U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Uterine corpus mixed epithelial and mesenchymal neoplasm

MedGen UID:
311425
•Concept ID:
C1519858
•
Neoplastic Process
Synonyms: body of uterus mixed neoplasm; malignant mixed epithelial and mesenchymal tumor of corpus uteri; Malignant mixed epithelial and mesenchymal tumor of corpus uteri; malignant mixed epithelial and mesenchymal tumour of corpus uteri; Mixed epithelial and mesenchymal cancer of corpus uteri; Uterine Corpus Mixed Epithelial and Mesenchymal Neoplasm; uterine corpus mixed epithelial and mesenchymal neoplasm; Uterine Corpus Mixed Epithelial and Mesenchymal Tumor; uterine corpus mixed epithelial and mesenchymal tumor; uterine corpus mixed epithelial and mesenchymal tumour
 
Monarch Initiative: MONDO:0016255
Orphanet: ORPHA213589

Definition

A primary, benign or malignant neoplasm of the uterine corpus characterized by the presence of an epithelial and a mesenchymal component. Representative examples include adenomyoma, adenosarcoma, and carcinosarcoma. [from NCI]

Professional guidelines

PubMed

Cancers of the corpus uteri treated in South Australian public hospitals: Trends in clinical management and survival across three decades.
Roder D, Selva-Nayagam S, Paramasivam S, Keefe D, Olver I, Miller C, Buckley E, Powell K, Fusco K, Buranyi-Trevarton D, Oehler M
Eur J Cancer Care (Engl) 2020 Sep;29(5):e13281. Epub 2020 Jul 8 doi: 10.1111/ecc.13281. PMID: 32639088

Recent clinical studies

Etiology

Racial and ethnic variations in the incidence of cancers of the uterine corpus, United States, 2001-2003.
Sabatino SA, Stewart SL, Wilson RJ
J Womens Health (Larchmt) 2009 Mar;18(3):285-94. doi: 10.1089/jwh.2008.1171. PMID: 19231990

Diagnosis

Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma.
El Hallani S, Arora R, Lin DI, Måsbäc A, Mateoiu C, McCluggage WG, Nucci MR, Otis CN, Parkash V, Parra-Herran C, Longacre TA
Am J Surg Pathol 2021 Mar 1;45(3):374-383. doi: 10.1097/PAS.0000000000001643. PMID: 33565764
ALK Is a Specific Diagnostic Marker for Inflammatory Myofibroblastic Tumor of the Uterus.
Mohammad N, Haimes JD, Mishkin S, Kudlow BA, Leong MY, Chew SH, Koay E, Whitehouse A, Cope N, Ali RH, Köbel M, Stewart CJR, McCluggage WG, Lee CH
Am J Surg Pathol 2018 Oct;42(10):1353-1359. doi: 10.1097/PAS.0000000000001120. PMID: 30015720
Malignant mixed Müllerian tumor with an extensive squamous-cell carcinomatous component: a potential pitfall in liquid-based cervical cytology.
Bongiovanni M, Vitale VA, Grassi P, Mazzucchelli L
Acta Cytol 2014;58(4):413-8. Epub 2014 Jul 18 doi: 10.1159/000364851. PMID: 25059755
Case of uterine cervical carcinosarcoma.
Iida T, Yasuda M, Kajiwara H, Minematsu T, Osamura RY, Itoh J, Inomo A, Hirasawa T, Muramatsu T, Murakami M
J Obstet Gynaecol Res 2005 Oct;31(5):404-8. doi: 10.1111/j.1447-0756.2005.00310.x. PMID: 16176508
Adenosarcoma of the uterine corpus associated with ovarian thecoma.
Nomura K, Aizawa S, Ushigome S
Pathol Int 2001 Sep;51(9):735-8. doi: 10.1046/j.1440-1827.2001.01259.x. PMID: 11696179

