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Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly

MedGen UID:
397690
Concept ID:
C2700007
Neoplastic Process
Synonyms: age-related EBV Positive B-cell lymphoproliferative disorder; EBV Positive diffuse large B-cell lymphoma of the elderly; EBV-Positive Diffuse Large B-Cell Lymphoma; EBV-Positive diffuse large B-cell lymphoma, NOS; EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified; EBV-positive DLBCL of the elderly; EBV-Positive DLBCL, NOS; Epstein-Barr virus positive diffuse large B-cell lymphoma of elderly; Epstein-Barr Virus Positive diffuse large B-cell lymphoma of the elderly; Epstein-Barr Virus Positive DLBCL, NOS; Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified; Senile EBV-associated B-cell lymphoproliferative disorder
SNOMED CT: Epstein-Barr virus positive diffuse large B-cell lymphoma of elderly (716788007); Epstein-Barr virus positive diffuse large B-cell lymphoma of elderly (716789004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0017346
Orphanet: ORPHA289661

Definition

A rare form of diffuse large B-cell lymphoma occurring most commonly in patients over the age of 50 (usually between 70-75 years of age), without overt immunodeficiency, and presenting with nodal and extranodal involvement (in sites such as the stomach, lung, skin and pancreas) and B symptoms (fever, night sweats, weight loss). The tumor is characterized by an aggressive course and a short survival rate. [from SNOMEDCT_US]

Term Hierarchy

Professional guidelines

PubMed

Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2022 Jul;97(7):951-965. Epub 2022 May 3 doi: 10.1002/ajh.26579. PMID: 35472248
Witte HM, Merz H, Biersack H, Bernard V, Riecke A, Gebauer J, Lehnert H, von Bubnoff N, Feller AC, Gebauer N
Br J Haematol 2020 Apr;189(2):257-268. Epub 2020 Jan 20 doi: 10.1111/bjh.16342. PMID: 31958882
Lu CH, Lee KF, Chen CC, Chen YY, Huang CE, Tsai PS, Tsou HY, Chou HJ, Chen MF, Chen PT, Lee KD, Lung J
Jpn J Clin Oncol 2014 Dec;44(12):1164-71. Epub 2014 Oct 15 doi: 10.1093/jjco/hyu155. PMID: 25320341

Recent clinical studies

Etiology

Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2022 Jul;97(7):951-965. Epub 2022 May 3 doi: 10.1002/ajh.26579. PMID: 35472248
Monabati A, Vahedi A, Safaei A, Noori S, Mokhtari M, Vahedi L, Zamani M
Asian Pac J Cancer Prev 2016;17(4):2285-9. doi: 10.7314/apjcp.2016.17.4.2285. PMID: 27221931
Song CG, Huang JJ, Li YJ, Xia Y, Wang Y, Bi XW, Jiang WQ, Huang HQ, Lin TY, Li ZM
PLoS One 2015;10(7):e0133973. Epub 2015 Jul 29 doi: 10.1371/journal.pone.0133973. PMID: 26222726Free PMC Article
Lu TX, Liang JH, Miao Y, Fan L, Wang L, Qu XY, Cao L, Gong QX, Wang Z, Zhang ZH, Xu W, Li JY
Sci Rep 2015 Jul 23;5:12168. doi: 10.1038/srep12168. PMID: 26202875Free PMC Article
Cohen M, Narbaitz M, Metrebian F, De Matteo E, Preciado MV, Chabay PA
Int J Cancer 2014 Dec 15;135(12):2816-24. Epub 2014 May 27 doi: 10.1002/ijc.28942. PMID: 24789501

Diagnosis

Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2022 Jul;97(7):951-965. Epub 2022 May 3 doi: 10.1002/ajh.26579. PMID: 35472248
Song CG, Huang JJ, Li YJ, Xia Y, Wang Y, Bi XW, Jiang WQ, Huang HQ, Lin TY, Li ZM
PLoS One 2015;10(7):e0133973. Epub 2015 Jul 29 doi: 10.1371/journal.pone.0133973. PMID: 26222726Free PMC Article
Lu TX, Liang JH, Miao Y, Fan L, Wang L, Qu XY, Cao L, Gong QX, Wang Z, Zhang ZH, Xu W, Li JY
Sci Rep 2015 Jul 23;5:12168. doi: 10.1038/srep12168. PMID: 26202875Free PMC Article
Adam P, Bonzheim I, Fend F, Quintanilla-Martínez L
Adv Anat Pathol 2011 Sep;18(5):349-55. doi: 10.1097/PAP.0b013e318229bf08. PMID: 21841405
Wong HH, Wang J
Leuk Lymphoma 2009 Mar;50(3):335-40. doi: 10.1080/10428190902725813. PMID: 19255922

