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Spinal chordoma

MedGen UID:
347800
•Concept ID:
C1859101
•
Neoplastic Process
Synonym: Vertebral chordoma
 
Monarch Initiative: MONDO:0002894

Definition

A chordoma that arises from the spine. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpinal chordoma

Professional guidelines

PubMed

Surgical Management of Spinal Chordoma: A Systematic Review and Single-Center Experience.
Baig Mirza A, Bartram J, Okasha M, Al Banna Q, Vastani A, Maratos E, Gullan R, Thomas N
World Neurosurg 2021 Dec;156:e111-e129. Epub 2021 Sep 22 doi: 10.1016/j.wneu.2021.09.001. PMID: 34506978
Current treatment strategy for newly diagnosed chordoma of the mobile spine and sacrum: results of an international survey.
Dea N, Fisher CG, Reynolds JJ, Schwab JH, Rhines LD, Gokaslan ZL, Bettegowda C, Sahgal A, Lazáry Á, Luzzati A, Boriani S, Gasbarrini A, Laufer I, Charest-Morin R, Wei F, Teixeira W, Germscheid NM, Hornicek FJ, DeLaney TF, Shin JH; AOSpine Knowledge Forum Tumor
J Neurosurg Spine 2018 Oct 19;30(1):119-125. doi: 10.3171/2018.6.SPINE18362. PMID: 30497218
Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: A Systematic Review.
Ailon T, Torabi R, Fisher CG, Rhines LD, Clarke MJ, Bettegowda C, Boriani S, Yamada YJ, Kawahara N, Varga PP, Shin JH, Saghal A, Gokaslan ZL
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S193-S198. doi: 10.1097/BRS.0000000000001812. PMID: 27753782Free PMC Article

Recent clinical studies

Etiology

Survival and treatment of cranial and spinal chordomas: a population-based study.
Zhang GJ, Cui YS, Li H
Neurosurg Rev 2022 Feb;45(1):637-647. Epub 2021 Jun 22 doi: 10.1007/s10143-021-01583-5. PMID: 34156550
Surgical Management of Spinal Chordoma: A Systematic Review and Single-Center Experience.
Baig Mirza A, Bartram J, Okasha M, Al Banna Q, Vastani A, Maratos E, Gullan R, Thomas N
World Neurosurg 2021 Dec;156:e111-e129. Epub 2021 Sep 22 doi: 10.1016/j.wneu.2021.09.001. PMID: 34506978
Clinicopathologic implications of CD8(+)/Foxp3(+) ratio and miR-574-3p/PD-L1 axis in spinal chordoma patients.
Zou MX, Guo KM, Lv GH, Huang W, Li J, Wang XB, Jiang Y, She XL
Cancer Immunol Immunother 2018 Feb;67(2):209-224. Epub 2017 Oct 20 doi: 10.1007/s00262-017-2080-1. PMID: 29051990
Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: A Systematic Review.
Ailon T, Torabi R, Fisher CG, Rhines LD, Clarke MJ, Bettegowda C, Boriani S, Yamada YJ, Kawahara N, Varga PP, Shin JH, Saghal A, Gokaslan ZL
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S193-S198. doi: 10.1097/BRS.0000000000001812. PMID: 27753782Free PMC Article
Prognostic factors in spinal chordoma: A systematic review.
Zou MX, Huang W, Wang XB, Li J, Lv GH, Deng YW
Clin Neurol Neurosurg 2015 Dec;139:110-8. Epub 2015 Sep 25 doi: 10.1016/j.clineuro.2015.09.012. PMID: 26432656

