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Benign chondrogenic neoplasm

MedGen UID:
208867
•Concept ID:
C0852519
•
Neoplastic Process
Synonyms: Benign Cartilaginous Neoplasm; benign cartilaginous neoplasm; Benign Cartilaginous Tumor; benign cartilaginous tumor; benign cartilaginous tumour; Benign Chondrogenic Neoplasm; benign chondrogenic neoplasm; Benign chondrogenic neoplasm of bone and articular cartilage; Benign Chondrogenic Tumor; benign chondrogenic tumor; benign chondrogenic tumour; Benign Neoplasm of Cartilage; benign neoplasm of cartilage; Benign Neoplasm of the Cartilage; benign neoplasm of the cartilage; Benign Tumor of Cartilage; benign tumor of cartilage; Benign Tumor of the Cartilage; benign tumor of the cartilage; benign tumour of cartilage; benign tumour of the cartilage; chondrogenic neoplasm, benign
SNOMED CT: Benign chondrogenic neoplasm (722690001); Benign chondrogenic neoplasm of bone and articular cartilage (722690001)
 
Monarch Initiative: MONDO:0024470

Definition

A cartilaginous matrix-producing neoplasm characterized by the presence of neoplastic chondrocytes. There is no evidence of atypical or malignant cytological and architectural features, invasive features, or metastases. Representative examples include osteochondroma and chondroma. [from NCI]

Professional guidelines

PubMed

Outcome of conservative and surgical treatment of enchondromas and atypical cartilaginous tumors of the long bones: retrospective analysis of 228 patients.
Omlor GW, Lohnherr V, Lange J, Gantz S, Mechtersheimer G, Merle C, Raiss P, Fellenberg J, Lehner B
BMC Musculoskelet Disord 2019 Mar 28;20(1):134. doi: 10.1186/s12891-019-2502-7. PMID: 30922289Free PMC Article
The biology and management of cartilaginous tumors: a role for targeting isocitrate dehydrogenase.
Tinoco G, Wilky BA, Paz-Mejia A, Rosenberg A, Trent JC
Am Soc Clin Oncol Educ Book 2015:e648-55. doi: 10.14694/EdBook_AM.2015.35.e648. PMID: 25993236

Recent clinical studies

Therapy

Chondroblastoma's Lung Metastases Treated with Denosumab in Pediatric Patient.
Focaccia M, Gambarotti M, Hakim R, Paioli A, Cesari M, Spazzoli B, Spinnato P, Donati D, Rocca M, Longhi A
Cancer Res Treat 2021 Jan;53(1):279-282. Epub 2020 Aug 6 doi: 10.4143/crt.2020.384. PMID: 32777878Free PMC Article
Outcome of conservative and surgical treatment of enchondromas and atypical cartilaginous tumors of the long bones: retrospective analysis of 228 patients.
Omlor GW, Lohnherr V, Lange J, Gantz S, Mechtersheimer G, Merle C, Raiss P, Fellenberg J, Lehner B
BMC Musculoskelet Disord 2019 Mar 28;20(1):134. doi: 10.1186/s12891-019-2502-7. PMID: 30922289Free PMC Article
The biology and management of cartilaginous tumors: a role for targeting isocitrate dehydrogenase.
Tinoco G, Wilky BA, Paz-Mejia A, Rosenberg A, Trent JC
Am Soc Clin Oncol Educ Book 2015:e648-55. doi: 10.14694/EdBook_AM.2015.35.e648. PMID: 25993236
Both a visual and a semiquantitative analysis for differentiating benign from malignant chondrogenic bone tumors using Tc-99m (V) DMSA scintigraphy: a prospective study.
Shinya T, Sato S, Kunisada T, Inai R, Yanai H, Ozaki T, Kanazawa S
Nucl Med Commun 2015 Aug;36(8):802-7. doi: 10.1097/MNM.0000000000000328. PMID: 25932541
Type X collagen expression and hypertrophic differentiation in chondrogenic neoplasias.
Aigner T, Frischholz S, Dertinger S, Beier F, Girkontaité I, von der Mark K
Histochem Cell Biol 1997 Jun;107(6):435-40. doi: 10.1007/s004180050130. PMID: 9243276