Therapy

Mullerian adenosarcoma of the uterine corpus associated with tamoxifen therapy: a report of six cases and a review of tamoxifen-associated endometrial lesions.
Clement PB, Oliva E, Young RH
Int J Gynecol Pathol 1996 Jul;15(3):222-9. doi: 10.1097/00004347-199607000-00006. PMID: 8811383

Prognosis

Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma.
El Hallani S, Arora R, Lin DI, Måsbäc A, Mateoiu C, McCluggage WG, Nucci MR, Otis CN, Parkash V, Parra-Herran C, Longacre TA
Am J Surg Pathol 2021 Mar 1;45(3):374-383. doi: 10.1097/PAS.0000000000001643. PMID: 33565764
ALK Is a Specific Diagnostic Marker for Inflammatory Myofibroblastic Tumor of the Uterus.
Mohammad N, Haimes JD, Mishkin S, Kudlow BA, Leong MY, Chew SH, Koay E, Whitehouse A, Cope N, Ali RH, Köbel M, Stewart CJR, McCluggage WG, Lee CH
Am J Surg Pathol 2018 Oct;42(10):1353-1359. doi: 10.1097/PAS.0000000000001120. PMID: 30015720
Malignant mixed Müllerian tumor with an extensive squamous-cell carcinomatous component: a potential pitfall in liquid-based cervical cytology.
Bongiovanni M, Vitale VA, Grassi P, Mazzucchelli L
Acta Cytol 2014;58(4):413-8. Epub 2014 Jul 18 doi: 10.1159/000364851. PMID: 25059755
Racial and ethnic variations in the incidence of cancers of the uterine corpus, United States, 2001-2003.
Sabatino SA, Stewart SL, Wilson RJ
J Womens Health (Larchmt) 2009 Mar;18(3):285-94. doi: 10.1089/jwh.2008.1171. PMID: 19231990
Case of uterine cervical carcinosarcoma.
Iida T, Yasuda M, Kajiwara H, Minematsu T, Osamura RY, Itoh J, Inomo A, Hirasawa T, Muramatsu T, Murakami M
J Obstet Gynaecol Res 2005 Oct;31(5):404-8. doi: 10.1111/j.1447-0756.2005.00310.x. PMID: 16176508

Clinical prediction guides

Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma.
El Hallani S, Arora R, Lin DI, Måsbäc A, Mateoiu C, McCluggage WG, Nucci MR, Otis CN, Parkash V, Parra-Herran C, Longacre TA
Am J Surg Pathol 2021 Mar 1;45(3):374-383. doi: 10.1097/PAS.0000000000001643. PMID: 33565764
ALK Is a Specific Diagnostic Marker for Inflammatory Myofibroblastic Tumor of the Uterus.
Mohammad N, Haimes JD, Mishkin S, Kudlow BA, Leong MY, Chew SH, Koay E, Whitehouse A, Cope N, Ali RH, Köbel M, Stewart CJR, McCluggage WG, Lee CH
Am J Surg Pathol 2018 Oct;42(10):1353-1359. doi: 10.1097/PAS.0000000000001120. PMID: 30015720
Malignant mixed Müllerian tumor with an extensive squamous-cell carcinomatous component: a potential pitfall in liquid-based cervical cytology.
Bongiovanni M, Vitale VA, Grassi P, Mazzucchelli L
Acta Cytol 2014;58(4):413-8. Epub 2014 Jul 18 doi: 10.1159/000364851. PMID: 25059755
Genomic aberrations in carcinomas of the uterine corpus.
Micci F, Teixeira MR, Haugom L, Kristensen G, Abeler VM, Heim S
Genes Chromosomes Cancer 2004 Jul;40(3):229-46. doi: 10.1002/gcc.20038. PMID: 15139002
Mullerian adenosarcoma of the uterine corpus associated with tamoxifen therapy: a report of six cases and a review of tamoxifen-associated endometrial lesions.
Clement PB, Oliva E, Young RH
Int J Gynecol Pathol 1996 Jul;15(3):222-9. doi: 10.1097/00004347-199607000-00006. PMID: 8811383

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...