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Lung Atypical Carcinoid Tumor

MedGen UID:
317846
•Concept ID:
C1708766
•
Neoplastic Process
Synonyms: Lung NET G2; Lung NET Grade 2; Lung NET, Grade 2; Lung Neuroendocrine Tumor G2; Lung Neuroendocrine Tumor Grade 2; Lung Neuroendocrine Tumor, Grade 2; Malignant carcinoid tumor of lung
SNOMED CT: Malignant carcinoid tumor of lung (123661000119106)

Definition

A carcinoid tumor of the lung showing focal necrotic changes or a number of mitotic figures between 2 and 10/10 high power fields. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Atypical Carcinoid Tumor

Professional guidelines

PubMed

Updates and management algorithm for neuroendocrine tumors of the uterine cervix.
Salvo G, Gonzalez Martin A, Gonzales NR, Frumovitz M
Int J Gynecol Cancer 2019 Jul;29(6):986-995. doi: 10.1136/ijgc-2019-000504. PMID: 31263021
Management of pulmonary neuroendocrine tumors.
Ramirez RA, Chauhan A, Gimenez J, Thomas KEH, Kokodis I, Voros BA
Rev Endocr Metab Disord 2017 Dec;18(4):433-442. doi: 10.1007/s11154-017-9429-9. PMID: 28868578
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Recent clinical studies

Etiology

Carcinoid tumors outside the abdomen.
Koehler K, Iams WT
Cancer Med 2023 Apr;12(7):7893-7903. Epub 2022 Dec 22 doi: 10.1002/cam4.5564. PMID: 36560885Free PMC Article
Lung carcinoid tumours: histology and Ki-67, the eternal rivalry.
Centonze G, Maisonneuve P, Simbolo M, Lagano V, Grillo F, Fabbri A, Prinzi N, Garzone G, Filugelli M, Pardo C, Mietta A, Pusceddu S, Sabella G, Bercich L, Mangogna A, Rolli L, Grisanti S, Benvenuti MR, Pastorino U, Roz L, Scarpa A, Berruti A, Capella C, Milione M
Histopathology 2023 Jan;82(2):324-339. Epub 2022 Oct 26 doi: 10.1111/his.14819. PMID: 36239545Free PMC Article
Small-Cell Carcinoma of the Lung: What We Learned about It?
Righi L, Volante M, Papotti M
Acta Cytol 2022;66(4):257-268. Epub 2021 Nov 16 doi: 10.1159/000519688. PMID: 34784591
Pulmonary Neuroendocrine Tumors.
Borczuk AC
Surg Pathol Clin 2020 Mar;13(1):35-55. Epub 2019 Nov 29 doi: 10.1016/j.path.2019.10.002. PMID: 32005434
Advanced typical and atypical carcinoid tumours of the lung: management recommendations.
Melosky B
Curr Oncol 2018 Jun;25(Suppl 1):S86-S93. Epub 2018 Jun 13 doi: 10.3747/co.25.3808. PMID: 29910651Free PMC Article

Diagnosis

Carcinoid tumors outside the abdomen.
Koehler K, Iams WT
Cancer Med 2023 Apr;12(7):7893-7903. Epub 2022 Dec 22 doi: 10.1002/cam4.5564. PMID: 36560885Free PMC Article
Pulmonary Neuroendocrine Tumors.
Borczuk AC
Surg Pathol Clin 2020 Mar;13(1):35-55. Epub 2019 Nov 29 doi: 10.1016/j.path.2019.10.002. PMID: 32005434
Updates and management algorithm for neuroendocrine tumors of the uterine cervix.
Salvo G, Gonzalez Martin A, Gonzales NR, Frumovitz M
Int J Gynecol Cancer 2019 Jul;29(6):986-995. doi: 10.1136/ijgc-2019-000504. PMID: 31263021
Management of pulmonary neuroendocrine tumors.
Ramirez RA, Chauhan A, Gimenez J, Thomas KEH, Kokodis I, Voros BA
Rev Endocr Metab Disord 2017 Dec;18(4):433-442. doi: 10.1007/s11154-017-9429-9. PMID: 28868578
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Therapy

