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Ovarian Sertoli-Leydig Cell Tumor with Heterologous Elements

MedGen UID:
276671
•Concept ID:
C1518730
•
Neoplastic Process

Definition

A Sertoli-Leydig cell tumor that arises from the ovary. It is characterized by the presence of epithelial and/or mesenchymal components and neoplasms that arise from these components. [from NCI]

Professional guidelines

PubMed

Management of early ovarian cancer: germ cell and sex cord-stromal tumors.
Gershenson DM
Gynecol Oncol 1994 Dec;55(3 Pt 2):S62-72. PMID: 7530680

Recent clinical studies

Etiology

Outcomes in ovarian Sertoli-Leydig cell tumor: A report from the International Pleuropulmonary Blastoma/DICER1 and Ovarian and Testicular Stromal Tumor Registries.
Nelson AT, Harris AK, Watson D, Kamihara J, Chen KS, Stall JN, Devins KM, Young RH, Olson DR, Mallinger PHR, Mitchell SG, Hoffman LM, Halliday G, Suleymanova AM, Glade Bender JL, Messinger YH, Herzog CE, Field AL, Frazier AL, Stewart DR, Dehner LP, Hill DA, Billmire DF, Schneider DT, Schultz KAP
Gynecol Oncol 2024 Jul;186:117-125. Epub 2024 Apr 23 doi: 10.1016/j.ygyno.2024.04.005. PMID: 38657450Free PMC Article
Pediatric ovarian Sertoli-Leydig cell tumors with heterologous rhabdomyosarcoma elements: Clinical case series and review of the literature.
Koo J, Garrington TP, Kerr K, Treece AL, Cost CR
Pediatr Blood Cancer 2020 Oct;67(10):e28621. Epub 2020 Jul 30 doi: 10.1002/pbc.28621. PMID: 32729194
Ovarian Sertoli-Leydig cell tumors: an analysis of 13 cases.
Guo Y, Wang J, Li Y, Wang Y
Arch Gynecol Obstet 2020 Jul;302(1):203-208. Epub 2020 May 19 doi: 10.1007/s00404-020-05588-1. PMID: 32430758
Sertoli-Leydig cell tumor of the ovary: Analysis of a single institution database and review of the literature.
Durmuş Y, Kılıç Ç, Çakır C, Yüksel D, Boran N, Karalök A, Boyraz G, Turan AT
J Obstet Gynaecol Res 2019 Jul;45(7):1311-1318. Epub 2019 May 20 doi: 10.1111/jog.13977. PMID: 31106943
Ovarian Sertoli-Leydig Cell Tumor With Heterologous Hepatocytes and a Hepatocellular Carcinomatous Element.
Yamamoto S, Sakai Y
Int J Gynecol Pathol 2019 May;38(3):247-252. doi: 10.1097/PGP.0000000000000499. PMID: 29620585

Diagnosis

Outcomes in ovarian Sertoli-Leydig cell tumor: A report from the International Pleuropulmonary Blastoma/DICER1 and Ovarian and Testicular Stromal Tumor Registries.
Nelson AT, Harris AK, Watson D, Kamihara J, Chen KS, Stall JN, Devins KM, Young RH, Olson DR, Mallinger PHR, Mitchell SG, Hoffman LM, Halliday G, Suleymanova AM, Glade Bender JL, Messinger YH, Herzog CE, Field AL, Frazier AL, Stewart DR, Dehner LP, Hill DA, Billmire DF, Schneider DT, Schultz KAP
Gynecol Oncol 2024 Jul;186:117-125. Epub 2024 Apr 23 doi: 10.1016/j.ygyno.2024.04.005. PMID: 38657450Free PMC Article
Ovarian Sertoli-Leydig cell tumors: an analysis of 13 cases.
Guo Y, Wang J, Li Y, Wang Y
Arch Gynecol Obstet 2020 Jul;302(1):203-208. Epub 2020 May 19 doi: 10.1007/s00404-020-05588-1. PMID: 32430758
Sertoli-Leydig cell tumor of the ovary: Analysis of a single institution database and review of the literature.
Durmuş Y, Kılıç Ç, Çakır C, Yüksel D, Boran N, Karalök A, Boyraz G, Turan AT
J Obstet Gynaecol Res 2019 Jul;45(7):1311-1318. Epub 2019 May 20 doi: 10.1111/jog.13977. PMID: 31106943
Ovarian sertoli-leydig cell tumors: A multicenter long-term clinicopathological analysis of 27 patients.
Akman L, Ertas IE, Gokcu M, Terek MC, Sanci M, Sanli UA, Zekioglu O, Ozsaran AA
J Cancer Res Ther 2016 Jan-Mar;12(1):290-4. doi: 10.4103/0973-1482.158037. PMID: 27072253
Ovarian Sertoli-Leydig Cell Tumor with Predominant Heterologous Mucinous Differentiation and Foci of Hepatocytic Differentiation: Case Report and Review of The Literature.
Liang L, Menzin A, Lovecchio JL, Navarro MD
Ann Clin Lab Sci 2015 Spring;45(3):348-51. PMID: 26116602

