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Small Intestinal Signet Ring Cell Carcinoma

MedGen UID:
313710
•Concept ID:
C1710110
•
Neoplastic Process
Synonym: Small Intestinal Signet-Ring Cell Carcinoma

Definition

An invasive adenocarcinoma that arises from the small intestine. It is characterized by the presence of malignant glandular cells in which the nucleus is pressed to one side by the presence of intracytoplasmic mucus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Intestinal Signet Ring Cell Carcinoma

Recent clinical studies

Etiology

Signet-ring cell carcinoma of the duodenal bulb presenting with gastrointestinal hemorrhage: a case report and literature review.
Ye N, Bao X, Zhao X, Wang B
BMC Gastroenterol 2022 May 9;22(1):226. doi: 10.1186/s12876-022-02267-0. PMID: 35534806Free PMC Article
Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Survival in signet ring cell carcinoma varies based on primary tumor location: a Surveillance, Epidemiology, and End Results database analysis.
Wu SG, Chen XT, Zhang WW, Sun JY, Li FY, He ZY, Pei XQ, Lin Q
Expert Rev Gastroenterol Hepatol 2018 Feb;12(2):209-214. Epub 2017 Dec 17 doi: 10.1080/17474124.2018.1416291. PMID: 29227748
Loss of ARID1A expression is associated with poor prognosis in small intestinal carcinoma.
Kim MJ, Gu MJ, Chang HK, Yu E
Histopathology 2015 Mar;66(4):508-16. Epub 2015 Jan 12 doi: 10.1111/his.12566. PMID: 25400081
Intestinal epithelial lesions associated with signet ring cell carcinoma of the colon and small intestine.
Mai KT, Isotalo PA, Guindi M, Burns BF, Parks W
Pathology 2002 Feb;34(1):51-6. doi: 10.1080/00313020120105642. PMID: 11902446

Diagnosis

Pseudoachalasia as the first manifestation of signet-ring cell duodenal carcinoma.
Trad N, Bel Hadj Mabrouk E, Mensi A, Zaimi Y, Ksantini M, Said Y
Tunis Med 2023 Feb 12;101(2):317-320. PMID: 37682279Free PMC Article
Signet-ring cell carcinoma of the duodenal bulb presenting with gastrointestinal hemorrhage: a case report and literature review.
Ye N, Bao X, Zhao X, Wang B
BMC Gastroenterol 2022 May 9;22(1):226. doi: 10.1186/s12876-022-02267-0. PMID: 35534806Free PMC Article
Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Signet ring cell carcinoma of the Ampulla of Vater: outcomes of patients in the United States.
Kinslow CJ, May MS, Kozak M, Pollom EL, Chang DT
HPB (Oxford) 2020 Dec;22(12):1759-1765. Epub 2020 Apr 18 doi: 10.1016/j.hpb.2020.03.024. PMID: 32317226
Analysis of clinical and histopathological findings in Russell body gastritis and duodenitis.
Altindag SD, Cakir E, Ekinci N, Avci A, Dilek FH
Ann Diagn Pathol 2019 Jun;40:66-71. Epub 2019 Apr 3 doi: 10.1016/j.anndiagpath.2019.04.003. PMID: 31031217

