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Fibromyalgia

MedGen UID:
42018
Concept ID:
C0016053
Disease or Syndrome
Synonyms: Diffuse Myofascial Pain Syndrome; Fibromyalgia Fibromyositis Syndrome; Fibromyalgia-Fibromyositis Syndrome; Fibromyalgia-Fibromyositis Syndromes; Fibromyalgias; Fibromyositis Fibromyalgia Syndrome; Fibromyositis-Fibromyalgia Syndrome; Fibromyositis-Fibromyalgia Syndromes; Fibrositides; Fibrositis; Muscular Rheumatism; Myofascial Pain Syndrome, Diffuse; Rheumatism, Muscular; Syndrome, Fibromyalgia-Fibromyositis; Syndrome, Fibromyositis-Fibromyalgia; Syndromes, Fibromyalgia-Fibromyositis; Syndromes, Fibromyositis-Fibromyalgia
SNOMED CT: Fibromyalgia (203082005); Muscular rheumatism (203102006); Myofascial pain syndrome (726531007); MPS - myofascial pain syndrome (726531007); Myofascial pain dysfunction syndrome (726531007); Myofascial trigger point syndrome (726531007); Fibromyositis (24693007); Fibrositis (56557000)
 
Monarch Initiative: MONDO:0005546
Orphanet: ORPHA41842

Definition

A chronic disorder of unknown etiology characterized by pain, stiffness, and tenderness in the muscles of neck, shoulders, back, hips, arms, and legs. Other signs and symptoms include headaches, fatigue, sleep disturbances, and painful menstruation. [from NCI]

Professional guidelines

PubMed

Siracusa R, Paola RD, Cuzzocrea S, Impellizzeri D
Int J Mol Sci 2021 Apr 9;22(8) doi: 10.3390/ijms22083891. PMID: 33918736Free PMC Article
Lefaucheur JP, Aleman A, Baeken C, Benninger DH, Brunelin J, Di Lazzaro V, Filipović SR, Grefkes C, Hasan A, Hummel FC, Jääskeläinen SK, Langguth B, Leocani L, Londero A, Nardone R, Nguyen JP, Nyffeler T, Oliveira-Maia AJ, Oliviero A, Padberg F, Palm U, Paulus W, Poulet E, Quartarone A, Rachid F, Rektorová I, Rossi S, Sahlsten H, Schecklmann M, Szekely D, Ziemann U
Clin Neurophysiol 2020 Feb;131(2):474-528. Epub 2020 Jan 1 doi: 10.1016/j.clinph.2019.11.002. PMID: 31901449
Chinn S, Caldwell W, Gritsenko K
Curr Pain Headache Rep 2016 Apr;20(4):25. doi: 10.1007/s11916-016-0556-x. PMID: 26922414

Curated

UK NICE Guideline NG193, Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain, 2021

Recent clinical studies

Etiology

Berwick R, Barker C, Goebel A; guideline development group
Clin Med (Lond) 2022 Nov;22(6):570-574. doi: 10.7861/clinmed.2022-0402. PMID: 36427885Free PMC Article
Bair MJ, Krebs EE
Ann Intern Med 2020 Mar 3;172(5):ITC33-ITC48. doi: 10.7326/AITC202003030. PMID: 32120395
Marques AP, Santo ASDE, Berssaneti AA, Matsutani LA, Yuan SLK
Rev Bras Reumatol Engl Ed 2017 Jul-Aug;57(4):356-363. Epub 2017 Feb 8 doi: 10.1016/j.rbre.2017.01.005. PMID: 28743363
Chinn S, Caldwell W, Gritsenko K
Curr Pain Headache Rep 2016 Apr;20(4):25. doi: 10.1007/s11916-016-0556-x. PMID: 26922414
Queiroz LP
Curr Pain Headache Rep 2013 Aug;17(8):356. doi: 10.1007/s11916-013-0356-5. PMID: 23801009

Diagnosis

Giorgi V, Sirotti S, Romano ME, Marotto D, Ablin JN, Salaffi F, Sarzi-Puttini P
Clin Exp Rheumatol 2022 Jun;40(6):1065-1072. Epub 2022 Jun 22 doi: 10.55563/clinexprheumatol/if9gk2. PMID: 35748720
Maffei ME
Int J Mol Sci 2020 Oct 23;21(21) doi: 10.3390/ijms21217877. PMID: 33114203Free PMC Article
Sarzi-Puttini P, Giorgi V, Marotto D, Atzeni F
Nat Rev Rheumatol 2020 Nov;16(11):645-660. Epub 2020 Oct 6 doi: 10.1038/s41584-020-00506-w. PMID: 33024295
Bair MJ, Krebs EE
Ann Intern Med 2020 Mar 3;172(5):ITC33-ITC48. doi: 10.7326/AITC202003030. PMID: 32120395
Clauw DJ
JAMA 2014 Apr 16;311(15):1547-55. doi: 10.1001/jama.2014.3266. PMID: 24737367

