U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lymphoid neoplasm

MedGen UID:
108626
•Concept ID:
C0598798
•
Neoplastic Process
Synonyms: Lymphocytic and Plasma Cell Neoplasm; lymphocytic and plasma cell neoplasm; Lymphocytic and Plasma Cell Tumor; lymphocytic and plasma cell tumor; Lymphocytic and Plasma Cell Tumour; lymphocytic and plasma cell tumour; Lymphocytic and Plasmacytic Neoplasm; lymphocytic and plasmacytic neoplasm; Lymphocytic Neoplasm; lymphocytic neoplasm; Lymphocytic Tumor; lymphocytic tumor; Lymphoid and Plasma Cell Tumor; lymphoid and plasma cell tumor; Lymphoid and Plasma Cell Tumour; lymphoid and plasma cell tumour; Lymphoid and Plasmacytic Neoplasm; lymphoid and plasmacytic neoplasm; Lymphoid and Plasmacytic Tumor; lymphoid and plasmacytic tumor; Lymphoid and Plasmacytic Tumour; lymphoid and plasmacytic tumour; Lymphoid Neoplasm; lymphoid neoplasm; Lymphoid Tumor; lymphoid tumor
SNOMED CT: Lymphoid neoplasm (414628006)
 
Monarch Initiative: MONDO:0005157

Definition

A neoplasm composed of a lymphocytic cell population which is usually malignant (clonal) by molecular genetic and/or immunophenotypic analysis. Lymphocytic neoplasms include Hodgkin and non-Hodgkin lymphomas, acute and chronic lymphocytic leukemias, and plasma cell neoplasms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphoid neoplasm

Professional guidelines

PubMed

Differences in the diagnosis and treatment of hematologic malignancies attributable to health insurance coverage.
Song EY, Shin S, Park H, Kim N, Yoon JH, Roh EY
Medicine (Baltimore) 2022 Mar 4;101(9):e29020. doi: 10.1097/MD.0000000000029020. PMID: 35244084Free PMC Article
Waldenström Macroglobulinemia: Review of Pathogenesis and Management.
Yun S, Johnson AC, Okolo ON, Arnold SJ, McBride A, Zhang L, Baz RC, Anwer F
Clin Lymphoma Myeloma Leuk 2017 May;17(5):252-262. Epub 2017 Mar 7 doi: 10.1016/j.clml.2017.02.028. PMID: 28366781Free PMC Article
High-dose chemotherapy with hematopoietic stem cell transplantation for the treatment of primary central nervous system lymphoma.
Campen CJ, Tombleson RL, Green MR
J Neurooncol 2011 Feb;101(3):345-55. Epub 2010 Jul 4 doi: 10.1007/s11060-010-0279-5. PMID: 20607357

Recent clinical studies

Etiology

EBV-driven lymphoid neoplasms associated with pediatric ALL maintenance therapy.
Elitzur S, Vora A, Burkhardt B, Inaba H, Attarbaschi A, Baruchel A, Escherich G, Gibson B, Liu HC, Loh M, Moorman AV, Möricke A, Pieters R, Uyttebroeck A, Baird S, Bartram J, Barzilai-Birenboim S, Batra S, Ben-Harosh M, Bertrand Y, Buitenkamp T, Caldwell K, Drut R, Geerlinks AV, Gilad G, Grainger J, Haouy S, Heaney N, Huang M, Ingham D, Krenova Z, Kuhlen M, Lehrnbecher T, Manabe A, Niggli F, Paris C, Revel-Vilk S, Rohrlich P, Sinno MG, Szczepanski T, Tamesberger M, Warrier R, Wolfl M, Nirel R, Izraeli S, Borkhardt A, Schmiegelow K
Blood 2023 Feb 16;141(7):743-755. doi: 10.1182/blood.2022016975. PMID: 36332176
Breast Implant-associated Anaplastic Large Cell Lymphoma.
Alotaibi S, Hamadani M, Al-Mansour M, Aljurf M
Clin Lymphoma Myeloma Leuk 2021 Mar;21(3):e272-e276. Epub 2020 Dec 13 doi: 10.1016/j.clml.2020.12.005. PMID: 33384263
Tea Drinking and Risk of Cancer Incidence: A Meta-Analysis of Prospective Cohort Studies and Evidence Evaluation.
Zhao LG, Li ZY, Feng GS, Ji XW, Tan YT, Li HL, Gunter MJ, Xiang YB
Adv Nutr 2021 Mar 31;12(2):402-412. doi: 10.1093/advances/nmaa117. PMID: 33002099Free PMC Article
Platelet-derived growth factor receptors (PDGFRs) fusion genes involvement in hematological malignancies.
Appiah-Kubi K, Lan T, Wang Y, Qian H, Wu M, Yao X, Wu Y, Chen Y
Crit Rev Oncol Hematol 2017 Jan;109:20-34. Epub 2016 Nov 21 doi: 10.1016/j.critrevonc.2016.11.008. PMID: 28010895
A comprehensive review of occupational and general population cancer risk: 1,3-Butadiene exposure-response modeling for all leukemia, acute myelogenous leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia, myeloid neoplasm and lymphoid neoplasm.
Sielken RL Jr, Valdez-Flores C
Chem Biol Interact 2015 Nov 5;241:50-8. Epub 2015 Jun 10 doi: 10.1016/j.cbi.2015.06.009. PMID: 26070419

