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Chondroblastoma

MedGen UID:
40270
•Concept ID:
C0008441
•
Neoplastic Process
Synonym: Chondroblastoma (disease)
SNOMED CT: Chondroblastoma morphology (9001003); Chondroblastoma (9001003); Chondromatous giant cell tumor (9001003); Codman's tumor (9001003)
 
HPO: HP:0030432
Monarch Initiative: MONDO:0004997

Definition

A usually benign tumor composed of cells which arise from chondroblasts or their precursors and which tend to differentiate into cartilage cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChondroblastoma

Professional guidelines

PubMed

Clear cell chondrosarcoma: a review of clinicopathologic characteristics, differential diagnoses, and patient management.
Alexiev BA, Vormittag-Nocito ER, Peabody TD, Samet J, Laskin WB
Hum Pathol 2023 Sep;139:126-134. Epub 2023 Jun 16 doi: 10.1016/j.humpath.2023.06.004. PMID: 37805864
Management of Primary Aggressive Tumors of the Knee.
Martin JR, Auran RL, Duran MD, de Comas AM, Jacofsky DJ
J Knee Surg 2022 May;35(6):585-596. Epub 2022 Feb 18 doi: 10.1055/s-0042-1743221. PMID: 35181876
The diagnosis and treatment of tibial intercondylar chondroblastoma.
Yang Z, Tao H, Ye Z, Huang X, Lin N, Yang M
Clinics (Sao Paulo) 2018 Nov 29;73:e540. doi: 10.6061/clinics/2018/e540. PMID: 30517285Free PMC Article

Recent clinical studies

Etiology

Analysis for clinical feature and outcome of chondroblastoma after surgical treatment: A single center experience of 92 cases.
Wang J, Du Z, Yang R, Tang X, Yan T, Guo W
J Orthop Sci 2022 Jan;27(1):235-241. Epub 2021 Jan 5 doi: 10.1016/j.jos.2020.12.009. PMID: 33419623
Pediatric Chondroblastoma and the Need for Lung Staging at Presentation.
Arkader A, Williams A, Binitie O, Thacker MM, Farfalli GL
J Pediatr Orthop 2020 Oct;40(9):e894-e897. doi: 10.1097/BPO.0000000000001631. PMID: 32658156
Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update.
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article
Cartilage-forming tumors.
Qasem SA, DeYoung BR
Semin Diagn Pathol 2014 Jan;31(1):10-20. Epub 2014 Jan 23 doi: 10.1053/j.semdp.2014.01.006. PMID: 24680178
Vertebral chondroblastoma.
Ilaslan H, Sundaram M, Unni KK
Skeletal Radiol 2003 Feb;32(2):66-71. Epub 2002 Nov 21 doi: 10.1007/s00256-002-0599-4. PMID: 12589483

Diagnosis

Benign Cartilage-forming Tumors.
Kerr DA, Cipriani NA
Surg Pathol Clin 2021 Dec;14(4):585-603. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.004. PMID: 34742482
Chondroblastoma-like Osteosarcoma.
Hmada YA, Bernieh A, Morris RW, Lewin J, Allen T
Arch Pathol Lab Med 2020 Jan;144(1):15-17. Epub 2019 Aug 7 doi: 10.5858/arpa.2019-0191-RA. PMID: 31389716
Chondroblastoma: An Update.
Chen W, DiFrancesco LM
Arch Pathol Lab Med 2017 Jun;141(6):867-871. doi: 10.5858/arpa.2016-0281-RS. PMID: 28557595
Benign bone tumors.
Steffner R
Cancer Treat Res 2014;162:31-63. doi: 10.1007/978-3-319-07323-1_3. PMID: 25070230
Vertebral chondroblastoma.
Ilaslan H, Sundaram M, Unni KK
Skeletal Radiol 2003 Feb;32(2):66-71. Epub 2002 Nov 21 doi: 10.1007/s00256-002-0599-4. PMID: 12589483

