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Cervical squamous intraepithelial neoplasia

MedGen UID:
234116
•Concept ID:
C1332922
•
Neoplastic Process
Synonyms: Cervical SIL; cervical sil; Cervical Squamous Intraepithelial Lesion; cervical squamous intraepithelial lesion; Cervical Squamous Intraepithelial Neoplasia; cervical squamous intraepithelial neoplasia; Cervix Squamous Intraepithelial Lesion; cervix squamous intraepithelial lesion; Cervix Uteri SIL; cervix uteri sil; Cervix Uteri Squamous Intraepithelial Lesion; cervix uteri squamous intraepithelial lesion; CIN; Squamous Intraepithelial Lesion of Cervix; squamous intraepithelial lesion of cervix; Squamous Intraepithelial Lesion of Cervix Uteri; squamous intraepithelial lesion of cervix uteri; Squamous Intraepithelial Lesion of the Cervix; squamous intraepithelial lesion of the cervix; Squamous Intraepithelial Lesion of the Cervix Uteri; squamous intraepithelial lesion of the cervix uteri; Squamous Intraepithelial Lesion of the Uterine Cervix; squamous intraepithelial lesion of the uterine cervix; Squamous Intraepithelial Lesion of Uterine Cervix; squamous intraepithelial lesion of uterine cervix; Uterine Cervix SIL; uterine cervix sil; Uterine Cervix Squamous Intraepithelial Lesion; uterine cervix squamous intraepithelial lesion
 
Monarch Initiative: MONDO:0042491

Definition

A neoplastic process that affects the squamous epithelium of the cervix. It is classified as cervical squamous intraepithelial neoplasia 1, 2, or 3, according to the degree of squamous cell maturation and cellular atypia, and the number of mitotic figures. [from NCI]

Professional guidelines

PubMed

Prevalence of human papillomavirus genotypes and precancerous cervical lesions in a screening population in the Republic of Korea, 2014-2016.
Ouh YT, Min KJ, Cho HW, Ki M, Oh JK, Shin SY, Hong JH, Lee JK
J Gynecol Oncol 2018 Jan;29(1):e14. doi: 10.3802/jgo.2018.29.e14. PMID: 29185272Free PMC Article
Diagnostic and Treatment Reproducibility of Cervical Intraepithelial Neoplasia / Squamous Intraepithelial Lesion and Factors Affecting the Diagnosis.
Sağlam A, Usubütün A, Dolgun A, Mutter GL, Salman MC, Kurtulan O, Akyol A, Özkan EA, Baykara S, Bülbül D, Calay Z, Eren F, Gümürdülü D, Haberal N, Ilvan Ş, Karaveli Ş, Koyuncuoğlu M, Müezzinoğlu B, Müftüoğlu KH, Özen Ö, Özdemir N, Peştereli E, Ulukuş Ç, Zekioğlu O
Turk Patoloji Derg 2017;1(1):177-191. doi: 10.5146/tjpath.2017.01400. PMID: 28832077
Long-term risk of invasive cervical cancer after treatment of squamous cervical intraepithelial neoplasia.
Soutter WP, Sasieni P, Panoskaltsis T
Int J Cancer 2006 Apr 15;118(8):2048-55. doi: 10.1002/ijc.21604. PMID: 16284947

