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Bladder Non-Invasive Urothelial Neoplasm

MedGen UID:
1678232
•Concept ID:
C4764202
•
Neoplastic Process

Definition

A non-invasive neoplasm that arises from the urothelial lining of the bladder. [from NCI]

Professional guidelines

PubMed

Consultation on UTUC, Stockholm 2018: aspects of treatment.
Jung H, Giusti G, Fajkovic H, Herrmann T, Jones R, Straub M, Baard J, Osther PJS, Brehmer M
World J Urol 2019 Nov;37(11):2279-2287. Epub 2019 May 23 doi: 10.1007/s00345-019-02811-w. PMID: 31123852Free PMC Article
Bladder Cancer Diagnosis and Follow-Up: The Current Status and Possible Role of Extracellular Vesicles.
Oeyen E, Hoekx L, De Wachter S, Baldewijns M, Ameye F, Mertens I
Int J Mol Sci 2019 Feb 14;20(4) doi: 10.3390/ijms20040821. PMID: 30769831Free PMC Article
Urethral recurrence after cystectomy: current preventative measures, diagnosis and management.
Chan Y, Fisher P, Tilki D, Evans CP
BJU Int 2016 Apr;117(4):563-9. Epub 2015 Dec 12 doi: 10.1111/bju.13370. PMID: 26556525

Recent clinical studies

Etiology

Plasma proteomic profiling discovers molecular features associated with upper tract urothelial carcinoma.
Qu Y, Yao Z, Xu N, Shi G, Su J, Ye S, Chang K, Li K, Wang Y, Tan S, Pei X, Chen Y, Qin Z, Feng J, Lv J, Zhu J, Ma F, Tang S, Xu W, Tian X, Anwaier A, Tian S, Xu W, Wu X, Zhu S, Zhu Y, Cao D, Sun M, Gan H, Zhao J, Zhang H, Ye D, Ding C
Cell Rep Med 2023 Sep 19;4(9):101166. Epub 2023 Aug 25 doi: 10.1016/j.xcrm.2023.101166. PMID: 37633276Free PMC Article
Non-Muscle Invasive Bladder Cancer with Variant Histology: Biological Features and Clinical Implications.
Sanguedolce F, Calò B, Mancini V, Zanelli M, Palicelli A, Zizzo M, Ascani S, Carrieri G, Cormio L
Oncology 2021;99(6):345-358. Epub 2021 Mar 18 doi: 10.1159/000514759. PMID: 33735905
Recent advances in pediatric bladder malignancies.
Lopes RI, Mello MF, Lorenzo AJ
F1000Res 2020;9 Epub 2020 Feb 25 doi: 10.12688/f1000research.19396.1. PMID: 32148770Free PMC Article
Tropomyosins: Potential Biomarkers for Urothelial Bladder Cancer.
Humayun-Zakaria N, Arnold R, Goel A, Ward D, Savill S, Bryan RT
Int J Mol Sci 2019 Mar 4;20(5) doi: 10.3390/ijms20051102. PMID: 30836651Free PMC Article
Precursor lesions of the urinary bladder.
McKenney JK
Histopathology 2019 Jan;74(1):68-76. doi: 10.1111/his.13762. PMID: 30565304

