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Low Grade Cervical Squamous Intraepithelial Neoplasia

MedGen UID:
309333
•Concept ID:
C1518005
•
Neoplastic Process
Synonyms: Cervical Squamous Intraepithelial Neoplasia 1; Low Grade Cervical Squamous Intraepithelial Lesion; Low-Grade Cervical SIL; Low-Grade Cervical Squamous Intraepithelial Lesion; Low-Grade CIN; Mild Squamous Dysplasia of the Cervix

Definition

A precancerous neoplastic process that affects the cervical squamous epithelium without evidence of invasion. It is usually associated with human papillomavirus infection. It is characterized by the presence of mild atypia in the superficial epithelial layer that may be associated with koilocytosis. Maturation is present in the upper two thirds of the epithelium. Mitotic figures are not numerous and are present in the basal third of the epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow Grade Cervical Squamous Intraepithelial Neoplasia

Professional guidelines

PubMed

Prevalence of human papillomavirus genotypes and precancerous cervical lesions in a screening population in the Republic of Korea, 2014-2016.
Ouh YT, Min KJ, Cho HW, Ki M, Oh JK, Shin SY, Hong JH, Lee JK
J Gynecol Oncol 2018 Jan;29(1):e14. doi: 10.3802/jgo.2018.29.e14. PMID: 29185272Free PMC Article

Recent clinical studies

Etiology

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) consensus statement on the management of vaginal intraepithelial neoplasia.
Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
Severe cervical inflammation and high-grade squamous intraepithelial lesions: a cross-sectional study.
Long T, Long L, Chen Y, Li Y, Tuo Y, Hu Y, Xie L, He G, Zhao W, Lu X, Lin Z
Arch Gynecol Obstet 2021 Feb;303(2):547-556. Epub 2020 Sep 26 doi: 10.1007/s00404-020-05804-y. PMID: 32980959
Developing Classifications of Laryngeal Dysplasia: The Historical Basis.
Hellquist H, Ferlito A, Mäkitie AA, Thompson LDR, Bishop JA, Agaimy A, Hernandez-Prera JC, Gnepp DR, Willems SM, Slootweg PJ, Rinaldo A
Adv Ther 2020 Jun;37(6):2667-2677. Epub 2020 Apr 23 doi: 10.1007/s12325-020-01348-4. PMID: 32329013Free PMC Article
Cervical squamous and glandular intraepithelial neoplasia: identification and current management approaches.
Wright VC
Salud Publica Mex 2003;45 Suppl 3:S417-29. doi: 10.1590/s0036-36342003000900016. PMID: 14746035
Cervical intraepithelial neoplasia.
Crum CP, McLachlin CM
J Cell Biochem Suppl 1995;23:71-9. doi: 10.1002/jcb.240590910. PMID: 8747380

Diagnosis

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Pure intraductal carcinoma of the parotid gland: Cytologic findings on FNA sample. Report of one case.
Barizzi J, Merlo E, Schönegg R, Pelloni R, Mazzuchelli L, Fulciniti F
Diagn Cytopathol 2017 Nov;45(11):1046-1049. Epub 2017 Jun 23 doi: 10.1002/dc.23770. PMID: 28646544
Raman spectroscopy for screening and diagnosis of cervical cancer.
Lyng FM, Traynor D, Ramos IR, Bonnier F, Byrne HJ
Anal Bioanal Chem 2015 Nov;407(27):8279-89. Epub 2015 Aug 16 doi: 10.1007/s00216-015-8946-1. PMID: 26277185
Histology of cervical intraepithelial neoplasia and the role of biomarkers.
Martin CM, O'Leary JJ
Best Pract Res Clin Obstet Gynaecol 2011 Oct;25(5):605-15. Epub 2011 Jun 1 doi: 10.1016/j.bpobgyn.2011.04.005. PMID: 21636328
Cervical intraepithelial neoplasia.
Crum CP, McLachlin CM
J Cell Biochem Suppl 1995;23:71-9. doi: 10.1002/jcb.240590910. PMID: 8747380

Therapy

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) consensus statement on the management of vaginal intraepithelial neoplasia.
Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
Evaluation of 5-aminolevulinic acid-mediated photodynamic therapy in postmenopausal women with persistent HPV infection with or without cervical and vaginal low-grade squamous intraepithelial lesions (CIN1/VaIN1).
Wang L, Liu X, Zhang J, Zhang Y, Jia L
Photodiagnosis Photodyn Ther 2022 Sep;39:103009. Epub 2022 Jul 10 doi: 10.1016/j.pdpdt.2022.103009. PMID: 35830950
HPV testing and vaccination in Europe.
Leeson SC, Alibegashvili T, Arbyn M, Bergeron C, Carriero C, Mergui JL, Nieminen P, Prendiville W, Redman CW, Rieck GC, Quaas J, Petry KU
J Low Genit Tract Dis 2014 Jan;18(1):61-9. doi: 10.1097/LGT.0b013e318286b8d3. PMID: 23774078
LUMA cervical imaging system.
Kendrick JE, Huh WK, Alvarez RD
Expert Rev Med Devices 2007 Mar;4(2):121-9. doi: 10.1586/17434440.4.2.121. PMID: 17359219
Cervical intraepithelial neoplasia.
Crum CP, McLachlin CM
J Cell Biochem Suppl 1995;23:71-9. doi: 10.1002/jcb.240590910. PMID: 8747380

