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Fibromyalgia

MedGen UID:
42018
•Concept ID:
C0016053
•
Disease or Syndrome
Synonyms: Diffuse Myofascial Pain Syndrome; Fibromyalgia Fibromyositis Syndrome; Fibromyalgia-Fibromyositis Syndrome; Fibromyalgia-Fibromyositis Syndromes; Fibromyalgias; Fibromyositis Fibromyalgia Syndrome; Fibromyositis-Fibromyalgia Syndrome; Fibromyositis-Fibromyalgia Syndromes; Fibrositides; Fibrositis; Muscular Rheumatism; Myofascial Pain Syndrome, Diffuse; Rheumatism, Muscular; Syndrome, Fibromyalgia-Fibromyositis; Syndrome, Fibromyositis-Fibromyalgia; Syndromes, Fibromyalgia-Fibromyositis; Syndromes, Fibromyositis-Fibromyalgia
SNOMED CT: Fibromyalgia (203082005); Muscular rheumatism (203102006); Myofascial pain syndrome (726531007); MPS - myofascial pain syndrome (726531007); Myofascial pain dysfunction syndrome (726531007); Myofascial trigger point syndrome (726531007); Fibromyositis (24693007); Fibrositis (56557000)
 
Monarch Initiative: MONDO:0005546
Orphanet: ORPHA41842

Definition

A chronic disorder of unknown etiology characterized by pain, stiffness, and tenderness in the muscles of neck, shoulders, back, hips, arms, and legs. Other signs and symptoms include headaches, fatigue, sleep disturbances, and painful menstruation. [from NCI]

Professional guidelines

PubMed

Fibromyalgia: Diagnosis and Management.
Winslow BT, Vandal C, Dang L
Am Fam Physician 2023 Feb;107(2):137-144. PMID: 36791450
Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update.
Siracusa R, Paola RD, Cuzzocrea S, Impellizzeri D
Int J Mol Sci 2021 Apr 9;22(8) doi: 10.3390/ijms22083891. PMID: 33918736Free PMC Article
Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014-2018).
Lefaucheur JP, Aleman A, Baeken C, Benninger DH, Brunelin J, Di Lazzaro V, Filipović SR, Grefkes C, Hasan A, Hummel FC, Jääskeläinen SK, Langguth B, Leocani L, Londero A, Nardone R, Nguyen JP, Nyffeler T, Oliveira-Maia AJ, Oliviero A, Padberg F, Palm U, Paulus W, Poulet E, Quartarone A, Rachid F, Rektorová I, Rossi S, Sahlsten H, Schecklmann M, Szekely D, Ziemann U
Clin Neurophysiol 2020 Feb;131(2):474-528. Epub 2020 Jan 1 doi: 10.1016/j.clinph.2019.11.002. PMID: 31901449

Curated

UK NICE Guideline NG193, Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain, 2021

Recent clinical studies

Etiology

Fibromyalgia interventions, obstacles and prospects: narrative review.
Wasti AZ, Mackawy AMH, Hussain A, Huq M, Ahmed H, Memon AG
Acta Myol 2023;42(2-3):71-81. Epub 2023 Sep 30 doi: 10.36185/2532-1900-334. PMID: 38090547Free PMC Article
The diagnosis of fibromyalgia syndrome.
Berwick R, Barker C, Goebel A; guideline development group
Clin Med (Lond) 2022 Nov;22(6):570-574. doi: 10.7861/clinmed.2022-0402. PMID: 36427885Free PMC Article
Fibromyalgia.
Bair MJ, Krebs EE
Ann Intern Med 2020 Mar 3;172(5):ITC33-ITC48. doi: 10.7326/AITC202003030. PMID: 32120395
Prevalence of fibromyalgia: literature review update.
Marques AP, Santo ASDE, Berssaneti AA, Matsutani LA, Yuan SLK
Rev Bras Reumatol Engl Ed 2017 Jul-Aug;57(4):356-363. Epub 2017 Feb 8 doi: 10.1016/j.rbre.2017.01.005. PMID: 28743363
Fibromyalgia Pathogenesis and Treatment Options Update.
Chinn S, Caldwell W, Gritsenko K
Curr Pain Headache Rep 2016 Apr;20(4):25. doi: 10.1007/s11916-016-0556-x. PMID: 26922414

