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Colorectal Mucinous Adenocarcinoma

MedGen UID:
317526
•Concept ID:
C1707439
•
Neoplastic Process

Definition

An invasive colorectal adenocarcinoma characterized by the presence of extracellular mucin pools that contain malignant glandular epithelial structures. The extracellular mucin pools occupy more than 50% of the malignant lesion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Mucinous Adenocarcinoma

Professional guidelines

PubMed

Mucinous colorectal adenocarcinoma: clinical pathology and treatment options.
Luo C, Cen S, Ding G, Wu W
Cancer Commun (Lond) 2019 Mar 29;39(1):13. doi: 10.1186/s40880-019-0361-0. PMID: 30922401Free PMC Article
Keratin subsets and monoclonal antibody HBME-1 in chordoma: immunohistochemical differential diagnosis between tumors simulating chordoma.
O'Hara BJ, Paetau A, Miettinen M
Hum Pathol 1998 Feb;29(2):119-26. doi: 10.1016/s0046-8177(98)90220-9. PMID: 9490269

Recent clinical studies

Etiology

Establishment and validation of a postoperative predictive model for patients with colorectal mucinous adenocarcinoma.
Wang P, Song Q, Lu M, Xia Q, Wang Z, Zhao Q, Ma X
World J Surg Oncol 2022 Oct 3;20(1):330. doi: 10.1186/s12957-022-02791-z. PMID: 36192778Free PMC Article
Survival after curative resection for stage I colorectal mucinous adenocarcinoma.
Huang L, Luo S, Lai S, Liu Z, Hu H, Chen M, Kang L
BMC Gastroenterol 2022 Apr 18;22(1):192. doi: 10.1186/s12876-022-02276-z. PMID: 35436867Free PMC Article
Serrated adenocarcinoma morphology in colorectal mucinous adenocarcinoma is associated with improved patient survival.
Lee CT, Huang YC, Hung LY, Chow NH, Su PF, Ho CL, Tsai HW, Chen YL, Lin SC, Lin BW, Lin PC, Lee JC
Oncotarget 2017 May 23;8(21):35165-35175. doi: 10.18632/oncotarget.16815. PMID: 28422723Free PMC Article
Clinicopathological and genetic differences between low-grade and high-grade colorectal mucinous adenocarcinomas.
Yoshioka Y, Togashi Y, Chikugo T, Kogita A, Taguri M, Terashima M, Mizukami T, Hayashi H, Sakai K, de Velasco MA, Tomida S, Fujita Y, Tokoro T, Ito A, Okuno K, Nishio K
Cancer 2015 Dec 15;121(24):4359-68. Epub 2015 Oct 21 doi: 10.1002/cncr.29676. PMID: 26488212
Clinicopathological characteristics and prognostic factors of advanced colorectal mucinous adenocarcinoma.
Yamaguchi T, Taniguchi H, Fujita S, Sekine S, Yamamoto S, Akasu T, Kushima R, Tani T, Moriya Y, Shimoda T
Histopathology 2012 Aug;61(2):162-9. Epub 2012 Mar 27 doi: 10.1111/j.1365-2559.2012.04235.x. PMID: 22448644

Diagnosis

Clinicopathological and prognostic features of colorectal mucinous adenocarcinomas: a systematic review and meta-analysis.
Wang X, Wang H, He H, Lv K, Yuan W, Chen J, Yang H
BMC Cancer 2024 Sep 19;24(1):1161. doi: 10.1186/s12885-024-12905-3. PMID: 39294609Free PMC Article
Signet ring cell component predicts aggressive behaviour in colorectal mucinous adenocarcinoma.
Song IH, Hong SM, Yu E, Yoon YS, Park IJ, Lim SB, Kim JC, Yu CS, Kim J
Pathology 2019 Jun;51(4):384-391. Epub 2019 Apr 24 doi: 10.1016/j.pathol.2019.03.001. PMID: 31029443
Prognosis and value of adjuvant chemotherapy in stage III mucinous colorectal carcinoma.
Hugen N, Verhoeven RH, Radema SA, de Hingh IH, Pruijt JF, Nagtegaal ID, Lemmens VE, de Wilt JH
Ann Oncol 2013 Nov;24(11):2819-24. Epub 2013 Sep 20 doi: 10.1093/annonc/mdt378. PMID: 24057984
The clinicopathological features of colorectal mucinous adenocarcinoma and a therapeutic strategy for the disease.
Numata M, Shiozawa M, Watanabe T, Tamagawa H, Yamamoto N, Morinaga S, Watanabe K, Godai T, Oshima T, Fujii S, Kunisaki C, Rino Y, Masuda M, Akaike M
World J Surg Oncol 2012 Jun 15;10:109. doi: 10.1186/1477-7819-10-109. PMID: 22703761Free PMC Article
Clinicopathological characteristics of mucinous and non-mucinous adenocarcinoma in the colon and rectum in Rajavithi Hospital, Thailand.
Jivapaisarnpong P, Boonthongtho K
J Med Assoc Thai 2011 Mar;94 Suppl 2:S41-5. PMID: 21717877

