U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Thymic Atypical Carcinoid Tumor

MedGen UID:
354249
•Concept ID:
C1710396
•
Neoplastic Process

Definition

A primary thymic carcinoid tumor, characterized by a high mitotic rate often associated with the presence of necrosis and nuclear pleomorphism. This type of thymic carcinoid tumor has a more aggressive clinical course, compared to typical thymic carcinoid tumors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThymic Atypical Carcinoid Tumor

Professional guidelines

PubMed

About thymic carcinomas: challenges in diagnosis and management.
Mlika M, Boudaya S, Braham E, Chermiti F, Sayi A, Marghli A, El Mezni F
Asian Cardiovasc Thorac Ann 2016 May;24(4):350-4. Epub 2016 Mar 21 doi: 10.1177/0218492316640129. PMID: 27002097
Radicality and prognosis of surgical treatment of thoracal carcinoid tumors: a review of 152 operated cases.
Vadász P, Kotsis L, Egerváry M, Pálffy G
Thorac Cardiovasc Surg 1999 Aug;47(4):235-9. doi: 10.1055/s-2007-1013150. PMID: 10522793

Recent clinical studies

Etiology

Analysis of 25 surgical cases of thymic neuroendocrine tumors and thymic carcinoma.
Midorikawa K, Miyahara S, Nishino N, Ueda Y, Waseda R, Shiraishi T, Sato T
J Cardiothorac Surg 2024 Apr 16;19(1):225. doi: 10.1186/s13019-024-02723-w. PMID: 38627811Free PMC Article
Carcinoid tumors outside the abdomen.
Koehler K, Iams WT
Cancer Med 2023 Apr;12(7):7893-7903. Epub 2022 Dec 22 doi: 10.1002/cam4.5564. PMID: 36560885Free PMC Article
Capecitabine and Temozolomide as a Promising Therapy for Advanced Thymic Atypical Carcinoid.
Wang X, Li Y, Duan J, Chen Y, Yuan B, Qi Z, Tan H
Oncologist 2019 Jun;24(6):798-802. Epub 2018 Nov 9 doi: 10.1634/theoncologist.2018-0291. PMID: 30413666Free PMC Article
CT and MRI findings of thymic carcinoid.
Shimamoto A, Ashizawa K, Kido Y, Hayashi H, Nagayasu T, Kawakami A, Mukae H, Hayashi T, Ohtsubo M, Shigematsu K, Nakazono T, Yabuuchi H, Uetani M
Br J Radiol 2017 Mar;90(1071):20150341. Epub 2017 Jan 20 doi: 10.1259/bjr.20150341. PMID: 28106503Free PMC Article
Bronchial and Thymic Carcinoid Tumors.
Litvak A, Pietanza MC
Hematol Oncol Clin North Am 2016 Feb;30(1):83-102. doi: 10.1016/j.hoc.2015.09.003. PMID: 26614370

Diagnosis

Carcinoid tumors outside the abdomen.
Koehler K, Iams WT
Cancer Med 2023 Apr;12(7):7893-7903. Epub 2022 Dec 22 doi: 10.1002/cam4.5564. PMID: 36560885Free PMC Article
Increased carbohydrate antigen 19-9 expression in a thymic neuroendocrine tumor.
Shimizu Y, Kanda S, Fukushima T, Kobayashi T, Kondo R, Koizumi T
Thorac Cancer 2021 Nov;12(21):2949-2952. Epub 2021 Sep 27 doi: 10.1111/1759-7714.14153. PMID: 34581018Free PMC Article
Bronchial and Thymic Carcinoid Tumors.
Litvak A, Pietanza MC
Hematol Oncol Clin North Am 2016 Feb;30(1):83-102. doi: 10.1016/j.hoc.2015.09.003. PMID: 26614370
Multiple thymic carcinoids.
Kawaguchi K, Usami N, Okasaka T, Yokoi K
Ann Thorac Surg 2011 Jun;91(6):1973-5. doi: 10.1016/j.athoracsur.2010.11.067. PMID: 21619996
Ectopic thymic carcinoid masquerading as a thyroid nodule.
Inzucchi SE, Pfaff-Amesse T
Thyroid 1998 Jul;8(7):589-95. doi: 10.1089/thy.1998.8.589. PMID: 9709912

