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Erythroplakia

MedGen UID:: 41862
•Concept ID:: C0014818
•: Disease or Syndrome

Synonyms:	Erythroplasia; Erythroplasias
SNOMED CT:	Erythroplakia (71379006); Erythroplasia (71379006)

Monarch Initiative:	MONDO:0023089

Definition

A clinical term that refers to the presence of a red flat and well defined lesion on the oral mucosa that is not caused by trauma, vascular, or inflammatory processes. It is a precancerous condition and is seen more commonly in middle aged or older males. It is associated with tobacco and alcohol consumption. Microscopic examination reveals severe epithelial dysplasia, carcinoma in situ, or invasive squamous cell carcinoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVErythroplakia

Pathological process
- Disease
  - Disorder by Site
    - Head and Neck Disorder
      - Head and Neck Precancerous Condition
        Oral Cavity and Lip Precancerous Condition
        Erythroplakia

Professional guidelines

PubMed

Treatment of Oral Dysplasia.

Clarkson E, Hadioonzadeh R, Peters SM
Dent Clin North Am 2024 Jan;68(1):133-149. Epub 2023 Aug 23 doi: 10.1016/j.cden.2023.07.008. PMID: 37951630

Management of oral potentially malignant disorders.

Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758

Oral potentially malignant disorders: A comprehensive review on clinical aspects and management.

Warnakulasuriya S
Oral Oncol 2020 Mar;102:104550. Epub 2020 Jan 22 doi: 10.1016/j.oraloncology.2019.104550. PMID: 31981993

See all (21)

Recent clinical studies

Etiology

Management of oral potentially malignant disorders.

Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758

Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer.

Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, Sloan P, Johnson NW
Oral Dis 2021 Nov;27(8):1862-1880. Epub 2020 Nov 26 doi: 10.1111/odi.13704. PMID: 33128420

Oral Potentially Malignant Disorders.

Wetzel SL, Wollenberg J
Dent Clin North Am 2020 Jan;64(1):25-37. doi: 10.1016/j.cden.2019.08.004. PMID: 31735231

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944

Oral potentially malignant disorders: risk of progression to malignancy.

Speight PM, Khurram SA, Kujan O
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):612-627. Epub 2017 Dec 29 doi: 10.1016/j.oooo.2017.12.011. PMID: 29396319

See all (152)

Diagnosis

Management of oral potentially malignant disorders.

Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758

Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer.

Oral Potentially Malignant Disorders.

Wetzel SL, Wollenberg J
Dent Clin North Am 2020 Jan;64(1):25-37. doi: 10.1016/j.cden.2019.08.004. PMID: 31735231

Clinical features and presentation of oral potentially malignant disorders.

Warnakulasuriya S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):582-590. Epub 2018 Apr 4 doi: 10.1016/j.oooo.2018.03.011. PMID: 29673799

Diseases of the tongue.

Mangold AR, Torgerson RR, Rogers RS 3rd
Clin Dermatol 2016 Jul-Aug;34(4):458-69. Epub 2016 Mar 8 doi: 10.1016/j.clindermatol.2016.02.018. PMID: 27343960

See all (141)

Therapy

Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder.

Lorenzo-Pouso AI, Lafuente-Ibáñez de Mendoza I, Pérez-Sayáns M, Pérez-Jardón A, Chamorro-Petronacci CM, Blanco-Carrión A, Aguirre-Urízar JM
J Oral Pathol Med 2022 Aug;51(7):585-593. Epub 2022 May 12 doi: 10.1111/jop.13304. PMID: 35488780 Free PMC Article

Oral health consequences of smokeless tobacco use.

Muthukrishnan A, Warnakulasuriya S
Indian J Med Res 2018 Jul;148(1):35-40. doi: 10.4103/ijmr.IJMR_1793_17. PMID: 30264752 Free PMC Article

Clinical features and presentation of oral potentially malignant disorders.

Warnakulasuriya S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):582-590. Epub 2018 Apr 4 doi: 10.1016/j.oooo.2018.03.011. PMID: 29673799

Oral potentially malignant disorders: risk of progression to malignancy.

Speight PM, Khurram SA, Kujan O
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):612-627. Epub 2017 Dec 29 doi: 10.1016/j.oooo.2017.12.011. PMID: 29396319

Oral cancer and oral erythroplakia: an update and implication for clinicians.

Villa A, Villa C, Abati S
Aust Dent J 2011 Sep;56(3):253-6. Epub 2011 Jul 10 doi: 10.1111/j.1834-7819.2011.01337.x. PMID: 21884139

See all (81)

Prognosis

Management of oral potentially malignant disorders.

Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758

Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.

Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325

Clinical features and presentation of oral potentially malignant disorders.

Warnakulasuriya S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):582-590. Epub 2018 Apr 4 doi: 10.1016/j.oooo.2018.03.011. PMID: 29673799

Oral erythroplakia-What is it?

Holmstrup P
Oral Dis 2018 Mar;24(1-2):138-143. doi: 10.1111/odi.12709. PMID: 29480616

Oral potentially malignant disorders: risk of progression to malignancy.

Speight PM, Khurram SA, Kujan O
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):612-627. Epub 2017 Dec 29 doi: 10.1016/j.oooo.2017.12.011. PMID: 29396319

See all (83)

Clinical prediction guides

Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder.

Common Oral Lesions.

Randall DA, Wilson Westmark NL, Neville BW
Am Fam Physician 2022 Apr 1;105(4):369-376. PMID: 35426641

Management of oral potentially malignant disorders.

Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758

Diabetes mellitus and oral cancer/oral potentially malignant disorders: A systematic review and meta-analysis.

Ramos-Garcia P, Roca-Rodriguez MDM, Aguilar-Diosdado M, Gonzalez-Moles MA
Oral Dis 2021 Apr;27(3):404-421. Epub 2020 Feb 18 doi: 10.1111/odi.13289. PMID: 31994293

Oral potentially malignant disorders: risk of progression to malignancy.

Speight PM, Khurram SA, Kujan O
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):612-627. Epub 2017 Dec 29 doi: 10.1016/j.oooo.2017.12.011. PMID: 29396319

See all (82)

Recent systematic reviews

Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder.

Oral leukoplakia and erythroplakia in young patients: a systematic review.

Roza ALOC, Kowalski LP, William WN Jr, de Castro G Jr, Chaves ALF, Araújo ALD, Ribeiro ACP, Brandão TB, Lopes MA, Vargas PA, Santos-Silva AR; Latin American Cooperative Oncology Group–Brazilian Group of Head and Neck Cancer
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Jan;131(1):73-84. Epub 2020 Sep 14 doi: 10.1016/j.oooo.2020.09.002. PMID: 33187936

Diabetes mellitus and oral cancer/oral potentially malignant disorders: A systematic review and meta-analysis.

Ramos-Garcia P, Roca-Rodriguez MDM, Aguilar-Diosdado M, Gonzalez-Moles MA
Oral Dis 2021 Apr;27(3):404-421. Epub 2020 Feb 18 doi: 10.1111/odi.13289. PMID: 31994293

Oral potentially malignant disorders: A comprehensive review on clinical aspects and management.

Warnakulasuriya S
Oral Oncol 2020 Mar;102:104550. Epub 2020 Jan 22 doi: 10.1016/j.oraloncology.2019.104550. PMID: 31981993

Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype.

Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979

See all (17)

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Erythroplakia

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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