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Orofacial cleft 3(OFC3)

MedGen UID:
318860
•Concept ID:
C1833369
•
Disease or Syndrome
Synonyms: CLEFT LIP WITH OR WITHOUT CLEFT PALATE, NONSYNDROMIC, 3; OFC3
 
Monarch Initiative: MONDO:0010927
OMIM®: 600757

Clinical features

From HPO
Abnormality of the face
MedGen UID:
871375
•Concept ID:
C4025871
•
Anatomical Abnormality
An abnormality of the face.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Prenatal diagnosis of cleft lip and cleft lip palate - a case series.
Marginean C, Sasarean V, Marginean CO, Melit LE, Marginean MO
Med Ultrason 2018 Dec 8;20(4):531-535. doi: 10.11152/mu-1582. PMID: 30534664
Clinical Finding and Management of 12 Orofacial Clefts Cases With Nevoid Basal Cell Carcinoma Syndrome.
Mui Lee L, Ma L, Jun Li T
Cleft Palate Craniofac J 2017 May;54(3):338-342. doi: 10.1597/14-323. PMID: 28471735
Fraser syndrome and cryptophthalmos: review of the diagnostic criteria and evidence for phenotypic modules in complex malformation syndromes.
Slavotinek AM, Tifft CJ
J Med Genet 2002 Sep;39(9):623-33. doi: 10.1136/jmg.39.9.623. PMID: 12205104Free PMC Article

Recent clinical studies

Etiology

Variations in Orofacial Clefts.
Jahanbin A, Jamalinasab A, Niazi AE
J Craniofac Surg 2021 Mar-Apr 01;32(2):e179-e182. doi: 10.1097/SCS.0000000000007027. PMID: 33705067
Feeding problems and gastrointestinal diseases in Down syndrome.
Ravel A, Mircher C, Rebillat AS, Cieuta-Walti C, Megarbane A
Arch Pediatr 2020 Jan;27(1):53-60. Epub 2019 Nov 26 doi: 10.1016/j.arcped.2019.11.008. PMID: 31784293
Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients.
Kloukos D, Fudalej P, Sequeira-Byron P, Katsaros C
Cochrane Database Syst Rev 2018 Aug 10;8(8):CD010403. doi: 10.1002/14651858.CD010403.pub3. PMID: 30095853Free PMC Article
Environmental and individual exposure and the risk of congenital anomalies: a review of recent epidemiological evidence.
Baldacci S, Gorini F, Santoro M, Pierini A, Minichilli F, Bianchi F
Epidemiol Prev 2018 May-Aug;42(3-4 Suppl 1):1-34. doi: 10.19191/EP18.3-4.S1.P001.057. PMID: 30066535
Evidence-Based Medicine: Cleft Palate.
Woo AS
Plast Reconstr Surg 2017 Jan;139(1):191e-203e. doi: 10.1097/PRS.0000000000002854. PMID: 28027255

Diagnosis

Feeding problems and gastrointestinal diseases in Down syndrome.
Ravel A, Mircher C, Rebillat AS, Cieuta-Walti C, Megarbane A
Arch Pediatr 2020 Jan;27(1):53-60. Epub 2019 Nov 26 doi: 10.1016/j.arcped.2019.11.008. PMID: 31784293
Prenatal diagnosis of cleft lip and cleft lip palate - a case series.
Marginean C, Sasarean V, Marginean CO, Melit LE, Marginean MO
Med Ultrason 2018 Dec 8;20(4):531-535. doi: 10.11152/mu-1582. PMID: 30534664
Environmental and individual exposure and the risk of congenital anomalies: a review of recent epidemiological evidence.
Baldacci S, Gorini F, Santoro M, Pierini A, Minichilli F, Bianchi F
Epidemiol Prev 2018 May-Aug;42(3-4 Suppl 1):1-34. doi: 10.19191/EP18.3-4.S1.P001.057. PMID: 30066535
Fraser Syndrome.
Saleem AA, Siddiqui SN
J Coll Physicians Surg Pak 2015 Oct;25 Suppl 2:S124-6. doi: 10.2015/JCPSP.S124S126. PMID: 26522198
Cri du chat syndrome: a critical review.
Rodríguez-Caballero A, Torres-Lagares D, Rodríguez-Pérez A, Serrera-Figallo MA, Hernández-Guisado JM, Machuca-Portillo G
Med Oral Patol Oral Cir Bucal 2010 May 1;15(3):e473-8. doi: 10.4317/medoral.15.e473. PMID: 20038906

