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Bladder Urothelial Dysplasia

MedGen UID:
285639
•Concept ID:
C1521918
•
Neoplastic Process
Synonym: Low-grade intraurothelial neoplasia
SNOMED CT: Low-grade intraurothelial neoplasia (399466007)

Definition

Intraurothelial neoplasia characterized by dysplastic changes which are not severe enough to warrant the diagnosis of bladder carcinoma in situ. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder Urothelial Dysplasia

Professional guidelines

PubMed

Best practices recommendations in the application of immunohistochemistry in the bladder lesions: report from the International Society of Urologic Pathology consensus conference.
Amin MB, Trpkov K, Lopez-Beltran A, Grignon D; Members of the ISUP Immunohistochemistry in Diagnostic Urologic Pathology Group
Am J Surg Pathol 2014 Aug;38(8):e20-34. doi: 10.1097/PAS.0000000000000240. PMID: 25029121
Prevention and treatment of urothelial premalignant and malignant lesions.
Wijkström H, Cohen SM, Gardiner RA, Kakizoe T, Schoenberg M, Steineck G, Tobisu K
Scand J Urol Nephrol Suppl 2000;(205):116-35. doi: 10.1080/00365590050509878. PMID: 11144892
Diagnosis and management of superficial bladder cancer.
Soloway MS
Semin Surg Oncol 1989;5(4):247-54. doi: 10.1002/ssu.2980050407. PMID: 2549605

Recent clinical studies

Etiology

Precursor lesions of the urinary bladder.
McKenney JK
Histopathology 2019 Jan;74(1):68-76. doi: 10.1111/his.13762. PMID: 30565304
Iatrogenic pathology of the urinary bladder.
Lopez-Beltran A, Montironi R, Raspollini MR, Cheng L, Netto GJ
Semin Diagn Pathol 2018 Jul;35(4):218-227. Epub 2018 Mar 14 doi: 10.1053/j.semdp.2018.03.001. PMID: 29576423
Iatrogenic changes in the urinary tract.
Lopez-Beltran A, Paner GP, Montironi R, Raspollini MR, Cheng L
Histopathology 2017 Jan;70(1):10-25. doi: 10.1111/his.13090. PMID: 27960233
The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part B: Prostate and Bladder Tumours.
Humphrey PA, Moch H, Cubilla AL, Ulbright TM, Reuter VE
Eur Urol 2016 Jul;70(1):106-119. Epub 2016 Mar 17 doi: 10.1016/j.eururo.2016.02.028. PMID: 26996659
Epidemiology and etiology of premalignant and malignant urothelial changes.
Cohen SM, Shirai T, Steineck G
Scand J Urol Nephrol Suppl 2000;(205):105-15. doi: 10.1080/00365590050509869. PMID: 11144890

Diagnosis

Urothelial carcinoma in situ: diagnostic update.
McKenney JK
Pathology 2021 Jan;53(1):86-95. Epub 2020 Nov 21 doi: 10.1016/j.pathol.2020.10.001. PMID: 33234229
Precursor lesions of the urinary bladder.
McKenney JK
Histopathology 2019 Jan;74(1):68-76. doi: 10.1111/his.13762. PMID: 30565304
Iatrogenic changes in the urinary tract.
Lopez-Beltran A, Paner GP, Montironi R, Raspollini MR, Cheng L
Histopathology 2017 Jan;70(1):10-25. doi: 10.1111/his.13090. PMID: 27960233
Dysplasia and carcinoma in situ of the urinary bladder.
Lopez-Beltran A, Marques RC, Montironi R, Reymundo C, Fonseca J, Cheng L
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):29-38. PMID: 26072632
Urothelial dysplasia of the bladder: diagnostic features and clinical significance.
Lopez-Beltran A, Montironi R, Vidal A, Scarpelli M, Cheng L
Anal Quant Cytopathol Histpathol 2013 Jun;35(3):121-9. PMID: 24344498

Therapy

TERT C228T mutation in non-malignant bladder urothelium is associated with intravesical recurrence for patients with non-muscle invasive bladder cancer.
Hayashi Y, Fujita K, Nojima S, Tomiyama E, Matsushita M, Koh Y, Nakano K, Wang C, Ishizuya Y, Kato T, Hatano K, Kawashima A, Ujike T, Uemura M, Imamura R, Morii E, Nonomura N
Mol Oncol 2020 Oct;14(10):2375-2383. Epub 2020 Jun 27 doi: 10.1002/1878-0261.12746. PMID: 32533903Free PMC Article
Iatrogenic pathology of the urinary bladder.
Lopez-Beltran A, Montironi R, Raspollini MR, Cheng L, Netto GJ
Semin Diagn Pathol 2018 Jul;35(4):218-227. Epub 2018 Mar 14 doi: 10.1053/j.semdp.2018.03.001. PMID: 29576423
Iatrogenic changes in the urinary tract.
Lopez-Beltran A, Paner GP, Montironi R, Raspollini MR, Cheng L
Histopathology 2017 Jan;70(1):10-25. doi: 10.1111/his.13090. PMID: 27960233
Use of markers in defining urothelial premalignant and malignant conditions.
Grossman HB, Schmitz-Dräger B, Fradet Y, Tribukait B
Scand J Urol Nephrol Suppl 2000;(205):94-104. doi: 10.1080/003655900750169347. PMID: 11144908
Prevention and treatment of urothelial premalignant and malignant lesions.
Wijkström H, Cohen SM, Gardiner RA, Kakizoe T, Schoenberg M, Steineck G, Tobisu K
Scand J Urol Nephrol Suppl 2000;(205):116-35. doi: 10.1080/00365590050509878. PMID: 11144892