Therapy

Berger AA, Keefe J, Winnick A, Gilbert E, Eskander JP, Yazdi C, Kaye AD, Viswanath O, Urits I
Best Pract Res Clin Anaesthesiol 2020 Sep;34(3):617-631. Epub 2020 Aug 15 doi: 10.1016/j.bpa.2020.08.010. PMID: 33004171
Zhang Y, Wang C
Curr Rheumatol Rep 2020 Sep 25;22(11):80. doi: 10.1007/s11926-020-00954-z. PMID: 32978666Free PMC Article
Lowry E, Marley J, McVeigh JG, McSorley E, Allsopp P, Kerr D
Nutrients 2020 Aug 31;12(9) doi: 10.3390/nu12092664. PMID: 32878326Free PMC Article
Sosa-Reina MD, Nunez-Nagy S, Gallego-Izquierdo T, Pecos-Martín D, Monserrat J, Álvarez-Mon M
Biomed Res Int 2017;2017:2356346. Epub 2017 Sep 20 doi: 10.1155/2017/2356346. PMID: 29291206Free PMC Article
Busch AJ, Webber SC, Brachaniec M, Bidonde J, Bello-Haas VD, Danyliw AD, Overend TJ, Richards RS, Sawant A, Schachter CL
Curr Pain Headache Rep 2011 Oct;15(5):358-67. doi: 10.1007/s11916-011-0214-2. PMID: 21725900Free PMC Article

Prognosis

Coles ML, Weissmann R, Uziel Y
Pediatr Rheumatol Online J 2021 Mar 1;19(1):22. doi: 10.1186/s12969-021-00493-6. PMID: 33648522Free PMC Article
Bair MJ, Krebs EE
Ann Intern Med 2020 Mar 3;172(5):ITC33-ITC48. doi: 10.7326/AITC202003030. PMID: 32120395
Arnold LM, Bennett RM, Crofford LJ, Dean LE, Clauw DJ, Goldenberg DL, Fitzcharles MA, Paiva ES, Staud R, Sarzi-Puttini P, Buskila D, Macfarlane GJ
J Pain 2019 Jun;20(6):611-628. Epub 2018 Nov 16 doi: 10.1016/j.jpain.2018.10.008. PMID: 30453109
Andrade CP, Zamunér AR, Forti M, Tamburús NY, Silva E
Eur J Phys Rehabil Med 2019 Feb;55(1):79-88. Epub 2018 Jul 6 doi: 10.23736/S1973-9087.18.05041-4. PMID: 29984564
Chakrabarty S, Zoorob R
Am Fam Physician 2007 Jul 15;76(2):247-54. PMID: 17695569

Clinical prediction guides

Puri BK, Lee GS
P R Health Sci J 2021 Dec;40(4):188-191. PMID: 35077079
Chaves C, Bittencourt PCT, Pelegrini A
Pain Med 2020 Oct 1;21(10):2212-2218. doi: 10.1093/pm/pnaa303. PMID: 33118602Free PMC Article
López-Ruiz M, Losilla JM, Monfort J, Portell M, Gutiérrez T, Poca V, Garcia-Fructuoso F, Llorente J, Garcia-Fontanals A, Deus J
PLoS One 2019;14(12):e0225836. Epub 2019 Dec 5 doi: 10.1371/journal.pone.0225836. PMID: 31805099Free PMC Article
Honda Y, Sakamoto J, Hamaue Y, Kataoka H, Kondo Y, Sasabe R, Goto K, Fukushima T, Oga S, Sasaki R, Tanaka N, Nakano J, Okita M
Pain Res Manag 2018;2018:2930632. Epub 2018 Oct 1 doi: 10.1155/2018/2930632. PMID: 30402199Free PMC Article
Uğurlu FG, Sezer N, Aktekin L, Fidan F, Tok F, Akkuş S
Acta Reumatol Port 2017 Jan-Mar;42(1):32-37. PMID: 28371571

Recent systematic reviews

Valera-Calero JA, Fernández-de-Las-Peñas C, Navarro-Santana MJ, Plaza-Manzano G
Int J Environ Res Public Health 2022 Aug 11;19(16) doi: 10.3390/ijerph19169904. PMID: 36011540Free PMC Article
Sarzi-Puttini P, Giorgi V, Marotto D, Atzeni F
Nat Rev Rheumatol 2020 Nov;16(11):645-660. Epub 2020 Oct 6 doi: 10.1038/s41584-020-00506-w. PMID: 33024295
Lowry E, Marley J, McVeigh JG, McSorley E, Allsopp P, Kerr D
Nutrients 2020 Aug 31;12(9) doi: 10.3390/nu12092664. PMID: 32878326Free PMC Article
Kim PS, Fishman MA
Curr Pain Headache Rep 2020 Aug 26;24(10):64. doi: 10.1007/s11916-020-00898-0. PMID: 32845365
Sosa-Reina MD, Nunez-Nagy S, Gallego-Izquierdo T, Pecos-Martín D, Monserrat J, Álvarez-Mon M
Biomed Res Int 2017;2017:2356346. Epub 2017 Sep 20 doi: 10.1155/2017/2356346. PMID: 29291206Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline NG193, Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain, 2021

    Consumer resources

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