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Ovarian clear cell cancer

MedGen UID:
276544
•Concept ID:
C1518230
•
Neoplastic Process
Synonyms: clear-cell ovarian carcinoma; Malignant Ovarian Clear Cell Neoplasm; malignant ovarian clear cell neoplasm; Malignant Ovarian Clear Cell Tumor; malignant ovarian clear cell tumor; malignant ovarian clear cell tumour; ovarian clear cell cancer; ovarian clear cell carcinoma
 
Monarch Initiative: MONDO:0000548

Definition

An invasive malignant neoplasm that arises from the ovary and is characterized by a predominance of clear and hobnail malignant epithelial cells. [from NCI]

Professional guidelines

PubMed

Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of ovarian clear cell cancer.
Wilkerson PM, Dedes KJ, Samartzis EP, Dedes I, Lambros MB, Natrajan R, Gauthier A, Piscuoglio S, Töpfer C, Vukovic V, Daley F, Weigelt B, Reis-Filho JS
Oncotarget 2017 Jan 24;8(4):6057-6066. doi: 10.18632/oncotarget.14011. PMID: 28002809Free PMC Article
Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.
Hampras SS, Sucheston-Campbell LE, Cannioto R, Chang-Claude J, Modugno F, Dörk T, Hillemanns P, Preus L, Knutson KL, Wallace PK, Hong CC, Friel G, Davis W, Nesline M, Pearce CL, Kelemen LE, Goodman MT, Bandera EV, Terry KL, Schoof N, Eng KH, Clay A, Singh PK, Joseph JM, Aben KK, Anton-Culver H, Antonenkova N, Baker H, Bean Y, Beckmann MW, Bisogna M, Bjorge L, Bogdanova N, Brinton LA, Brooks-Wilson A, Bruinsma F, Butzow R, Campbell IG, Carty K, Cook LS, Cramer DW, Cybulski C, Dansonka-Mieszkowska A, Dennis J, Despierre E, Dicks E, Doherty JA, du Bois A, Dürst M, Easton D, Eccles D, Edwards RP, Ekici AB, Fasching PA, Fridley BL, Gao YT, Gentry-Maharaj A, Giles GG, Glasspool R, Gronwald J, Harrington P, Harter P, Hasmad HN, Hein A, Heitz F, Hildebrandt MA, Hogdall C, Hogdall E, Hosono S, Iversen ES, Jakubowska A, Jensen A, Ji BT, Karlan BY, Kellar M, Kelley JL, Kiemeney LA, Klapdor R, Kolomeyevskaya N, Krakstad C, Kjaer SK, Kruszka B, Kupryjanczyk J, Lambrechts D, Lambrechts S, Le ND, Lee AW, Lele S, Leminen A, Lester J, Levine DA, Liang D, Lissowska J, Liu S, Lu K, Lubinski J, Lundvall L, Massuger LF, Matsuo K, McGuire V, McLaughlin JR, McNeish I, Menon U, Moes-Sosnowska J, Narod SA, Nedergaard L, Nevanlinna H, Nickels S, Olson SH, Orlow I, Weber RP, Paul J, Pejovic T, Pelttari LM, Perkins B, Permuth-Wey J, Pike MC, Plisiecka-Halasa J, Poole EM, Risch HA, Rossing MA, Rothstein JH, Rudolph A, Runnebaum IB, Rzepecka IK, Salvesen HB, Schernhammer E, Schmitt K, Schwaab I, Shu XO, Shvetsov YB, Siddiqui N, Sieh W, Song H, Southey MC, Tangen IL, Teo SH, Thompson PJ, Timorek A, Tsai YY, Tworoger SS, Tyrer J, van Altena AM, Vergote I, Vierkant RA, Walsh C, Wang-Gohrke S, Wentzensen N, Whittemore AS, Wicklund KG, Wilkens LR, Wu AH, Wu X, Woo YL, Yang H, Zheng W, Ziogas A, Gayther SA, Ramus SJ, Sellers TA, Schildkraut JM, Phelan CM, Berchuck A, Chenevix-Trench G, Cunningham JM, Pharoah PP, Ness RB, Odunsi K, Goode EL, Moysich KB
Oncotarget 2016 Oct 25;7(43):69097-69110. doi: 10.18632/oncotarget.10215. PMID: 27533245Free PMC Article
Treatment issues in clear cell carcinoma of the ovary: a different entity?
Pectasides D, Pectasides E, Psyrri A, Economopoulos T
Oncologist 2006 Nov-Dec;11(10):1089-94. doi: 10.1634/theoncologist.11-10-1089. PMID: 17110628