Diagnosis

EBV-driven lymphoid neoplasms associated with pediatric ALL maintenance therapy.
Elitzur S, Vora A, Burkhardt B, Inaba H, Attarbaschi A, Baruchel A, Escherich G, Gibson B, Liu HC, Loh M, Moorman AV, Möricke A, Pieters R, Uyttebroeck A, Baird S, Bartram J, Barzilai-Birenboim S, Batra S, Ben-Harosh M, Bertrand Y, Buitenkamp T, Caldwell K, Drut R, Geerlinks AV, Gilad G, Grainger J, Haouy S, Heaney N, Huang M, Ingham D, Krenova Z, Kuhlen M, Lehrnbecher T, Manabe A, Niggli F, Paris C, Revel-Vilk S, Rohrlich P, Sinno MG, Szczepanski T, Tamesberger M, Warrier R, Wolfl M, Nirel R, Izraeli S, Borkhardt A, Schmiegelow K
Blood 2023 Feb 16;141(7):743-755. doi: 10.1182/blood.2022016975. PMID: 36332176
Updates on eosinophilic disorders.
Tzankov A, Reichard KK, Hasserjian RP, Arber DA, Orazi A, Wang SA
Virchows Arch 2023 Jan;482(1):85-97. Epub 2022 Sep 7 doi: 10.1007/s00428-022-03402-8. PMID: 36068374
Breast Implant-associated Anaplastic Large Cell Lymphoma.
Alotaibi S, Hamadani M, Al-Mansour M, Aljurf M
Clin Lymphoma Myeloma Leuk 2021 Mar;21(3):e272-e276. Epub 2020 Dec 13 doi: 10.1016/j.clml.2020.12.005. PMID: 33384263
Pseudolymphomatous Atypical Fibroxanthoma.
Garcia Castro R, Viñolas-Cuadros A, Moyano-Bueno D, Conde-Ferreiros A, Cardeñoso E, Santos-Briz A
Am J Dermatopathol 2020 Dec;42(12):972-976. doi: 10.1097/DAD.0000000000001761. PMID: 32769551
Waldenström macroglobulinaemia.
Ghobrial IM, Gertz MA, Fonseca R
Lancet Oncol 2003 Nov;4(11):679-85. doi: 10.1016/s1470-2045(03)01246-4. PMID: 14602248

Therapy

KIR3DL2 contributes to the typing of acute adult T-cell leukemia and is a potential therapeutic target.
Cheminant M, Lhermitte L, Bruneau J, Sicard H, Bonnafous C, Touzart A, Bourbon E, Ortonne N, Genestier L, Gaulard P, Palmic P, Suarez F, Frenzel L, Naveau L, Bazarbachi A, Dussiot M, Waast L, Avettand-Fenoel V, Brouzes C, Pique C, Lepelletier Y, Asnafi V, Marçais A, Hermine O
Blood 2022 Sep 29;140(13):1522-1532. doi: 10.1182/blood.2022016765. PMID: 35687761
Genomic and transcriptomic profiling reveals distinct molecular subsets associated with outcomes in mantle cell lymphoma.
Yi S, Yan Y, Jin M, Bhattacharya S, Wang Y, Wu Y, Yang L, Gine E, Clot G, Chen L, Yu Y, Zou D, Wang J, Phan AT, Cui R, Li F, Sun Q, Zhai Q, Wang T, Yu Z, Liu L, Liu W, Lyv R, Sui W, Huang W, Xiong W, Wang H, Li C, Xiao Z, Hao M, Wang J, Cheng T, Bea S, Herrera AF, Danilov A, Campo E, Ngo VN, Qiu L, Wang L
J Clin Invest 2022 Feb 1;132(3) doi: 10.1172/JCI153283. PMID: 34882582Free PMC Article
Breast Implant-associated Anaplastic Large Cell Lymphoma.
Alotaibi S, Hamadani M, Al-Mansour M, Aljurf M
Clin Lymphoma Myeloma Leuk 2021 Mar;21(3):e272-e276. Epub 2020 Dec 13 doi: 10.1016/j.clml.2020.12.005. PMID: 33384263
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
A comprehensive review of occupational and general population cancer risk: 1,3-Butadiene exposure-response modeling for all leukemia, acute myelogenous leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia, myeloid neoplasm and lymphoid neoplasm.
Sielken RL Jr, Valdez-Flores C
Chem Biol Interact 2015 Nov 5;241:50-8. Epub 2015 Jun 10 doi: 10.1016/j.cbi.2015.06.009. PMID: 26070419

