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Malignant thyroid stimulating hormone producing neoplasm of pituitary gland

MedGen UID:
277341
•Concept ID:
C1334627
•
Neoplastic Process
Synonyms: Malignant Pituitary Gland Thyrotropinoma; malignant pituitary gland thyrotropinoma; Malignant Pituitary Thyrotropinoma; malignant pituitary thyrotropinoma; Malignant Thyroid Stimulating Hormone Producing Neoplasm of Pituitary; malignant thyroid stimulating hormone producing neoplasm of pituitary; Malignant Thyroid Stimulating Hormone Producing Neoplasm of Pituitary Gland; malignant thyroid stimulating hormone producing neoplasm of pituitary gland; Malignant Thyroid Stimulating Hormone Producing Neoplasm of the Pituitary; malignant thyroid stimulating hormone producing neoplasm of the pituitary; Malignant Thyroid Stimulating Hormone Producing Neoplasm of the Pituitary Gland; malignant thyroid stimulating hormone producing neoplasm of the pituitary gland; Malignant Thyroid Stimulating Hormone Producing Pituitary Gland Neoplasm; malignant thyroid stimulating hormone producing pituitary gland neoplasm; Malignant Thyroid Stimulating Hormone Producing Pituitary Gland Tumor; malignant thyroid stimulating hormone producing pituitary gland tumor; malignant thyroid stimulating hormone producing pituitary gland tumour; Malignant Thyroid Stimulating Hormone Producing Pituitary Neoplasm; malignant thyroid stimulating hormone producing pituitary neoplasm; Malignant Thyroid Stimulating Hormone Producing Pituitary Tumor; malignant thyroid stimulating hormone producing pituitary tumor; malignant thyroid stimulating hormone producing pituitary tumour; Malignant Thyroid Stimulating Hormone Producing Tumor; malignant thyroid stimulating hormone producing tumor; Malignant Thyroid Stimulating Hormone Producing Tumor of Pituitary; malignant thyroid stimulating hormone producing tumor of pituitary; Malignant Thyroid Stimulating Hormone Producing Tumor of Pituitary Gland; malignant thyroid stimulating hormone producing tumor of pituitary gland; Malignant Thyroid Stimulating Hormone Producing Tumor of the Pituitary; malignant thyroid stimulating hormone producing tumor of the pituitary; Malignant Thyroid Stimulating Hormone Producing Tumor of the Pituitary Gland; malignant thyroid stimulating hormone producing tumor of the pituitary gland; malignant thyroid stimulating hormone producing tumour; malignant thyroid stimulating hormone producing tumour of pituitary; malignant thyroid stimulating hormone producing tumour of pituitary gland; malignant thyroid stimulating hormone producing tumour of the pituitary; malignant thyroid stimulating hormone producing tumour of the pituitary gland; Malignant Thyroid Stimulating Hormone Secreting Neoplasm of Pituitary; malignant thyroid stimulating hormone secreting neoplasm of pituitary; Malignant Thyroid Stimulating Hormone Secreting Neoplasm of Pituitary Gland; malignant thyroid stimulating hormone secreting neoplasm of pituitary gland; Malignant Thyroid Stimulating Hormone Secreting Neoplasm of the Pituitary; malignant thyroid stimulating hormone secreting neoplasm of the pituitary; Malignant Thyroid Stimulating Hormone Secreting Neoplasm of the Pituitary Gland; malignant thyroid stimulating hormone secreting neoplasm of the pituitary gland; Malignant Thyroid Stimulating Hormone Secreting Pituitary Gland Neoplasm; malignant thyroid stimulating hormone secreting pituitary gland neoplasm; Malignant Thyroid Stimulating Hormone Secreting Pituitary Gland Tumor; malignant thyroid stimulating hormone secreting pituitary gland tumor; malignant thyroid stimulating hormone secreting pituitary gland tumour; Malignant Thyroid Stimulating Hormone Secreting Pituitary Neoplasm; malignant thyroid stimulating hormone secreting pituitary neoplasm; Malignant Thyroid Stimulating Hormone Secreting Pituitary Tumor; malignant thyroid stimulating hormone secreting pituitary tumor; malignant thyroid stimulating hormone secreting pituitary tumour; Malignant Thyroid Stimulating Hormone Secreting Tumor of Pituitary; malignant thyroid stimulating hormone secreting tumor of pituitary; Malignant Thyroid Stimulating Hormone Secreting Tumor of Pituitary Gland; malignant thyroid stimulating hormone secreting