T-Cell Prolymphocytic Leukemia, Cerebriform Cell Variant

MedGen UID:: 277780
•Concept ID:: C1336551
•: Neoplastic Process

Synonyms:

T-Cell Prolymphocytic Leukemia, Sezary Cell-like Variant; T-Cell Prolymphocytic Leukemia, Sézary Cell-like Variant

Definition

A T-cell prolymphocytic leukemia characterized by the presence of neoplastic prolymphocytes with irregular or cerebriform nuclear outline. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVT-Cell Prolymphocytic Leukemia, Cerebriform Cell Variant

Hematologic disorder
- Hematopoietic and lymphoid cell neoplasm
  - Lymphoid neoplasm
    - T-cell and NK-cell neoplasm
      - Neoplasm of mature T-cells or NK-cells
        T-cell prolymphocytic leukemia
        T-Cell Prolymphocytic Leukemia, Cerebriform Cell Variant

Recent clinical studies

Etiology

T-Cell Prolymphocytic Leukemia With t(X;14)(q28;q11.2): A Clinicopathologic Study of 15 Cases.

Hu Z, Medeiros LJ, Xu M, Yuan J, Peker D, Shao L, Tang Z, Mai B, Thakral B, Rios A, Hu S, Wang W
Am J Clin Pathol 2023 Apr 4;159(4):325-336. doi: 10.1093/ajcp/aqac166. PMID: 36883805

See all (1)

Diagnosis

T-Cell Prolymphocytic Leukemia With t(X;14)(q28;q11.2): A Clinicopathologic Study of 15 Cases.

Hu Z, Medeiros LJ, Xu M, Yuan J, Peker D, Shao L, Tang Z, Mai B, Thakral B, Rios A, Hu S, Wang W
Am J Clin Pathol 2023 Apr 4;159(4):325-336. doi: 10.1093/ajcp/aqac166. PMID: 36883805

Small cell variant anaplastic large cell lymphoma presenting as leukemia: A case report and review of Literature.

Dutta R, Ramteke P, Mathur SR, Saxena R, Pati HP, Mallick S
Indian J Pathol Microbiol 2022 Jul-Sep;65(3):705-708. doi: 10.4103/ijpm.ijpm_443_21. PMID: 35900509

T-cell prolymphocytic leukemia in Japan: is it a variant?

Kameoka J, Takahashi N, Noji H, Murai K, Tajima K, Kameoka Y, Sato S, Shichishima T, Ishida Y, Harigae H, Sawada K
Int J Hematol 2012 Jun;95(6):660-7. Epub 2012 Apr 24 doi: 10.1007/s12185-012-1077-y. PMID: 22527853

Sezary cell leukaemia: a distinct T cell disorder or a variant form of T prolymphocytic leukaemia?

Pawson R, Matutes E, Brito-Babapulle V, Maljaie H, Hedges M, Mercieca J, Dyer M, Catovsky D
Leukemia 1997 Jul;11(7):1009-13. doi: 10.1038/sj.leu.2400710. PMID: 9204983

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Prognosis

Cerebriform variant type of T cell prolymphocytic leukemia with complex karyotype including an additional segment at 1p36.1.

Kasahara S, Tsurumi H, Shibata Y, Matsumoto T, Nakamura N, Nakamura H, Kanemura N, Goto N, Hara T, Moriwaki H
Int J Hematol 2012 Nov;96(5):674-8. Epub 2012 Oct 5 doi: 10.1007/s12185-012-1176-9. PMID: 23054642

T-cell prolymphocytic leukemia in Japan: is it a variant?

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Clinical prediction guides

T-cell prolymphocytic leukemia in Japan: is it a variant?

Relationship of T leukaemias with cerebriform nuclei to T-prolymphocytic leukaemia: a cytogenetic analysis with in situ hybridization.

Brito-Babapulle V, Maljaie SH, Matutes E, Hedges M, Yuille M, Catovsky D
Br J Haematol 1997 Mar;96(4):724-32. doi: 10.1046/j.1365-2141.1997.9702605.x. PMID: 9074412

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T-Cell Prolymphocytic Leukemia, Cerebriform Cell Variant

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Related information

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