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Cervical squamous intraepithelial neoplasia

MedGen UID:
234116
Concept ID:
C1332922
Neoplastic Process
Synonyms: Cervical SIL; cervical sil; Cervical Squamous Intraepithelial Lesion; cervical squamous intraepithelial lesion; Cervical Squamous Intraepithelial Neoplasia; cervical squamous intraepithelial neoplasia; Cervix Squamous Intraepithelial Lesion; cervix squamous intraepithelial lesion; Cervix Uteri SIL; cervix uteri sil; Cervix Uteri Squamous Intraepithelial Lesion; cervix uteri squamous intraepithelial lesion; CIN; Squamous Intraepithelial Lesion of Cervix; squamous intraepithelial lesion of cervix; Squamous Intraepithelial Lesion of Cervix Uteri; squamous intraepithelial lesion of cervix uteri; Squamous Intraepithelial Lesion of the Cervix; squamous intraepithelial lesion of the cervix; Squamous Intraepithelial Lesion of the Cervix Uteri; squamous intraepithelial lesion of the cervix uteri; Squamous Intraepithelial Lesion of the Uterine Cervix; squamous intraepithelial lesion of the uterine cervix; Squamous Intraepithelial Lesion of Uterine Cervix; squamous intraepithelial lesion of uterine cervix; Uterine Cervix SIL; uterine cervix sil; Uterine Cervix Squamous Intraepithelial Lesion; uterine cervix squamous intraepithelial lesion
 
Monarch Initiative: MONDO:0042491

Definition

A neoplastic process that affects the squamous epithelium of the cervix. It is classified as cervical squamous intraepithelial neoplasia 1, 2, or 3, according to the degree of squamous cell maturation and cellular atypia, and the number of mitotic figures. [from NCI]

Professional guidelines

PubMed

Ouh YT, Min KJ, Cho HW, Ki M, Oh JK, Shin SY, Hong JH, Lee JK
J Gynecol Oncol 2018 Jan;29(1):e14. doi: 10.3802/jgo.2018.29.e14. PMID: 29185272Free PMC Article
Sağlam A, Usubütün A, Dolgun A, Mutter GL, Salman MC, Kurtulan O, Akyol A, Özkan EA, Baykara S, Bülbül D, Calay Z, Eren F, Gümürdülü D, Haberal N, Ilvan Ş, Karaveli Ş, Koyuncuoğlu M, Müezzinoğlu B, Müftüoğlu KH, Özen Ö, Özdemir N, Peştereli E, Ulukuş Ç, Zekioğlu O
Turk Patoloji Derg 2017;1(1):177-191. doi: 10.5146/tjpath.2017.01400. PMID: 28832077
Soutter WP, Sasieni P, Panoskaltsis T
Int J Cancer 2006 Apr 15;118(8):2048-55. doi: 10.1002/ijc.21604. PMID: 16284947

Recent clinical studies

Etiology

Liu J, Wang Y, Wan X, Zou J, Zhu Y, Lv W, Shen Y
J Gynecol Oncol 2023 Jan;34(1):e8. Epub 2022 Nov 15 doi: 10.3802/jgo.2023.34.e8. PMID: 36424703Free PMC Article
Paczos T, Bonham A, Canavesi C, Rolland JP, O'Connell R
J Low Genit Tract Dis 2021 Apr 1;25(2):137-141. doi: 10.1097/LGT.0000000000000590. PMID: 33587529Free PMC Article
Xie Y, Feng Y, Li W, Zhan F, Huang G, Hu H, Xiong Y, Tan B, Chen T
Front Cell Infect Microbiol 2020;10:538336. Epub 2020 Dec 7 doi: 10.3389/fcimb.2020.538336. PMID: 33365275Free PMC Article
Fachetti-Machado G, Figueiredo-Alves RR, Moreira MAR
Rev Bras Ginecol Obstet 2018 Jul;40(7):410-416. Epub 2018 Jul 11 doi: 10.1055/s-0038-1666995. PMID: 29996168
Rahimi S, Marani C, Gardner F, Yeoh CC, Akaev I, Votano S
Technol Cancer Res Treat 2018 Jan 1;17:1533034617753811. doi: 10.1177/1533034617753811. PMID: 29375019Free PMC Article

