U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Salivary Gland Sebaceous Adenoma

MedGen UID:
277631
•Concept ID:
C1335908
•
Neoplastic Process

Definition

A rare, benign, encapsulated epithelial tumor composed of cells that form solid, variably shaped islands and cysts, both showing focal sebaceous differentiation. The mean age of patients is reported to be 58 years, and most tumors occur in the parotid gland. There is a male predominance. Most patients are asymptomatic. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary Gland Sebaceous Adenoma

Professional guidelines

PubMed

Cytologic features of sebaceous, lymphadenoma, and sebaceous lymphadenocarcinoma: Differential diagnostic considerations.
Vazmitsel M, Esebua M, Layfield LJ
Diagn Cytopathol 2020 May;48(5):424-429. Epub 2020 Jan 22 doi: 10.1002/dc.24357. PMID: 31967730

Recent clinical studies

Etiology

A rare case of sebaceous lymphadenoma: Cytohistological correlation of preoperative cytomorphologic findings.
Ronen N, Massey B, Javakhishvili N, Giorgadze T
Ann Diagn Pathol 2022 Dec;61:152058. Epub 2022 Oct 29 doi: 10.1016/j.anndiagpath.2022.152058. PMID: 36334412
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Sebaceous epithelial-myoepithelial carcinoma of the salivary gland: clinicopathologic and immunohistochemical analysis of 6 cases of a new histologic variant.
Shinozaki A, Nagao T, Endo H, Kato N, Hirokawa M, Mizobuchi K, Komatsu M, Igarashi T, Yokoyama M, Masuda S, Sano K, Izumi M, Fukayama M, Mukai K
Am J Surg Pathol 2008 Jun;32(6):913-23. doi: 10.1097/PAS.0b013e318160852a. PMID: 18425042
Histopathology of malignant salivary gland tumours.
Seifert G
Eur J Cancer B Oral Oncol 1992 Jul;28B(1):49-56. doi: 10.1016/0964-1955(92)90013-q. PMID: 1330147
Sebaceous neoplasms of salivary gland origin. Report of 21 cases.
Gnepp DR, Brannon R
Cancer 1984 May 15;53(10):2155-70. doi: 10.1002/1097-0142(19840515)53:10<2155::aid-cncr2820531026>3.0.co;2-f. PMID: 6704903

Diagnosis

Cytologic features of sebaceous, lymphadenoma, and sebaceous lymphadenocarcinoma: Differential diagnostic considerations.
Vazmitsel M, Esebua M, Layfield LJ
Diagn Cytopathol 2020 May;48(5):424-429. Epub 2020 Jan 22 doi: 10.1002/dc.24357. PMID: 31967730
Pleomorphic adenoma: a rare presentation in buccal salivary gland with extensive squamous and mucous metaplasia.
Urs AB, Augustine J, Negi D, Kumar RD, Ghosh S
Pan Afr Med J 2019;33:147. Epub 2019 Jun 26 doi: 10.11604/pamj.2019.33.147.17550. PMID: 31558944Free PMC Article
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Oncocytic lipoadenoma of the salivary gland: a clinicopathologic analysis of 7 cases and review of the literature.
Lau SK, Thompson LD
Head Neck Pathol 2015 Mar;9(1):39-46. Epub 2014 Apr 16 doi: 10.1007/s12105-014-0543-7. PMID: 24737102Free PMC Article
Salivary adenocarcinoma, not otherwise specified: a collection of orphans.
Li J, Wang BY, Nelson M, Li L, Hu Y, Urken ML, Brandwein-Gensler M
Arch Pathol Lab Med 2004 Dec;128(12):1385-94. doi: 10.5858/2004-128-1385-SANOSA. PMID: 15578883

Prognosis

Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Analysis of histologic follow-up and risk of malignancy for salivary gland neoplasm of uncertain malignant potential proposed by the Milan System for Reporting Salivary Gland Cytopathology.
Liu H, Ljungren C, Lin F, Zarka MA, Chen L
Cancer Cytopathol 2018 Jul;126(7):490-497. Epub 2018 Apr 18 doi: 10.1002/cncy.22002. PMID: 29669190
Oncocytic lipoadenoma of the parotid gland: a report of a new case and review of the literature.
Mitsimponas KT, Agaimy A, Schlittenbauer T, Nkenke E, Neukam FW
Int J Clin Exp Pathol 2012;5(9):1000-6. Epub 2012 Oct 20 PMID: 23119120Free PMC Article
Sebaceous epithelial-myoepithelial carcinoma of the salivary gland: clinicopathologic and immunohistochemical analysis of 6 cases of a new histologic variant.
Shinozaki A, Nagao T, Endo H, Kato N, Hirokawa M, Mizobuchi K, Komatsu M, Igarashi T, Yokoyama M, Masuda S, Sano K, Izumi M, Fukayama M, Mukai K
Am J Surg Pathol 2008 Jun;32(6):913-23. doi: 10.1097/PAS.0b013e318160852a. PMID: 18425042
Histopathology of malignant salivary gland tumours.
Seifert G
Eur J Cancer B Oral Oncol 1992 Jul;28B(1):49-56. doi: 10.1016/0964-1955(92)90013-q. PMID: 1330147

Clinical prediction guides

Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Histopathological Findings of Intraoral Pleomorphic Adenomas: A Retrospective Study of a Case Series.
Pérez-de-Oliveira ME, Leonel ACLDS, de Castro JFL, Carvalho EJA, Vargas PA, Perez DEDC
Int J Surg Pathol 2019 Oct;27(7):729-735. Epub 2019 Jun 12 doi: 10.1177/1066896919854181. PMID: 31187672
Sebaceous epithelial-myoepithelial carcinoma of the salivary gland: clinicopathologic and immunohistochemical analysis of 6 cases of a new histologic variant.
Shinozaki A, Nagao T, Endo H, Kato N, Hirokawa M, Mizobuchi K, Komatsu M, Igarashi T, Yokoyama M, Masuda S, Sano K, Izumi M, Fukayama M, Mukai K
Am J Surg Pathol 2008 Jun;32(6):913-23. doi: 10.1097/PAS.0b013e318160852a. PMID: 18425042
Oncocytic myoepithelioma and pleomorphic adenoma of the salivary glands.
Skálová A, Michal M, Ryska A, Simpson RH, Kinkor Z, Walter J, Leivo I
Virchows Arch 1999 Jun;434(6):537-46. doi: 10.1007/s004280050381. PMID: 10394890
Sebaceous neoplasms of salivary gland origin. Report of 21 cases.
Gnepp DR, Brannon R
Cancer 1984 May 15;53(10):2155-70. doi: 10.1002/1097-0142(19840515)53:10<2155::aid-cncr2820531026>3.0.co;2-f. PMID: 6704903

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...