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Thymic mucoepidermoid carcinoma

MedGen UID:
277383
•Concept ID:
C1334814
•
Neoplastic Process
Synonyms: Mucoepidermoid Carcinoma of the Thymus; mucoepidermoid carcinoma of the Thymus; Mucoepidermoid Carcinoma of Thymus; mucoepidermoid carcinoma of Thymus; Thymic Mucoepidermoid Carcinoma; thymic mucoepidermoid carcinoma; Thymus Mucoepidermoid Carcinoma; Thymus mucoepidermoid carcinoma; thymus mucoepidermoid carcinoma
 
Monarch Initiative: MONDO:0003086

Definition

A rare primary thymic carcinoma, characterized by the presence of squamous cells, intermediate type cells, and mucus-producing cells. The prognosis depends on histologic grade and stage. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThymic mucoepidermoid carcinoma

Professional guidelines

PubMed

The potency of curative-intent treatment for advanced thymic carcinoma.
Okuma Y, Horio H, Hosomi Y, Watanabe K, Maeda Y, Okamura T, Hishima T
Lung Cancer 2014 May;84(2):175-81. Epub 2014 Mar 2 doi: 10.1016/j.lungcan.2014.02.012. PMID: 24646831

Recent clinical studies

Etiology

Thymic mucoepidermoid carcinomas: a clinicopathologic study of 10 cases and review of the literature.
Nonaka D, Klimstra D, Rosai J
Am J Surg Pathol 2004 Nov;28(11):1526-31. doi: 10.1097/01.pas.0000137999.23780.2a. PMID: 15489658

Diagnosis

Thymic Mucoepidermoid Carcinoma: A Clinicopathologic and Molecular Study.
Murase T, Nakano S, Sakane T, Domen H, Chiyo M, Nagasaka S, Tanaka M, Kawahara Y, Toishi M, Tanaka T, Nakamura S, Sawabata N, Okami J, Mukaida H, Tzankov A, Szolkowska M, Porubsky S, Marx A, Roden AC, Inagaki H
Am J Surg Pathol 2022 Aug 1;46(8):1160-1169. Epub 2022 Mar 22 doi: 10.1097/PAS.0000000000001886. PMID: 35319525
Thymic Mucoepidermoid Carcinoma: A Systematic Review and Meta-analysis.
Hamza A, Younes AI, Kalhor N
Adv Anat Pathol 2019 Nov;26(6):341-345. doi: 10.1097/PAP.0000000000000250. PMID: 31593977
Unusual combined thymic mucoepidermoid carcinoma and thymoma: a case report and review of literature.
Wu SG, Li Y, Li B, Tian XY, Li Z
Diagn Pathol 2014 Jan 20;9:8. doi: 10.1186/1746-1596-9-8. PMID: 24444077Free PMC Article
Analysis of MAML2 rearrangement in mucoepidermoid carcinoma of the thymus.
Roden AC, Erickson-Johnson MR, Yi ES, García JJ
Hum Pathol 2013 Dec;44(12):2799-805. Epub 2013 Oct 14 doi: 10.1016/j.humpath.2013.07.031. PMID: 24134933
Thymic mucoepidermoid carcinomas: a clinicopathologic study of 10 cases and review of the literature.
Nonaka D, Klimstra D, Rosai J
Am J Surg Pathol 2004 Nov;28(11):1526-31. doi: 10.1097/01.pas.0000137999.23780.2a. PMID: 15489658

Therapy

Response of a thymic mucoepidermoid carcinoma to combination chemotherapy with cisplatin and irinotecan: a case report.
Fuse ET, Kamimura M, Takeda Y, Kawaishi M, Kimura S, Niino H, Saito K, Kobayashi N, Kudo K
Lung Cancer 2008 Mar;59(3):403-6. Epub 2007 Aug 17 doi: 10.1016/j.lungcan.2007.07.003. PMID: 17707547

Prognosis

Thymic Mucoepidermoid Carcinoma: A Systematic Review and Meta-analysis.
Hamza A, Younes AI, Kalhor N
Adv Anat Pathol 2019 Nov;26(6):341-345. doi: 10.1097/PAP.0000000000000250. PMID: 31593977
Thymic Mucoepidermoid Carcinoma: Report of a Case With CTRC1/3-MALM2 Molecular Studies.
Prieto-Granada CN, Inagaki H, Mueller J
Int J Surg Pathol 2015 Jun;23(4):277-83. Epub 2015 Mar 17 doi: 10.1177/1066896915576959. PMID: 25782731
Response of a thymic mucoepidermoid carcinoma to combination chemotherapy with cisplatin and irinotecan: a case report.
Fuse ET, Kamimura M, Takeda Y, Kawaishi M, Kimura S, Niino H, Saito K, Kobayashi N, Kudo K
Lung Cancer 2008 Mar;59(3):403-6. Epub 2007 Aug 17 doi: 10.1016/j.lungcan.2007.07.003. PMID: 17707547
Thymic mucoepidermoid carcinomas: a clinicopathologic study of 10 cases and review of the literature.
Nonaka D, Klimstra D, Rosai J
Am J Surg Pathol 2004 Nov;28(11):1526-31. doi: 10.1097/01.pas.0000137999.23780.2a. PMID: 15489658

Clinical prediction guides

Unusual combined thymic mucoepidermoid carcinoma and thymoma: a case report and review of literature.
Wu SG, Li Y, Li B, Tian XY, Li Z
Diagn Pathol 2014 Jan 20;9:8. doi: 10.1186/1746-1596-9-8. PMID: 24444077Free PMC Article
Analysis of MAML2 rearrangement in mucoepidermoid carcinoma of the thymus.
Roden AC, Erickson-Johnson MR, Yi ES, García JJ
Hum Pathol 2013 Dec;44(12):2799-805. Epub 2013 Oct 14 doi: 10.1016/j.humpath.2013.07.031. PMID: 24134933

Recent systematic reviews

Thymic Mucoepidermoid Carcinoma: A Systematic Review and Meta-analysis.
Hamza A, Younes AI, Kalhor N
Adv Anat Pathol 2019 Nov;26(6):341-345. doi: 10.1097/PAP.0000000000000250. PMID: 31593977

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