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Urethral urothelial papilloma

MedGen UID:
275549
•Concept ID:
C1519826
•
Neoplastic Process
Synonyms: urethra urothelial papilloma; Urethral Urothelial Papilloma; urethral urothelial papilloma
 
Monarch Initiative: MONDO:0002221

Definition

A rare benign neoplasm that arises from the urethra and is characterized by the presence of a papillary growth with a central fibrovascular core. The latter is lined by normal urothelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUrethral urothelial papilloma

Recent clinical studies

Etiology

Carcinoma of the urethra.
Zhang M, Adeniran AJ, Vikram R, Tamboli P, Pettaway C, Bondaruk J, Liu J, Baggerly K, Czerniak B
Hum Pathol 2018 Feb;72:35-44. Epub 2017 Aug 18 doi: 10.1016/j.humpath.2017.08.006. PMID: 28827100Free PMC Article
Bladder urothelial neoplasms in pediatric age: experience at three tertiary centers.
Berrettini A, Castagnetti M, Salerno A, Nappo SG, Manzoni G, Rigamonti W, Caione P
J Pediatr Urol 2015 Feb;11(1):26.e1-5. Epub 2014 Sep 28 doi: 10.1016/j.jpurol.2014.08.008. PMID: 25305695
Long-term clinical outcome of inverted urothelial papilloma including cases with focal papillary pattern: is continuous surveillance necessary?
Patel P, Reikie BA, Maxwell JP, Yilmaz A, Gotto GT, Trpkov K
Urology 2013 Oct;82(4):857-60. doi: 10.1016/j.urology.2013.06.040. PMID: 24074985
Urothelial polyps from anterior urethra in a prepubertal female child: a rare entity.
Goel P, Manchanda V, Mohta A, Gupta CR, Das P, Srivastav S
J Pediatr Surg 2012 Dec;47(12):e13-5. doi: 10.1016/j.jpedsurg.2012.08.012. PMID: 23217909

Diagnosis

Invasive high-grade urothelial carcinoma of the bladder, renal pelvis, ureter, and prostatic urethra arising in a background of urothelial carcinoma with an inverted growth pattern: a contemporary clinicopathological analysis of 91 cases.
Gutierrez CM, Alemozaffar M, Osunkoya AO
Hum Pathol 2019 Oct;92:18-24. Epub 2019 Jul 24 doi: 10.1016/j.humpath.2019.07.005. PMID: 31351154
Carcinoma of the urethra.
Zhang M, Adeniran AJ, Vikram R, Tamboli P, Pettaway C, Bondaruk J, Liu J, Baggerly K, Czerniak B
Hum Pathol 2018 Feb;72:35-44. Epub 2017 Aug 18 doi: 10.1016/j.humpath.2017.08.006. PMID: 28827100Free PMC Article
Bladder urothelial neoplasms in pediatric age: experience at three tertiary centers.
Berrettini A, Castagnetti M, Salerno A, Nappo SG, Manzoni G, Rigamonti W, Caione P
J Pediatr Urol 2015 Feb;11(1):26.e1-5. Epub 2014 Sep 28 doi: 10.1016/j.jpurol.2014.08.008. PMID: 25305695
Natural history of urothelial inverted papilloma.
Sung MT, Maclennan GT, Lopez-Beltran A, Montironi R, Cheng L
Cancer 2006 Dec 1;107(11):2622-7. doi: 10.1002/cncr.22311. PMID: 17078053
Inverted papillomas of the prostatic urethra.
Fine SW, Chan TY, Epstein JI
Am J Surg Pathol 2006 Aug;30(8):975-9. doi: 10.1097/00000478-200608000-00007. PMID: 16861968

Therapy

The prophylaxis of nonindustrial urothelial tumours.
Mount BM
Can Med Assoc J 1973 Jun 23;108(12):1531-2 passim. PMID: 4197537Free PMC Article

Prognosis

Bladder urothelial neoplasms in pediatric age: experience at three tertiary centers.
Berrettini A, Castagnetti M, Salerno A, Nappo SG, Manzoni G, Rigamonti W, Caione P
J Pediatr Urol 2015 Feb;11(1):26.e1-5. Epub 2014 Sep 28 doi: 10.1016/j.jpurol.2014.08.008. PMID: 25305695
Long-term clinical outcome of inverted urothelial papilloma including cases with focal papillary pattern: is continuous surveillance necessary?
Patel P, Reikie BA, Maxwell JP, Yilmaz A, Gotto GT, Trpkov K
Urology 2013 Oct;82(4):857-60. doi: 10.1016/j.urology.2013.06.040. PMID: 24074985
Natural history of urothelial inverted papilloma.
Sung MT, Maclennan GT, Lopez-Beltran A, Montironi R, Cheng L
Cancer 2006 Dec 1;107(11):2622-7. doi: 10.1002/cncr.22311. PMID: 17078053
Inverted papillomas of the prostatic urethra.
Fine SW, Chan TY, Epstein JI
Am J Surg Pathol 2006 Aug;30(8):975-9. doi: 10.1097/00000478-200608000-00007. PMID: 16861968
Upper urinary tract urothelial tumors.
Batata M, Grabstald H
Urol Clin North Am 1976 Feb;3(1):79-86. PMID: 936370

Clinical prediction guides

Carcinoma of the urethra.
Zhang M, Adeniran AJ, Vikram R, Tamboli P, Pettaway C, Bondaruk J, Liu J, Baggerly K, Czerniak B
Hum Pathol 2018 Feb;72:35-44. Epub 2017 Aug 18 doi: 10.1016/j.humpath.2017.08.006. PMID: 28827100Free PMC Article
Inverted papillomas of the prostatic urethra.
Fine SW, Chan TY, Epstein JI
Am J Surg Pathol 2006 Aug;30(8):975-9. doi: 10.1097/00000478-200608000-00007. PMID: 16861968
Histology and histogenesis of two different types of inverted urothelial papillomas.
Kunze E, Schauer A, Schmitt M
Cancer 1983 Jan 15;51(2):348-58. doi: 10.1002/1097-0142(19830115)51:2<348::aid-cncr2820510231>3.0.co;2-o. PMID: 6821821

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