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Salivary Gland Sebaceous Adenoma

MedGen UID:
277631
•Concept ID:
C1335908
•
Neoplastic Process

Definition

A rare, benign, encapsulated epithelial tumor composed of cells that form solid, variably shaped islands and cysts, both showing focal sebaceous differentiation. The mean age of patients is reported to be 58 years, and most tumors occur in the parotid gland. There is a male predominance. Most patients are asymptomatic. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary Gland Sebaceous Adenoma

Professional guidelines

PubMed

Cytologic features of sebaceous, lymphadenoma, and sebaceous lymphadenocarcinoma: Differential diagnostic considerations.
Vazmitsel M, Esebua M, Layfield LJ
Diagn Cytopathol 2020 May;48(5):424-429. Epub 2020 Jan 22 doi: 10.1002/dc.24357. PMID: 31967730

Recent clinical studies

Etiology

Oral cavity salivary gland pleomorphic adenoma: a histomorphological case series.
Rajbhar R, Margam S, Fernandes G
Ann Diagn Pathol 2024 Aug;71:152306. Epub 2024 Apr 9 doi: 10.1016/j.anndiagpath.2024.152306. PMID: 38614034
A rare case of sebaceous lymphadenoma: Cytohistological correlation of preoperative cytomorphologic findings.
Ronen N, Massey B, Javakhishvili N, Giorgadze T
Ann Diagn Pathol 2022 Dec;61:152058. Epub 2022 Oct 29 doi: 10.1016/j.anndiagpath.2022.152058. PMID: 36334412
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Histopathology of malignant salivary gland tumours.
Seifert G
Eur J Cancer B Oral Oncol 1992 Jul;28B(1):49-56. doi: 10.1016/0964-1955(92)90013-q. PMID: 1330147
Sebaceous neoplasms of salivary gland origin. Report of 21 cases.
Gnepp DR, Brannon R
Cancer 1984 May 15;53(10):2155-70. doi: 10.1002/1097-0142(19840515)53:10<2155::aid-cncr2820531026>3.0.co;2-f. PMID: 6704903

Diagnosis

Pleomorphic adenoma: Indeed, a versatile tumor.
Sharma R, Khera S, Yadav T, Badkur M
J Cancer Res Ther 2024 Jul 1;20(5):1611-1614. Epub 2023 May 3 doi: 10.4103/jcrt.jcrt_2259_22. PMID: 39412930
Cytologic features of sebaceous, lymphadenoma, and sebaceous lymphadenocarcinoma: Differential diagnostic considerations.
Vazmitsel M, Esebua M, Layfield LJ
Diagn Cytopathol 2020 May;48(5):424-429. Epub 2020 Jan 22 doi: 10.1002/dc.24357. PMID: 31967730
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Oncocytic lipoadenoma of the salivary gland: a clinicopathologic analysis of 7 cases and review of the literature.
Lau SK, Thompson LD
Head Neck Pathol 2015 Mar;9(1):39-46. Epub 2014 Apr 16 doi: 10.1007/s12105-014-0543-7. PMID: 24737102Free PMC Article
Salivary adenocarcinoma, not otherwise specified: a collection of orphans.
Li J, Wang BY, Nelson M, Li L, Hu Y, Urken ML, Brandwein-Gensler M
Arch Pathol Lab Med 2004 Dec;128(12):1385-94. doi: 10.5858/2004-128-1385-SANOSA. PMID: 15578883

Prognosis

Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Analysis of histologic follow-up and risk of malignancy for salivary gland neoplasm of uncertain malignant potential proposed by the Milan System for Reporting Salivary Gland Cytopathology.
Liu H, Ljungren C, Lin F, Zarka MA, Chen L
Cancer Cytopathol 2018 Jul;126(7):490-497. Epub 2018 Apr 18 doi: 10.1002/cncy.22002. PMID: 29669190
Sebaceous adenoma of the submandibular gland: a case report.
Zare-Mahmoodabadi R, Salehinejad J, Saghafi S, Ghazi N, Mahmoudi P, Harraji A
J Oral Sci 2009 Dec;51(4):641-4. doi: 10.2334/josnusd.51.641. PMID: 20032620
Sebaceous epithelial-myoepithelial carcinoma of the salivary gland: clinicopathologic and immunohistochemical analysis of 6 cases of a new histologic variant.
Shinozaki A, Nagao T, Endo H, Kato N, Hirokawa M, Mizobuchi K, Komatsu M, Igarashi T, Yokoyama M, Masuda S, Sano K, Izumi M, Fukayama M, Mukai K
Am J Surg Pathol 2008 Jun;32(6):913-23. doi: 10.1097/PAS.0b013e318160852a. PMID: 18425042
Histopathology of malignant salivary gland tumours.
Seifert G
Eur J Cancer B Oral Oncol 1992 Jul;28B(1):49-56. doi: 10.1016/0964-1955(92)90013-q. PMID: 1330147

Clinical prediction guides

Oral cavity salivary gland pleomorphic adenoma: a histomorphological case series.
Rajbhar R, Margam S, Fernandes G
Ann Diagn Pathol 2024 Aug;71:152306. Epub 2024 Apr 9 doi: 10.1016/j.anndiagpath.2024.152306. PMID: 38614034
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Histopathological Findings of Intraoral Pleomorphic Adenomas: A Retrospective Study of a Case Series.
Pérez-de-Oliveira ME, Leonel ACLDS, de Castro JFL, Carvalho EJA, Vargas PA, Perez DEDC
Int J Surg Pathol 2019 Oct;27(7):729-735. Epub 2019 Jun 12 doi: 10.1177/1066896919854181. PMID: 31187672
Sebaceous adenoma of the parotid gland.
de Vicente Rodríguez JC, Fresno Forcelledo MF, González García M, Aguilar Andrea C
Med Oral Patol Oral Cir Bucal 2006 Aug 1;11(5):E446-8. PMID: 16878064
Sebaceous neoplasms of salivary gland origin. Report of 21 cases.
Gnepp DR, Brannon R
Cancer 1984 May 15;53(10):2155-70. doi: 10.1002/1097-0142(19840515)53:10<2155::aid-cncr2820531026>3.0.co;2-f. PMID: 6704903

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