Diagnosis

Liu J, Wang Y, Wan X, Zou J, Zhu Y, Lv W, Shen Y
J Gynecol Oncol 2023 Jan;34(1):e8. Epub 2022 Nov 15 doi: 10.3802/jgo.2023.34.e8. PMID: 36424703Free PMC Article
Paczos T, Bonham A, Canavesi C, Rolland JP, O'Connell R
J Low Genit Tract Dis 2021 Apr 1;25(2):137-141. doi: 10.1097/LGT.0000000000000590. PMID: 33587529Free PMC Article
Fachetti-Machado G, Figueiredo-Alves RR, Moreira MAR
Rev Bras Ginecol Obstet 2018 Jul;40(7):410-416. Epub 2018 Jul 11 doi: 10.1055/s-0038-1666995. PMID: 29996168
Rahimi S, Marani C, Gardner F, Yeoh CC, Akaev I, Votano S
Technol Cancer Res Treat 2018 Jan 1;17:1533034617753811. doi: 10.1177/1533034617753811. PMID: 29375019Free PMC Article
Sobel G, Páska C, Szabó I, Kiss A, Kádár A, Schaff Z
Hum Pathol 2005 Feb;36(2):162-9. doi: 10.1016/j.humpath.2004.12.001. PMID: 15754293

Therapy

Liu J, Wang Y, Wan X, Zou J, Zhu Y, Lv W, Shen Y
J Gynecol Oncol 2023 Jan;34(1):e8. Epub 2022 Nov 15 doi: 10.3802/jgo.2023.34.e8. PMID: 36424703Free PMC Article
Ray P, Thumuluru KM, Kaul V
Arch Gynecol Obstet 2009 Feb;279(2):109-11. Epub 2008 May 7 doi: 10.1007/s00404-008-0674-8. PMID: 18461342
Khanna N, Dalby R, Tan M, Arnold S, Stern J, Frazer N
Gynecol Oncol 2007 Dec;107(3):554-62. Epub 2007 Oct 1 doi: 10.1016/j.ygyno.2007.08.074. PMID: 17905420
Barua R
Arch Pathol Lab Med 1989 Aug;113(8):945-7. PMID: 2757497

Prognosis

Sato M, Inoue A, Takasawa A, Takasawa K, Kyuno D, Ono Y, Magara K, Osanai M
Med Mol Morphol 2023 Sep;56(3):187-193. Epub 2023 Apr 19 doi: 10.1007/s00795-023-00353-0. PMID: 37074500
Fachetti-Machado G, Figueiredo-Alves RR, Moreira MAR
Rev Bras Ginecol Obstet 2018 Jul;40(7):410-416. Epub 2018 Jul 11 doi: 10.1055/s-0038-1666995. PMID: 29996168
Rahimi S, Marani C, Gardner F, Yeoh CC, Akaev I, Votano S
Technol Cancer Res Treat 2018 Jan 1;17:1533034617753811. doi: 10.1177/1533034617753811. PMID: 29375019Free PMC Article
Patel A, Thampy N, Hemming D, Naik R
BJOG 2010 Aug;117(9):1051-9. Epub 2010 Jan 26 doi: 10.1111/j.1471-0528.2009.02477.x. PMID: 20105162
Abulafia O, Triest WE, Sherer DM
Gynecol Oncol 1999 Feb;72(2):220-31. doi: 10.1006/gyno.1998.5152. PMID: 10021305

Clinical prediction guides

Sato M, Inoue A, Takasawa A, Takasawa K, Kyuno D, Ono Y, Magara K, Osanai M
Med Mol Morphol 2023 Sep;56(3):187-193. Epub 2023 Apr 19 doi: 10.1007/s00795-023-00353-0. PMID: 37074500
Paczos T, Bonham A, Canavesi C, Rolland JP, O'Connell R
J Low Genit Tract Dis 2021 Apr 1;25(2):137-141. doi: 10.1097/LGT.0000000000000590. PMID: 33587529Free PMC Article
Fachetti-Machado G, Figueiredo-Alves RR, Moreira MAR
Rev Bras Ginecol Obstet 2018 Jul;40(7):410-416. Epub 2018 Jul 11 doi: 10.1055/s-0038-1666995. PMID: 29996168
Rahimi S, Marani C, Gardner F, Yeoh CC, Akaev I, Votano S
Technol Cancer Res Treat 2018 Jan 1;17:1533034617753811. doi: 10.1177/1533034617753811. PMID: 29375019Free PMC Article
Sobel G, Páska C, Szabó I, Kiss A, Kádár A, Schaff Z
Hum Pathol 2005 Feb;36(2):162-9. doi: 10.1016/j.humpath.2004.12.001. PMID: 15754293

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