Recent clinical studies

Etiology

Enhanced glycolysis in the myometrium with ectopic endometrium of patients with adenomyosis: a preliminary study.
Huang S, Huang X, Wen X, Liu X, Ma H, Xie L, Wang Y, Liu S, Guan Y, Li K
Gynecol Endocrinol 2024 Dec;40(1):2332411. Epub 2024 Mar 27 doi: 10.1080/09513590.2024.2332411. PMID: 38537663
Comparison of the safety between cervical conization and hysterectomy for patients with cervical adenocarcinoma in situ.
Liu J, Wang Y, Wan X, Zou J, Zhu Y, Lv W, Shen Y
J Gynecol Oncol 2023 Jan;34(1):e8. Epub 2022 Nov 15 doi: 10.3802/jgo.2023.34.e8. PMID: 36424703Free PMC Article
Near-Histologic Resolution Images of Cervical Dysplasia Obtained With Gabor Domain Optical Coherence Microscopy.
Paczos T, Bonham A, Canavesi C, Rolland JP, O'Connell R
J Low Genit Tract Dis 2021 Apr 1;25(2):137-141. doi: 10.1097/LGT.0000000000000590. PMID: 33587529Free PMC Article
Performance of Conventional Cytology and Colposcopy for the Diagnosis of Cervical Squamous and Glandular Neoplasias.
Fachetti-Machado G, Figueiredo-Alves RR, Moreira MAR
Rev Bras Ginecol Obstet 2018 Jul;40(7):410-416. Epub 2018 Jul 11 doi: 10.1055/s-0038-1666995. PMID: 29996168
Endocervicoscopy and Biopsy to Detect Cervical Intraepithelial Squamous Neoplasia in Nonvisible Squamocolumnar Junction With Unsatisfactory Colposcopy: A Pilot Study.
Rahimi S, Marani C, Gardner F, Yeoh CC, Akaev I, Votano S
Technol Cancer Res Treat 2018 Jan 1;17:1533034617753811. doi: 10.1177/1533034617753811. PMID: 29375019Free PMC Article

Diagnosis

Comparison of the safety between cervical conization and hysterectomy for patients with cervical adenocarcinoma in situ.
Liu J, Wang Y, Wan X, Zou J, Zhu Y, Lv W, Shen Y
J Gynecol Oncol 2023 Jan;34(1):e8. Epub 2022 Nov 15 doi: 10.3802/jgo.2023.34.e8. PMID: 36424703Free PMC Article
Near-Histologic Resolution Images of Cervical Dysplasia Obtained With Gabor Domain Optical Coherence Microscopy.
Paczos T, Bonham A, Canavesi C, Rolland JP, O'Connell R
J Low Genit Tract Dis 2021 Apr 1;25(2):137-141. doi: 10.1097/LGT.0000000000000590. PMID: 33587529Free PMC Article
Performance of Conventional Cytology and Colposcopy for the Diagnosis of Cervical Squamous and Glandular Neoplasias.
Fachetti-Machado G, Figueiredo-Alves RR, Moreira MAR
Rev Bras Ginecol Obstet 2018 Jul;40(7):410-416. Epub 2018 Jul 11 doi: 10.1055/s-0038-1666995. PMID: 29996168
Endocervicoscopy and Biopsy to Detect Cervical Intraepithelial Squamous Neoplasia in Nonvisible Squamocolumnar Junction With Unsatisfactory Colposcopy: A Pilot Study.
Rahimi S, Marani C, Gardner F, Yeoh CC, Akaev I, Votano S
Technol Cancer Res Treat 2018 Jan 1;17:1533034617753811. doi: 10.1177/1533034617753811. PMID: 29375019Free PMC Article
Increased expression of claudins in cervical squamous intraepithelial neoplasia and invasive carcinoma.
Sobel G, Páska C, Szabó I, Kiss A, Kádár A, Schaff Z
Hum Pathol 2005 Feb;36(2):162-9. doi: 10.1016/j.humpath.2004.12.001. PMID: 15754293

Therapy

Comparison of 5-ALA-PDT and LEEP of cervical squamous intraepithelial neoplasia (CIN2) with high-risk human papillomavirus infection in childbearing age women: A non-randomized controlled polit study.
Wang L, Liu X, Zhang J, Song M, Liu H, Xu Y, Meng L, Zhang Y, Jia L
Photodiagnosis Photodyn Ther 2024 Apr;46:104044. Epub 2024 Mar 11 doi: 10.1016/j.pdpdt.2024.104044. PMID: 38467338
Comparison of the safety between cervical conization and hysterectomy for patients with cervical adenocarcinoma in situ.
Liu J, Wang Y, Wan X, Zou J, Zhu Y, Lv W, Shen Y
J Gynecol Oncol 2023 Jan;34(1):e8. Epub 2022 Nov 15 doi: 10.3802/jgo.2023.34.e8. PMID: 36424703Free PMC Article
Primary care sector versus treatment centre follow up for post-treatment cervical squamous intraepithelial neoplasia (SIL).
Ray P, Thumuluru KM, Kaul V
Arch Gynecol Obstet 2009 Feb;279(2):109-11. Epub 2008 May 7 doi: 10.1007/s00404-008-0674-8. PMID: 18461342
Phase I/II clinical safety studies of terameprocol vaginal ointment.
Khanna N, Dalby R, Tan M, Arnold S, Stern J, Frazer N
Gynecol Oncol 2007 Dec;107(3):554-62. Epub 2007 Oct 1 doi: 10.1016/j.ygyno.2007.08.074. PMID: 17905420
Post-cone biopsy traumatic neuroma of the uterine cervix.
Barua R
Arch Pathol Lab Med 1989 Aug;113(8):945-7. PMID: 2757497