Diagnosis

Plasma proteomic profiling discovers molecular features associated with upper tract urothelial carcinoma.
Qu Y, Yao Z, Xu N, Shi G, Su J, Ye S, Chang K, Li K, Wang Y, Tan S, Pei X, Chen Y, Qin Z, Feng J, Lv J, Zhu J, Ma F, Tang S, Xu W, Tian X, Anwaier A, Tian S, Xu W, Wu X, Zhu S, Zhu Y, Cao D, Sun M, Gan H, Zhao J, Zhang H, Ye D, Ding C
Cell Rep Med 2023 Sep 19;4(9):101166. Epub 2023 Aug 25 doi: 10.1016/j.xcrm.2023.101166. PMID: 37633276Free PMC Article
Circulating and urinary tumour DNA in urothelial carcinoma - upper tract, lower tract and metastatic disease.
Rose KM, Huelster HL, Meeks JJ, Faltas BM, Sonpavde GP, Lerner SP, Ross JS, Spiess PE, Grass GD, Jain RK, Kamat AM, Vosoughi A, Wang L, Wang X, Li R
Nat Rev Urol 2023 Jul;20(7):406-419. Epub 2023 Mar 28 doi: 10.1038/s41585-023-00725-2. PMID: 36977797
News in the classification of WHO 2022 bladder tumors.
Raspollini MR, Comperat EM, Lopez-Beltran A, Montironi R, Cimadamore A, Tsuzuki T, Netto GJ
Pathologica 2022 Feb;115(1):32-40. Epub 2023 Jan 25 doi: 10.32074/1591-951X-838. PMID: 36704871Free PMC Article
Can urinary biomarkers replace cystoscopy?
Maas M, Bedke J, Stenzl A, Todenhöfer T
World J Urol 2019 Sep;37(9):1741-1749. Epub 2018 Oct 3 doi: 10.1007/s00345-018-2505-2. PMID: 30283995
The occult urothelial cancer.
Ragonese M, Racioppi M, D'Agostino D, Di Gianfrancesco L, Lenci N, Bientinesi R, Palermo G, Sacco E, Pinto F, Bassi PF
Urologia 2016 May 24;83(2):55-60. Epub 2016 Mar 14 doi: 10.5301/uro.5000131. PMID: 26481721

Therapy

5-year outcomes after stereotactic ablative body radiotherapy for primary renal cell carcinoma: an individual patient data meta-analysis from IROCK (the International Radiosurgery Consortium of the Kidney).
Siva S, Ali M, Correa RJM, Muacevic A, Ponsky L, Ellis RJ, Lo SS, Onishi H, Swaminath A, McLaughlin M, Morgan SC, Cury FL, Teh BS, Mahadevan A, Kaplan ID, Chu W, Grubb W, Hannan R, Staehler M, Warner A, Louie AV
Lancet Oncol 2022 Dec;23(12):1508-1516. Epub 2022 Nov 16 doi: 10.1016/S1470-2045(22)00656-8. PMID: 36400098
Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma.
Boot A, Jiang N, Rozen SG
Theranostics 2020;10(12):5578-5580. Epub 2020 Apr 21 doi: 10.7150/thno.46489. PMID: 32373232Free PMC Article
Targeting FGFR in bladder cancer: ready for clinical practice?
De Keukeleire S, De Maeseneer D, Jacobs C, Rottey S
Acta Clin Belg 2020 Feb;75(1):49-56. Epub 2019 Oct 31 doi: 10.1080/17843286.2019.1685738. PMID: 31671027
Consultation on UTUC, Stockholm 2018: aspects of treatment.
Jung H, Giusti G, Fajkovic H, Herrmann T, Jones R, Straub M, Baard J, Osther PJS, Brehmer M
World J Urol 2019 Nov;37(11):2279-2287. Epub 2019 May 23 doi: 10.1007/s00345-019-02811-w. PMID: 31123852Free PMC Article
Can urinary biomarkers replace cystoscopy?
Maas M, Bedke J, Stenzl A, Todenhöfer T
World J Urol 2019 Sep;37(9):1741-1749. Epub 2018 Oct 3 doi: 10.1007/s00345-018-2505-2. PMID: 30283995

Prognosis

Plasma proteomic profiling discovers molecular features associated with upper tract urothelial carcinoma.
Qu Y, Yao Z, Xu N, Shi G, Su J, Ye S, Chang K, Li K, Wang Y, Tan S, Pei X, Chen Y, Qin Z, Feng J, Lv J, Zhu J, Ma F, Tang S, Xu W, Tian X, Anwaier A, Tian S, Xu W, Wu X, Zhu S, Zhu Y, Cao D, Sun M, Gan H, Zhao J, Zhang H, Ye D, Ding C
Cell Rep Med 2023 Sep 19;4(9):101166. Epub 2023 Aug 25 doi: 10.1016/j.xcrm.2023.101166. PMID: 37633276Free PMC Article
Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review.
Aveta A, Cilio S, Contieri R, Spena G, Napolitano L, Manfredi C, Franco A, Crocerossa F, Cerrato C, Ferro M, Del Giudice F, Verze P, Lasorsa F, Salonia A, Nair R, Walz J, Lucarelli G, Pandolfo SD
Int J Mol Sci 2023 Jun 29;24(13) doi: 10.3390/ijms241310846. PMID: 37446024Free PMC Article
Circulating and urinary tumour DNA in urothelial carcinoma - upper tract, lower tract and metastatic disease.
Rose KM, Huelster HL, Meeks JJ, Faltas BM, Sonpavde GP, Lerner SP, Ross JS, Spiess PE, Grass GD, Jain RK, Kamat AM, Vosoughi A, Wang L, Wang X, Li R
Nat Rev Urol 2023 Jul;20(7):406-419. Epub 2023 Mar 28 doi: 10.1038/s41585-023-00725-2. PMID: 36977797
Non-Muscle Invasive Bladder Cancer with Variant Histology: Biological Features and Clinical Implications.
Sanguedolce F, Calò B, Mancini V, Zanelli M, Palicelli A, Zizzo M, Ascani S, Carrieri G, Cormio L
Oncology 2021;99(6):345-358. Epub 2021 Mar 18 doi: 10.1159/000514759. PMID: 33735905
Recent advances in pediatric bladder malignancies.
Lopes RI, Mello MF, Lorenzo AJ
F1000Res 2020;9 Epub 2020 Feb 25 doi: 10.12688/f1000research.19396.1. PMID: 32148770Free PMC Article