Prognosis

Chondroblastoma's Lung Metastases Treated with Denosumab in Pediatric Patient.
Focaccia M, Gambarotti M, Hakim R, Paioli A, Cesari M, Spazzoli B, Spinnato P, Donati D, Rocca M, Longhi A
Cancer Res Treat 2021 Jan;53(1):279-282. Epub 2020 Aug 6 doi: 10.4143/crt.2020.384. PMID: 32777878Free PMC Article
Metabolic profiling of serum in patients with cartilage tumours using (1) H-NMR spectroscopy: A pilot study.
López-Garrido L, Bañuelos-Hernández AE, Pérez-Hernández E, Tecualt-Gómez R, Quiroz-Williams J, Ariza-Castolo A, Becerra-Martínez E, Pérez-Hernández N
Magn Reson Chem 2020 Jan;58(1):65-76. Epub 2019 Jul 19 doi: 10.1002/mrc.4925. PMID: 31323132
Intracranial dural based chondroma.
Reinshagen C, Redjal N, Sajed DP, Nahed BV, Walcott BP
J Clin Neurosci 2016 Mar;25:161-3. Epub 2015 Oct 24 doi: 10.1016/j.jocn.2015.05.052. PMID: 26602798
Both a visual and a semiquantitative analysis for differentiating benign from malignant chondrogenic bone tumors using Tc-99m (V) DMSA scintigraphy: a prospective study.
Shinya T, Sato S, Kunisada T, Inai R, Yanai H, Ozaki T, Kanazawa S
Nucl Med Commun 2015 Aug;36(8):802-7. doi: 10.1097/MNM.0000000000000328. PMID: 25932541
Differentiation and proliferative activity in benign and malignant cartilage tumors of bone.
Hasegawa T, Seki K, Yang P, Hirose T, Hizawa K, Wada T, Wakabayashi J
Hum Pathol 1995 Aug;26(8):838-45. doi: 10.1016/0046-8177(95)90004-7. PMID: 7543439

Clinical prediction guides

Fusion of the Genes for Interferon Regulatory Factor 2 Binding Protein 2 (IRF2BP2) and Caudal Type Homeobox 1 (CDX1) in a Chondrogenic Tumor.
Panagopoulos I, Gorunova L, Lobmaier I, Heim S
In Vivo 2023 Nov-Dec;37(6):2459-2463. doi: 10.21873/invivo.13352. PMID: 37905608Free PMC Article
Outcome of conservative and surgical treatment of enchondromas and atypical cartilaginous tumors of the long bones: retrospective analysis of 228 patients.
Omlor GW, Lohnherr V, Lange J, Gantz S, Mechtersheimer G, Merle C, Raiss P, Fellenberg J, Lehner B
BMC Musculoskelet Disord 2019 Mar 28;20(1):134. doi: 10.1186/s12891-019-2502-7. PMID: 30922289Free PMC Article
Both a visual and a semiquantitative analysis for differentiating benign from malignant chondrogenic bone tumors using Tc-99m (V) DMSA scintigraphy: a prospective study.
Shinya T, Sato S, Kunisada T, Inai R, Yanai H, Ozaki T, Kanazawa S
Nucl Med Commun 2015 Aug;36(8):802-7. doi: 10.1097/MNM.0000000000000328. PMID: 25932541
Non-squamous cell neoplasms of the larynx: radiologic-pathologic correlation.
Becker M, Moulin G, Kurt AM, Dulgerov P, Vukanovic S, Zbären P, Marchal F, Rüfenacht DA, Terrier F
Radiographics 1998 Sep-Oct;18(5):1189-209. doi: 10.1148/radiographics.18.5.9747615. PMID: 9747615
Differentiation and proliferative activity in benign and malignant cartilage tumors of bone.
Hasegawa T, Seki K, Yang P, Hirose T, Hizawa K, Wada T, Wakabayashi J
Hum Pathol 1995 Aug;26(8):838-45. doi: 10.1016/0046-8177(95)90004-7. PMID: 7543439

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