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Chondroblastoma

MedGen UID:
40270
•Concept ID:
C0008441
•
Neoplastic Process
Synonym: Chondroblastoma (disease)
SNOMED CT: Chondroblastoma morphology (9001003); Chondroblastoma (9001003); Chondromatous giant cell tumor (9001003); Codman's tumor (9001003)
 
HPO: HP:0030432
Monarch Initiative: MONDO:0004997

Definition

A usually benign tumor composed of cells which arise from chondroblasts or their precursors and which tend to differentiate into cartilage cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChondroblastoma

Professional guidelines

PubMed

Clear cell chondrosarcoma: a review of clinicopathologic characteristics, differential diagnoses, and patient management.
Alexiev BA, Vormittag-Nocito ER, Peabody TD, Samet J, Laskin WB
Hum Pathol 2023 Sep;139:126-134. Epub 2023 Jun 16 doi: 10.1016/j.humpath.2023.06.004. PMID: 37805864
Management of Primary Aggressive Tumors of the Knee.
Martin JR, Auran RL, Duran MD, de Comas AM, Jacofsky DJ
J Knee Surg 2022 May;35(6):585-596. Epub 2022 Feb 18 doi: 10.1055/s-0042-1743221. PMID: 35181876
The diagnosis and treatment of tibial intercondylar chondroblastoma.
Yang Z, Tao H, Ye Z, Huang X, Lin N, Yang M
Clinics (Sao Paulo) 2018 Nov 29;73:e540. doi: 10.6061/clinics/2018/e540. PMID: 30517285Free PMC Article

Recent clinical studies

Etiology

Chondroblastoma in adult age.
Angelini A, Hassani M, Mavrogenis AF, Trovarelli G, Romagnoli C, Berizzi A, Ruggieri P
Eur J Orthop Surg Traumatol 2017 Aug;27(6):843-849. Epub 2017 Jun 20 doi: 10.1007/s00590-017-1996-7. PMID: 28634924
Cartilage-forming tumors.
Qasem SA, DeYoung BR
Semin Diagn Pathol 2014 Jan;31(1):10-20. Epub 2014 Jan 23 doi: 10.1053/j.semdp.2014.01.006. PMID: 24680178
Chondroblastoma of the triquetrum.
Wu CT, Chen AC, Wang CJ, Wang CW, Fu CJ, Wong YC
Pediatr Neonatol 2013 Aug;54(4):278-80. Epub 2013 Jan 16 doi: 10.1016/j.pedneo.2012.11.017. PMID: 23597548
Vertebral chondroblastoma.
Ilaslan H, Sundaram M, Unni KK
Skeletal Radiol 2003 Feb;32(2):66-71. Epub 2002 Nov 21 doi: 10.1007/s00256-002-0599-4. PMID: 12589483
Primary patellar tumors.
Ferguson PC, Griffin AM, Bell RS
Clin Orthop Relat Res 1997 Mar;(336):199-204. doi: 10.1097/00003086-199703000-00028. PMID: 9060506

Diagnosis

Benign Cartilage-forming Tumors.
Kerr DA, Cipriani NA
Surg Pathol Clin 2021 Dec;14(4):585-603. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.004. PMID: 34742482
Calcaneal Bone Tumors.
Temple EW, Prusa RD
Clin Podiatr Med Surg 2021 Apr;38(2):227-233. Epub 2021 Jan 26 doi: 10.1016/j.cpm.2020.12.007. PMID: 33745653
Chondroblastoma-like Osteosarcoma.
Hmada YA, Bernieh A, Morris RW, Lewin J, Allen T
Arch Pathol Lab Med 2020 Jan;144(1):15-17. Epub 2019 Aug 7 doi: 10.5858/arpa.2019-0191-RA. PMID: 31389716
Chondroblastoma: An Update.
Chen W, DiFrancesco LM
Arch Pathol Lab Med 2017 Jun;141(6):867-871. doi: 10.5858/arpa.2016-0281-RS. PMID: 28557595
Cartilage-forming tumors.
Qasem SA, DeYoung BR
Semin Diagn Pathol 2014 Jan;31(1):10-20. Epub 2014 Jan 23 doi: 10.1053/j.semdp.2014.01.006. PMID: 24680178