Clinical prediction guides

Plasma proteomic profiling discovers molecular features associated with upper tract urothelial carcinoma.
Qu Y, Yao Z, Xu N, Shi G, Su J, Ye S, Chang K, Li K, Wang Y, Tan S, Pei X, Chen Y, Qin Z, Feng J, Lv J, Zhu J, Ma F, Tang S, Xu W, Tian X, Anwaier A, Tian S, Xu W, Wu X, Zhu S, Zhu Y, Cao D, Sun M, Gan H, Zhao J, Zhang H, Ye D, Ding C
Cell Rep Med 2023 Sep 19;4(9):101166. Epub 2023 Aug 25 doi: 10.1016/j.xcrm.2023.101166. PMID: 37633276Free PMC Article
Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review.
Aveta A, Cilio S, Contieri R, Spena G, Napolitano L, Manfredi C, Franco A, Crocerossa F, Cerrato C, Ferro M, Del Giudice F, Verze P, Lasorsa F, Salonia A, Nair R, Walz J, Lucarelli G, Pandolfo SD
Int J Mol Sci 2023 Jun 29;24(13) doi: 10.3390/ijms241310846. PMID: 37446024Free PMC Article
Circulating and urinary tumour DNA in urothelial carcinoma - upper tract, lower tract and metastatic disease.
Rose KM, Huelster HL, Meeks JJ, Faltas BM, Sonpavde GP, Lerner SP, Ross JS, Spiess PE, Grass GD, Jain RK, Kamat AM, Vosoughi A, Wang L, Wang X, Li R
Nat Rev Urol 2023 Jul;20(7):406-419. Epub 2023 Mar 28 doi: 10.1038/s41585-023-00725-2. PMID: 36977797
Non-Muscle Invasive Bladder Cancer with Variant Histology: Biological Features and Clinical Implications.
Sanguedolce F, Calò B, Mancini V, Zanelli M, Palicelli A, Zizzo M, Ascani S, Carrieri G, Cormio L
Oncology 2021;99(6):345-358. Epub 2021 Mar 18 doi: 10.1159/000514759. PMID: 33735905
The occult urothelial cancer.
Ragonese M, Racioppi M, D'Agostino D, Di Gianfrancesco L, Lenci N, Bientinesi R, Palermo G, Sacco E, Pinto F, Bassi PF
Urologia 2016 May 24;83(2):55-60. Epub 2016 Mar 14 doi: 10.5301/uro.5000131. PMID: 26481721

Recent systematic reviews

Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review.
Aveta A, Cilio S, Contieri R, Spena G, Napolitano L, Manfredi C, Franco A, Crocerossa F, Cerrato C, Ferro M, Del Giudice F, Verze P, Lasorsa F, Salonia A, Nair R, Walz J, Lucarelli G, Pandolfo SD
Int J Mol Sci 2023 Jun 29;24(13) doi: 10.3390/ijms241310846. PMID: 37446024Free PMC Article
Diagnostic and prognostic roles of CK20 in the pathology of urothelial lesions. A systematic review.
Sanguedolce F, Russo D, Calò B, Cindolo L, Carrieri G, Cormio L
Pathol Res Pract 2019 Jun;215(6):152413. Epub 2019 Apr 6 doi: 10.1016/j.prp.2019.04.005. PMID: 30987832

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