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Erythroplakia

MedGen UID:
41862
Concept ID:
C0014818
Disease or Syndrome
Synonyms: Erythroplasia; Erythroplasias
SNOMED CT: Erythroplakia (71379006); Erythroplasia (71379006)
 
Monarch Initiative: MONDO:0023089

Definition

A clinical term that refers to the presence of a red flat and well defined lesion on the oral mucosa that is not caused by trauma, vascular, or inflammatory processes. It is a precancerous condition and is seen more commonly in middle aged or older males. It is associated with tobacco and alcohol consumption. Microscopic examination reveals severe epithelial dysplasia, carcinoma in situ, or invasive squamous cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVErythroplakia

Professional guidelines

PubMed

Clarkson E, Hadioonzadeh R, Peters SM
Dent Clin North Am 2024 Jan;68(1):133-149. Epub 2023 Aug 23 doi: 10.1016/j.cden.2023.07.008. PMID: 37951630
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Warnakulasuriya S
Oral Oncol 2020 Mar;102:104550. Epub 2020 Jan 22 doi: 10.1016/j.oraloncology.2019.104550. PMID: 31981993

Recent clinical studies

Etiology

Randall DA, Wilson Westmark NL, Neville BW
Am Fam Physician 2022 Apr 1;105(4):369-376. PMID: 35426641
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, Sloan P, Johnson NW
Oral Dis 2021 Nov;27(8):1862-1880. Epub 2020 Nov 26 doi: 10.1111/odi.13704. PMID: 33128420
Wetzel SL, Wollenberg J
Dent Clin North Am 2020 Jan;64(1):25-37. doi: 10.1016/j.cden.2019.08.004. PMID: 31735231
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944

Diagnosis

Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, Sloan P, Johnson NW
Oral Dis 2021 Nov;27(8):1862-1880. Epub 2020 Nov 26 doi: 10.1111/odi.13704. PMID: 33128420
Wetzel SL, Wollenberg J
Dent Clin North Am 2020 Jan;64(1):25-37. doi: 10.1016/j.cden.2019.08.004. PMID: 31735231
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Warnakulasuriya S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):582-590. Epub 2018 Apr 4 doi: 10.1016/j.oooo.2018.03.011. PMID: 29673799
Mangold AR, Torgerson RR, Rogers RS 3rd
Clin Dermatol 2016 Jul-Aug;34(4):458-69. Epub 2016 Mar 8 doi: 10.1016/j.clindermatol.2016.02.018. PMID: 27343960

Therapy

Lorenzo-Pouso AI, Lafuente-Ibáñez de Mendoza I, Pérez-Sayáns M, Pérez-Jardón A, Chamorro-Petronacci CM, Blanco-Carrión A, Aguirre-Urízar JM
J Oral Pathol Med 2022 Aug;51(7):585-593. Epub 2022 May 12 doi: 10.1111/jop.13304. PMID: 35488780Free PMC Article
Muthukrishnan A, Warnakulasuriya S
Indian J Med Res 2018 Jul;148(1):35-40. doi: 10.4103/ijmr.IJMR_1793_17. PMID: 30264752Free PMC Article
Warnakulasuriya S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):582-590. Epub 2018 Apr 4 doi: 10.1016/j.oooo.2018.03.011. PMID: 29673799
Speight PM, Khurram SA, Kujan O
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):612-627. Epub 2017 Dec 29 doi: 10.1016/j.oooo.2017.12.011. PMID: 29396319
Villa A, Villa C, Abati S
Aust Dent J 2011 Sep;56(3):253-6. Epub 2011 Jul 10 doi: 10.1111/j.1834-7819.2011.01337.x. PMID: 21884139

Prognosis

Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325
Warnakulasuriya S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):582-590. Epub 2018 Apr 4 doi: 10.1016/j.oooo.2018.03.011. PMID: 29673799
Holmstrup P
Oral Dis 2018 Mar;24(1-2):138-143. doi: 10.1111/odi.12709. PMID: 29480616
Speight PM, Khurram SA, Kujan O
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):612-627. Epub 2017 Dec 29 doi: 10.1016/j.oooo.2017.12.011. PMID: 29396319

Clinical prediction guides

Lorenzo-Pouso AI, Lafuente-Ibáñez de Mendoza I, Pérez-Sayáns M, Pérez-Jardón A, Chamorro-Petronacci CM, Blanco-Carrión A, Aguirre-Urízar JM
J Oral Pathol Med 2022 Aug;51(7):585-593. Epub 2022 May 12 doi: 10.1111/jop.13304. PMID: 35488780Free PMC Article
Randall DA, Wilson Westmark NL, Neville BW
Am Fam Physician 2022 Apr 1;105(4):369-376. PMID: 35426641
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Ramos-Garcia P, Roca-Rodriguez MDM, Aguilar-Diosdado M, Gonzalez-Moles MA
Oral Dis 2021 Apr;27(3):404-421. Epub 2020 Feb 18 doi: 10.1111/odi.13289. PMID: 31994293
Speight PM, Khurram SA, Kujan O
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):612-627. Epub 2017 Dec 29 doi: 10.1016/j.oooo.2017.12.011. PMID: 29396319

Recent systematic reviews

Lorenzo-Pouso AI, Lafuente-Ibáñez de Mendoza I, Pérez-Sayáns M, Pérez-Jardón A, Chamorro-Petronacci CM, Blanco-Carrión A, Aguirre-Urízar JM
J Oral Pathol Med 2022 Aug;51(7):585-593. Epub 2022 May 12 doi: 10.1111/jop.13304. PMID: 35488780Free PMC Article
Roza ALOC, Kowalski LP, William WN Jr, de Castro G Jr, Chaves ALF, Araújo ALD, Ribeiro ACP, Brandão TB, Lopes MA, Vargas PA, Santos-Silva AR; Latin American Cooperative Oncology Group–Brazilian Group of Head and Neck Cancer
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Jan;131(1):73-84. Epub 2020 Sep 14 doi: 10.1016/j.oooo.2020.09.002. PMID: 33187936
Ramos-Garcia P, Roca-Rodriguez MDM, Aguilar-Diosdado M, Gonzalez-Moles MA
Oral Dis 2021 Apr;27(3):404-421. Epub 2020 Feb 18 doi: 10.1111/odi.13289. PMID: 31994293
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979
Mello FW, Miguel AFP, Dutra KL, Porporatti AL, Warnakulasuriya S, Guerra ENS, Rivero ERC
J Oral Pathol Med 2018 Aug;47(7):633-640. Epub 2018 Jun 6 doi: 10.1111/jop.12726. PMID: 29738071

Supplemental Content

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