tumor of pituitary gland; Malignant Thyroid Stimulating Hormone Secreting Tumor of the Pituitary; malignant thyroid stimulating hormone secreting tumor of the pituitary; Malignant Thyroid Stimulating Hormone Secreting Tumor of the Pituitary Gland; malignant thyroid stimulating hormone secreting tumor of the pituitary gland; malignant thyroid stimulating hormone secreting tumour of pituitary; malignant thyroid stimulating hormone secreting tumour of pituitary gland; malignant thyroid stimulating hormone secreting tumour of the pituitary; malignant thyroid stimulating hormone secreting tumour of the pituitary gland; Malignant Thyrotropinoma; malignant thyrotropinoma; Malignant Thyrotropinoma of Pituitary; malignant thyrotropinoma of pituitary; Malignant Thyrotropinoma of Pituitary Gland; malignant thyrotropinoma of pituitary gland; Malignant Thyrotropinoma of the Pituitary; malignant thyrotropinoma of the pituitary; Malignant Thyrotropinoma of the Pituitary Gland; malignant thyrotropinoma of the pituitary gland; Malignant TSH Producing Neoplasm of Pituitary; malignant TSH producing neoplasm of pituitary; Malignant TSH Producing Neoplasm of Pituitary Gland; malignant TSH producing neoplasm of pituitary gland; Malignant TSH Producing Neoplasm of the Pituitary; malignant TSH producing neoplasm of the pituitary; Malignant TSH Producing Neoplasm of the Pituitary Gland; malignant TSH producing neoplasm of the pituitary gland; Malignant TSH Producing Pituitary Gland Neoplasm; malignant TSH producing pituitary gland neoplasm; Malignant TSH Producing Pituitary Gland Tumor; malignant TSH producing pituitary gland tumor; malignant TSH producing pituitary gland tumour; Malignant TSH Producing Pituitary Neoplasm; malignant TSH producing pituitary neoplasm; Malignant TSH Producing Pituitary Tumor; malignant TSH producing pituitary tumor; malignant TSH producing pituitary tumour; Malignant TSH Producing Tumor of Pituitary; malignant TSH producing tumor of pituitary; Malignant TSH Producing Tumor of Pituitary Gland; malignant TSH producing tumor of pituitary gland; Malignant TSH Producing Tumor of the Pituitary; malignant TSH producing tumor of the pituitary; Malignant TSH Producing Tumor of the Pituitary Gland; malignant TSH producing tumor of the pituitary gland; malignant TSH producing tumour of pituitary; malignant TSH producing tumour of pituitary gland; malignant TSH producing tumour of the pituitary; malignant TSH producing tumour of the pituitary gland; Malignant TSH Secreting Neoplasm of Pituitary; malignant TSH secreting neoplasm of pituitary; Malignant TSH Secreting Neoplasm of Pituitary Gland; malignant TSH secreting neoplasm of pituitary gland; Malignant TSH Secreting Neoplasm of the Pituitary; malignant TSH secreting neoplasm of the pituitary; Malignant TSH Secreting Neoplasm of the Pituitary Gland; malignant TSH secreting neoplasm of the pituitary gland; Malignant TSH Secreting Pituitary Gland Neoplasm; malignant TSH secreting pituitary gland neoplasm; Malignant TSH Secreting Pituitary Gland Tumor; malignant TSH secreting pituitary gland tumor; malignant TSH secreting pituitary gland tumour; Malignant TSH Secreting Pituitary Neoplasm; malignant TSH secreting pituitary neoplasm; Malignant TSH Secreting Pituitary Tumor; malignant TSH secreting pituitary tumor; malignant TSH secreting pituitary tumour; Malignant TSH Secreting Tumor of Pituitary; malignant TSH secreting tumor of pituitary; Malignant TSH Secreting Tumor of Pituitary Gland; malignant TSH secreting tumor of pituitary gland; Malignant TSH Secreting Tumor of the Pituitary; malignant TSH secreting tumor of the pituitary; Malignant TSH Secreting Tumor of the Pituitary Gland; malignant TSH secreting tumor of the pituitary gland; malignant TSH secreting tumour of pituitary; malignant TSH secreting tumour of pituitary gland; malignant TSH secreting tumour of the pituitary; malignant TSH secreting tumour of the pituitary gland; Metastatic Thyrotroph Pituitary Neuroendocrine Tumor; Metastatic TSH-Producing PitNET; Thyrotropin Producing Pituitary Gland Carcinoma; thyrotropin producing pituitary gland carcinoma; TSH Producing Pituitary Gland Carcinoma; TSH producing pituitary gland carcinoma; TSH-producing pituitary gland carcinoma
 