Therapy

Establishment and validation of a postoperative predictive model for patients with colorectal mucinous adenocarcinoma.
Wang P, Song Q, Lu M, Xia Q, Wang Z, Zhao Q, Ma X
World J Surg Oncol 2022 Oct 3;20(1):330. doi: 10.1186/s12957-022-02791-z. PMID: 36192778Free PMC Article
Prognostic significance of perioperative chemotherapy on resectable colorectal mucinous adenocarcinoma liver metastasis.
Li C, Su D, Peng J, Fang Y, Zhou W, Li S, Luo B, Wan D, Pan Z
Ann Palliat Med 2019 Nov;8(5):690-697. Epub 2019 Oct 16 doi: 10.21037/apm.2019.09.16. PMID: 31735042
Prognosis and value of adjuvant chemotherapy in stage III mucinous colorectal carcinoma.
Hugen N, Verhoeven RH, Radema SA, de Hingh IH, Pruijt JF, Nagtegaal ID, Lemmens VE, de Wilt JH
Ann Oncol 2013 Nov;24(11):2819-24. Epub 2013 Sep 20 doi: 10.1093/annonc/mdt378. PMID: 24057984

Prognosis

Survival after curative resection for stage I colorectal mucinous adenocarcinoma.
Huang L, Luo S, Lai S, Liu Z, Hu H, Chen M, Kang L
BMC Gastroenterol 2022 Apr 18;22(1):192. doi: 10.1186/s12876-022-02276-z. PMID: 35436867Free PMC Article
Serrated adenocarcinoma morphology in colorectal mucinous adenocarcinoma is associated with improved patient survival.
Lee CT, Huang YC, Hung LY, Chow NH, Su PF, Ho CL, Tsai HW, Chen YL, Lin SC, Lin BW, Lin PC, Lee JC
Oncotarget 2017 May 23;8(21):35165-35175. doi: 10.18632/oncotarget.16815. PMID: 28422723Free PMC Article
Clinicopathological and genetic differences between low-grade and high-grade colorectal mucinous adenocarcinomas.
Yoshioka Y, Togashi Y, Chikugo T, Kogita A, Taguri M, Terashima M, Mizukami T, Hayashi H, Sakai K, de Velasco MA, Tomida S, Fujita Y, Tokoro T, Ito A, Okuno K, Nishio K
Cancer 2015 Dec 15;121(24):4359-68. Epub 2015 Oct 21 doi: 10.1002/cncr.29676. PMID: 26488212
Prognosis and value of adjuvant chemotherapy in stage III mucinous colorectal carcinoma.
Hugen N, Verhoeven RH, Radema SA, de Hingh IH, Pruijt JF, Nagtegaal ID, Lemmens VE, de Wilt JH
Ann Oncol 2013 Nov;24(11):2819-24. Epub 2013 Sep 20 doi: 10.1093/annonc/mdt378. PMID: 24057984
Clinicopathological characteristics and prognostic factors of advanced colorectal mucinous adenocarcinoma.
Yamaguchi T, Taniguchi H, Fujita S, Sekine S, Yamamoto S, Akasu T, Kushima R, Tani T, Moriya Y, Shimoda T
Histopathology 2012 Aug;61(2):162-9. Epub 2012 Mar 27 doi: 10.1111/j.1365-2559.2012.04235.x. PMID: 22448644

Clinical prediction guides

Clinicopathological and prognostic features of colorectal mucinous adenocarcinomas: a systematic review and meta-analysis.
Wang X, Wang H, He H, Lv K, Yuan W, Chen J, Yang H
BMC Cancer 2024 Sep 19;24(1):1161. doi: 10.1186/s12885-024-12905-3. PMID: 39294609Free PMC Article
Survival after curative resection for stage I colorectal mucinous adenocarcinoma.
Huang L, Luo S, Lai S, Liu Z, Hu H, Chen M, Kang L
BMC Gastroenterol 2022 Apr 18;22(1):192. doi: 10.1186/s12876-022-02276-z. PMID: 35436867Free PMC Article
Signet ring cell component predicts aggressive behaviour in colorectal mucinous adenocarcinoma.
Song IH, Hong SM, Yu E, Yoon YS, Park IJ, Lim SB, Kim JC, Yu CS, Kim J
Pathology 2019 Jun;51(4):384-391. Epub 2019 Apr 24 doi: 10.1016/j.pathol.2019.03.001. PMID: 31029443
Serrated adenocarcinoma morphology in colorectal mucinous adenocarcinoma is associated with improved patient survival.
Lee CT, Huang YC, Hung LY, Chow NH, Su PF, Ho CL, Tsai HW, Chen YL, Lin SC, Lin BW, Lin PC, Lee JC
Oncotarget 2017 May 23;8(21):35165-35175. doi: 10.18632/oncotarget.16815. PMID: 28422723Free PMC Article
Clinical significance of signet-ring cells in colorectal mucinous adenocarcinoma.
Sung CO, Seo JW, Kim KM, Do IG, Kim SW, Park CK
Mod Pathol 2008 Dec;21(12):1533-41. Epub 2008 Oct 10 doi: 10.1038/modpathol.2008.170. PMID: 18849918

Recent systematic reviews

Clinicopathological and prognostic features of colorectal mucinous adenocarcinomas: a systematic review and meta-analysis.
Wang X, Wang H, He H, Lv K, Yuan W, Chen J, Yang H
BMC Cancer 2024 Sep 19;24(1):1161. doi: 10.1186/s12885-024-12905-3. PMID: 39294609Free PMC Article

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