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Benign urinary system neoplasm

MedGen UID:
146348
•Concept ID:
C0686167
•
Neoplastic Process
Synonyms: benign neoplasm of the urinary tract; Benign neoplasm of urinary system; Benign neoplasm of urinary tract; benign neoplasm of urinary tract; benign tumor of the urinary tract; Benign tumor of urinary tract; benign tumor of urinary tract; benign tumour of the urinary tract; benign tumour of urinary tract; Benign Urinary System Neoplasm; benign urinary system neoplasm; Benign Urinary System Tumor; benign urinary tract neoplasm; benign urinary tract tumor; benign urinary tract tumour; renal system benign neoplasm; urinary system benign neoplasm
SNOMED CT: Benign tumor of urinary tract (92468007); Benign neoplasm of urinary system (92468007); Benign neoplasm of urinary tract (92468007)
 
Monarch Initiative: MONDO:0004180

Definition

A neoplasm that arises from the organs that comprise the urinary system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Evaluation and management of urethral and periurethral masses in women.
Zuo SW, Napoe GS
Curr Opin Obstet Gynecol 2023 Dec 1;35(6):517-524. Epub 2023 Aug 29 doi: 10.1097/GCO.0000000000000914. PMID: 37678190
Nephrogenic Adenoma: Clinical Features, Management, and Diagnostic Pitfalls.
Gordetsky J, Gennaro KH, Selph JP, Rais-Bahrami S
Urology 2016 Sep;95:29-33. Epub 2016 Apr 29 doi: 10.1016/j.urology.2016.04.032. PMID: 27138263
Update on the Diagnosis and Management of Renal Angiomyolipoma.
Flum AS, Hamoui N, Said MA, Yang XJ, Casalino DD, McGuire BB, Perry KT, Nadler RB
J Urol 2016 Apr;195(4 Pt 1):834-46. Epub 2015 Nov 21 doi: 10.1016/j.juro.2015.07.126. PMID: 26612197

Recent clinical studies

Etiology

Global burden of benign prostatic hyperplasia, urinary tract infections, urolithiasis, bladder cancer, kidney cancer, and prostate cancer from 1990 to 2021.
Zi H, Liu MY, Luo LS, Huang Q, Luo PC, Luan HH, Huang J, Wang DQ, Wang YB, Zhang YY, Yu RP, Li YT, Zheng H, Liu TZ, Fan Y, Zeng XT
Mil Med Res 2024 Sep 18;11(1):64. doi: 10.1186/s40779-024-00569-w. PMID: 39294748Free PMC Article
Children's Oncology Group's 2023 blueprint for research: Renal tumors.
Geller JI, Hong AL, Vallance KL, Evageliou N, Aldrink JH, Cost NG, Treece AL, Renfro LA, Mullen EA; COG Renal Tumor Committee
Pediatr Blood Cancer 2023 Sep;70 Suppl 6(Suppl 6):e30586. Epub 2023 Jul 21 doi: 10.1002/pbc.30586. PMID: 37477907Free PMC Article
Hematuria.
Peterson LM, Reed HS
Prim Care 2019 Jun;46(2):265-273. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.008. PMID: 31030828
Neonatal renal tumours.
Powis M
Early Hum Dev 2010 Oct;86(10):607-12. doi: 10.1016/j.earlhumdev.2010.08.018. PMID: 20888153
Imaging of angiomyolipomas.
Lemaitre L, Claudon M, Dubrulle F, Mazeman E
Semin Ultrasound CT MR 1997 Apr;18(2):100-14. doi: 10.1016/s0887-2171(97)90054-8. PMID: 9163829

Diagnosis

Global burden of benign prostatic hyperplasia, urinary tract infections, urolithiasis, bladder cancer, kidney cancer, and prostate cancer from 1990 to 2021.
Zi H, Liu MY, Luo LS, Huang Q, Luo PC, Luan HH, Huang J, Wang DQ, Wang YB, Zhang YY, Yu RP, Li YT, Zheng H, Liu TZ, Fan Y, Zeng XT
Mil Med Res 2024 Sep 18;11(1):64. doi: 10.1186/s40779-024-00569-w. PMID: 39294748Free PMC Article
Comprehensive proteogenomic characterization of rare kidney tumors.
Li GX, Chen L, Hsiao Y, Mannan R, Zhang Y, Luo J, Petralia F, Cho H, Hosseini N, Leprevost FDV, Calinawan A, Li Y, Anand S, Dagar A, Geffen Y, Kumar-Sinha C, Chugh S, Le A, Ponce S, Guo S, Zhang C, Schnaubelt M, Al Deen NN, Chen F, Caravan W, Houston A, Hopkins A, Newton CJ, Wang X, Polasky DA, Haynes S, Yu F, Jing X, Chen S, Robles AI, Mesri M, Thiagarajan M, An E, Getz GA, Linehan WM, Hostetter G, Jewell SD, Chan DW, Wang P, Omenn GS, Mehra R, Ricketts CJ, Ding L, Chinnaiyan AM, Cieslik MP, Dhanasekaran SM, Zhang H, Nesvizhskii AI; Clinical Proteomic Tumor Analysis Consortium
Cell Rep Med 2024 May 21;5(5):101547. Epub 2024 May 3 doi: 10.1016/j.xcrm.2024.101547. PMID: 38703764Free PMC Article
Hematuria.
Peterson LM, Reed HS
Prim Care 2019 Jun;46(2):265-273. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.008. PMID: 31030828
Neonatal renal tumours.
Powis M
Early Hum Dev 2010 Oct;86(10):607-12. doi: 10.1016/j.earlhumdev.2010.08.018. PMID: 20888153
Nephrogenic adenoma.
Amin W, Parwani AV
Pathol Res Pract 2010 Oct 15;206(10):659-62. Epub 2010 Jul 8 doi: 10.1016/j.prp.2010.06.001. PMID: 20619548