Prognosis

Urinary Bladder Cancer Induced by N-Butyl-N-(4-Hydroxybutyl)-Nitrosamine.
Zupančič D, Romih R
Methods Mol Biol 2024;2773:25-32. doi: 10.1007/978-1-0716-3714-2_3. PMID: 38236533
Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder.
Bruch PG, Plage H, Hofbauer S, Kornienko K, Weinberger S, Roßner F, Schallenberg S, Kluth M, Lennartz M, Blessin NC, Marx AH, Samtleben H, Fisch M, Rink M, Slojewski M, Kaczmarek K, Ecke T, Hallmann S, Koch S, Adamini N, Minner S, Simon R, Sauter G, Zecha H, Klatte T, Schlomm T, Horst D, Elezkurtaj S
Exp Mol Pathol 2023 Jun;131:104860. Epub 2023 Apr 14 doi: 10.1016/j.yexmp.2023.104860. PMID: 36997051
The evolution of bladder cancer genomics: What have we learned and how can we use it?
Audenet F, Attalla K, Sfakianos JP
Urol Oncol 2018 Jul;36(7):313-320. Epub 2018 Mar 21 doi: 10.1016/j.urolonc.2018.02.017. PMID: 29573965
Pathology of upper tract urothelial carcinoma with emphasis on staging.
Mazzucchelli R, Scarpelli M, Galosi AB, Di Primio R, Lopez-Beltran A, Cheng L, Montironi R
Int J Immunopathol Pharmacol 2014 Oct-Dec;27(4):509-16. doi: 10.1177/039463201402700406. PMID: 25572730
Epidemiology and etiology of premalignant and malignant urothelial changes.
Cohen SM, Shirai T, Steineck G
Scand J Urol Nephrol Suppl 2000;(205):105-15. doi: 10.1080/00365590050509869. PMID: 11144890

Clinical prediction guides

Use of Artificial Intelligence for the Interpretable Prediction of the Pathologic Diagnosis and Molecular Abnormalities of Flat Urothelial Lesions.
Nishikawa T, Matsuzaki I, Ryuta I, Musangile FY, Sagan K, Nishikawa M, Mikasa Y, Takahashi Y, Kojima F, Murata SI
Am J Pathol 2023 Jan;193(1):39-50. Epub 2022 Oct 29 doi: 10.1016/j.ajpath.2022.09.013. PMID: 36341995
TERT Promoter Mutation Analysis of Whole-Organ Mapping Bladder Cancers.
Weyerer V, Eckstein M, Strissel PL, Wullweber A, Lange F, Tögel L, Geppert CI, Sikic D, Taubert H, Wach S, Wullich B, Hartmann A, Stoehr R, Giedl J
Genes (Basel) 2021 Feb 5;12(2) doi: 10.3390/genes12020230. PMID: 33562516Free PMC Article
Diagnostic difficulties in cases of papillary urothelial neoplasm of low malignant potential, urothelial proliferation of uncertain malignant potential, urothelial dysplasia and urothelial papilloma: A review of current literature.
Jaworski D, Szylberg Ł, Gzil A, Stawinski P, Kasperska A, Marszałek A
Ann Diagn Pathol 2019 Jun;40:182-188. Epub 2017 Dec 17 doi: 10.1016/j.anndiagpath.2017.12.007. PMID: 29395466
The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part B: Prostate and Bladder Tumours.
Humphrey PA, Moch H, Cubilla AL, Ulbright TM, Reuter VE
Eur Urol 2016 Jul;70(1):106-119. Epub 2016 Mar 17 doi: 10.1016/j.eururo.2016.02.028. PMID: 26996659
Clear cell urothelial carcinoma of the urinary bladder: a case report and review of the literature.
Knez VM, Barrow W, Lucia MS, Wilson S, La Rosa FG
J Med Case Rep 2014 Aug 14;8:275. doi: 10.1186/1752-1947-8-275. PMID: 25124389Free PMC Article

Recent systematic reviews

A systematic review and meta-analysis of CK20, CD44, Ki67 and p53 as immunohistochemical markers in bladder carcinoma in situ.
Straccia P, Fiorentino V, Martini M, Pierconti F
Actas Urol Esp (Engl Ed) 2022 Nov;46(9):521-530. Epub 2022 Aug 6 doi: 10.1016/j.acuroe.2022.08.013. PMID: 36216762

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