Therapy

Efficacy of denosumab treatment for lung metastasis secondary to proximal humerus chondroblastoma.
Samargandi R, Bernard M, Miquelestorena-Standley E, Nail LRL
Saudi Med J 2024 Jun;45(6):633-638. doi: 10.15537/smj.2024.45.6.20230720. PMID: 38830665Free PMC Article
The effect of adjuvant cryotherapy added to well-performed high-speed burr curettage on the long-term surgical outcomes of chondroblastoma cases.
Yurtbay A, Coşkun HS, Çinka H, Erdoğan F, Büyükceran İ, Dabak N
Jt Dis Relat Surg 2023 Apr 26;34(2):338-345. doi: 10.52312/jdrs.2023.936. PMID: 37462637Free PMC Article
Chondroblastoma Expresses RANKL by RNA In Situ Hybridization and May Respond to Denosumab Therapy.
Suster DI, Kurzawa P, Neyaz A, Jarzembowski JA, Lozano-Calderon S, Raskin K, Schwab J, Choy E, Chebib I, Deshpande V
Am J Surg Pathol 2020 Dec;44(12):1581-1590. doi: 10.1097/PAS.0000000000001568. PMID: 32826531
Chondroblastoma in adult age.
Angelini A, Hassani M, Mavrogenis AF, Trovarelli G, Romagnoli C, Berizzi A, Ruggieri P
Eur J Orthop Surg Traumatol 2017 Aug;27(6):843-849. Epub 2017 Jun 20 doi: 10.1007/s00590-017-1996-7. PMID: 28634924
Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group.
Tallini G, Dorfman H, Brys P, Dal Cin P, De Wever I, Fletcher CD, Jonson K, Mandahl N, Mertens F, Mitelman F, Rosai J, Rydholm A, Samson I, Sciot R, Van den Berghe H, Vanni R, Willén H
J Pathol 2002 Feb;196(2):194-203. doi: 10.1002/path.1023. PMID: 11793371

Prognosis

Chondroblastoma-like Osteosarcoma.
Hmada YA, Bernieh A, Morris RW, Lewin J, Allen T
Arch Pathol Lab Med 2020 Jan;144(1):15-17. Epub 2019 Aug 7 doi: 10.5858/arpa.2019-0191-RA. PMID: 31389716
Common Tumors and Tumor-like Lesions of the Shoulder.
Lee DH, Hills JM, Jordanov MI, Jaffe KA
J Am Acad Orthop Surg 2019 Apr 1;27(7):236-245. doi: 10.5435/JAAOS-D-17-00449. PMID: 30320728
Chondroblastoma of the triquetrum.
Wu CT, Chen AC, Wang CJ, Wang CW, Fu CJ, Wong YC
Pediatr Neonatol 2013 Aug;54(4):278-80. Epub 2013 Jan 16 doi: 10.1016/j.pedneo.2012.11.017. PMID: 23597548
Benign bone tumors--recent developments.
Garcia RA, Inwards CY, Unni KK
Semin Diagn Pathol 2011 Feb;28(1):73-85. doi: 10.1053/j.semdp.2011.02.013. PMID: 21675379
Vertebral chondroblastoma.
Ilaslan H, Sundaram M, Unni KK
Skeletal Radiol 2003 Feb;32(2):66-71. Epub 2002 Nov 21 doi: 10.1007/s00256-002-0599-4. PMID: 12589483

Clinical prediction guides

Analysis for clinical feature and outcome of chondroblastoma after surgical treatment: A single center experience of 92 cases.
Wang J, Du Z, Yang R, Tang X, Yan T, Guo W
J Orthop Sci 2022 Jan;27(1):235-241. Epub 2021 Jan 5 doi: 10.1016/j.jos.2020.12.009. PMID: 33419623
Benign Cartilage-forming Tumors.
Kerr DA, Cipriani NA
Surg Pathol Clin 2021 Dec;14(4):585-603. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.004. PMID: 34742482
Differential Diagnosis of Cartilaginous Lesions of Bone.
Suster D, Hung YP, Nielsen GP
Arch Pathol Lab Med 2020 Jan;144(1):71-82. doi: 10.5858/arpa.2019-0441-RA. PMID: 31877083
Chondroblastoma.
Garin IE, Wang EH
J Orthop Surg (Hong Kong) 2008 Apr;16(1):84-7. doi: 10.1177/230949900801600119. PMID: 18453666
Malignant and benign bone tumors.
Miller SL, Hoffer FA
Radiol Clin North Am 2001 Jul;39(4):673-99. doi: 10.1016/s0033-8389(05)70305-5. PMID: 11549165

Recent systematic reviews

Functional Prognosis Following Temporal Bone Chondroblastoma Resection: A Systematic Review and Case Illustration.
Miyagawa K, Enomoto T, Morishita T, Aoki M, Nonaka M, Abe H, Nabeshima K, Inoue T
World Neurosurg 2022 Feb;158:e287-e297. Epub 2021 Nov 1 doi: 10.1016/j.wneu.2021.10.174. PMID: 34737097
Surgical treatment of benign osteolytic lesions in the femoral head and neck: a systematic review.
Shi J, Zhao Z, Yan T, Guo W, Yang R, Tang X, Qu H, Dong S
BMC Musculoskelet Disord 2021 Jun 16;22(1):549. doi: 10.1186/s12891-021-04442-y. PMID: 34134687Free PMC Article
Temporal Bone Chondroblastoma: Systematic Review of Clinical Features and Outcomes.
Omar AT 2nd, Arbizo JL, Ong KMC, Olivar CMG, Rivera JP, Chiong CM, Cabungcal ACA, Khu KJO
World Neurosurg 2020 Oct;142:e260-e270. Epub 2020 Jun 27 doi: 10.1016/j.wneu.2020.06.192. PMID: 32603862

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