Lung Neuroendocrine Tumors: How Does Molecular Profiling Help?
Sun TY, Hendifar A, Padda SK
Curr Oncol Rep 2022 Jul;24(7):819-824. Epub 2022 Mar 19 doi: 10.1007/s11912-022-01253-9. PMID: 35305210
Characterization, Prognosis, and Treatment of Patients With Metastatic Lung Carcinoid Tumors.
Robelin P, Hadoux J, Forestier J, Planchard D, Hervieu V, Berdelou A, Scoazec JY, Valette PJ, Leboulleux S, Ducreux M, Lombard-Bohas C, Baudin E, Walter T
J Thorac Oncol 2019 Jun;14(6):993-1002. Epub 2019 Feb 13 doi: 10.1016/j.jtho.2019.02.002. PMID: 30771520
Unmet Medical Needs in Pulmonary Neuroendocrine (Carcinoid) Neoplasms.
Baudin E, Hayes AR, Scoazec JY, Filosso PL, Lim E, Kaltsas G, Frilling A, Chen J, Kos-Kudła B, Gorbunova V, Wiedenmann B, Nieveen van Dijkum E, Ćwikła JB, Falkerby J, Valle JW, Kulke MH, Caplin ME; ENETS 2016 Munich Advisory Board Participants; ENETS 2016 Munich Advisory Board Participants
Neuroendocrinology 2019;108(1):7-17. Epub 2018 Sep 24 doi: 10.1159/000493980. PMID: 30248673
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Lung cancer preneoplasia.
Wistuba II, Gazdar AF
Annu Rev Pathol 2006;1:331-48. doi: 10.1146/annurev.pathol.1.110304.100103. PMID: 18039118

Prognosis

Carcinoid tumors outside the abdomen.
Koehler K, Iams WT
Cancer Med 2023 Apr;12(7):7893-7903. Epub 2022 Dec 22 doi: 10.1002/cam4.5564. PMID: 36560885Free PMC Article
Updates and management algorithm for neuroendocrine tumors of the uterine cervix.
Salvo G, Gonzalez Martin A, Gonzales NR, Frumovitz M
Int J Gynecol Cancer 2019 Jul;29(6):986-995. doi: 10.1136/ijgc-2019-000504. PMID: 31263021
Classification and Pathology of Lung Cancer.
Zheng M
Surg Oncol Clin N Am 2016 Jul;25(3):447-68. doi: 10.1016/j.soc.2016.02.003. PMID: 27261908
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Bronchopulmonary neuroendocrine tumors.
Gustafsson BI, Kidd M, Chan A, Malfertheiner MV, Modlin IM
Cancer 2008 Jul 1;113(1):5-21. doi: 10.1002/cncr.23542. PMID: 18473355

Clinical prediction guides

Lung carcinoid tumours: histology and Ki-67, the eternal rivalry.
Centonze G, Maisonneuve P, Simbolo M, Lagano V, Grillo F, Fabbri A, Prinzi N, Garzone G, Filugelli M, Pardo C, Mietta A, Pusceddu S, Sabella G, Bercich L, Mangogna A, Rolli L, Grisanti S, Benvenuti MR, Pastorino U, Roz L, Scarpa A, Berruti A, Capella C, Milione M
Histopathology 2023 Jan;82(2):324-339. Epub 2022 Oct 26 doi: 10.1111/his.14819. PMID: 36239545Free PMC Article
Lung Neuroendocrine Tumors: How Does Molecular Profiling Help?
Sun TY, Hendifar A, Padda SK
Curr Oncol Rep 2022 Jul;24(7):819-824. Epub 2022 Mar 19 doi: 10.1007/s11912-022-01253-9. PMID: 35305210
Small-Cell Carcinoma of the Lung: What We Learned about It?
Righi L, Volante M, Papotti M
Acta Cytol 2022;66(4):257-268. Epub 2021 Nov 16 doi: 10.1159/000519688. PMID: 34784591
Clinical implications of lung neuroendocrine neoplasm classification.
Metovic J, Barella M, Harari S, Pattini L, Albini A, Sonzogni A, Veronesi G, Papotti M, Pelosi G
Expert Rev Anticancer Ther 2021 Apr;21(4):377-387. Epub 2020 Dec 24 doi: 10.1080/14737140.2021.1862654. PMID: 33306420
Cyto-histology in NET: what is necessary today and what is the future?
Inzani F, Petrone G, Fadda G, Rindi G
Rev Endocr Metab Disord 2017 Dec;18(4):381-391. doi: 10.1007/s11154-017-9428-x. PMID: 28871510

Recent systematic reviews

An Assessment of Circulating Chromogranin A as a Biomarker of Bronchopulmonary Neuroendocrine Neoplasia: A Systematic Review and Meta-Analysis.
Malczewska A, Kidd M, Matar S, Kos-Kudła B, Bodei L, Oberg K, Modlin IM
Neuroendocrinology 2020;110(3-4):198-216. Epub 2019 Jul 5 doi: 10.1159/000500525. PMID: 31266019
The utility of 18F-FDG and 68Ga-DOTA-Peptide PET/CT in the evaluation of primary pulmonary carcinoid: A systematic review and meta-analysis.
Jiang Y, Hou G, Cheng W
Medicine (Baltimore) 2019 Mar;98(10):e14769. doi: 10.1097/MD.0000000000014769. PMID: 30855482Free PMC Article
The use of Ki-67 labeling index to grade pulmonary well-differentiated neuroendocrine neoplasms: current best evidence.
Marchevsky AM, Hendifar A, Walts AE
Mod Pathol 2018 Oct;31(10):1523-1531. Epub 2018 May 25 doi: 10.1038/s41379-018-0076-9. PMID: 29802361
Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists.
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

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