Therapy

Caries in children with and without orofacial clefting: A systematic review and meta-analysis.
Grewcock RE, Innes NPT, Mossey PA, Robertson MD
Oral Dis 2022 Jul;28(5):1400-1411. Epub 2022 Mar 22 doi: 10.1111/odi.14183. PMID: 35263806Free PMC Article
Maternal Cigarette Smoking and Cleft Lip and Palate: A Systematic Review and Meta-Analysis.
Fell M, Dack K, Chummun S, Sandy J, Wren Y, Lewis S
Cleft Palate Craniofac J 2022 Sep;59(9):1185-1200. Epub 2021 Sep 27 doi: 10.1177/10556656211040015. PMID: 34569861Free PMC Article
Biomaterials for Cleft Lip and Palate Regeneration.
Martín-Del-Campo M, Rosales-Ibañez R, Rojo L
Int J Mol Sci 2019 May 2;20(9) doi: 10.3390/ijms20092176. PMID: 31052503Free PMC Article
Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients.
Kloukos D, Fudalej P, Sequeira-Byron P, Katsaros C
Cochrane Database Syst Rev 2018 Aug 10;8(8):CD010403. doi: 10.1002/14651858.CD010403.pub3. PMID: 30095853Free PMC Article
Environmental and individual exposure and the risk of congenital anomalies: a review of recent epidemiological evidence.
Baldacci S, Gorini F, Santoro M, Pierini A, Minichilli F, Bianchi F
Epidemiol Prev 2018 May-Aug;42(3-4 Suppl 1):1-34. doi: 10.19191/EP18.3-4.S1.P001.057. PMID: 30066535

Prognosis

Variant analyses of candidate genes in orofacial clefts in multi-ethnic populations.
Li M, Olotu J, Buxo-Martinez CJ, Mossey PA, Anand D, Busch T, Alade A, Gowans LJJ, Eshete M, Adeyemo WL, Naicker T, Awotoye WO, Gupta S, Adeleke C, Bravo V, Huang S, Adamson OO, Toraño AM, Bello CA, Soto M, Soto M, Ledesma R, Marquez M, Cordero JF, Lopez-Del Valle LM, Salcedo MI, Debs N, Petrin A, Malloy H, Elhadi K, James O, Ogunlewe MO, Abate F, Hailu A, Mohammed I, Gravem P, Deribew M, Gesses M, Hassan M, Pape J, Obiri-Yeboah S, Arthur FKN, Oti AA, Donkor P, Marazita ML, Lachke SA, Adeyemo AA, Murray JC, Butali A
Oral Dis 2022 Oct;28(7):1921-1935. Epub 2021 Jun 21 doi: 10.1111/odi.13932. PMID: 34061439Free PMC Article
Incidence, Risk Factors, and Mortality Associated With Orofacial Cleft Among Children in Ontario, Canada.
Malic CC, Lam M, Donelle J, Richard L, Vigod SN, Benchimol EI
JAMA Netw Open 2020 Feb 5;3(2):e1921036. doi: 10.1001/jamanetworkopen.2019.21036. PMID: 32049294
MR Imaging of the Fetal Face: Comprehensive Review.
Nagarajan M, Sharbidre KG, Bhabad SH, Byrd SE
Radiographics 2018 May-Jun;38(3):962-980. Epub 2018 Apr 13 doi: 10.1148/rg.2018170142. PMID: 29652578
Cri du chat syndrome: a critical review.
Rodríguez-Caballero A, Torres-Lagares D, Rodríguez-Pérez A, Serrera-Figallo MA, Hernández-Guisado JM, Machuca-Portillo G
Med Oral Patol Oral Cir Bucal 2010 May 1;15(3):e473-8. doi: 10.4317/medoral.15.e473. PMID: 20038906
The spectrum of orofacial clefting.
Eppley BL, van Aalst JA, Robey A, Havlik RJ, Sadove AM
Plast Reconstr Surg 2005 Jun;115(7):101e-114e. doi: 10.1097/01.prs.0000164494.45986.91. PMID: 15923821