Recent clinical studies

Etiology

Ovarian clear cell cancer associated with Trousseau syndrome: A case report and literature review.
You Y, Chen X, Jiang Y, Cheng W
Medicine (Baltimore) 2022 Nov 25;101(47):e32106. doi: 10.1097/MD.0000000000032106. PMID: 36451485Free PMC Article
Utility of adjuvant whole abdominal radiation therapy in ovarian clear cell cancer (OCCC): a pragmatic cohort study of women with classic immuno-phenotypic signature.
Stevens MJ, West S, Gard G, Renaud C, Nevell D, Roderick S, Le A
Radiat Oncol 2021 Feb 6;16(1):29. doi: 10.1186/s13014-021-01750-4. PMID: 33549120Free PMC Article
Serum D-dimer, albumin and systemic inflammatory response markers in ovarian clear cell carcinoma and their prognostic implications.
Chen W, Zhong S, Shan B, Zhou S, Wu X, Yang H, Ye S
J Ovarian Res 2020 Aug 8;13(1):89. doi: 10.1186/s13048-020-00693-w. PMID: 32771026Free PMC Article
Spontaneous arterial thrombosis in a patient with advanced ovarian clear cell cancer: a case report and literature review.
Chen J, Sun H, Wu M, Zhong X, Zhang Y
J Int Med Res 2020 Jun;48(6):300060520926742. doi: 10.1177/0300060520926742. PMID: 32485125Free PMC Article
IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer.
Anglesio MS, George J, Kulbe H, Friedlander M, Rischin D, Lemech C, Power J, Coward J, Cowin PA, House CM, Chakravarty P, Gorringe KL, Campbell IG; Australian Ovarian Cancer Study Group, Okamoto A, Birrer MJ, Huntsman DG, de Fazio A, Kalloger SE, Balkwill F, Gilks CB, Bowtell DD
Clin Cancer Res 2011 Apr 15;17(8):2538-48. Epub 2011 Feb 22 doi: 10.1158/1078-0432.CCR-10-3314. PMID: 21343371

Diagnosis

Ovarian clear cell cancer associated with Trousseau syndrome: A case report and literature review.
You Y, Chen X, Jiang Y, Cheng W
Medicine (Baltimore) 2022 Nov 25;101(47):e32106. doi: 10.1097/MD.0000000000032106. PMID: 36451485Free PMC Article
Altered cervicovaginal microbiota in premenopausal ovarian cancer patients.
Morikawa A, Kawabata A, Shirahige K, Akiyama T, Okamoto A, Sutani T
Gene 2022 Feb 15;811:146083. Epub 2021 Nov 29 doi: 10.1016/j.gene.2021.146083. PMID: 34856363
Utility of adjuvant whole abdominal radiation therapy in ovarian clear cell cancer (OCCC): a pragmatic cohort study of women with classic immuno-phenotypic signature.
Stevens MJ, West S, Gard G, Renaud C, Nevell D, Roderick S, Le A
Radiat Oncol 2021 Feb 6;16(1):29. doi: 10.1186/s13014-021-01750-4. PMID: 33549120Free PMC Article
Serum D-dimer, albumin and systemic inflammatory response markers in ovarian clear cell carcinoma and their prognostic implications.
Chen W, Zhong S, Shan B, Zhou S, Wu X, Yang H, Ye S
J Ovarian Res 2020 Aug 8;13(1):89. doi: 10.1186/s13048-020-00693-w. PMID: 32771026Free PMC Article
Phenoxodiol Increases Cisplatin Sensitivity in Ovarian Clear Cancer Cells Through XIAP Down-regulation and Autophagy Inhibition.
Miyamoto M, Takano M, Aoyama T, Soyama H, Ishibashi H, Kato K, Iwahashi H, Takasaki K, Kuwahara M, Matuura H, Sakamoto T, Yoshikawa T, Furuya K
Anticancer Res 2018 Jan;38(1):301-306. doi: 10.21873/anticanres.12222. PMID: 29277787

