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Malignant Mixed Epithelial and Mesenchymal Neoplasm of the Cervix

MedGen UID:
274750
•Concept ID:
C1518168
•
Neoplastic Process
Synonym: Malignant Cervical Mixed Epithelial and Mesenchymal Neoplasm

Definition

A mixed epithelial and mesenchymal neoplasm that arises from the cervix. It is characterized by the presence of malignant mesenchymal elements and benign or malignant epithelial elements. This category includes adenosarcoma and carcinosarcoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Mixed Epithelial and Mesenchymal Neoplasm of the Cervix

Recent clinical studies

Etiology

Incidence of occult uterine sarcoma and other unexpected pathologies in patients having surgery for presumed myomas: A retrospective observational study.
Mühlenbrock MV, Navarrete-Rey P, Kovoor E, Guzman-Rojas R, Troncoso F, Miranda-Mendoza I
J Gynecol Obstet Hum Reprod 2021 Sep;50(7):101992. Epub 2020 Nov 17 doi: 10.1016/j.jogoh.2020.101992. PMID: 33217603
Mesonephric carcinosarcoma of the uterine cervix: a case report.
Lopez-Chardi L, González-Bosquet E, Rovira Zurriaga C, Laïlla Vicens JM
Eur J Gynaecol Oncol 2013;34(4):336-8. PMID: 24020142
Papillary adenofibroma of the cervix: a case report.
Haberal A, Cil AP, Gunes M, Cavusoglu D
Ultrasound Obstet Gynecol 2005 Aug;26(2):186-7. doi: 10.1002/uog.1948. PMID: 16041681

Diagnosis

Immunohistochemical and genetic characteristics of HPV-associated endocervical carcinoma with an invasive stratified mucin-producing carcinoma (ISMC) component.
Park E, Kim YT, Kim S, Nam EJ, Cho NH
Mod Pathol 2021 Sep;34(9):1738-1749. Epub 2021 Jun 8 doi: 10.1038/s41379-021-00829-3. PMID: 34103667
Incidence of occult uterine sarcoma and other unexpected pathologies in patients having surgery for presumed myomas: A retrospective observational study.
Mühlenbrock MV, Navarrete-Rey P, Kovoor E, Guzman-Rojas R, Troncoso F, Miranda-Mendoza I
J Gynecol Obstet Hum Reprod 2021 Sep;50(7):101992. Epub 2020 Nov 17 doi: 10.1016/j.jogoh.2020.101992. PMID: 33217603
ALK Is a Specific Diagnostic Marker for Inflammatory Myofibroblastic Tumor of the Uterus.
Mohammad N, Haimes JD, Mishkin S, Kudlow BA, Leong MY, Chew SH, Koay E, Whitehouse A, Cope N, Ali RH, Köbel M, Stewart CJR, McCluggage WG, Lee CH
Am J Surg Pathol 2018 Oct;42(10):1353-1359. doi: 10.1097/PAS.0000000000001120. PMID: 30015720
Tumor rupture as an initial manifestation of malignant mesonephric mixed tumor: a case report and review of the literature.
Tseng CE, Chen CH, Chen SJ, Chi CL
Int J Clin Exp Pathol 2014;7(3):1212-7. Epub 2014 Feb 15 PMID: 24696739Free PMC Article
Papillary adenofibroma of the cervix: a case report.
Haberal A, Cil AP, Gunes M, Cavusoglu D
Ultrasound Obstet Gynecol 2005 Aug;26(2):186-7. doi: 10.1002/uog.1948. PMID: 16041681

Therapy

Metastasizing uterine mullerian adenosarcoma in a young female: Diagnostic enigma.
Patnayak R, Rukmangadha N, Architha P, Reddy GS, Lakshmi AY, Kannan T, Jena A
Indian J Pathol Microbiol 2018 Jul-Sep;61(3):440-442. doi: 10.4103/IJPM.IJPM_1_18. PMID: 30004077