Diagnosis

Fibromyalgia: Diagnosis and Management.
Winslow BT, Vandal C, Dang L
Am Fam Physician 2023 Feb;107(2):137-144. PMID: 36791450
Fibromyalgia: one year in review 2022.
Giorgi V, Sirotti S, Romano ME, Marotto D, Ablin JN, Salaffi F, Sarzi-Puttini P
Clin Exp Rheumatol 2022 Jun;40(6):1065-1072. Epub 2022 Jun 22 doi: 10.55563/clinexprheumatol/if9gk2. PMID: 35748720
Fibromyalgia: Recent Advances in Diagnosis, Classification, Pharmacotherapy and Alternative Remedies.
Maffei ME
Int J Mol Sci 2020 Oct 23;21(21) doi: 10.3390/ijms21217877. PMID: 33114203Free PMC Article
Fibromyalgia.
Bair MJ, Krebs EE
Ann Intern Med 2020 Mar 3;172(5):ITC33-ITC48. doi: 10.7326/AITC202003030. PMID: 32120395
Fibromyalgia: a clinical review.
Clauw DJ
JAMA 2014 Apr 16;311(15):1547-55. doi: 10.1001/jama.2014.3266. PMID: 24737367

Therapy

Acupuncture and Chronic Musculoskeletal Pain.
Zhang Y, Wang C
Curr Rheumatol Rep 2020 Sep 25;22(11):80. doi: 10.1007/s11926-020-00954-z. PMID: 32978666Free PMC Article
Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis.
Lowry E, Marley J, McVeigh JG, McSorley E, Allsopp P, Kerr D
Nutrients 2020 Aug 31;12(9) doi: 10.3390/nu12092664. PMID: 32878326Free PMC Article
Effectiveness of Therapeutic Exercise in Fibromyalgia Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Sosa-Reina MD, Nunez-Nagy S, Gallego-Izquierdo T, Pecos-Martín D, Monserrat J, Álvarez-Mon M
Biomed Res Int 2017;2017:2356346. Epub 2017 Sep 20 doi: 10.1155/2017/2356346. PMID: 29291206Free PMC Article
Aerobic exercise training for adults with fibromyalgia.
Bidonde J, Busch AJ, Schachter CL, Overend TJ, Kim SY, Góes SM, Boden C, Foulds HJ
Cochrane Database Syst Rev 2017 Jun 21;6(6):CD012700. doi: 10.1002/14651858.CD012700. PMID: 28636204Free PMC Article
Exercise therapy for fibromyalgia.
Busch AJ, Webber SC, Brachaniec M, Bidonde J, Bello-Haas VD, Danyliw AD, Overend TJ, Richards RS, Sawant A, Schachter CL
Curr Pain Headache Rep 2011 Oct;15(5):358-67. doi: 10.1007/s11916-011-0214-2. PMID: 21725900Free PMC Article

