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Orofacial cleft 3(OFC3)

MedGen UID:
318860
Concept ID:
C1833369
Disease or Syndrome
Synonyms: CLEFT LIP WITH OR WITHOUT CLEFT PALATE, NONSYNDROMIC, 3; OFC3
 
Monarch Initiative: MONDO:0010927
OMIM®: 600757

Clinical features

From HPO
Abnormality of the face
MedGen UID:
871375
Concept ID:
C4025871
Anatomical Abnormality
An abnormality of the face.

Professional guidelines

PubMed

Nelson-Piercy C, Dean C, Shehmar M, Gadsby R, O'Hara M, Hodson K, Nana M; Royal College of Obstetricians and Gynaecologists
BJOG 2024 Jun;131(7):e1-e30. Epub 2024 Feb 4 doi: 10.1111/1471-0528.17739. PMID: 38311315
Bromley R, Adab N, Bluett-Duncan M, Clayton-Smith J, Christensen J, Edwards K, Greenhalgh J, Hill RA, Jackson CF, Khanom S, McGinty RN, Tudur Smith C, Pulman J, Marson AG
Cochrane Database Syst Rev 2023 Aug 29;8(8):CD010224. doi: 10.1002/14651858.CD010224.pub3. PMID: 37647086Free PMC Article
Markovic M
Int Dent J 1986 Sep;36(3):131-9. PMID: 3464567

Recent clinical studies

Etiology

Robinson K, Mosley TJ, Rivera-González KS, Jabbarpour CR, Curtis SW, Adeyemo WL, Beaty TH, Butali A, Buxó CJ, Cutler DJ, Epstein MP, Gowans LJJ, Hecht JT, Murray JC, Shaw GM, Uribe LM, Weinberg SM, Brand H, Marazita ML, Lipinski RJ, Leslie EJ
HGG Adv 2023 Oct 12;4(4):100234. Epub 2023 Aug 25 doi: 10.1016/j.xhgg.2023.100234. PMID: 37719664Free PMC Article
Bromley R, Adab N, Bluett-Duncan M, Clayton-Smith J, Christensen J, Edwards K, Greenhalgh J, Hill RA, Jackson CF, Khanom S, McGinty RN, Tudur Smith C, Pulman J, Marson AG
Cochrane Database Syst Rev 2023 Aug 29;8(8):CD010224. doi: 10.1002/14651858.CD010224.pub3. PMID: 37647086Free PMC Article
Ravel A, Mircher C, Rebillat AS, Cieuta-Walti C, Megarbane A
Arch Pediatr 2020 Jan;27(1):53-60. Epub 2019 Nov 26 doi: 10.1016/j.arcped.2019.11.008. PMID: 31784293
Mendes SMDA, Espinosa DDSG, Moreira PEO, Marques D, Fagundes NCF, Ribeiro-Dos-Santos Â
J Oral Pathol Med 2020 Mar;49(3):201-209. Epub 2019 Sep 17 doi: 10.1111/jop.12950. PMID: 31479540
Baldacci S, Gorini F, Santoro M, Pierini A, Minichilli F, Bianchi F
Epidemiol Prev 2018 May-Aug;42(3-4 Suppl 1):1-34. doi: 10.19191/EP18.3-4.S1.P001.057. PMID: 30066535

Diagnosis

Nelson-Piercy C, Dean C, Shehmar M, Gadsby R, O'Hara M, Hodson K, Nana M; Royal College of Obstetricians and Gynaecologists
BJOG 2024 Jun;131(7):e1-e30. Epub 2024 Feb 4 doi: 10.1111/1471-0528.17739. PMID: 38311315
Ravel A, Mircher C, Rebillat AS, Cieuta-Walti C, Megarbane A
Arch Pediatr 2020 Jan;27(1):53-60. Epub 2019 Nov 26 doi: 10.1016/j.arcped.2019.11.008. PMID: 31784293
Baldacci S, Gorini F, Santoro M, Pierini A, Minichilli F, Bianchi F
Epidemiol Prev 2018 May-Aug;42(3-4 Suppl 1):1-34. doi: 10.19191/EP18.3-4.S1.P001.057. PMID: 30066535
Saleem AA, Siddiqui SN
J Coll Physicians Surg Pak 2015 Oct;25 Suppl 2:S124-6. doi: 10.2015/JCPSP.S124S126. PMID: 26522198
Rodríguez-Caballero A, Torres-Lagares D, Rodríguez-Pérez A, Serrera-Figallo MA, Hernández-Guisado JM, Machuca-Portillo G
Med Oral Patol Oral Cir Bucal 2010 May 1;15(3):e473-8. doi: 10.4317/medoral.15.e473. PMID: 20038906

Therapy

Nelson-Piercy C, Dean C, Shehmar M, Gadsby R, O'Hara M, Hodson K, Nana M; Royal College of Obstetricians and Gynaecologists
BJOG 2024 Jun;131(7):e1-e30. Epub 2024 Feb 4 doi: 10.1111/1471-0528.17739. PMID: 38311315
Huang Z, Wu J, Qiu Y, Lin J, Huang W, Ma X, Zhang H, Yang X
BMC Pregnancy Childbirth 2023 Dec 1;23(1):829. doi: 10.1186/s12884-023-06104-4. PMID: 38041018Free PMC Article
Bromley R, Adab N, Bluett-Duncan M, Clayton-Smith J, Christensen J, Edwards K, Greenhalgh J, Hill RA, Jackson CF, Khanom S, McGinty RN, Tudur Smith C, Pulman J, Marson AG
Cochrane Database Syst Rev 2023 Aug 29;8(8):CD010224. doi: 10.1002/14651858.CD010224.pub3. PMID: 37647086Free PMC Article
Baldacci S, Gorini F, Santoro M, Pierini A, Minichilli F, Bianchi F
Epidemiol Prev 2018 May-Aug;42(3-4 Suppl 1):1-34. doi: 10.19191/EP18.3-4.S1.P001.057. PMID: 30066535
Bell JC, Raynes-Greenow C, Bower C, Turner RM, Roberts CL, Nassar N
Birth Defects Res A Clin Mol Teratol 2013 Feb;97(2):101-8. Epub 2013 Feb 1 doi: 10.1002/bdra.23110. PMID: 23371924