Diagnosis

Imaging of spinal chordoma and benign notochordal cell tumor (BNCT) with radiologic pathologic correlation.
Murphey MD, Minn MJ, Contreras AL, Koeller KK, Shih RY, Inwards CY, Yamaguchi T
Skeletal Radiol 2023 Mar;52(3):349-363. Epub 2022 Sep 5 doi: 10.1007/s00256-022-04158-7. PMID: 36063190
Survival and treatment of cranial and spinal chordomas: a population-based study.
Zhang GJ, Cui YS, Li H
Neurosurg Rev 2022 Feb;45(1):637-647. Epub 2021 Jun 22 doi: 10.1007/s10143-021-01583-5. PMID: 34156550
Cutaneous Metastasis from Cervical Spinal Chordoma: Case Report and Literature Review.
Berlucchi S, Nasi D, Zunarelli E, Valluzzi A, Alicandri Ciufelli M, Presutti L, Pavesi G
World Neurosurg 2020 May;137:296-303. Epub 2020 Feb 15 doi: 10.1016/j.wneu.2020.02.018. PMID: 32068172
Intradural cervical chordoma with diffuse spinal leptomeningeal spread: case report and review of the literature.
Zhang J, Gao CP, Liu XJ, Xu WJ
Eur Spine J 2018 Jul;27(Suppl 3):440-445. Epub 2018 Jan 8 doi: 10.1007/s00586-017-5443-6. PMID: 29313091
Prognostic factors in spinal chordoma: A systematic review.
Zou MX, Huang W, Wang XB, Li J, Lv GH, Deng YW
Clin Neurol Neurosurg 2015 Dec;139:110-8. Epub 2015 Sep 25 doi: 10.1016/j.clineuro.2015.09.012. PMID: 26432656

Therapy

Immunohistochemical markers predicting long-term recurrence following clival and spinal chordoma resection: a multicenter study.
Ghaith AK, Akinduro OO, Alexander AY, Goyal A, Bon-Nieves A, de Macedo Filho L, Otamendi-Lopez A, Nathani KR, Abode-Iyamah K, Jentoft ME, Bendok BR, Clarke MJ, Link MJ, Van Gompel JJ, Quiñones-Hinojosa A, Bydon M
Neurosurg Focus 2023 Jun;54(6):E15. doi: 10.3171/2023.3.FOCUS22653. PMID: 37552641
Periocular Manifestations of Afatinib Therapy.
Joganathan V, Norris JH
Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):e12-e13. doi: 10.1097/IOP.0000000000001277. PMID: 30531213
Long-Term Clinical Safety of High-Dose Proton Radiation Therapy Delivered With Pencil Beam Scanning Technique for Extracranial Chordomas and Chondrosarcomas in Adult Patients: Clinical Evidence of Spinal Cord Tolerance.
Stieb S, Snider JW 3rd, Placidi L, Kliebsch U, Lomax AJ, Schneider RA, Weber DC
Int J Radiat Oncol Biol Phys 2018 Jan 1;100(1):218-225. Epub 2017 Sep 4 doi: 10.1016/j.ijrobp.2017.08.037. PMID: 29029887
Effects of primary and recurrent sacral chordoma on the motor and nociceptive function of hindlimbs in rats: an orthotopic spine model.
Sarabia-Estrada R, Ruiz-Valls A, Shah SR, Ahmed AK, Ordonez AA, Rodriguez FJ, Guerrero-Cazares H, Jimenez-Estrada I, Velarde E, Tyler B, Li Y, Phillips NA, Goodwin CR, Petteys RJ, Jain SK, Gallia GL, Gokaslan ZL, Quinones-Hinojosa A, Sciubba DM
J Neurosurg Spine 2017 Aug;27(2):215-226. Epub 2017 Jun 9 doi: 10.3171/2016.12.SPINE16917. PMID: 28598292
Radiolucent Carbon Fiber-Reinforced Pedicle Screws for Treatment of Spinal Tumors: Advantages for Radiation Planning and Follow-Up Imaging.
Ringel F, Ryang YM, Kirschke JS, Müller BS, Wilkens JJ, Brodard J, Combs SE, Meyer B
World Neurosurg 2017 Sep;105:294-301. Epub 2017 May 3 doi: 10.1016/j.wneu.2017.04.091. PMID: 28478252