Prognosis

The Prognostic Value and Immunological Role of STEAP1 in Pan-Cancer: A Result of Data-Based Analysis.
Zhao C, Xiong K, Ji Z, Liu F, Li X
Oxid Med Cell Longev 2022;2022:8297011. Epub 2022 Mar 11 doi: 10.1155/2022/8297011. PMID: 35313641Free PMC Article
Genomic and transcriptomic profiling reveals distinct molecular subsets associated with outcomes in mantle cell lymphoma.
Yi S, Yan Y, Jin M, Bhattacharya S, Wang Y, Wu Y, Yang L, Gine E, Clot G, Chen L, Yu Y, Zou D, Wang J, Phan AT, Cui R, Li F, Sun Q, Zhai Q, Wang T, Yu Z, Liu L, Liu W, Lyv R, Sui W, Huang W, Xiong W, Wang H, Li C, Xiao Z, Hao M, Wang J, Cheng T, Bea S, Herrera AF, Danilov A, Campo E, Ngo VN, Qiu L, Wang L
J Clin Invest 2022 Feb 1;132(3) doi: 10.1172/JCI153283. PMID: 34882582Free PMC Article
Breast Implant-associated Anaplastic Large Cell Lymphoma.
Alotaibi S, Hamadani M, Al-Mansour M, Aljurf M
Clin Lymphoma Myeloma Leuk 2021 Mar;21(3):e272-e276. Epub 2020 Dec 13 doi: 10.1016/j.clml.2020.12.005. PMID: 33384263
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Genetic alterations and their clinical implications in DLBCL.
Miao Y, Medeiros LJ, Li Y, Li J, Young KH
Nat Rev Clin Oncol 2019 Oct;16(10):634-652. doi: 10.1038/s41571-019-0225-1. PMID: 31127191

Clinical prediction guides

The Prognostic Value and Immunological Role of STEAP1 in Pan-Cancer: A Result of Data-Based Analysis.
Zhao C, Xiong K, Ji Z, Liu F, Li X
Oxid Med Cell Longev 2022;2022:8297011. Epub 2022 Mar 11 doi: 10.1155/2022/8297011. PMID: 35313641Free PMC Article
Tea Drinking and Risk of Cancer Incidence: A Meta-Analysis of Prospective Cohort Studies and Evidence Evaluation.
Zhao LG, Li ZY, Feng GS, Ji XW, Tan YT, Li HL, Gunter MJ, Xiang YB
Adv Nutr 2021 Mar 31;12(2):402-412. doi: 10.1093/advances/nmaa117. PMID: 33002099Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Genetic alterations and their clinical implications in DLBCL.
Miao Y, Medeiros LJ, Li Y, Li J, Young KH
Nat Rev Clin Oncol 2019 Oct;16(10):634-652. doi: 10.1038/s41571-019-0225-1. PMID: 31127191
Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia.
Nadeu F, Delgado J, Royo C, Baumann T, Stankovic T, Pinyol M, Jares P, Navarro A, Martín-García D, Beà S, Salaverria I, Oldreive C, Aymerich M, Suárez-Cisneros H, Rozman M, Villamor N, Colomer D, López-Guillermo A, González M, Alcoceba M, Terol MJ, Colado E, Puente XS, López-Otín C, Enjuanes A, Campo E
Blood 2016 Apr 28;127(17):2122-30. Epub 2016 Feb 2 doi: 10.1182/blood-2015-07-659144. PMID: 26837699Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...