Prognosis

Elevated expression of endocan in the development of cervical squamous neoplasia of the uterus.
Sato M, Inoue A, Takasawa A, Takasawa K, Kyuno D, Ono Y, Magara K, Osanai M
Med Mol Morphol 2023 Sep;56(3):187-193. Epub 2023 Apr 19 doi: 10.1007/s00795-023-00353-0. PMID: 37074500
Performance of Conventional Cytology and Colposcopy for the Diagnosis of Cervical Squamous and Glandular Neoplasias.
Fachetti-Machado G, Figueiredo-Alves RR, Moreira MAR
Rev Bras Ginecol Obstet 2018 Jul;40(7):410-416. Epub 2018 Jul 11 doi: 10.1055/s-0038-1666995. PMID: 29996168
Endocervicoscopy and Biopsy to Detect Cervical Intraepithelial Squamous Neoplasia in Nonvisible Squamocolumnar Junction With Unsatisfactory Colposcopy: A Pilot Study.
Rahimi S, Marani C, Gardner F, Yeoh CC, Akaev I, Votano S
Technol Cancer Res Treat 2018 Jan 1;17:1533034617753811. doi: 10.1177/1533034617753811. PMID: 29375019Free PMC Article
Primary care sector versus treatment centre follow up for post-treatment cervical squamous intraepithelial neoplasia (SIL).
Ray P, Thumuluru KM, Kaul V
Arch Gynecol Obstet 2009 Feb;279(2):109-11. Epub 2008 May 7 doi: 10.1007/s00404-008-0674-8. PMID: 18461342
Angiogenesis in malignancies of the female genital tract.
Abulafia O, Triest WE, Sherer DM
Gynecol Oncol 1999 Feb;72(2):220-31. doi: 10.1006/gyno.1998.5152. PMID: 10021305

Clinical prediction guides

Enhanced glycolysis in the myometrium with ectopic endometrium of patients with adenomyosis: a preliminary study.
Huang S, Huang X, Wen X, Liu X, Ma H, Xie L, Wang Y, Liu S, Guan Y, Li K
Gynecol Endocrinol 2024 Dec;40(1):2332411. Epub 2024 Mar 27 doi: 10.1080/09513590.2024.2332411. PMID: 38537663
Elevated expression of endocan in the development of cervical squamous neoplasia of the uterus.
Sato M, Inoue A, Takasawa A, Takasawa K, Kyuno D, Ono Y, Magara K, Osanai M
Med Mol Morphol 2023 Sep;56(3):187-193. Epub 2023 Apr 19 doi: 10.1007/s00795-023-00353-0. PMID: 37074500
Near-Histologic Resolution Images of Cervical Dysplasia Obtained With Gabor Domain Optical Coherence Microscopy.
Paczos T, Bonham A, Canavesi C, Rolland JP, O'Connell R
J Low Genit Tract Dis 2021 Apr 1;25(2):137-141. doi: 10.1097/LGT.0000000000000590. PMID: 33587529Free PMC Article
Performance of Conventional Cytology and Colposcopy for the Diagnosis of Cervical Squamous and Glandular Neoplasias.
Fachetti-Machado G, Figueiredo-Alves RR, Moreira MAR
Rev Bras Ginecol Obstet 2018 Jul;40(7):410-416. Epub 2018 Jul 11 doi: 10.1055/s-0038-1666995. PMID: 29996168
Endocervicoscopy and Biopsy to Detect Cervical Intraepithelial Squamous Neoplasia in Nonvisible Squamocolumnar Junction With Unsatisfactory Colposcopy: A Pilot Study.
Rahimi S, Marani C, Gardner F, Yeoh CC, Akaev I, Votano S
Technol Cancer Res Treat 2018 Jan 1;17:1533034617753811. doi: 10.1177/1533034617753811. PMID: 29375019Free PMC Article

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