U.S. flag

An official website of the United States government


Send to:

Choose Destination

Sclerotic vertebral body

MedGen UID:
Concept ID:
Synonyms: Sclerosis of vertebral bodies; Sclerotic vertebral bodies; Vertebral body sclerosis
HPO: HP:0100861


Increase in bone density of the vertebral body. [from HPO]

Term Hierarchy

Conditions with this feature

Worth disease
MedGen UID:
Concept ID:
Disease or Syndrome
Autosomal dominant endosteal hyperostosis is a generalized bone dysplasia characterized by a cortical thickening of the long bones, with no alteration in external shape, and a remarkable resistance of the bone to fracture. The skeleton is normal in childhood. Facial metamorphoses occur in adolescence, as the forehead flattens, the mandible becomes elongated, and the gonial angle decreases. An enlarging osseous prominence (torus palatinus) develops in the hard palate, which may lead to malocclusion or loss of teeth (summary by Van Wesenbeeck et al., 2003).
Brain abnormalities, neurodegeneration, and dysosteosclerosis
MedGen UID:
Concept ID:
Disease or Syndrome
Brain abnormalities, neurodegeneration, and dysosteosclerosis (BANDDOS) is an autosomal recessive disorder characterized by brain abnormalities, progressive neurologic deterioration, and sclerotic bone dysplasia similar to dysosteosclerosis (DOS). The age at onset is highly variable: some patients may present in infancy with hydrocephalus, global developmental delay, and hypotonia, whereas others may have onset of symptoms in the late teens or early twenties after normal development. Neurologic features include loss of previous motor and language skills, cognitive impairment, spasticity, and focal seizures. Brain imaging shows periventricular white matter abnormalities and calcifications, large cisterna magna or Dandy-Walker malformation, and sometimes agenesis of the corpus callosum (summary by Guo et al., 2019).

Professional guidelines


Chandra SP, Singh P, Kumar R, Agarwal D, Tandon V, Kale SS, Sarkar C
Spine J 2019 Jan;19(1):131-143. Epub 2018 Jun 8 doi: 10.1016/j.spinee.2018.05.015. PMID: 29890263
Boxer DI, Pratt C, Hine AL, McNicol M
Br J Radiol 1992 Jun;65(774):476-9. doi: 10.1259/0007-1285-65-774-476. PMID: 1628177

Recent clinical studies


George J, Lai FM
Singapore Med J 1995 Apr;36(2):224-7. PMID: 7676275
Schechter MS, Collins JD
Spine (Phila Pa 1976) 1983 Oct;8(7):804-5. PMID: 6665585
Broderick TW, Resnick D, Goergen TG, Alazraki N
Spine (Phila Pa 1976) 1978 Jun;3(2):167-70. doi: 10.1097/00007632-197806000-00013. PMID: 96538

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...