Prognosis

Juvenile primary Fibromyalgia Syndrome: epidemiology, etiology, pathogenesis, clinical manifestations and diagnosis.
Coles ML, Weissmann R, Uziel Y
Pediatr Rheumatol Online J 2021 Mar 1;19(1):22. doi: 10.1186/s12969-021-00493-6. PMID: 33648522Free PMC Article
Fibromyalgia.
Bair MJ, Krebs EE
Ann Intern Med 2020 Mar 3;172(5):ITC33-ITC48. doi: 10.7326/AITC202003030. PMID: 32120395
AAPT Diagnostic Criteria for Fibromyalgia.
Arnold LM, Bennett RM, Crofford LJ, Dean LE, Clauw DJ, Goldenberg DL, Fitzcharles MA, Paiva ES, Staud R, Sarzi-Puttini P, Buskila D, Macfarlane GJ
J Pain 2019 Jun;20(6):611-628. Epub 2018 Nov 16 doi: 10.1016/j.jpain.2018.10.008. PMID: 30453109
Effects of aquatic training and detraining on women with fibromyalgia: controlled randomized clinical trial.
Andrade CP, Zamunér AR, Forti M, Tamburús NY, Silva E
Eur J Phys Rehabil Med 2019 Feb;55(1):79-88. Epub 2018 Jul 6 doi: 10.23736/S1973-9087.18.05041-4. PMID: 29984564
Fibromyalgia criteria and severity scales for clinical and epidemiological studies: a modification of the ACR Preliminary Diagnostic Criteria for Fibromyalgia.
Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Häuser W, Katz RS, Mease P, Russell AS, Russell IJ, Winfield JB
J Rheumatol 2011 Jun;38(6):1113-22. Epub 2011 Feb 1 doi: 10.3899/jrheum.100594. PMID: 21285161

Clinical prediction guides

Tinnitus in Fibromyalgia.
Puri BK, Lee GS
P R Health Sci J 2021 Dec;40(4):188-191. PMID: 35077079
Ingestion of a THC-Rich Cannabis Oil in People with Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Chaves C, Bittencourt PCT, Pelegrini A
Pain Med 2020 Oct 1;21(10):2212-2218. doi: 10.1093/pm/pnaa303. PMID: 33118602Free PMC Article
Fibromyalgia and dissociative symptoms.
Duarte JM, Crow C, Antik A, Appiani F, Caride A
CNS Spectr 2019 Dec;24(6):605-608. doi: 10.1017/S1092852918001608. PMID: 30894235
Fibrofog and fibromyalgia: a narrative review and implications for clinical practice.
Kravitz HM, Katz RS
Rheumatol Int 2015 Jul;35(7):1115-25. Epub 2015 Jan 13 doi: 10.1007/s00296-014-3208-7. PMID: 25583051
Joint counts in inflammatory arthritis.
Scott IC, Scott DL
Clin Exp Rheumatol 2014 Sep-Oct;32(5 Suppl 85):S-7-12. Epub 2014 Oct 30 PMID: 25365082

Recent systematic reviews

Efficacy of Dry Needling and Acupuncture in Patients with Fibromyalgia: A Systematic Review and Meta-Analysis.
Valera-Calero JA, Fernández-de-Las-Peñas C, Navarro-Santana MJ, Plaza-Manzano G
Int J Environ Res Public Health 2022 Aug 11;19(16) doi: 10.3390/ijerph19169904. PMID: 36011540Free PMC Article
Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment.
Sarzi-Puttini P, Giorgi V, Marotto D, Atzeni F
Nat Rev Rheumatol 2020 Nov;16(11):645-660. Epub 2020 Oct 6 doi: 10.1038/s41584-020-00506-w. PMID: 33024295
Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis.
Lowry E, Marley J, McVeigh JG, McSorley E, Allsopp P, Kerr D
Nutrients 2020 Aug 31;12(9) doi: 10.3390/nu12092664. PMID: 32878326Free PMC Article
Effectiveness of Therapeutic Exercise in Fibromyalgia Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Sosa-Reina MD, Nunez-Nagy S, Gallego-Izquierdo T, Pecos-Martín D, Monserrat J, Álvarez-Mon M
Biomed Res Int 2017;2017:2356346. Epub 2017 Sep 20 doi: 10.1155/2017/2356346. PMID: 29291206Free PMC Article
Health benefits of tai chi: What is the evidence?
Huston P, McFarlane B
Can Fam Physician 2016 Nov;62(11):881-890. PMID: 28661865Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

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    Curated

    • NICE, 2021
      UK NICE Guideline NG193, Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain, 2021

    Consumer resources

    Reviews

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