Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Orofacial cleft 2(OFC2)

MedGen UID:: 400499
•Concept ID:: C1864323
•: Disease or Syndrome

Synonyms:	CLEFT LIP WITH OR WITHOUT CLEFT PALATE, NONSYNDROMIC, 2; OFC2

Monarch Initiative:	MONDO:0011276
OMIM®:	602966

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVOrofacial cleft
- CROGVOrofacial cleft 1
- CROGVOrofacial cleft 2
- CROGVOrofacial cleft 3
- CROGVOrofacial cleft 4
- CROGVOrofacial cleft 5
- CROGVOrofacial cleft 8
- CROGVOrofacial cleft 9
- CROGVOrofacial cleft 10
- CROGVOrofacial cleft 11
- CROGVOrofacial cleft 12
- CROGVOrofacial cleft 13
- CROGVOrofacial cleft 6, susceptibility to

Phenotypic abnormality
- Abnormality of head or neck
  - Abnormality of the head
    - Craniofacial cleft
      - Orofacial cleft
        Orofacial cleft 2

Professional guidelines

PubMed

Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child.

Bromley R, Adab N, Bluett-Duncan M, Clayton-Smith J, Christensen J, Edwards K, Greenhalgh J, Hill RA, Jackson CF, Khanom S, McGinty RN, Tudur Smith C, Pulman J, Marson AG
Cochrane Database Syst Rev 2023 Aug 29;8(8):CD010224. doi: 10.1002/14651858.CD010224.pub3. PMID: 37647086 Free PMC Article

Oral management of children/adolescents with ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome: A scoping review.

Garrocho-Rangel A, Serrano-Aguilar G, Hernández-Molinar Y, Aranda-Romo S, Alejandri-Gamboa V, Pozos-Guillén A
Spec Care Dentist 2023 Mar;43(2):152-162. Epub 2022 Jul 25 doi: 10.1111/scd.12752. PMID: 35879828

Prenatal diagnosis and assessment of facial clefts: where are we now?

To WW
Hong Kong Med J 2012 Apr;18(2):146-52. PMID: 22477739

See all (31)

Recent clinical studies

Etiology

Association between gestational exposure and risk of orofacial clefts: a systematic review and meta-analysis.

Huang Z, Wu J, Qiu Y, Lin J, Huang W, Ma X, Zhang H, Yang X
BMC Pregnancy Childbirth 2023 Dec 1;23(1):829. doi: 10.1186/s12884-023-06104-4. PMID: 38041018 Free PMC Article

Caries in children with and without orofacial clefting: A systematic review and meta-analysis.

Grewcock RE, Innes NPT, Mossey PA, Robertson MD
Oral Dis 2022 Jul;28(5):1400-1411. Epub 2022 Mar 22 doi: 10.1111/odi.14183. PMID: 35263806 Free PMC Article

Variations in Orofacial Clefts.

Jahanbin A, Jamalinasab A, Niazi AE
J Craniofac Surg 2021 Mar-Apr 01;32(2):e179-e182. doi: 10.1097/SCS.0000000000007027. PMID: 33705067

Evidence-Based Medicine: Cleft Palate.

Woo AS
Plast Reconstr Surg 2017 Jan;139(1):191e-203e. doi: 10.1097/PRS.0000000000002854. PMID: 28027255

Toward an orofacial gene regulatory network.

Kousa YA, Schutte BC
Dev Dyn 2016 Mar;245(3):220-32. Epub 2015 Sep 17 doi: 10.1002/dvdy.24341. PMID: 26332872 Free PMC Article

See all (601)

Diagnosis

Ankyloglossia: Typical Characteristics, Effects on Function, and Clinical Implications.

Kummer AW
Semin Speech Lang 2023 Aug;44(4):217-229. Epub 2023 Sep 25 doi: 10.1055/s-0043-1772598. PMID: 37748489

Clinical and Molecular Genetic Analysis of Cases with Ectodermal Dysplasia.

Yapijakis C, Douka A, Gintoni I, Agiannitopoulos K, Vlachakis D, Chrousos GP
Adv Exp Med Biol 2023;1423:181-186. doi: 10.1007/978-3-031-31978-5_15. PMID: 37525042

Orofacial Cleft and Mandibular Prognathism-Human Genetics and Animal Models.

Jaruga A, Ksiazkiewicz J, Kuzniarz K, Tylzanowski P
Int J Mol Sci 2022 Jan 16;23(2) doi: 10.3390/ijms23020953. PMID: 35055138 Free PMC Article

Feeding problems and gastrointestinal diseases in Down syndrome.

Ravel A, Mircher C, Rebillat AS, Cieuta-Walti C, Megarbane A
Arch Pediatr 2020 Jan;27(1):53-60. Epub 2019 Nov 26 doi: 10.1016/j.arcped.2019.11.008. PMID: 31784293

Environmental and individual exposure and the risk of congenital anomalies: a review of recent epidemiological evidence.

Baldacci S, Gorini F, Santoro M, Pierini A, Minichilli F, Bianchi F
Epidemiol Prev 2018 May-Aug;42(3-4 Suppl 1):1-34. doi: 10.19191/EP18.3-4.S1.P001.057. PMID: 30066535

See all (191)

Therapy

Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child.

Caries in children with and without orofacial clefting: A systematic review and meta-analysis.

Grewcock RE, Innes NPT, Mossey PA, Robertson MD
Oral Dis 2022 Jul;28(5):1400-1411. Epub 2022 Mar 22 doi: 10.1111/odi.14183. PMID: 35263806 Free PMC Article

Biomaterials for Cleft Lip and Palate Regeneration.

