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T-Cell Prolymphocytic Leukemia, Cerebriform Cell Variant

MedGen UID:
277780
•Concept ID:
C1336551
•
Neoplastic Process
Synonyms: T-Cell Prolymphocytic Leukemia, Sezary Cell-like Variant; T-Cell Prolymphocytic Leukemia, Sézary Cell-like Variant

Definition

A T-cell prolymphocytic leukemia characterized by the presence of neoplastic prolymphocytes with irregular or cerebriform nuclear outline. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVT-Cell Prolymphocytic Leukemia, Cerebriform Cell Variant

Recent clinical studies

Etiology

T-Cell Prolymphocytic Leukemia With t(X;14)(q28;q11.2): A Clinicopathologic Study of 15 Cases.
Hu Z, Medeiros LJ, Xu M, Yuan J, Peker D, Shao L, Tang Z, Mai B, Thakral B, Rios A, Hu S, Wang W
Am J Clin Pathol 2023 Apr 4;159(4):325-336. doi: 10.1093/ajcp/aqac166. PMID: 36883805

Diagnosis

T-Cell Prolymphocytic Leukemia With t(X;14)(q28;q11.2): A Clinicopathologic Study of 15 Cases.
Hu Z, Medeiros LJ, Xu M, Yuan J, Peker D, Shao L, Tang Z, Mai B, Thakral B, Rios A, Hu S, Wang W
Am J Clin Pathol 2023 Apr 4;159(4):325-336. doi: 10.1093/ajcp/aqac166. PMID: 36883805
Small cell variant anaplastic large cell lymphoma presenting as leukemia: A case report and review of Literature.
Dutta R, Ramteke P, Mathur SR, Saxena R, Pati HP, Mallick S
Indian J Pathol Microbiol 2022 Jul-Sep;65(3):705-708. doi: 10.4103/ijpm.ijpm_443_21. PMID: 35900509
T-cell prolymphocytic leukemia in Japan: is it a variant?
Kameoka J, Takahashi N, Noji H, Murai K, Tajima K, Kameoka Y, Sato S, Shichishima T, Ishida Y, Harigae H, Sawada K
Int J Hematol 2012 Jun;95(6):660-7. Epub 2012 Apr 24 doi: 10.1007/s12185-012-1077-y. PMID: 22527853
Sezary cell leukaemia: a distinct T cell disorder or a variant form of T prolymphocytic leukaemia?
Pawson R, Matutes E, Brito-Babapulle V, Maljaie H, Hedges M, Mercieca J, Dyer M, Catovsky D
Leukemia 1997 Jul;11(7):1009-13. doi: 10.1038/sj.leu.2400710. PMID: 9204983

Prognosis

Cerebriform variant type of T cell prolymphocytic leukemia with complex karyotype including an additional segment at 1p36.1.
Kasahara S, Tsurumi H, Shibata Y, Matsumoto T, Nakamura N, Nakamura H, Kanemura N, Goto N, Hara T, Moriwaki H
Int J Hematol 2012 Nov;96(5):674-8. Epub 2012 Oct 5 doi: 10.1007/s12185-012-1176-9. PMID: 23054642
T-cell prolymphocytic leukemia in Japan: is it a variant?
Kameoka J, Takahashi N, Noji H, Murai K, Tajima K, Kameoka Y, Sato S, Shichishima T, Ishida Y, Harigae H, Sawada K
Int J Hematol 2012 Jun;95(6):660-7. Epub 2012 Apr 24 doi: 10.1007/s12185-012-1077-y. PMID: 22527853

Clinical prediction guides

T-cell prolymphocytic leukemia in Japan: is it a variant?
Kameoka J, Takahashi N, Noji H, Murai K, Tajima K, Kameoka Y, Sato S, Shichishima T, Ishida Y, Harigae H, Sawada K
Int J Hematol 2012 Jun;95(6):660-7. Epub 2012 Apr 24 doi: 10.1007/s12185-012-1077-y. PMID: 22527853
Relationship of T leukaemias with cerebriform nuclei to T-prolymphocytic leukaemia: a cytogenetic analysis with in situ hybridization.
Brito-Babapulle V, Maljaie SH, Matutes E, Hedges M, Yuille M, Catovsky D
Br J Haematol 1997 Mar;96(4):724-32. doi: 10.1046/j.1365-2141.1997.9702605.x. PMID: 9074412

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