Therapy

Medeiros LJ, Marques-Piubelli ML, Sangiorgio VFI, Ruiz-Cordero R, Vega F, Feldman AL, Chapman JR, Clemens MW, Hunt KK, Evans MG, Khoo C, Lade S, Silberman M, Morkowski J, Pina EM, Mills DC, Bates CM, Magno WB, Sohani AR, Sieling BA, O'Donoghue JM, Bacon CM, Patani N, Televantou D, Turner SD, Johnson L, MacNeill F, Wotherspoon AC, Iyer SP, Malpica LE, Patel KP, Xu J, Miranda RN
Mod Pathol 2021 Dec;34(12):2154-2167. Epub 2021 Jul 5 doi: 10.1038/s41379-021-00863-1. PMID: 34226673
Yoon SE, Kim SJ, Yoon DH, Koh Y, Mun YC, Do YR, Choi YS, Yang DH, Kim MK, Lee GW, Suh C, Ko YH, Kim WS
Ann Hematol 2020 Jun;99(6):1283-1291. Epub 2020 Apr 24 doi: 10.1007/s00277-020-04005-6. PMID: 32333154Free PMC Article
Song CG, Huang JJ, Li YJ, Xia Y, Wang Y, Bi XW, Jiang WQ, Huang HQ, Lin TY, Li ZM
PLoS One 2015;10(7):e0133973. Epub 2015 Jul 29 doi: 10.1371/journal.pone.0133973. PMID: 26222726Free PMC Article
Ozsan N, Cagirgan S, Saydam G, Gunes A, Hekimgil M
Pathol Res Pract 2013 Aug;209(8):471-8. Epub 2013 May 9 doi: 10.1016/j.prp.2013.04.014. PMID: 23726928
Lee E, Kim TM, Lim Y, Jeon YK, Go H, Kim CW, Heo DS
J Clin Oncol 2013 Jul 1;31(19):e332-4. Epub 2013 May 28 doi: 10.1200/JCO.2012.44.7375. PMID: 23715578

Prognosis

Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2022 Jul;97(7):951-965. Epub 2022 May 3 doi: 10.1002/ajh.26579. PMID: 35472248
Hong JY, Ko YH, Kim SJ, Kim WS
Curr Opin Oncol 2015 Sep;27(5):392-8. doi: 10.1097/CCO.0000000000000210. PMID: 26258272
Song CG, Huang JJ, Li YJ, Xia Y, Wang Y, Bi XW, Jiang WQ, Huang HQ, Lin TY, Li ZM
PLoS One 2015;10(7):e0133973. Epub 2015 Jul 29 doi: 10.1371/journal.pone.0133973. PMID: 26222726Free PMC Article
Adam P, Bonzheim I, Fend F, Quintanilla-Martínez L
Adv Anat Pathol 2011 Sep;18(5):349-55. doi: 10.1097/PAP.0b013e318229bf08. PMID: 21841405
Castillo JJ, Beltran BE, Miranda RN, Paydas S, Winer ES, Butera JN
Oncologist 2011;16(1):87-96. Epub 2011 Jan 6 doi: 10.1634/theoncologist.2010-0213. PMID: 21212426Free PMC Article

Clinical prediction guides

Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2022 Jul;97(7):951-965. Epub 2022 May 3 doi: 10.1002/ajh.26579. PMID: 35472248
Lu TX, Liang JH, Miao Y, Fan L, Wang L, Qu XY, Cao L, Gong QX, Wang Z, Zhang ZH, Xu W, Li JY
Sci Rep 2015 Jul 23;5:12168. doi: 10.1038/srep12168. PMID: 26202875Free PMC Article
Cohen M, Narbaitz M, Metrebian F, De Matteo E, Preciado MV, Chabay PA
Int J Cancer 2014 Dec 15;135(12):2816-24. Epub 2014 May 27 doi: 10.1002/ijc.28942. PMID: 24789501
Ozsan N, Cagirgan S, Saydam G, Gunes A, Hekimgil M
Pathol Res Pract 2013 Aug;209(8):471-8. Epub 2013 May 9 doi: 10.1016/j.prp.2013.04.014. PMID: 23726928
Castillo JJ, Beltran BE, Miranda RN, Paydas S, Winer ES, Butera JN
Oncologist 2011;16(1):87-96. Epub 2011 Jan 6 doi: 10.1634/theoncologist.2010-0213. PMID: 21212426Free PMC Article

Recent systematic reviews

Barzyk GA, Sheriff V
Anticancer Res 2020 Nov;40(11):5951-5968. doi: 10.21873/anticanres.14616. PMID: 33109533

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