Prognosis

Nelson-Piercy C, Dean C, Shehmar M, Gadsby R, O'Hara M, Hodson K, Nana M; Royal College of Obstetricians and Gynaecologists
BJOG 2024 Jun;131(7):e1-e30. Epub 2024 Feb 4 doi: 10.1111/1471-0528.17739. PMID: 38311315
Malic CC, Lam M, Donelle J, Richard L, Vigod SN, Benchimol EI
JAMA Netw Open 2020 Feb 5;3(2):e1921036. doi: 10.1001/jamanetworkopen.2019.21036. PMID: 32049294
Nagarajan M, Sharbidre KG, Bhabad SH, Byrd SE
Radiographics 2018 May-Jun;38(3):962-980. Epub 2018 Apr 13 doi: 10.1148/rg.2018170142. PMID: 29652578
Scott AR, Nguyen H, Kelly JC, Sidman JD
Int J Pediatr Otorhinolaryngol 2014 Apr;78(4):679-83. Epub 2014 Feb 7 doi: 10.1016/j.ijporl.2014.01.039. PMID: 24582076
Rodríguez-Caballero A, Torres-Lagares D, Rodríguez-Pérez A, Serrera-Figallo MA, Hernández-Guisado JM, Machuca-Portillo G
Med Oral Patol Oral Cir Bucal 2010 May 1;15(3):e473-8. doi: 10.4317/medoral.15.e473. PMID: 20038906

Clinical prediction guides

Nelson-Piercy C, Dean C, Shehmar M, Gadsby R, O'Hara M, Hodson K, Nana M; Royal College of Obstetricians and Gynaecologists
BJOG 2024 Jun;131(7):e1-e30. Epub 2024 Feb 4 doi: 10.1111/1471-0528.17739. PMID: 38311315
Bromley R, Adab N, Bluett-Duncan M, Clayton-Smith J, Christensen J, Edwards K, Greenhalgh J, Hill RA, Jackson CF, Khanom S, McGinty RN, Tudur Smith C, Pulman J, Marson AG
Cochrane Database Syst Rev 2023 Aug 29;8(8):CD010224. doi: 10.1002/14651858.CD010224.pub3. PMID: 37647086Free PMC Article
Schuler CF 4th, O'Shea KM, Troost JP, Kaul B, Launius CM, Cannon J, Manthei DM, Freigeh GE, Sanders GM, Hogan SP, Lukacs NW, Baker JR Jr
J Clin Invest 2023 Aug 15;133(16) doi: 10.1172/JCI168965. PMID: 37402149Free PMC Article
Sarmiento K, Valencia S, Gracia G, Hurtado-Villa P, Zarante I
Cleft Palate Craniofac J 2018 Apr;55(4):517-520. Epub 2017 Dec 20 doi: 10.1177/1055665617741062. PMID: 29554446
Sabbagh HJ, Hassan MH, Innes NP, Baik AA, Mossey PA
Cleft Palate Craniofac J 2014 Sep;51(5):501-13. Epub 2013 May 2 doi: 10.1597/12-209. PMID: 23638915

Recent systematic reviews

Bromley R, Adab N, Bluett-Duncan M, Clayton-Smith J, Christensen J, Edwards K, Greenhalgh J, Hill RA, Jackson CF, Khanom S, McGinty RN, Tudur Smith C, Pulman J, Marson AG
Cochrane Database Syst Rev 2023 Aug 29;8(8):CD010224. doi: 10.1002/14651858.CD010224.pub3. PMID: 37647086Free PMC Article
Marzouk T, Alves IL, Wong CL, DeLucia L, McKinney CM, Pendleton C, Howe BJ, Marazita ML, Peter TK, Kopycka-Kedzierawski DT, Morrison CS, Malmstrom H, Wang H, Shope ET
JDR Clin Trans Res 2021 Oct;6(4):368-381. Epub 2020 Oct 8 doi: 10.1177/2380084420964795. PMID: 33030085Free PMC Article
Chi CC, Wang SH, Wojnarowska F, Kirtschig G, Davies E, Bennett C
Cochrane Database Syst Rev 2015 Oct 26;2015(10):CD007346. doi: 10.1002/14651858.CD007346.pub3. PMID: 26497573Free PMC Article
Sabbagh HJ, Hassan MH, Innes NP, Elkodary HM, Little J, Mossey PA
PLoS One 2015;10(3):e0116963. Epub 2015 Mar 11 doi: 10.1371/journal.pone.0116963. PMID: 25760440Free PMC Article
Sabbagh HJ, Hassan MH, Innes NP, Baik AA, Mossey PA
Cleft Palate Craniofac J 2014 Sep;51(5):501-13. Epub 2013 May 2 doi: 10.1597/12-209. PMID: 23638915

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