Martín-Del-Campo M, Rosales-Ibañez R, Rojo L
Int J Mol Sci 2019 May 2;20(9) doi: 10.3390/ijms20092176. PMID: 31052503 Free PMC Article

Environmental and individual exposure and the risk of congenital anomalies: a review of recent epidemiological evidence.

Baldacci S, Gorini F, Santoro M, Pierini A, Minichilli F, Bianchi F
Epidemiol Prev 2018 May-Aug;42(3-4 Suppl 1):1-34. doi: 10.19191/EP18.3-4.S1.P001.057. PMID: 30066535

Influence of mineral and vitamin supplements on pregnancy outcome.

Hovdenak N, Haram K
Eur J Obstet Gynecol Reprod Biol 2012 Oct;164(2):127-32. Epub 2012 Jul 6 doi: 10.1016/j.ejogrb.2012.06.020. PMID: 22771225

See all (162)

Prognosis

Imaging Factors Affecting Prenatal Counseling in Orofacial Clefts.

Hermann AL, Soupre V, Vande Perre S, Guilbaud L, Quenum-Miraillet G, Blondiaux E, Picard A, Jouannic JM, Dhombres F, Garel C
Fetal Diagn Ther 2023;50(2):70-83. Epub 2023 Feb 28 doi: 10.1159/000529821. PMID: 36854283

Mutations in Van Der Woude Families From Ethiopia.

Eshete M, Alade A, Abate F, Mossey PA, Awotoye WA, Busch T, Hailu A, Demissie Y, Butali A
J Craniofac Surg 2022 Mar-Apr 01;33(2):e138-e140. doi: 10.1097/SCS.0000000000008142. PMID: 34643600 Free PMC Article

Cleft Lip and Palate in Ectodermal Dysplasia.

Ganske IM, Irwin T, Langa O, Upton J 3rd, Tan WH, Mulliken JB
Cleft Palate Craniofac J 2021 Feb;58(2):237-243. Epub 2020 Aug 30 doi: 10.1177/1055665620949124. PMID: 32864997

Seasonal Variation of Orofacial Clefts.

Sofianos C, Christofides EA, Phiri SE
J Craniofac Surg 2018 Mar;29(2):368-371. doi: 10.1097/SCS.0000000000004226. PMID: 29215449

The spectrum of orofacial clefting.

Eppley BL, van Aalst JA, Robey A, Havlik RJ, Sadove AM
Plast Reconstr Surg 2005 Jun;115(7):101e-114e. doi: 10.1097/01.prs.0000164494.45986.91. PMID: 15923821

See all (124)

Clinical prediction guides

Association between gestational exposure and risk of orofacial clefts: a systematic review and meta-analysis.

Huang Z, Wu J, Qiu Y, Lin J, Huang W, Ma X, Zhang H, Yang X
BMC Pregnancy Childbirth 2023 Dec 1;23(1):829. doi: 10.1186/s12884-023-06104-4. PMID: 38041018 Free PMC Article

Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child.

Tooth abnormalities associated with non-syndromic cleft lip and palate: systematic review and meta-analysis.

Fonseca-Souza G, de Oliveira LB, Wambier LM, Scariot R, Feltrin-Souza J
Clin Oral Investig 2022 Aug;26(8):5089-5103. Epub 2022 Jun 21 doi: 10.1007/s00784-022-04540-8. PMID: 35729285

The Era of the Genome and Dental Medicine.

Divaris K
J Dent Res 2019 Aug;98(9):949-955. doi: 10.1177/0022034519845674. PMID: 31329043 Free PMC Article

Seasonal Variation of Orofacial Clefts.

Sofianos C, Christofides EA, Phiri SE
J Craniofac Surg 2018 Mar;29(2):368-371. doi: 10.1097/SCS.0000000000004226. PMID: 29215449

See all (268)

Recent systematic reviews

Association between gestational exposure and risk of orofacial clefts: a systematic review and meta-analysis.

Huang Z, Wu J, Qiu Y, Lin J, Huang W, Ma X, Zhang H, Yang X
BMC Pregnancy Childbirth 2023 Dec 1;23(1):829. doi: 10.1186/s12884-023-06104-4. PMID: 38041018 Free PMC Article

Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child.

Tooth abnormalities associated with non-syndromic cleft lip and palate: systematic review and meta-analysis.

Fonseca-Souza G, de Oliveira LB, Wambier LM, Scariot R, Feltrin-Souza J
Clin Oral Investig 2022 Aug;26(8):5089-5103. Epub 2022 Jun 21 doi: 10.1007/s00784-022-04540-8. PMID: 35729285

Caries in children with and without orofacial clefting: A systematic review and meta-analysis.

Grewcock RE, Innes NPT, Mossey PA, Robertson MD
Oral Dis 2022 Jul;28(5):1400-1411. Epub 2022 Mar 22 doi: 10.1111/odi.14183. PMID: 35263806 Free PMC Article

Global Birth Prevalence of Orofacial Clefts: A Systematic Review.

Panamonta V, Pradubwong S, Panamonta M, Chowchuen B
J Med Assoc Thai 2015 Aug;98 Suppl 7:S11-21. PMID: 26742364

See all (37)

MedGen

National Center for Biotechnology Information

Send to:

Orofacial cleft 2(OFC2)

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Molecular resources

Consumer resources

Reviews

Related information

Recent activity