Therapy

Ovarian Sertoli-Leydig Cell Tumor With Heterologous Hepatocytes and a Hepatocellular Carcinomatous Element.
Yamamoto S, Sakai Y
Int J Gynecol Pathol 2019 May;38(3):247-252. doi: 10.1097/PGP.0000000000000499. PMID: 29620585
Ovarian sertoli-leydig cell tumors: A multicenter long-term clinicopathological analysis of 27 patients.
Akman L, Ertas IE, Gokcu M, Terek MC, Sanci M, Sanli UA, Zekioglu O, Ozsaran AA
J Cancer Res Ther 2016 Jan-Mar;12(1):290-4. doi: 10.4103/0973-1482.158037. PMID: 27072253
A clinicopathological analysis of 40 cases of ovarian Sertoli-Leydig cell tumors.
Gui T, Cao D, Shen K, Yang J, Zhang Y, Yu Q, Wan X, Xiang Y, Xiao Y, Guo L
Gynecol Oncol 2012 Nov;127(2):384-9. Epub 2012 Jul 28 doi: 10.1016/j.ygyno.2012.07.114. PMID: 22850410
Chemotherapy of ovarian germ cell tumors and sex cord stromal tumors.
Gershenson DM
Semin Surg Oncol 1994 Jul-Aug;10(4):290-8. doi: 10.1002/ssu.2980100410. PMID: 8091071
Management of early ovarian cancer: germ cell and sex cord-stromal tumors.
Gershenson DM
Gynecol Oncol 1994 Dec;55(3 Pt 2):S62-72. PMID: 7530680

Prognosis

Outcomes in ovarian Sertoli-Leydig cell tumor: A report from the International Pleuropulmonary Blastoma/DICER1 and Ovarian and Testicular Stromal Tumor Registries.
Nelson AT, Harris AK, Watson D, Kamihara J, Chen KS, Stall JN, Devins KM, Young RH, Olson DR, Mallinger PHR, Mitchell SG, Hoffman LM, Halliday G, Suleymanova AM, Glade Bender JL, Messinger YH, Herzog CE, Field AL, Frazier AL, Stewart DR, Dehner LP, Hill DA, Billmire DF, Schneider DT, Schultz KAP
Gynecol Oncol 2024 Jul;186:117-125. Epub 2024 Apr 23 doi: 10.1016/j.ygyno.2024.04.005. PMID: 38657450Free PMC Article
Pediatric ovarian Sertoli-Leydig cell tumors with heterologous rhabdomyosarcoma elements: Clinical case series and review of the literature.
Koo J, Garrington TP, Kerr K, Treece AL, Cost CR
Pediatr Blood Cancer 2020 Oct;67(10):e28621. Epub 2020 Jul 30 doi: 10.1002/pbc.28621. PMID: 32729194
Ovarian Sertoli-Leydig cell tumors: an analysis of 13 cases.
Guo Y, Wang J, Li Y, Wang Y
Arch Gynecol Obstet 2020 Jul;302(1):203-208. Epub 2020 May 19 doi: 10.1007/s00404-020-05588-1. PMID: 32430758
Ovarian sertoli-leydig cell tumors: A multicenter long-term clinicopathological analysis of 27 patients.
Akman L, Ertas IE, Gokcu M, Terek MC, Sanci M, Sanli UA, Zekioglu O, Ozsaran AA
J Cancer Res Ther 2016 Jan-Mar;12(1):290-4. doi: 10.4103/0973-1482.158037. PMID: 27072253
Ovarian Sertoli-Leydig cell tumors. A clinicopathological analysis of 207 cases.
Young RH, Scully RE
Am J Surg Pathol 1985 Aug;9(8):543-69. doi: 10.1097/00000478-198508000-00001. PMID: 3911780

Clinical prediction guides

Ovarian Sex Cord-Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD.
Young RH
Arch Pathol Lab Med 2018 Dec;142(12):1459-1484. doi: 10.5858/arpa.2018-0291-RA. PMID: 30500284
Sertoli - Leydig cell tumor with retiform areas and overgrowth of rhabdomyosarcomatous elements: case report and literature review.
Burnik Papler T, Frković Grazio S, Kobal B
J Ovarian Res 2016 Jul 30;9(1):46. doi: 10.1186/s13048-016-0257-4. PMID: 27473538Free PMC Article
Immunohistochemical and ultrastructural analysis of a poorly differentiated pediatric age Sertoli-Leydig cell tumor.
Sun X, Hawkins H, Castro CY, Eltorky MA
Exp Mol Pathol 2007 Feb;82(1):63-7. Epub 2006 Oct 4 doi: 10.1016/j.yexmp.2006.08.001. PMID: 17022971
Retiform Sertoli-Leydig cell tumours: clinical, morphological and immunohistochemical findings.
Mooney EE, Nogales FF, Bergeron C, Tavassoli FA
Histopathology 2002 Aug;41(2):110-7. doi: 10.1046/j.1365-2559.2002.01426.x. PMID: 12147087
An ovarian Sertoli-Leydig cell tumor with heterologous mucinous gland and NSE-immunoreactive-cell.
Arai N, Misugi K, Kamiya T, Shima S
Arch Gynecol Obstet 1988;243(1):55-60. doi: 10.1007/BF00931552. PMID: 2457358

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