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Thyroid Gland Follicular Carcinoma, Clear Cell Variant

MedGen UID:
353543
•Concept ID:
C1707409
•
Neoplastic Process
Synonym: Clear Cell Variant Thyroid Gland Follicular Carcinoma

Definition

A morphologic variant of follicular carcinoma of the thyroid gland characterized by the predominance of malignant follicular clear cells. These cells lack the nuclear features that characterize the papillary carcinomas of the thyroid gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Follicular Carcinoma, Clear Cell Variant

Professional guidelines

PubMed

Usefulness of galectin-3 immunohistochemistry in differential diagnosis between thyroid follicular carcinoma and follicular adenoma.
Jakubiak-Wielganowicz M, Kubiak R, Sygut J, Pomorski L, Kordek R
Pol J Pathol 2003;54(2):111-5. PMID: 14575419

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
TROP-2 and 5hmC expression in follicular-patterned thyroid neoplasm emphasizing tiny well-formed papillae.
Seok JY, Fan X
Ann Diagn Pathol 2022 Apr;57:151903. Epub 2022 Jan 31 doi: 10.1016/j.anndiagpath.2022.151903. PMID: 35121239
Ovarian Clear Cell Carcinoma in Cowden Syndrome.
Yauy K, Imbert-Bouteille M, Bubien V, Lindet-Bourgeois C, Rathat G, Perrochia H, MacGrogan G, Longy M, Bessis D, Tinat J, Baert-Desurmont S, Blanluet M, Perre PV, Baudry K, Pujol P, Corsini C
J Natl Compr Canc Netw 2019 Jan;17(1):7-11. doi: 10.6004/jnccn.2018.7065. PMID: 30659124
Primary Cutaneous Follicle Center Lymphoma Clear Cell Variant: Expanding the Spectrum of Cutaneous Clear Cell Neoplasms.
Cassisa A, Colpani F, Rinaldi R, Cima L
Am J Dermatopathol 2018 Nov;40(11):849-853. doi: 10.1097/DAD.0000000000001195. PMID: 29877892
Clear-cell carcinomas of thyroid gland: a clinicopathological study of 13 cases.
Schröder S, Böcker W
Histopathology 1986 Jan;10(1):75-89. doi: 10.1111/j.1365-2559.1986.tb02462.x. PMID: 3957248

Diagnosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Cribriform-Morular Thyroid Carcinoma Is a Distinct Thyroid Malignancy of Uncertain Cytogenesis.
Boyraz B, Sadow PM, Asa SL, Dias-Santagata D, Nosé V, Mete O
Endocr Pathol 2021 Sep;32(3):327-335. Epub 2021 May 21 doi: 10.1007/s12022-021-09683-0. PMID: 34019236Free PMC Article
Ovarian Clear Cell Carcinoma in Cowden Syndrome.
Yauy K, Imbert-Bouteille M, Bubien V, Lindet-Bourgeois C, Rathat G, Perrochia H, MacGrogan G, Longy M, Bessis D, Tinat J, Baert-Desurmont S, Blanluet M, Perre PV, Baudry K, Pujol P, Corsini C
J Natl Compr Canc Netw 2019 Jan;17(1):7-11. doi: 10.6004/jnccn.2018.7065. PMID: 30659124
Follicular patterned lesions of the thyroid gland: a practical algorithmic approach.
Chetty R
J Clin Pathol 2011 Sep;64(9):737-41. Epub 2011 May 18 doi: 10.1136/jclinpath-2011-200121. PMID: 21593347
The many faces and mimics of papillary thyroid carcinoma.
Albores-Saavedra J, Wu J
Endocr Pathol 2006 Spring;17(1):1-18. doi: 10.1385/ep:17:1:1. PMID: 16760576

Therapy

Signet ring cell variant of follicular thyroid carcinoma: Report of two cases with focus on morphological, expressional and genetic characteristics.
Hysek M, Jatta K, Stenman A, Darai-Ramqvist E, Zedenius J, Höög A, Juhlin CC
Diagn Pathol 2019 Nov 7;14(1):127. doi: 10.1186/s13000-019-0904-3. PMID: 31699114Free PMC Article
A clear cell variant of follicular carcinoma presenting as an autonomously functioning thyroid nodule.
Schneider PW, Meier DA, Balon H
Thyroid 2000 Mar;10(3):269-73. doi: 10.1089/thy.2000.10.269. PMID: 10779142

Prognosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Signet ring cell variant of follicular thyroid carcinoma: Report of two cases with focus on morphological, expressional and genetic characteristics.
Hysek M, Jatta K, Stenman A, Darai-Ramqvist E, Zedenius J, Höög A, Juhlin CC
Diagn Pathol 2019 Nov 7;14(1):127. doi: 10.1186/s13000-019-0904-3. PMID: 31699114Free PMC Article
Primary Cutaneous Follicle Center Lymphoma Clear Cell Variant: Expanding the Spectrum of Cutaneous Clear Cell Neoplasms.
Cassisa A, Colpani F, Rinaldi R, Cima L
Am J Dermatopathol 2018 Nov;40(11):849-853. doi: 10.1097/DAD.0000000000001195. PMID: 29877892
Follicular patterned lesions of the thyroid gland: a practical algorithmic approach.
Chetty R
J Clin Pathol 2011 Sep;64(9):737-41. Epub 2011 May 18 doi: 10.1136/jclinpath-2011-200121. PMID: 21593347
The many faces and mimics of papillary thyroid carcinoma.
Albores-Saavedra J, Wu J
Endocr Pathol 2006 Spring;17(1):1-18. doi: 10.1385/ep:17:1:1. PMID: 16760576

Clinical prediction guides

TROP-2 and 5hmC expression in follicular-patterned thyroid neoplasm emphasizing tiny well-formed papillae.
Seok JY, Fan X
Ann Diagn Pathol 2022 Apr;57:151903. Epub 2022 Jan 31 doi: 10.1016/j.anndiagpath.2022.151903. PMID: 35121239
Cribriform-Morular Thyroid Carcinoma Is a Distinct Thyroid Malignancy of Uncertain Cytogenesis.
Boyraz B, Sadow PM, Asa SL, Dias-Santagata D, Nosé V, Mete O
Endocr Pathol 2021 Sep;32(3):327-335. Epub 2021 May 21 doi: 10.1007/s12022-021-09683-0. PMID: 34019236Free PMC Article
Ovarian Clear Cell Carcinoma in Cowden Syndrome.
Yauy K, Imbert-Bouteille M, Bubien V, Lindet-Bourgeois C, Rathat G, Perrochia H, MacGrogan G, Longy M, Bessis D, Tinat J, Baert-Desurmont S, Blanluet M, Perre PV, Baudry K, Pujol P, Corsini C
J Natl Compr Canc Netw 2019 Jan;17(1):7-11. doi: 10.6004/jnccn.2018.7065. PMID: 30659124
Clear Cell Variant of a Follicular Thyroid Tumor With Uncertain Malignant Potential: A Case Report.
Juhlin CC, Bränström R, Shabo I, Höög A
Int J Surg Pathol 2019 May;27(3):290-293. Epub 2018 Oct 29 doi: 10.1177/1066896918809490. PMID: 30370813
Follicular patterned lesions of the thyroid gland: a practical algorithmic approach.
Chetty R
J Clin Pathol 2011 Sep;64(9):737-41. Epub 2011 May 18 doi: 10.1136/jclinpath-2011-200121. PMID: 21593347

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