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Minor Salivary Gland Undifferentiated Carcinoma

MedGen UID:
277374
•Concept ID:
C1334775
•
Neoplastic Process
Synonyms: Anaplastic Carcinoma of Minor Salivary Gland; Anaplastic Carcinoma of the Minor Salivary Gland; Anaplastic Minor Salivary Gland Carcinoma; Undifferentiated Carcinoma of Minor Salivary Gland; Undifferentiated Carcinoma of the Minor Salivary Gland

Definition

A carcinoma that affects the minor salivary glands and is characterized by the presence of undifferentiated, anaplastic malignant epithelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMinor Salivary Gland Undifferentiated Carcinoma

Professional guidelines

PubMed

Management of Malignant Salivary Gland Conditions.
Pang J, Houlton JJ
Surg Clin North Am 2022 Apr;102(2):325-333. doi: 10.1016/j.suc.2021.12.008. PMID: 35344700
Postoperative Management of Salivary Gland Tumors.
Joshi NP, Broughman JR
Curr Treat Options Oncol 2021 Feb 9;22(3):23. doi: 10.1007/s11864-021-00820-9. PMID: 33560478
Management of salivary gland carcinomas - a review.
Wang X, Luo Y, Li M, Yan H, Sun M, Fan T
Oncotarget 2017 Jan 17;8(3):3946-3956. doi: 10.18632/oncotarget.13952. PMID: 27992367Free PMC Article

Recent clinical studies

Etiology

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214. doi: 10.14639/0392-100X-N1379. PMID: 34264913Free PMC Article
The Evaluation and Management of Carcinoma of the Minor Salivary Glands.
Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489
Postoperative Management of Salivary Gland Tumors.
Joshi NP, Broughman JR
Curr Treat Options Oncol 2021 Feb 9;22(3):23. doi: 10.1007/s11864-021-00820-9. PMID: 33560478
Major and minor salivary gland tumours.
Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526
Minor salivary gland neoplasms.
Dalgic A, Karakoc O, Aydin U, Hidir Y, Gamsizkan M, Karahatay S, Gerek M
J Craniofac Surg 2014 May;25(3):e289-91. doi: 10.1097/SCS.0000000000000723. PMID: 24777018

Diagnosis

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214. doi: 10.14639/0392-100X-N1379. PMID: 34264913Free PMC Article
Major and minor salivary gland tumours.
Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526
Mucoepidermoid carcinoma.
Devaraju R, Gantala R, Aitha H, Gotoor SG
BMJ Case Rep 2014 Aug 1;2014:bcr-2013-202776. doi: 10.1136/bcr-2013-202776. PMID: 25085946Free PMC Article
CT and MR imaging findings of palatal tumors.
Kato H, Kanematsu M, Makita H, Kato K, Hatakeyama D, Shibata T, Mizuta K, Aoki M
Eur J Radiol 2014 Mar;83(3):e137-46. Epub 2013 Dec 12 doi: 10.1016/j.ejrad.2013.11.028. PMID: 24377674
Salivary glands.
Saunders JR Jr, Hirata RM, Jaques DA
Surg Clin North Am 1986 Feb;66(1):59-81. doi: 10.1016/s0039-6109(16)43829-6. PMID: 3003940

Therapy

Postoperative Management of Salivary Gland Tumors.
Joshi NP, Broughman JR
Curr Treat Options Oncol 2021 Feb 9;22(3):23. doi: 10.1007/s11864-021-00820-9. PMID: 33560478
Prediction of Minor Salivary Gland Carcinoma: A Novel Nomogram and Risk Classification System for Overall Survival and Cancer-Specific Survival.
Lan LF, Gao CK, Ma CW
Otolaryngol Head Neck Surg 2021 Feb;164(2):359-368. Epub 2020 Jul 21 doi: 10.1177/0194599820938323. PMID: 32692284
Current management of the neck in salivary gland carcinomas.
Green B, Rahimi S, Brennan PA
J Oral Pathol Med 2017 Mar;46(3):161-166. Epub 2016 May 27 doi: 10.1111/jop.12458. PMID: 27230064
Major and minor salivary gland tumors.
Guzzo M, Locati LD, Prott FJ, Gatta G, McGurk M, Licitra L
Crit Rev Oncol Hematol 2010 May;74(2):134-48. Epub 2009 Nov 24 doi: 10.1016/j.critrevonc.2009.10.004. PMID: 19939701
Update and perspectives on non-surgical treatment of salivary gland malignancies.
Airoldi M, Cortesina G, Giordano C, Pedani F, Cavalot A, Marcato P, Beatrice F, Bumma C
Acta Otorhinolaryngol Ital 2003 Oct;23(5):368-76. PMID: 15108487