Therapy

Liposomal DQ in Combination with Copper Inhibits ARID1A Mutant Ovarian Cancer Growth.
Kang X, Wang Q, Wu S, Wang C, Annaji M, Huang CH, Shen J, Chen P, Babu RJ
Biomolecules 2023 Apr 25;13(5) doi: 10.3390/biom13050744. PMID: 37238613Free PMC Article
Serum D-dimer, albumin and systemic inflammatory response markers in ovarian clear cell carcinoma and their prognostic implications.
Chen W, Zhong S, Shan B, Zhou S, Wu X, Yang H, Ye S
J Ovarian Res 2020 Aug 8;13(1):89. doi: 10.1186/s13048-020-00693-w. PMID: 32771026Free PMC Article
Spontaneous arterial thrombosis in a patient with advanced ovarian clear cell cancer: a case report and literature review.
Chen J, Sun H, Wu M, Zhong X, Zhang Y
J Int Med Res 2020 Jun;48(6):300060520926742. doi: 10.1177/0300060520926742. PMID: 32485125Free PMC Article
Adjuvant chemotherapy in patients with stage I endometrioid or clear cell ovarian cancer in the platinum era: a Surveillance, Epidemiology, and End Results Cohort Study, 2000-2013.
Oseledchyk A, Leitao MM Jr, Konner J, O'Cearbhaill RE, Zamarin D, Sonoda Y, Gardner GJ, Long Roche K, Aghajanian CA, Grisham RN, Brown CL, Snyder A, Chi DS, Soslow RA, Abu-Rustum NR, Zivanovic O
Ann Oncol 2017 Dec 1;28(12):2985-2993. doi: 10.1093/annonc/mdx525. PMID: 28950307Free PMC Article
IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer.
Anglesio MS, George J, Kulbe H, Friedlander M, Rischin D, Lemech C, Power J, Coward J, Cowin PA, House CM, Chakravarty P, Gorringe KL, Campbell IG; Australian Ovarian Cancer Study Group, Okamoto A, Birrer MJ, Huntsman DG, de Fazio A, Kalloger SE, Balkwill F, Gilks CB, Bowtell DD
Clin Cancer Res 2011 Apr 15;17(8):2538-48. Epub 2011 Feb 22 doi: 10.1158/1078-0432.CCR-10-3314. PMID: 21343371