Prognosis

Clinical Regression of High-Grade Cervical Intraepithelial Neoplasia Is Associated With Absence of FAM19A4/miR124-2 DNA Methylation (CONCERVE Study).
Kremer WW, Dick S, Heideman DAM, Steenbergen RDM, Bleeker MCG, Verhoeve HR, van Baal WM, van Trommel N, Kenter GG, Meijer CJLM, Berkhof J
J Clin Oncol 2022 Sep 10;40(26):3037-3046. Epub 2022 May 5 doi: 10.1200/JCO.21.02433. PMID: 35512257Free PMC Article
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Can We Reduce Overtreatment of Cervical High-Grade Squamous Intraepithelial Lesions?
Bradbury M, Rabasa J, Murcia MT, Dinarès MC, Sainz A, Castellet C, Pérez-Benavente A, Gil-Moreno A, Centeno C
J Low Genit Tract Dis 2022 Jan 1;26(1):20-26. doi: 10.1097/LGT.0000000000000635. PMID: 34928250
The role of endocervicoscopy in women with cervical intraepithelial neoplasia: a systematic review of the literature.
Della Corte L, Mercorio A, Giampaolino P, Vitale SG, Vizzielli G, Bifulco G, Lavitola G
Updates Surg 2022 Aug;74(4):1239-1245. Epub 2021 Nov 5 doi: 10.1007/s13304-021-01193-2. PMID: 34739708
Histology of cervical intraepithelial neoplasia and the role of biomarkers.
Martin CM, O'Leary JJ
Best Pract Res Clin Obstet Gynaecol 2011 Oct;25(5):605-15. Epub 2011 Jun 1 doi: 10.1016/j.bpobgyn.2011.04.005. PMID: 21636328

Clinical prediction guides

Cervical Cancer Screening: A Review.
Perkins RB, Wentzensen N, Guido RS, Schiffman M
JAMA 2023 Aug 8;330(6):547-558. doi: 10.1001/jama.2023.13174. PMID: 37552298
Colposcopy Standards: Guidelines for Endocervical Curettage at Colposcopy.
Massad LS, Perkins RB, Naresh A, Nelson EL, Spiryda L, Gecsi KS, Mulhem E, Kostas-Polston E, Zou T, Giles TL, Wentzensen N
J Low Genit Tract Dis 2023 Jan 1;27(1):97-101. Epub 2022 Oct 12 doi: 10.1097/LGT.0000000000000710. PMID: 36222824Free PMC Article
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Wnt3a/β-Catenin/CBP Activation in the Progression of Cervical Intraepithelial Neoplasia.
Feng D, Lin J, Wang W, Yan K, Liang H, Liang J, Yu H, Ling B
Pathol Oncol Res 2021;27:609620. Epub 2021 Mar 31 doi: 10.3389/pore.2021.609620. PMID: 34257574Free PMC Article
Histology of cervical intraepithelial neoplasia and the role of biomarkers.
Martin CM, O'Leary JJ
Best Pract Res Clin Obstet Gynaecol 2011 Oct;25(5):605-15. Epub 2011 Jun 1 doi: 10.1016/j.bpobgyn.2011.04.005. PMID: 21636328

Recent systematic reviews

Recurrence After Biopsy-Confirmed Cervical High-Grade Intraepithelial Lesion Followed by Negative Conization: A Systematic Review and Meta-analysis.
Viveros-Carreño D, Mora-Soto N, Rodríguez J, Rauh-Hain JA, Ramírez PT, López Varón M, Krause KJ, Grillo-Ardila CF, Jeronimo J, Pareja R
J Low Genit Tract Dis 2024 Jan 1;28(1):26-31. Epub 2023 Nov 4 doi: 10.1097/LGT.0000000000000779. PMID: 37924263Free PMC Article
The role of endocervicoscopy in women with cervical intraepithelial neoplasia: a systematic review of the literature.
Della Corte L, Mercorio A, Giampaolino P, Vitale SG, Vizzielli G, Bifulco G, Lavitola G
Updates Surg 2022 Aug;74(4):1239-1245. Epub 2021 Nov 5 doi: 10.1007/s13304-021-01193-2. PMID: 34739708
Cervical Stratified Mucin-Producing Intraepithelial Lesion: A Systematic Review of Diagnosis and Management.
Wolf JL, Billingsley CC, Kendler A, Jackson AL
J Low Genit Tract Dis 2020 Jul;24(3):259-264. doi: 10.1097/LGT.0000000000000536. PMID: 32332219
Guidelines for Cervical Cancer Screening in Immunosuppressed Women Without HIV Infection.
Moscicki AB, Flowers L, Huchko MJ, Long ME, MacLaughlin KL, Murphy J, Spiryda LB, Gold MA
J Low Genit Tract Dis 2019 Apr;23(2):87-101. doi: 10.1097/LGT.0000000000000468. PMID: 30907775
Colposcopic triage methods for detecting cervical intraepithelial neoplasia grade 3 after cytopathological diagnosis of low-grade squamous intraepithelial lesion: a systematic review on diagnostic tests.
Corrêa Fde M, Russomano FB, Oliveira CA
Sao Paulo Med J 2012;130(1):44-52. doi: 10.1590/s1516-31802012000100008. PMID: 22344359Free PMC Article

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