Prognosis

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214. doi: 10.14639/0392-100X-N1379. PMID: 34264913Free PMC Article
Postoperative Management of Salivary Gland Tumors.
Joshi NP, Broughman JR
Curr Treat Options Oncol 2021 Feb 9;22(3):23. doi: 10.1007/s11864-021-00820-9. PMID: 33560478
Polymorphous Adenocarcinoma.
Katabi N, Xu B
Surg Pathol Clin 2021 Mar;14(1):127-136. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.011. PMID: 33526217Free PMC Article
Major and minor salivary gland tumours.
Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526
Newly described salivary gland tumors.
Skalova A, Michal M, Simpson RH
Mod Pathol 2017 Jan;30(s1):S27-S43. doi: 10.1038/modpathol.2016.167. PMID: 28060365

Clinical prediction guides

Histopathological evaluation of minor salivary gland aberrations in oral squamous cell carcinoma.
Bhola R, Narwal A, Kamboj M, Devi A, Anand R, Chatterjee S
J Cancer Res Ther 2023 Jan-Mar;19(2):299-303. doi: 10.4103/jcrt.jcrt_1832_21. PMID: 37313908
Clinical and demographic features of minor salivary gland tumors: A collaborative study of 480 cases.
Bruzinga FFB, Fernandes FCF, Dias FR, Lima MG, de Souza PEA, de Aguiar MCF, Grossmann SMC
Oral Dis 2023 Apr;29(3):1028-1038. Epub 2022 Jan 18 doi: 10.1111/odi.14119. PMID: 34965007
Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study.
Alsanie I, Rajab S, Cottom H, Adegun O, Agarwal R, Jay A, Graham L, James J, Barrett AW, van Heerden W, de Vito M, Canesso A, Adisa AO, Akinshipo AO, Ajayi OF, Nwoga MC, Okwuosa CU, Omitola OG, Orikpete EV, Soluk-Tekkesin M, Bello IO, Qannam A, Gonzalez W, Pérez-de-Oliveira ME, Santos-Silva AR, Vargas PA, Toh EW, Khurram SA
Head Neck Pathol 2022 Dec;16(4):1043-1054. Epub 2022 May 27 doi: 10.1007/s12105-022-01459-0. PMID: 35622296Free PMC Article
Polymorphous adenocarcinoma of salivary glands.
Mimica X, Katabi N, McGill MR, Hay A, Zanoni DK, Shah JP, Wong RJ, Cohen MA, Patel SG, Ganly I
Oral Oncol 2019 Aug;95:52-58. Epub 2019 Jun 7 doi: 10.1016/j.oraloncology.2019.06.002. PMID: 31345394Free PMC Article
Cribriform adenocarcinoma of the tongue and minor salivary glands: a review.
Michal M, Kacerovska D, Kazakov DV
Head Neck Pathol 2013 Jul;7 Suppl 1(Suppl 1):S3-11. Epub 2013 Jul 3 doi: 10.1007/s12105-013-0457-9. PMID: 23821209Free PMC Article

Recent systematic reviews

Treatment and outcomes of minor salivary gland cancers of the larynx and trachea: a systematic review.
Montenegro C, Mattavelli D, Lancini D, Paderno A, Marazzi E, Rampinelli V, Tomasoni M, Piazza C
Acta Otorhinolaryngol Ital 2023 Dec;43(6):365-374. Epub 2023 Oct 10 doi: 10.14639/0392-100X-N2635. PMID: 37814980Free PMC Article
Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma.
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Cribriform adenocarcinoma of the tongue and minor salivary glands: a systematic review of an uncommon clinicopathological entity.
De Luca P, Tassone D, de Campora L, Simone M, Marra P, Colacurcio V, Scarpa A, Costarelli L, Camaioni A
Eur Arch Otorhinolaryngol 2022 Jun;279(6):2719-2725. Epub 2021 Oct 23 doi: 10.1007/s00405-021-07140-6. PMID: 34687340
Laryngeal Adenoid Cystic Carcinoma: A Systematic Review.
Marchiano E, Chin OY, Fang CH, Park RC, Baredes S, Eloy JA
Otolaryngol Head Neck Surg 2016 Mar;154(3):433-9. Epub 2015 Dec 23 doi: 10.1177/0194599815621884. PMID: 26701176
Clinicopathological characteristics and perineural invasion in adenoid cystic carcinoma: a systematic review.
Dantas AN, Morais EF, Macedo RA, Tinôco JM, Morais Mde L
Braz J Otorhinolaryngol 2015 May-Jun;81(3):329-35. Epub 2015 Mar 30 doi: 10.1016/j.bjorl.2014.07.016. PMID: 25962319Free PMC Article

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