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Clear Cell Intrahepatic Cholangiocarcinoma

MedGen UID:
317517
Concept ID:
C1707406
Neoplastic Process

Definition

A morphologic variant of intrahepatic cholangiocarcinoma composed of malignant glandular epithelium, an abundant fibrous stroma, and the presence of clear cells. Clinical symptoms include abdominal pain, weight loss and malaise. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClear Cell Intrahepatic Cholangiocarcinoma

Professional guidelines

PubMed

Dokduang H, Juntana S, Techasen A, Namwat N, Yongvanit P, Khuntikeo N, Riggins GJ, Loilome W
Tumour Biol 2013 Dec;34(6):3519-28. Epub 2013 Jun 29 doi: 10.1007/s13277-013-0930-9. PMID: 23812726
Fayter D, Corbett M, Heirs M, Fox D, Eastwood A
Health Technol Assess 2010 Jul;14(37):1-288. doi: 10.3310/hta14370. PMID: 20663420
Gütgemann I, Haas S, Berg JP, Zhou H, Büttner R, Fischer HP
Virchows Arch 2006 Apr;448(4):407-11. Epub 2006 Jan 13 doi: 10.1007/s00428-005-0145-6. PMID: 16411132

Recent clinical studies

Etiology

Katabathina VS, Khanna L, Surabhi VR, Minervini M, Shanbhogue K, Dasyam AK, Prasad SR
Radiographics 2022 Sep-Oct;42(5):1338-1357. Epub 2022 Jul 1 doi: 10.1148/rg.210206. PMID: 35776676
Pol S, Vallet-Pichard A, Hermine O
Nat Rev Gastroenterol Hepatol 2018 May;15(5):283-290. Epub 2018 Jan 17 doi: 10.1038/nrgastro.2017.172. PMID: 29339810
Kim HJ, Kim JS, Joo MK, Lee BJ, Kim JH, Yeon JE, Park JJ, Byun KS, Bak YT
World J Gastroenterol 2015 Dec 28;21(48):13418-31. doi: 10.3748/wjg.v21.i48.13418. PMID: 26730152Free PMC Article
Schlageter M, Terracciano LM, D'Angelo S, Sorrentino P
World J Gastroenterol 2014 Nov 21;20(43):15955-64. doi: 10.3748/wjg.v20.i43.15955. PMID: 25473149Free PMC Article
Patel T
Nat Clin Pract Gastroenterol Hepatol 2006 Jan;3(1):33-42. doi: 10.1038/ncpgasthep0389. PMID: 16397610

Diagnosis

Katabathina VS, Khanna L, Surabhi VR, Minervini M, Shanbhogue K, Dasyam AK, Prasad SR
Radiographics 2022 Sep-Oct;42(5):1338-1357. Epub 2022 Jul 1 doi: 10.1148/rg.210206. PMID: 35776676
El Jabbour T, Lagana SM, Lee H
World J Gastroenterol 2019 Apr 14;25(14):1653-1665. doi: 10.3748/wjg.v25.i14.1653. PMID: 31011252Free PMC Article
Kim HJ, Kim JS, Joo MK, Lee BJ, Kim JH, Yeon JE, Park JJ, Byun KS, Bak YT
World J Gastroenterol 2015 Dec 28;21(48):13418-31. doi: 10.3748/wjg.v21.i48.13418. PMID: 26730152Free PMC Article
Wei B, Guo C, Liu S, Sun MZ
Clin Chim Acta 2015 Jul 20;447:72-8. Epub 2015 Jun 3 doi: 10.1016/j.cca.2015.05.016. PMID: 26048190
Patel T
Nat Clin Pract Gastroenterol Hepatol 2006 Jan;3(1):33-42. doi: 10.1038/ncpgasthep0389. PMID: 16397610