Therapy

Everolimus in combination with octreotide LAR in thymic atypical carcinoid.
Sakane T, Nakano T, Hagui E, Haneda H, Okuda K
Thorac Cancer 2023 May;14(15):1404-1407. Epub 2023 Apr 10 doi: 10.1111/1759-7714.14887. PMID: 37037489Free PMC Article
Subxiphoid approach for robotic single-site-assisted thymectomy.
Park SY, Han KN, Hong JI, Kim HK, Kim DJ, Choi YH
Eur J Cardiothorac Surg 2020 Aug 1;58(Suppl_1):i34-i38. doi: 10.1093/ejcts/ezaa036. PMID: 32061087
Capecitabine and Temozolomide as a Promising Therapy for Advanced Thymic Atypical Carcinoid.
Wang X, Li Y, Duan J, Chen Y, Yuan B, Qi Z, Tan H
Oncologist 2019 Jun;24(6):798-802. Epub 2018 Nov 9 doi: 10.1634/theoncologist.2018-0291. PMID: 30413666Free PMC Article
Metastatic thymic carcinoid responds to chemoradiation and octreotide: A case report.
Mei Z, Wang H, Ren S, Wei J, Gu Y
Medicine (Baltimore) 2018 Nov;97(47):e13286. doi: 10.1097/MD.0000000000013286. PMID: 30461637Free PMC Article
Bronchial and Thymic Carcinoid Tumors.
Litvak A, Pietanza MC
Hematol Oncol Clin North Am 2016 Feb;30(1):83-102. doi: 10.1016/j.hoc.2015.09.003. PMID: 26614370

Prognosis

Carcinoid tumors outside the abdomen.
Koehler K, Iams WT
Cancer Med 2023 Apr;12(7):7893-7903. Epub 2022 Dec 22 doi: 10.1002/cam4.5564. PMID: 36560885Free PMC Article
Increased carbohydrate antigen 19-9 expression in a thymic neuroendocrine tumor.
Shimizu Y, Kanda S, Fukushima T, Kobayashi T, Kondo R, Koizumi T
Thorac Cancer 2021 Nov;12(21):2949-2952. Epub 2021 Sep 27 doi: 10.1111/1759-7714.14153. PMID: 34581018Free PMC Article
Bronchial and Thymic Carcinoid Tumors.
Litvak A, Pietanza MC
Hematol Oncol Clin North Am 2016 Feb;30(1):83-102. doi: 10.1016/j.hoc.2015.09.003. PMID: 26614370
Thoracic carcinoids: radiologic-pathologic correlation.
Rosado de Christenson ML, Abbott GF, Kirejczyk WM, Galvin JR, Travis WD
Radiographics 1999 May-Jun;19(3):707-36. doi: 10.1148/radiographics.19.3.g99ma11707. PMID: 10336200
Pulmonary and thymic carcinoid tumors.
Dusmet ME, McKneally MF
World J Surg 1996 Feb;20(2):189-95. doi: 10.1007/s002689900029. PMID: 8661816

Clinical prediction guides

Analysis of 25 surgical cases of thymic neuroendocrine tumors and thymic carcinoma.
Midorikawa K, Miyahara S, Nishino N, Ueda Y, Waseda R, Shiraishi T, Sato T
J Cardiothorac Surg 2024 Apr 16;19(1):225. doi: 10.1186/s13019-024-02723-w. PMID: 38627811Free PMC Article
Long-term effect of everolimus in recurrent thymic neuroendocrine neoplasia.
Lang M, Hackert T, Anamaterou C
Clin Endocrinol (Oxf) 2021 Nov;95(5):744-751. Epub 2021 Aug 26 doi: 10.1111/cen.14572. PMID: 34323309
Typical and Atypical Carcinoid Tumors of the Mediastinum: A Biomarker Analysis of 27 Cases With Clinical Correlation.
Zaleski M, Kalhor N, Moran CA
Int J Surg Pathol 2021 Jun;29(4):358-367. Epub 2020 Nov 27 doi: 10.1177/1066896920976845. PMID: 33243039
Molecular Classification of Neuroendocrine Tumors of the Thymus.
Dinter H, Bohnenberger H, Beck J, Bornemann-Kolatzki K, Schütz E, Küffer S, Klein L, Franks TJ, Roden A, Emmert A, Hinterthaner M, Marino M, Brcic L, Popper H, Weis CA, Pelosi G, Marx A, Ströbel P
J Thorac Oncol 2019 Aug;14(8):1472-1483. Epub 2019 Apr 28 doi: 10.1016/j.jtho.2019.04.015. PMID: 31042566
Investigation on Computed Tomography Features of Primary Thymic Atypical Carcinoid Tumors.
Kan X, Wang P, Gong Z, Gao F, Zhang Y, Ge Y
J Comput Assist Tomogr 2017 Nov/Dec;41(6):990-994. doi: 10.1097/RCT.0000000000000615. PMID: 28448415

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...