Therapy

Extremely rare mucinous adenocarcinoma of the small bowel causing bilateral metastatic Kukenberg tumors of the ovaries: A case report.
Zhu L, Liu Y, Chen S, Yang G, Wang C
Medicine (Baltimore) 2024 Nov 1;103(44):e40397. doi: 10.1097/MD.0000000000040397. PMID: 39496016
A case of small bowel adenocarcinoma wherein nivolumab conferred temporary benefit in disease control.
Iijima K, Oozeki M, Ikeda K, Honda H, Ishibashi H, Yamaoka M, Fujieda S, Saitoh H, Goto M, Araki M, Amagai K
Clin J Gastroenterol 2020 Jun;13(3):372-376. Epub 2019 Nov 7 doi: 10.1007/s12328-019-01064-9. PMID: 31701367
Occurrence of signet-ring cell carcinoma with cholangiocarcinoma 25 years after choledochal cyst excision: A case report.
Zhang C, Zhou J, Kou K, Liu S, We F, Wang G
Medicine (Baltimore) 2018 Feb;97(8):e9956. doi: 10.1097/MD.0000000000009956. PMID: 29465585Free PMC Article
Outcomes of screening gastroscopy in first-degree relatives of patients fulfilling hereditary diffuse gastric cancer criteria.
van der Post RS, van Dieren J, Grelack A, Hoogerbrugge N, van der Kolk LE, Snaebjornsson P, Lansdorp-Vogelaar I, van Krieken JH, Bisseling TM, Cats A
Gastrointest Endosc 2018 Feb;87(2):397-404.e2. Epub 2017 Apr 25 doi: 10.1016/j.gie.2017.04.016. PMID: 28455161
Signet ring cell carcinoma in adenomatous polyp at site of ureterosigmoidostomy 16 years after conversion to ileal conduit.
Sohn M, Füzesi L, Deutz F, Lagrange W, Kirkpatrick JC, Braun JC
J Urol 1990 Apr;143(4):805-7. doi: 10.1016/s0022-5347(17)40102-9. PMID: 2156089

Prognosis

Signet-ring cell carcinoma of the duodenal bulb presenting with gastrointestinal hemorrhage: a case report and literature review.
Ye N, Bao X, Zhao X, Wang B
BMC Gastroenterol 2022 May 9;22(1):226. doi: 10.1186/s12876-022-02267-0. PMID: 35534806Free PMC Article
Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Signet ring cell carcinoma of the Ampulla of Vater: outcomes of patients in the United States.
Kinslow CJ, May MS, Kozak M, Pollom EL, Chang DT
HPB (Oxford) 2020 Dec;22(12):1759-1765. Epub 2020 Apr 18 doi: 10.1016/j.hpb.2020.03.024. PMID: 32317226
Poorly Cohesive (Signet Ring Cell) Carcinoma of the Ampulla of Vater.
Tuncel D, Basturk O, Bradley KT, Kim GE, Xue Y, Reid MD, Balci S, Erbarut I, Adsay V
Int J Surg Pathol 2020 May;28(3):236-244. Epub 2019 Oct 15 doi: 10.1177/1066896919880968. PMID: 31612756
Survival in signet ring cell carcinoma varies based on primary tumor location: a Surveillance, Epidemiology, and End Results database analysis.
Wu SG, Chen XT, Zhang WW, Sun JY, Li FY, He ZY, Pei XQ, Lin Q
Expert Rev Gastroenterol Hepatol 2018 Feb;12(2):209-214. Epub 2017 Dec 17 doi: 10.1080/17474124.2018.1416291. PMID: 29227748

Clinical prediction guides

Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Deep-Hipo: Multi-scale receptive field deep learning for histopathological image analysis.
Kosaraju SC, Hao J, Koh HM, Kang M
Methods 2020 Jul 1;179:3-13. Epub 2020 May 19 doi: 10.1016/j.ymeth.2020.05.012. PMID: 32442672
Analysis of clinical and histopathological findings in Russell body gastritis and duodenitis.
Altindag SD, Cakir E, Ekinci N, Avci A, Dilek FH
Ann Diagn Pathol 2019 Jun;40:66-71. Epub 2019 Apr 3 doi: 10.1016/j.anndiagpath.2019.04.003. PMID: 31031217
Intramucosal colorectal carcinoma with invasion of the lamina propria: a study by the Japanese Society for Cancer of the Colon and Rectum.
Kojima M, Shimazaki H, Iwaya K, Nakamura T, Kawachi H, Ichikawa K, Sekine S, Ishiguro S, Shimoda T, Kushima R, Yao T, Fujimori T, Hase K, Watanabe T, Sugihara K, Lauwers GY, Ochiai A
Hum Pathol 2017 Aug;66:230-237. Epub 2017 Jul 13 doi: 10.1016/j.humpath.2017.04.031. PMID: 28711649
Loss of ARID1A expression is associated with poor prognosis in small intestinal carcinoma.
Kim MJ, Gu MJ, Chang HK, Yu E
Histopathology 2015 Mar;66(4):508-16. Epub 2015 Jan 12 doi: 10.1111/his.12566. PMID: 25400081

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