Monarch Initiative: MONDO:0003836

Definition

TSH-producing pituitary neuroendocrine tumor that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant thyroid stimulating hormone producing neoplasm of pituitary gland

Professional guidelines

PubMed

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Surgical treatment and outcome of TSH-producing pituitary adenomas.
Rotermund R, Riedel N, Burkhardt T, Matschke J, Schmidt NO, Aberle J, Flitsch J
Acta Neurochir (Wien) 2017 Jul;159(7):1219-1226. Epub 2017 Feb 15 doi: 10.1007/s00701-017-3105-4. PMID: 28204898
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483

Recent clinical studies

Etiology

Pituitary adenomas registry in Thailand.
Kwancharoen R, Deerochanawong C, Peerapatdit T, Salvatori R
J Clin Neurosci 2023 Sep;115:138-147. Epub 2023 Aug 10 doi: 10.1016/j.jocn.2023.07.026. PMID: 37572520
The utility of dynamic MRI in differentiating the hormone-producing ability of pituitary adenomas.
Amano T, Masumoto T, Akutsu H, Sakamoto N, Hoshiai S, Mori K, Nakajima T
Jpn J Radiol 2021 Aug;39(8):741-748. Epub 2021 Apr 21 doi: 10.1007/s11604-021-01121-9. PMID: 33881731Free PMC Article
Association between thyroid function and serum cortisol in cortisol-producing adenoma patients.
Cai R, Zhou W, Jiang L, Jiang Y, Su T, Zhang C, Zhou W, Ning G, Wang W
Endocrine 2020 Jul;69(1):196-203. Epub 2020 Apr 14 doi: 10.1007/s12020-020-02278-5. PMID: 32291738
Long-Term Effect of Cranial Radiotherapy on Pituitary-Hypothalamus Area in Childhood Acute Lymphoblastic Leukemia Survivors.
Follin C, Erfurth EM
Curr Treat Options Oncol 2016 Sep;17(9):50. doi: 10.1007/s11864-016-0426-0. PMID: 27476159Free PMC Article
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067

Diagnosis

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067
Pituitary hyperplasia.
Horvath E, Kovacs K, Scheithauer BW
Pituitary 1999 May;1(3-4):169-79. doi: 10.1023/a:1009952930425. PMID: 11081195
Central hyperthyroidism.
McDermott MT, Ridgway EC
Endocrinol Metab Clin North Am 1998 Mar;27(1):187-203. doi: 10.1016/s0889-8529(05)70306-6. PMID: 9534036

Therapy

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Giant pituitary adenoma: histological types, clinical features and therapeutic approaches.
Iglesias P, Rodríguez Berrocal V, Díez JJ
Endocrine 2018 Sep;61(3):407-421. Epub 2018 Jun 16 doi: 10.1007/s12020-018-1645-x. PMID: 29909598
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067
Cushing's syndrome.
Howlett TA, Rees LH, Besser GM
Clin Endocrinol Metab 1985 Nov;14(4):911-45. doi: 10.1016/s0300-595x(85)80083-9. PMID: 3002679

Prognosis

Pituitary adenomas registry in Thailand.
Kwancharoen R, Deerochanawong C, Peerapatdit T, Salvatori R
J Clin Neurosci 2023 Sep;115:138-147. Epub 2023 Aug 10 doi: 10.1016/j.jocn.2023.07.026. PMID: 37572520
UPDATE ON THE CLINICOPATHOLOGY OF PITUITARY ADENOMAS.
Lim CT, Korbonits M
Endocr Pract 2018 May;24(5):473-488. Epub 2018 Mar 2 doi: 10.4158/EP-2018-0034. PMID: 29498920
Epidemiology and biomarker profile of pituitary adenohypophysial tumors.
Mete O, Cintosun A, Pressman I, Asa SL
Mod Pathol 2018 Jun;31(6):900-909. Epub 2018 Feb 12 doi: 10.1038/s41379-018-0016-8. PMID: 29434339
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067
Cushing's syndrome.
Howlett TA, Rees LH, Besser GM
Clin Endocrinol Metab 1985 Nov;14(4):911-45. doi: 10.1016/s0300-595x(85)80083-9. PMID: 3002679

Clinical prediction guides

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
UPDATE ON THE CLINICOPATHOLOGY OF PITUITARY ADENOMAS.
Lim CT, Korbonits M
Endocr Pract 2018 May;24(5):473-488. Epub 2018 Mar 2 doi: 10.4158/EP-2018-0034. PMID: 29498920
Epidemiology and biomarker profile of pituitary adenohypophysial tumors.
Mete O, Cintosun A, Pressman I, Asa SL
Mod Pathol 2018 Jun;31(6):900-909. Epub 2018 Feb 12 doi: 10.1038/s41379-018-0016-8. PMID: 29434339
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067

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