Therapy

Granular cell tumors of the urethra.
Evmorfopoulos K, Tzortzis V, Vlachostergios PJ
Cancer Treat Res Commun 2023;35:100695. Epub 2023 Mar 17 doi: 10.1016/j.ctarc.2023.100695. PMID: 36940531
Role of α- and β-adrenergic signaling in phenotypic targeting: significance in benign and malignant urologic disease.
Archer M, Dogra N, Dovey Z, Ganta T, Jang HS, Khusid JA, Lantz A, Mihalopoulos M, Stockert JA, Zahalka A, Björnebo L, Gaglani S, Noh MR, Kaplan SA, Mehrazin R, Badani KK, Wiklund P, Tsao K, Lundon DJ, Mohamed N, Lucien F, Padanilam B, Gupta M, Tewari AK, Kyprianou N
Cell Commun Signal 2021 Jul 20;19(1):78. doi: 10.1186/s12964-021-00755-6. PMID: 34284799Free PMC Article
Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response.
Zhang Y, Narayanan SP, Mannan R, Raskind G, Wang X, Vats P, Su F, Hosseini N, Cao X, Kumar-Sinha C, Ellison SJ, Giordano TJ, Morgan TM, Pitchiaya S, Alva A, Mehra R, Cieslik M, Dhanasekaran SM, Chinnaiyan AM
Proc Natl Acad Sci U S A 2021 Jun 15;118(24) doi: 10.1073/pnas.2103240118. PMID: 34099557Free PMC Article
Urinary biomarkers in bladder cancer: A review of the current landscape and future directions.
Ng K, Stenzl A, Sharma A, Vasdev N
Urol Oncol 2021 Jan;39(1):41-51. Epub 2020 Sep 9 doi: 10.1016/j.urolonc.2020.08.016. PMID: 32919875
Should Small Renal Masses Be Biopsied?
Leão RR, Ahmad AE, Richard PO
Curr Urol Rep 2017 Jan;18(1):7. doi: 10.1007/s11934-017-0653-3. PMID: 28188595

Prognosis

Global burden of benign prostatic hyperplasia, urinary tract infections, urolithiasis, bladder cancer, kidney cancer, and prostate cancer from 1990 to 2021.
Zi H, Liu MY, Luo LS, Huang Q, Luo PC, Luan HH, Huang J, Wang DQ, Wang YB, Zhang YY, Yu RP, Li YT, Zheng H, Liu TZ, Fan Y, Zeng XT
Mil Med Res 2024 Sep 18;11(1):64. doi: 10.1186/s40779-024-00569-w. PMID: 39294748Free PMC Article
Comprehensive proteogenomic characterization of rare kidney tumors.
Li GX, Chen L, Hsiao Y, Mannan R, Zhang Y, Luo J, Petralia F, Cho H, Hosseini N, Leprevost FDV, Calinawan A, Li Y, Anand S, Dagar A, Geffen Y, Kumar-Sinha C, Chugh S, Le A, Ponce S, Guo S, Zhang C, Schnaubelt M, Al Deen NN, Chen F, Caravan W, Houston A, Hopkins A, Newton CJ, Wang X, Polasky DA, Haynes S, Yu F, Jing X, Chen S, Robles AI, Mesri M, Thiagarajan M, An E, Getz GA, Linehan WM, Hostetter G, Jewell SD, Chan DW, Wang P, Omenn GS, Mehra R, Ricketts CJ, Ding L, Chinnaiyan AM, Cieslik MP, Dhanasekaran SM, Zhang H, Nesvizhskii AI; Clinical Proteomic Tumor Analysis Consortium
Cell Rep Med 2024 May 21;5(5):101547. Epub 2024 May 3 doi: 10.1016/j.xcrm.2024.101547. PMID: 38703764Free PMC Article
AI-powered radiomics: revolutionizing detection of urologic malignancies.
Gelikman DG, Rais-Bahrami S, Pinto PA, Turkbey B
Curr Opin Urol 2024 Jan 1;34(1):1-7. Epub 2023 Nov 1 doi: 10.1097/MOU.0000000000001144. PMID: 37909882Free PMC Article
Acrometastasis: a literature review.
Stomeo D, Tulli A, Ziranu A, Perisano C, De Santis V, Maccauro G
Eur Rev Med Pharmacol Sci 2015 Aug;19(15):2906-15. PMID: 26241547
Nephrogenic adenoma.
Amin W, Parwani AV
Pathol Res Pract 2010 Oct 15;206(10):659-62. Epub 2010 Jul 8 doi: 10.1016/j.prp.2010.06.001. PMID: 20619548

