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Testicular yolk sac tumor, solid pattern

MedGen UID:
308263
•Concept ID:
C1515312
•
Neoplastic Process
Synonyms: solid pattern testicular yolk sac tumor; solid pattern testicular yolk sac tumour; Testicular Yolk Sac Tumor, Solid Pattern; testicular yolk sac tumor, solid pattern
 
Monarch Initiative: MONDO:0004198

Definition

A yolk sac tumor that arises from the testis and is characterized by the presence of aggregates of polygonal malignant cells with clear cytoplasm and prominent nucleoli. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular yolk sac tumor, solid pattern

Professional guidelines

PubMed

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
The differential diagnosis of yolk sac tumor and seminoma. Usefulness of cytokeratin, alpha-fetoprotein, and alpha-1-antitrypsin immunoperoxidase reactions.
Eglen DE, Ulbright TM
Am J Clin Pathol 1987 Sep;88(3):328-32. doi: 10.1093/ajcp/88.3.328. PMID: 2443003

Recent clinical studies

Etiology

"Dissecting Gonadoblastoma" of Scully: A Morphologic Variant That Often Mimics Germinoma.
Kao CS, Idrees MT, Young RH, Ulbright TM
Am J Surg Pathol 2016 Oct;40(10):1417-23. doi: 10.1097/PAS.0000000000000704. PMID: 27454939
High-level expression of divergent endodermal lineage markers in gonadal and extra-gonadal yolk sac tumors.
Shojaei H, Hong H, Redline RW
Mod Pathol 2016 Oct;29(10):1278-88. Epub 2016 Jul 22 doi: 10.1038/modpathol.2016.131. PMID: 27443515
Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases.
Cornejo KM, Frazier L, Lee RS, Kozakewich HP, Young RH
Am J Surg Pathol 2015 Aug;39(8):1121-31. doi: 10.1097/PAS.0000000000000432. PMID: 25828390
Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems.
Young RH
Mod Pathol 2005 Feb;18 Suppl 2:S81-98. doi: 10.1038/modpathol.3800311. PMID: 15502809
Pathogenesis of testicular germ cell tumours.
Looijenga LH, Oosterhuis JW
Rev Reprod 1999 May;4(2):90-100. doi: 10.1530/ror.0.0040090. PMID: 10357096

Diagnosis

FoxA2 is a reliable marker for the diagnosis of yolk sac tumour postpubertal-type.
Ricci C, Ambrosi F, Franceschini T, Giunchi F, Di Filippo G, Franchini E, Massari F, Mollica V, Tateo V, Bianchi FM, Colecchia M, Acosta AM, Fiorentino M
Histopathology 2023 Sep;83(3):465-476. Epub 2023 Jun 14 doi: 10.1111/his.14968. PMID: 37317674
Pure post-pubertal yolk sac tumor of the testis: An extremely rare and aggressive entity.
Patel S, Satturwar S, Khan W, Ashman D, Quiroga-Garza GM
Ann Diagn Pathol 2023 Apr;63:152086. Epub 2022 Dec 23 doi: 10.1016/j.anndiagpath.2022.152086. PMID: 36580878
Recent advances in the regulation of testicular germ cell tumors by microRNAs.
Batool A, Liu XM, Zhang CL, Hao CF, Chen SR, Liu YX
Front Biosci (Landmark Ed) 2019 Mar 1;24(4):765-776. doi: 10.2741/4749. PMID: 30844711
Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases.
Cornejo KM, Frazier L, Lee RS, Kozakewich HP, Young RH
Am J Surg Pathol 2015 Aug;39(8):1121-31. doi: 10.1097/PAS.0000000000000432. PMID: 25828390
Solid pattern yolk sac tumor: a morphologic and immunohistochemical study of 52 cases.
Kao CS, Idrees MT, Young RH, Ulbright TM
Am J Surg Pathol 2012 Mar;36(3):360-7. doi: 10.1097/PAS.0b013e31823c510b. PMID: 22261704

