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Nephrogenic adenoma of the urethra

MedGen UID:
277847
•Concept ID:
C1336889
•
Disease or Syndrome
Synonyms: Nephrogenic Adenoma of the Urethra; nephrogenic adenoma of the urethra; Nephrogenic Adenoma of Urethra; nephrogenic adenoma of urethra; urethra nephrogenic adenoma; Urethral Nephrogenic Adenoma; urethral nephrogenic adenoma
 
Monarch Initiative: MONDO:0004464

Definition

A metaplastic lesion of the urothelium found in the urethra. It is characterized by the presence of aggregates of cuboidal or hobnail cells and represents a reaction of the urothelium to injury caused by instrumentation, surgery or calculi. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNephrogenic adenoma of the urethra

Professional guidelines

PubMed

Nephrogenic Adenoma: Clinical Features, Management, and Diagnostic Pitfalls.
Gordetsky J, Gennaro KH, Selph JP, Rais-Bahrami S
Urology 2016 Sep;95:29-33. Epub 2016 Apr 29 doi: 10.1016/j.urology.2016.04.032. PMID: 27138263
Expression of alpha-methylacyl-CoA racemase (P504S) in nephrogenic adenoma: a significant immunohistochemical pitfall compounding the differential diagnosis with prostatic adenocarcinoma.
Skinnider BF, Oliva E, Young RH, Amin MB
Am J Surg Pathol 2004 Jun;28(6):701-5. doi: 10.1097/01.pas.0000126759.43227.d9. PMID: 15166661

Recent clinical studies

Diagnosis

Nephrogenic adenoma mimicking carcinoma: a potential pitfall in cytodiagnosis.
Henke AC, Callaghan EJ, Timmerman TG, Hughes JH
Diagn Cytopathol 2000 Jan;22(1):49-51. doi: 10.1002/(sici)1097-0339(200001)22:1<49::aid-dc13>3.0.co;2-j. PMID: 10613974
Clear cell adenocarcinoma and nephrogenic adenoma of the urethra and urinary bladder: a histopathologic and immunohistochemical comparison.
Gilcrease MZ, Delgado R, Vuitch F, Albores-Saavedra J
Hum Pathol 1998 Dec;29(12):1451-6. doi: 10.1016/s0046-8177(98)90015-6. PMID: 9865832

Clinical prediction guides

Clear cell adenocarcinoma and nephrogenic adenoma of the urethra and urinary bladder: a histopathologic and immunohistochemical comparison.
Gilcrease MZ, Delgado R, Vuitch F, Albores-Saavedra J
Hum Pathol 1998 Dec;29(12):1451-6. doi: 10.1016/s0046-8177(98)90015-6. PMID: 9865832

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