Clinical prediction guides

Tooth abnormalities associated with non-syndromic cleft lip and palate: systematic review and meta-analysis.
Fonseca-Souza G, de Oliveira LB, Wambier LM, Scariot R, Feltrin-Souza J
Clin Oral Investig 2022 Aug;26(8):5089-5103. Epub 2022 Jun 21 doi: 10.1007/s00784-022-04540-8. PMID: 35729285
Alkali and alkaline earth elements in maternal serum and occurrence of orofacial clefts in offspring.
Yin S, Wei J, Wang C, Jin L, Wang L, Li Z, Zhang Y, Yin C, Ren A
Reprod Toxicol 2022 Jun;110:97-104. Epub 2022 Apr 6 doi: 10.1016/j.reprotox.2022.04.001. PMID: 35398174
Maternal Cigarette Smoking and Cleft Lip and Palate: A Systematic Review and Meta-Analysis.
Fell M, Dack K, Chummun S, Sandy J, Wren Y, Lewis S
Cleft Palate Craniofac J 2022 Sep;59(9):1185-1200. Epub 2021 Sep 27 doi: 10.1177/10556656211040015. PMID: 34569861Free PMC Article
Parental consanguinity and nonsyndromic orofacial clefts in children: a systematic review and meta-analyses.
Sabbagh HJ, Hassan MH, Innes NP, Baik AA, Mossey PA
Cleft Palate Craniofac J 2014 Sep;51(5):501-13. Epub 2013 May 2 doi: 10.1597/12-209. PMID: 23638915
The spectrum of orofacial clefting.
Eppley BL, van Aalst JA, Robey A, Havlik RJ, Sadove AM
Plast Reconstr Surg 2005 Jun;115(7):101e-114e. doi: 10.1097/01.prs.0000164494.45986.91. PMID: 15923821

Recent systematic reviews

Tooth abnormalities associated with non-syndromic cleft lip and palate: systematic review and meta-analysis.
Fonseca-Souza G, de Oliveira LB, Wambier LM, Scariot R, Feltrin-Souza J
Clin Oral Investig 2022 Aug;26(8):5089-5103. Epub 2022 Jun 21 doi: 10.1007/s00784-022-04540-8. PMID: 35729285
Caries in children with and without orofacial clefting: A systematic review and meta-analysis.
Grewcock RE, Innes NPT, Mossey PA, Robertson MD
Oral Dis 2022 Jul;28(5):1400-1411. Epub 2022 Mar 22 doi: 10.1111/odi.14183. PMID: 35263806Free PMC Article
Maternal Cigarette Smoking and Cleft Lip and Palate: A Systematic Review and Meta-Analysis.
Fell M, Dack K, Chummun S, Sandy J, Wren Y, Lewis S
Cleft Palate Craniofac J 2022 Sep;59(9):1185-1200. Epub 2021 Sep 27 doi: 10.1177/10556656211040015. PMID: 34569861Free PMC Article
Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients.
Kloukos D, Fudalej P, Sequeira-Byron P, Katsaros C
Cochrane Database Syst Rev 2018 Aug 10;8(8):CD010403. doi: 10.1002/14651858.CD010403.pub3. PMID: 30095853Free PMC Article
Parental consanguinity and nonsyndromic orofacial clefts in children: a systematic review and meta-analyses.
Sabbagh HJ, Hassan MH, Innes NP, Baik AA, Mossey PA
Cleft Palate Craniofac J 2014 Sep;51(5):501-13. Epub 2013 May 2 doi: 10.1597/12-209. PMID: 23638915

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