Therapy

Seminoma with tubular, microcystic, and related patterns: a study of 28 cases of unusual morphologic variants that often cause confusion with yolk sac tumor.
Ulbright TM, Young RH
Am J Surg Pathol 2005 Apr;29(4):500-5. doi: 10.1097/01.pas.0000155146.60670.3f. PMID: 15767805
Establishment of a testicular carcinoma cell line producing alpha-fetoprotein.
Ueno M, Nakashima J, Ohigashi T, Deguchi N, Ban S, Akita M, Murai M
BJU Int 2001 Oct;88(6):611-21. doi: 10.1046/j.1464-410x.2001.02357.x. PMID: 11678760
Microcystic Leydig cell tumors mimicking yolk sac tumor: a report of four cases.
Billings SD, Roth LM, Ulbright TM
Am J Surg Pathol 1999 May;23(5):546-51. doi: 10.1097/00000478-199905000-00008. PMID: 10328086

Prognosis

Recent advances in the regulation of testicular germ cell tumors by microRNAs.
Batool A, Liu XM, Zhang CL, Hao CF, Chen SR, Liu YX
Front Biosci (Landmark Ed) 2019 Mar 1;24(4):765-776. doi: 10.2741/4749. PMID: 30844711
"Dissecting Gonadoblastoma" of Scully: A Morphologic Variant That Often Mimics Germinoma.
Kao CS, Idrees MT, Young RH, Ulbright TM
Am J Surg Pathol 2016 Oct;40(10):1417-23. doi: 10.1097/PAS.0000000000000704. PMID: 27454939
Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases.
Cornejo KM, Frazier L, Lee RS, Kozakewich HP, Young RH
Am J Surg Pathol 2015 Aug;39(8):1121-31. doi: 10.1097/PAS.0000000000000432. PMID: 25828390
Solid pattern yolk sac tumor: a morphologic and immunohistochemical study of 52 cases.
Kao CS, Idrees MT, Young RH, Ulbright TM
Am J Surg Pathol 2012 Mar;36(3):360-7. doi: 10.1097/PAS.0b013e31823c510b. PMID: 22261704
Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems.
Young RH
Mod Pathol 2005 Feb;18 Suppl 2:S81-98. doi: 10.1038/modpathol.3800311. PMID: 15502809

Clinical prediction guides

High-level expression of divergent endodermal lineage markers in gonadal and extra-gonadal yolk sac tumors.
Shojaei H, Hong H, Redline RW
Mod Pathol 2016 Oct;29(10):1278-88. Epub 2016 Jul 22 doi: 10.1038/modpathol.2016.131. PMID: 27443515
Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases.
Cornejo KM, Frazier L, Lee RS, Kozakewich HP, Young RH
Am J Surg Pathol 2015 Aug;39(8):1121-31. doi: 10.1097/PAS.0000000000000432. PMID: 25828390
Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis.
Kraggerud SM, Hoei-Hansen CE, Alagaratnam S, Skotheim RI, Abeler VM, Rajpert-De Meyts E, Lothe RA
Endocr Rev 2013 Jun;34(3):339-76. Epub 2013 Apr 10 doi: 10.1210/er.2012-1045. PMID: 23575763Free PMC Article
Solid pattern yolk sac tumor: a morphologic and immunohistochemical study of 52 cases.
Kao CS, Idrees MT, Young RH, Ulbright TM
Am J Surg Pathol 2012 Mar;36(3):360-7. doi: 10.1097/PAS.0b013e31823c510b. PMID: 22261704
Seminoma with tubular, microcystic, and related patterns: a study of 28 cases of unusual morphologic variants that often cause confusion with yolk sac tumor.
Ulbright TM, Young RH
Am J Surg Pathol 2005 Apr;29(4):500-5. doi: 10.1097/01.pas.0000155146.60670.3f. PMID: 15767805

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