Prognosis

Imaging of spinal chordoma and benign notochordal cell tumor (BNCT) with radiologic pathologic correlation.
Murphey MD, Minn MJ, Contreras AL, Koeller KK, Shih RY, Inwards CY, Yamaguchi T
Skeletal Radiol 2023 Mar;52(3):349-363. Epub 2022 Sep 5 doi: 10.1007/s00256-022-04158-7. PMID: 36063190
Survival and treatment of cranial and spinal chordomas: a population-based study.
Zhang GJ, Cui YS, Li H
Neurosurg Rev 2022 Feb;45(1):637-647. Epub 2021 Jun 22 doi: 10.1007/s10143-021-01583-5. PMID: 34156550
Coexpression of HHLA2 and PD-L1 on Tumor Cells Independently Predicts the Survival of Spinal Chordoma Patients.
Xia C, Huang W, Chen YL, Fu HB, Tang M, Zhang TL, Li J, Lv GH, Yan YG, Ouyang ZH, Yao N, Wang C, Zou MX
Front Immunol 2021;12:797407. Epub 2022 Jan 25 doi: 10.3389/fimmu.2021.797407. PMID: 35145510Free PMC Article
Prognostic Factors in Patients With Spinal Chordoma: An Integrative Analysis of 682 Patients.
Zhou J, Sun J, Bai HX, Huang X, Zou Y, Tan X, Zhang Z, Tang X, Tao Y, Xiao B, Zhang PJ, Yang L
Neurosurgery 2017 Nov 1;81(5):812-823. doi: 10.1093/neuros/nyx081. PMID: 28368502
Prognostic factors in spinal chordoma: A systematic review.
Zou MX, Huang W, Wang XB, Li J, Lv GH, Deng YW
Clin Neurol Neurosurg 2015 Dec;139:110-8. Epub 2015 Sep 25 doi: 10.1016/j.clineuro.2015.09.012. PMID: 26432656

Clinical prediction guides

Coexpression of HHLA2 and PD-L1 on Tumor Cells Independently Predicts the Survival of Spinal Chordoma Patients.
Xia C, Huang W, Chen YL, Fu HB, Tang M, Zhang TL, Li J, Lv GH, Yan YG, Ouyang ZH, Yao N, Wang C, Zou MX
Front Immunol 2021;12:797407. Epub 2022 Jan 25 doi: 10.3389/fimmu.2021.797407. PMID: 35145510Free PMC Article
Clinical Impact of the Immune Microenvironment in Spinal Chordoma: Immunoscore as an Independent Favorable Prognostic Factor.
Zou MX, Lv GH, Wang XB, Huang W, Li J, Jiang Y, She XL
Neurosurgery 2019 Jun 1;84(6):E318-E333. doi: 10.1093/neuros/nyy274. PMID: 30032257
Development of Machine Learning Algorithms for Prediction of 5-Year Spinal Chordoma Survival.
Karhade AV, Thio Q, Ogink P, Kim J, Lozano-Calderon S, Raskin K, Schwab JH
World Neurosurg 2018 Nov;119:e842-e847. Epub 2018 Aug 8 doi: 10.1016/j.wneu.2018.07.276. PMID: 30096498
Prognostic Factors in Patients With Spinal Chordoma: An Integrative Analysis of 682 Patients.
Zhou J, Sun J, Bai HX, Huang X, Zou Y, Tan X, Zhang Z, Tang X, Tao Y, Xiao B, Zhang PJ, Yang L
Neurosurgery 2017 Nov 1;81(5):812-823. doi: 10.1093/neuros/nyx081. PMID: 28368502
Prognostic factors in spinal chordoma: A systematic review.
Zou MX, Huang W, Wang XB, Li J, Lv GH, Deng YW
Clin Neurol Neurosurg 2015 Dec;139:110-8. Epub 2015 Sep 25 doi: 10.1016/j.clineuro.2015.09.012. PMID: 26432656

Recent systematic reviews

Surgical Management of Spinal Chordoma: A Systematic Review and Single-Center Experience.
Baig Mirza A, Bartram J, Okasha M, Al Banna Q, Vastani A, Maratos E, Gullan R, Thomas N
World Neurosurg 2021 Dec;156:e111-e129. Epub 2021 Sep 22 doi: 10.1016/j.wneu.2021.09.001. PMID: 34506978
Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: A Systematic Review.
Ailon T, Torabi R, Fisher CG, Rhines LD, Clarke MJ, Bettegowda C, Boriani S, Yamada YJ, Kawahara N, Varga PP, Shin JH, Saghal A, Gokaslan ZL
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S193-S198. doi: 10.1097/BRS.0000000000001812. PMID: 27753782Free PMC Article
Prognostic factors in spinal chordoma: A systematic review.
Zou MX, Huang W, Wang XB, Li J, Lv GH, Deng YW
Clin Neurol Neurosurg 2015 Dec;139:110-8. Epub 2015 Sep 25 doi: 10.1016/j.clineuro.2015.09.012. PMID: 26432656

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