Therapy

Wabitsch S, Tandon M, Ruf B, Zhang Q, McCallen JD, McVey JC, Ma C, Green BL, Diggs LP, Heinrich B, Greten TF
Cell Mol Gastroenterol Hepatol 2021;12(3):1166-1178. Epub 2021 May 23 doi: 10.1016/j.jcmgh.2021.05.011. PMID: 34033968Free PMC Article
Marzouk O, Lakshmaiah S, Anjarwalla S
BMJ Case Rep 2020 Dec 22;13(12) doi: 10.1136/bcr-2020-237683. PMID: 33370986Free PMC Article
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Hyman DM, Puzanov I, Subbiah V, Faris JE, Chau I, Blay JY, Wolf J, Raje NS, Diamond EL, Hollebecque A, Gervais R, Elez-Fernandez ME, Italiano A, Hofheinz RD, Hidalgo M, Chan E, Schuler M, Lasserre SF, Makrutzki M, Sirzen F, Veronese ML, Tabernero J, Baselga J
N Engl J Med 2015 Aug 20;373(8):726-36. doi: 10.1056/NEJMoa1502309. PMID: 26287849Free PMC Article
Skrabanek P, McPartlin J, Powell D
Medicine (Baltimore) 1980 Jul;59(4):262-82. doi: 10.1097/00005792-198007000-00003. PMID: 6993843

Prognosis

Liao W, Du J, Li L, Wu X, Chen X, Feng Q, Xu L, Chen X, Liao M, Huang J, Yuan K, Zeng Y
J Exp Clin Cancer Res 2023 May 18;42(1):125. doi: 10.1186/s13046-023-02699-w. PMID: 37198696Free PMC Article
Maslinska M, Dmowska-Chalaba J, Jakubaszek M
Front Immunol 2021;12:787422. Epub 2022 Jan 25 doi: 10.3389/fimmu.2021.787422. PMID: 35145508Free PMC Article
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
El Jabbour T, Lagana SM, Lee H
World J Gastroenterol 2019 Apr 14;25(14):1653-1665. doi: 10.3748/wjg.v25.i14.1653. PMID: 31011252Free PMC Article
Wei B, Guo C, Liu S, Sun MZ
Clin Chim Acta 2015 Jul 20;447:72-8. Epub 2015 Jun 3 doi: 10.1016/j.cca.2015.05.016. PMID: 26048190

Clinical prediction guides

Liao W, Du J, Li L, Wu X, Chen X, Feng Q, Xu L, Chen X, Liao M, Huang J, Yuan K, Zeng Y
J Exp Clin Cancer Res 2023 May 18;42(1):125. doi: 10.1186/s13046-023-02699-w. PMID: 37198696Free PMC Article
Masclef L, Ahmed O, Estavoyer B, Larrivée B, Labrecque N, Nijnik A, Affar EB
Cell Death Differ 2021 Feb;28(2):606-625. Epub 2021 Jan 18 doi: 10.1038/s41418-020-00709-4. PMID: 33462414Free PMC Article
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
El Jabbour T, Lagana SM, Lee H
World J Gastroenterol 2019 Apr 14;25(14):1653-1665. doi: 10.3748/wjg.v25.i14.1653. PMID: 31011252Free PMC Article
Hyman DM, Puzanov I, Subbiah V, Faris JE, Chau I, Blay JY, Wolf J, Raje NS, Diamond EL, Hollebecque A, Gervais R, Elez-Fernandez ME, Italiano A, Hofheinz RD, Hidalgo M, Chan E, Schuler M, Lasserre SF, Makrutzki M, Sirzen F, Veronese ML, Tabernero J, Baselga J
N Engl J Med 2015 Aug 20;373(8):726-36. doi: 10.1056/NEJMoa1502309. PMID: 26287849Free PMC Article

Recent systematic reviews

Zhong C, Lang Q, Yu J, Wu S, Xu F, Tian Y
Clin Exp Immunol 2020 Apr;200(1):12-21. Epub 2020 Feb 4 doi: 10.1111/cei.13413. PMID: 31901178Free PMC Article
Fiorino S, Bacchi-Reggiani L, de Biase D, Fornelli A, Masetti M, Tura A, Grizzi F, Zanello M, Mastrangelo L, Lombardi R, Acquaviva G, di Tommaso L, Bondi A, Visani M, Sabbatani S, Pontoriero L, Fabbri C, Cuppini A, Pession A, Jovine E
World J Gastroenterol 2015 Dec 7;21(45):12896-953. doi: 10.3748/wjg.v21.i45.12896. PMID: 26668515Free PMC Article
Fayter D, Corbett M, Heirs M, Fox D, Eastwood A
Health Technol Assess 2010 Jul;14(37):1-288. doi: 10.3310/hta14370. PMID: 20663420

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