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Fibroblastic Reticular Cell Tumor

MedGen UID:
415157
•Concept ID:
C2825739
•
Neoplastic Process
Synonyms: Fibroblastic reticular cell neoplasm; Fibroblastic reticular cell tumor
SNOMED CT: Fibroblastic reticular cell tumor (450912008); Fibroblastic reticular cell neoplasm (721314003); Fibroblastic reticular cell tumor (721314003)

Definition

A very rare dendritic cell tumor affecting the lymph nodes, spleen, and soft tissues. Morphologically it is similar to the interdigitating dendritic cell sarcoma or follicular dendritic cell sarcoma. The tumor cells are positive for cytokeratin and CD68. Clinical outcome is variable. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFibroblastic Reticular Cell Tumor

Professional guidelines

PubMed

Structural Vulnerabilities in DLBCL for Enhanced Treatment Strategies.
Cristaldi V, Lund AW
Cancer Res 2023 Aug 15;83(16):2643-2644. doi: 10.1158/0008-5472.CAN-23-1956. PMID: 37404051
B cell/stromal cell crosstalk in health, disease, and treatment: Follicular lymphoma as a paradigm.
Lamaison C, Tarte K
Immunol Rev 2021 Jul;302(1):273-285. Epub 2021 May 31 doi: 10.1111/imr.12983. PMID: 34060097
Dendritic cell and histiocytic neoplasms: biology, diagnosis, and treatment.
Dalia S, Shao H, Sagatys E, Cualing H, Sokol L
Cancer Control 2014 Oct;21(4):290-300. doi: 10.1177/107327481402100405. PMID: 25310210

Recent clinical studies

Etiology

Spinal Cord Compression Caused by Fibroblastic Reticular Cell Tumor (FRCT) Originating from Thoracic Spine.
Baig Mirza A, Visagan R, Reisz Z, Bodi I, Bell D, Grahovac G
World Neurosurg 2020 Sep;141:20-24. Epub 2020 Jun 1 doi: 10.1016/j.wneu.2020.05.190. PMID: 32497850

Diagnosis

Fibroblastic reticular cell tumor of eyelid: Rare case report and review of literature.
Mishra PP, Madan K, Biswas S, Kini Rao AC
Indian J Pathol Microbiol 2024 Jan-Mar;67(1):166-168. doi: 10.4103/ijpm.ijpm_908_21. PMID: 38358212
Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series.
Saygin C, Uzunaslan D, Ozguroglu M, Senocak M, Tuzuner N
Crit Rev Oncol Hematol 2013 Nov;88(2):253-71. Epub 2013 Jun 5 doi: 10.1016/j.critrevonc.2013.05.006. PMID: 23755890
Fibroblastic reticular cell tumor of the spleen: report of a case and review of the entity.
Martel M, Sarli D, Colecchia M, Coppa J, Romito R, Schiavo M, Mazzaferro V, Rosai J
Hum Pathol 2003 Sep;34(9):954-7. doi: 10.1016/s0046-8177(03)00399-x. PMID: 14562295

Prognosis

Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series.
Saygin C, Uzunaslan D, Ozguroglu M, Senocak M, Tuzuner N
Crit Rev Oncol Hematol 2013 Nov;88(2):253-71. Epub 2013 Jun 5 doi: 10.1016/j.critrevonc.2013.05.006. PMID: 23755890

Clinical prediction guides

Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series.
Saygin C, Uzunaslan D, Ozguroglu M, Senocak M, Tuzuner N
Crit Rev Oncol Hematol 2013 Nov;88(2):253-71. Epub 2013 Jun 5 doi: 10.1016/j.critrevonc.2013.05.006. PMID: 23755890

Recent systematic reviews

Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series.
Saygin C, Uzunaslan D, Ozguroglu M, Senocak M, Tuzuner N
Crit Rev Oncol Hematol 2013 Nov;88(2):253-71. Epub 2013 Jun 5 doi: 10.1016/j.critrevonc.2013.05.006. PMID: 23755890

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