X, Feng Y, Li Y, Zhang X, Cui W, Jia X
Mol Cancer 2020 Feb 27;19(1):41. doi: 10.1186/s12943-020-01165-x. PMID: 32103760Free PMC Article
Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression.
Isakov N
Semin Cancer Biol 2018 Feb;48:36-52. Epub 2017 May 29 doi: 10.1016/j.semcancer.2017.04.012. PMID: 28571764
Final report of the safety assessment of niacinamide and niacin.
Cosmetic Ingredient Review Expert Panel
Int J Toxicol 2005;24 Suppl 5:1-31. doi: 10.1080/10915810500434183. PMID: 16596767

Recent systematic reviews

miR-429 as biomarker for diagnosis, treatment and prognosis of cancers and its potential action mechanisms: A systematic literature review.
Guo CM, Liu SQ, Sun MZ
Neoplasma 2020 Mar;67(2):215-228. Epub 2019 Dec 23 doi: 10.4149/neo_2019_190401N282. PMID: 31884798
Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge.
Hung YC, Pan TL, Hu WL
Oxid Med Cell Longev 2016;2016:5293284. Epub 2016 Aug 4 doi: 10.1155/2016/5293284. PMID: 27579153Free PMC Article
Statins in the chemoprevention of colorectal cancer in established animal models of sporadic and colitis-associated cancer.
Pikoulis E, Margonis GA, Angelou A, Zografos GC, Antoniou E
Eur J Cancer Prev 2016 Mar;25(2):102-8. doi: 10.1097/CEJ.0000000000000152. PMID: 25768976
Association between growth hormone therapy and mortality, cancer and cardiovascular risk: systematic review and meta-analysis.
Deodati A, Ferroli BB, Cianfarani S
Growth Horm IGF Res 2014 Aug;24(4):105-11. Epub 2014 Apr 13 doi: 10.1016/j.ghir.2014.02.001. PMID: 24818783
Systematic review of wireless phone use and brain cancer and other head tumors.
Repacholi MH, Lerchl A, Röösli M, Sienkiewicz Z, Auvinen A, Breckenkamp J, d'Inzeo G, Elliott P, Frei P, Heinrich S, Lagroye I, Lahkola A, McCormick DL, Thomas S, Vecchia P
Bioelectromagnetics 2012 Apr;33(3):187-206. Epub 2011 Oct 21 doi: 10.1002/bem.20716. PMID: 22021071

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