Therapy

Chondroblastoma Expresses RANKL by RNA In Situ Hybridization and May Respond to Denosumab Therapy.
Suster DI, Kurzawa P, Neyaz A, Jarzembowski JA, Lozano-Calderon S, Raskin K, Schwab J, Choy E, Chebib I, Deshpande V
Am J Surg Pathol 2020 Dec;44(12):1581-1590. doi: 10.1097/PAS.0000000000001568. PMID: 32826531
Chondroblastoma: An evaluation of the recurrences and functional outcomes following treatment.
Özer D, Arıkan Y, Gür V, Gök C, Akman YE
Acta Orthop Traumatol Turc 2018 Nov;52(6):415-418. Epub 2018 Sep 22 doi: 10.1016/j.aott.2018.07.004. PMID: 30249436Free PMC Article
Chondroblastoma in adult age.
Angelini A, Hassani M, Mavrogenis AF, Trovarelli G, Romagnoli C, Berizzi A, Ruggieri P
Eur J Orthop Surg Traumatol 2017 Aug;27(6):843-849. Epub 2017 Jun 20 doi: 10.1007/s00590-017-1996-7. PMID: 28634924
Proximal Tibia Chondroblastoma Treated With Curettage and Bone Graft and Cement Use.
Cho HS, Park YK, Oh JH, Lee JH, Han I, Kim HS
Orthopedics 2016 Jan-Feb;39(1):e80-5. Epub 2015 Dec 30 doi: 10.3928/01477447-20151222-04. PMID: 26726978
Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group.
Tallini G, Dorfman H, Brys P, Dal Cin P, De Wever I, Fletcher CD, Jonson K, Mandahl N, Mertens F, Mitelman F, Rosai J, Rydholm A, Samson I, Sciot R, Van den Berghe H, Vanni R, Willén H
J Pathol 2002 Feb;196(2):194-203. doi: 10.1002/path.1023. PMID: 11793371

Prognosis

Chondroblastoma-like Osteosarcoma.
Hmada YA, Bernieh A, Morris RW, Lewin J, Allen T
Arch Pathol Lab Med 2020 Jan;144(1):15-17. Epub 2019 Aug 7 doi: 10.5858/arpa.2019-0191-RA. PMID: 31389716
Common Tumors and Tumor-like Lesions of the Shoulder.
Lee DH, Hills JM, Jordanov MI, Jaffe KA
J Am Acad Orthop Surg 2019 Apr 1;27(7):236-245. doi: 10.5435/JAAOS-D-17-00449. PMID: 30320728
Tumors of the Epiphyses.
Grimm NL, Tainter DM, Eward WC, Brigman BE
JBJS Rev 2017 May;5(5):e4. doi: 10.2106/JBJS.RVW.16.00080. PMID: 28538290
Benign bone tumors--recent developments.
Garcia RA, Inwards CY, Unni KK
Semin Diagn Pathol 2011 Feb;28(1):73-85. doi: 10.1053/j.semdp.2011.02.013. PMID: 21675379
Vertebral chondroblastoma.
Ilaslan H, Sundaram M, Unni KK
Skeletal Radiol 2003 Feb;32(2):66-71. Epub 2002 Nov 21 doi: 10.1007/s00256-002-0599-4. PMID: 12589483

Clinical prediction guides

Analysis of Clinical Manifestations and Prognostic Factors Affecting Osteosarcoma.
Wei J, Liang Z, Xu G
Dis Markers 2022;2022:1599112. Epub 2022 Aug 4 doi: 10.1155/2022/1599112. PMID: 35968499Free PMC Article
Analysis for clinical feature and outcome of chondroblastoma after surgical treatment: A single center experience of 92 cases.
Wang J, Du Z, Yang R, Tang X, Yan T, Guo W
J Orthop Sci 2022 Jan;27(1):235-241. Epub 2021 Jan 5 doi: 10.1016/j.jos.2020.12.009. PMID: 33419623
Benign Cartilage-forming Tumors.
Kerr DA, Cipriani NA
Surg Pathol Clin 2021 Dec;14(4):585-603. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.004. PMID: 34742482
Differential Diagnosis of Cartilaginous Lesions of Bone.
Suster D, Hung YP, Nielsen GP
Arch Pathol Lab Med 2020 Jan;144(1):71-82. doi: 10.5858/arpa.2019-0441-RA. PMID: 31877083
Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update.
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article

Recent systematic reviews

Functional Prognosis Following Temporal Bone Chondroblastoma Resection: A Systematic Review and Case Illustration.
Miyagawa K, Enomoto T, Morishita T, Aoki M, Nonaka M, Abe H, Nabeshima K, Inoue T
World Neurosurg 2022 Feb;158:e287-e297. Epub 2021 Nov 1 doi: 10.1016/j.wneu.2021.10.174. PMID: 34737097
Surgical treatment of benign osteolytic lesions in the femoral head and neck: a systematic review.
Shi J, Zhao Z, Yan T, Guo W, Yang R, Tang X, Qu H, Dong S
BMC Musculoskelet Disord 2021 Jun 16;22(1):549. doi: 10.1186/s12891-021-04442-y. PMID: 34134687Free PMC Article
Temporal Bone Chondroblastoma: Systematic Review of Clinical Features and Outcomes.
Omar AT 2nd, Arbizo JL, Ong KMC, Olivar CMG, Rivera JP, Chiong CM, Cabungcal ACA, Khu KJO
World Neurosurg 2020 Oct;142:e260-e270. Epub 2020 Jun 27 doi: 10.1016/j.wneu.2020.06.192. PMID: 32603862

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