Clinical prediction guides

Comprehensive proteogenomic characterization of rare kidney tumors.
Li GX, Chen L, Hsiao Y, Mannan R, Zhang Y, Luo J, Petralia F, Cho H, Hosseini N, Leprevost FDV, Calinawan A, Li Y, Anand S, Dagar A, Geffen Y, Kumar-Sinha C, Chugh S, Le A, Ponce S, Guo S, Zhang C, Schnaubelt M, Al Deen NN, Chen F, Caravan W, Houston A, Hopkins A, Newton CJ, Wang X, Polasky DA, Haynes S, Yu F, Jing X, Chen S, Robles AI, Mesri M, Thiagarajan M, An E, Getz GA, Linehan WM, Hostetter G, Jewell SD, Chan DW, Wang P, Omenn GS, Mehra R, Ricketts CJ, Ding L, Chinnaiyan AM, Cieslik MP, Dhanasekaran SM, Zhang H, Nesvizhskii AI; Clinical Proteomic Tumor Analysis Consortium
Cell Rep Med 2024 May 21;5(5):101547. Epub 2024 May 3 doi: 10.1016/j.xcrm.2024.101547. PMID: 38703764Free PMC Article
Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response.
Zhang Y, Narayanan SP, Mannan R, Raskind G, Wang X, Vats P, Su F, Hosseini N, Cao X, Kumar-Sinha C, Ellison SJ, Giordano TJ, Morgan TM, Pitchiaya S, Alva A, Mehra R, Cieslik M, Dhanasekaran SM, Chinnaiyan AM
Proc Natl Acad Sci U S A 2021 Jun 15;118(24) doi: 10.1073/pnas.2103240118. PMID: 34099557Free PMC Article
Urinary biomarkers in bladder cancer: A review of the current landscape and future directions.
Ng K, Stenzl A, Sharma A, Vasdev N
Urol Oncol 2021 Jan;39(1):41-51. Epub 2020 Sep 9 doi: 10.1016/j.urolonc.2020.08.016. PMID: 32919875
Pathomics in urology.
Schuettfort VM, Pradere B, Rink M, Comperat E, Shariat SF
Curr Opin Urol 2020 Nov;30(6):823-831. doi: 10.1097/MOU.0000000000000813. PMID: 32881725
Should Small Renal Masses Be Biopsied?
Leão RR, Ahmad AE, Richard PO
Curr Urol Rep 2017 Jan;18(1):7. doi: 10.1007/s11934-017-0653-3. PMID: 28188595

Recent systematic reviews

Cancer Metastases to the Hand: A Systematic Review and Meta-analysis.
Dow T, Davis C, ElAbd R, Lalonde D, Williams J
Hand (N Y) 2024 Sep;19(6):865-874. Epub 2023 Mar 1 doi: 10.1177/15589447231153175. PMID: 36856295Free PMC Article
Diagnostic Imaging in the Evaluation of Asymptomatic Microhematuria: Systematic Review and Meta-analysis.
Taylor JI, Souter LH, Barocas DA, Boorjian SA, Raman JD, Lotan Y
J Urol 2023 Jun;209(6):1099-1106. Epub 2023 Mar 8 doi: 10.1097/JU.0000000000003395. PMID: 36883858
Quality Indicators in the Clinical Specialty of Urology: A Systematic Review.
Koh HJW, Whitelock-Wainwright E, Gasevic D, Rankin D, Romero L, Frydenberg M, Evans S, Talic S
Eur Urol Focus 2023 May;9(3):435-446. Epub 2022 Dec 26 doi: 10.1016/j.euf.2022.12.004. PMID: 36577611
Urinary microbiota and prostatic diseases: the key for the lock? A systematic review.
Mjaess G, Karam A, Roumeguère T, Diamand R, Aoun F, McVary K, Moul JW, De Nunzio C, Albisinni S
Prostate Cancer Prostatic Dis 2023 Sep;26(3):451-460. Epub 2022 Oct 8 doi: 10.1038/s41391-022-00602-w. PMID: 36209236
Gender differences in benign renal masses.
Mauermann J, de Martino M, Waldert M, Haitel A, Klingler HC, Remzi M, Klatte T
World J Urol 2013 Oct;31(5):1051-7. Epub 2013 Feb 16 doi: 10.1007/s00345-013-1032-4. PMID: 23417319

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