Prognosis

Ovarian clear cell cancer associated with Trousseau syndrome: A case report and literature review.
You Y, Chen X, Jiang Y, Cheng W
Medicine (Baltimore) 2022 Nov 25;101(47):e32106. doi: 10.1097/MD.0000000000032106. PMID: 36451485Free PMC Article
Utility of adjuvant whole abdominal radiation therapy in ovarian clear cell cancer (OCCC): a pragmatic cohort study of women with classic immuno-phenotypic signature.
Stevens MJ, West S, Gard G, Renaud C, Nevell D, Roderick S, Le A
Radiat Oncol 2021 Feb 6;16(1):29. doi: 10.1186/s13014-021-01750-4. PMID: 33549120Free PMC Article
Serum D-dimer, albumin and systemic inflammatory response markers in ovarian clear cell carcinoma and their prognostic implications.
Chen W, Zhong S, Shan B, Zhou S, Wu X, Yang H, Ye S
J Ovarian Res 2020 Aug 8;13(1):89. doi: 10.1186/s13048-020-00693-w. PMID: 32771026Free PMC Article
Adjuvant chemotherapy in patients with stage I endometrioid or clear cell ovarian cancer in the platinum era: a Surveillance, Epidemiology, and End Results Cohort Study, 2000-2013.
Oseledchyk A, Leitao MM Jr, Konner J, O'Cearbhaill RE, Zamarin D, Sonoda Y, Gardner GJ, Long Roche K, Aghajanian CA, Grisham RN, Brown CL, Snyder A, Chi DS, Soslow RA, Abu-Rustum NR, Zivanovic O
Ann Oncol 2017 Dec 1;28(12):2985-2993. doi: 10.1093/annonc/mdx525. PMID: 28950307Free PMC Article
Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of ovarian clear cell cancer.
Wilkerson PM, Dedes KJ, Samartzis EP, Dedes I, Lambros MB, Natrajan R, Gauthier A, Piscuoglio S, Töpfer C, Vukovic V, Daley F, Weigelt B, Reis-Filho JS
Oncotarget 2017 Jan 24;8(4):6057-6066. doi: 10.18632/oncotarget.14011. PMID: 28002809Free PMC Article

Clinical prediction guides

Noncanonical IL6 Signaling-Mediated Activation of YAP Regulates Cell Migration and Invasion in Ovarian Clear Cell Cancer.
Azar WJ, Christie EL, Mitchell C, Liu DS, Au-Yeung G, Bowtell DDL
Cancer Res 2020 Nov 15;80(22):4960-4971. Epub 2020 Sep 11 doi: 10.1158/0008-5472.CAN-19-3044. PMID: 32917727
Serum D-dimer, albumin and systemic inflammatory response markers in ovarian clear cell carcinoma and their prognostic implications.
Chen W, Zhong S, Shan B, Zhou S, Wu X, Yang H, Ye S
J Ovarian Res 2020 Aug 8;13(1):89. doi: 10.1186/s13048-020-00693-w. PMID: 32771026Free PMC Article
ARID1A mutation sensitizes most ovarian clear cell carcinomas to BET inhibitors.
Berns K, Caumanns JJ, Hijmans EM, Gennissen AMC, Severson TM, Evers B, Wisman GBA, Jan Meersma G, Lieftink C, Beijersbergen RL, Itamochi H, van der Zee AGJ, de Jong S, Bernards R
Oncogene 2018 Aug;37(33):4611-4625. Epub 2018 May 15 doi: 10.1038/s41388-018-0300-6. PMID: 29760405Free PMC Article
Adjuvant chemotherapy in patients with stage I endometrioid or clear cell ovarian cancer in the platinum era: a Surveillance, Epidemiology, and End Results Cohort Study, 2000-2013.
Oseledchyk A, Leitao MM Jr, Konner J, O'Cearbhaill RE, Zamarin D, Sonoda Y, Gardner GJ, Long Roche K, Aghajanian CA, Grisham RN, Brown CL, Snyder A, Chi DS, Soslow RA, Abu-Rustum NR, Zivanovic O
Ann Oncol 2017 Dec 1;28(12):2985-2993. doi: 10.1093/annonc/mdx525. PMID: 28950307Free PMC Article
Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of ovarian clear cell cancer.
Wilkerson PM, Dedes KJ, Samartzis EP, Dedes I, Lambros MB, Natrajan R, Gauthier A, Piscuoglio S, Töpfer C, Vukovic V, Daley F, Weigelt B, Reis-Filho JS
Oncotarget 2017 Jan 24;8(4):6057-6066. doi: 10.18632/oncotarget.14011. PMID: 28002809Free PMC Article

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