Prognosis

Imaging findings of uterine adenosarcoma with sarcomatous overgrowth: two case reports, emphasizing restricted diffusion on diffusion weighted imaging.
Nakai G, Matsutani H, Yamada T, Ohmichi M, Yamamoto K, Osuga K
BMC Womens Health 2021 Dec 16;21(1):416. doi: 10.1186/s12905-021-01567-z. PMID: 34915866Free PMC Article
Incidence of occult uterine sarcoma and other unexpected pathologies in patients having surgery for presumed myomas: A retrospective observational study.
Mühlenbrock MV, Navarrete-Rey P, Kovoor E, Guzman-Rojas R, Troncoso F, Miranda-Mendoza I
J Gynecol Obstet Hum Reprod 2021 Sep;50(7):101992. Epub 2020 Nov 17 doi: 10.1016/j.jogoh.2020.101992. PMID: 33217603
Landscape of Immune Checkpoint Inhibition in Carcinosarcoma (MMMT): Analysis of IDO-1, PD-L1 and PD-1.
Hacking S, Chavarria H, Jin C, Perry A, Nasim M
Pathol Res Pract 2020 Apr;216(4):152847. Epub 2020 Jan 31 doi: 10.1016/j.prp.2020.152847. PMID: 32085927
ALK Is a Specific Diagnostic Marker for Inflammatory Myofibroblastic Tumor of the Uterus.
Mohammad N, Haimes JD, Mishkin S, Kudlow BA, Leong MY, Chew SH, Koay E, Whitehouse A, Cope N, Ali RH, Köbel M, Stewart CJR, McCluggage WG, Lee CH
Am J Surg Pathol 2018 Oct;42(10):1353-1359. doi: 10.1097/PAS.0000000000001120. PMID: 30015720
Tumor rupture as an initial manifestation of malignant mesonephric mixed tumor: a case report and review of the literature.
Tseng CE, Chen CH, Chen SJ, Chi CL
Int J Clin Exp Pathol 2014;7(3):1212-7. Epub 2014 Feb 15 PMID: 24696739Free PMC Article

Clinical prediction guides

Imaging findings of uterine adenosarcoma with sarcomatous overgrowth: two case reports, emphasizing restricted diffusion on diffusion weighted imaging.
Nakai G, Matsutani H, Yamada T, Ohmichi M, Yamamoto K, Osuga K
BMC Womens Health 2021 Dec 16;21(1):416. doi: 10.1186/s12905-021-01567-z. PMID: 34915866Free PMC Article
Incidence of occult uterine sarcoma and other unexpected pathologies in patients having surgery for presumed myomas: A retrospective observational study.
Mühlenbrock MV, Navarrete-Rey P, Kovoor E, Guzman-Rojas R, Troncoso F, Miranda-Mendoza I
J Gynecol Obstet Hum Reprod 2021 Sep;50(7):101992. Epub 2020 Nov 17 doi: 10.1016/j.jogoh.2020.101992. PMID: 33217603
Landscape of Immune Checkpoint Inhibition in Carcinosarcoma (MMMT): Analysis of IDO-1, PD-L1 and PD-1.
Hacking S, Chavarria H, Jin C, Perry A, Nasim M
Pathol Res Pract 2020 Apr;216(4):152847. Epub 2020 Jan 31 doi: 10.1016/j.prp.2020.152847. PMID: 32085927
ALK Is a Specific Diagnostic Marker for Inflammatory Myofibroblastic Tumor of the Uterus.
Mohammad N, Haimes JD, Mishkin S, Kudlow BA, Leong MY, Chew SH, Koay E, Whitehouse A, Cope N, Ali RH, Köbel M, Stewart CJR, McCluggage WG, Lee CH
Am J Surg Pathol 2018 Oct;42(10):1353-1359. doi: 10.1097/PAS.0000000000001120. PMID: 30015720
Comparative analysis of P16 and P53 expression in uterine malignant mixed mullerian tumors.
Buza N, Tavassoli FA
Int J Gynecol Pathol 2009 Nov;28(6):514-21. doi: 10.1097/PGP.0b013e3181a934e9. PMID: 19851197

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