U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fibromyalgia

MedGen UID:
42018
Concept ID:
C0016053
Disease or Syndrome
Synonyms: Diffuse Myofascial Pain Syndrome; Fibromyalgia Fibromyositis Syndrome; Fibromyalgia-Fibromyositis Syndrome; Fibromyalgia-Fibromyositis Syndromes; Fibromyalgias; Fibromyositis Fibromyalgia Syndrome; Fibromyositis-Fibromyalgia Syndrome; Fibromyositis-Fibromyalgia Syndromes; Fibrositides; Fibrositis; Muscular Rheumatism; Myofascial Pain Syndrome, Diffuse; Rheumatism, Muscular; Syndrome, Fibromyalgia-Fibromyositis; Syndrome, Fibromyositis-Fibromyalgia; Syndromes, Fibromyalgia-Fibromyositis; Syndromes, Fibromyositis-Fibromyalgia
SNOMED CT: Fibromyalgia (203082005); Muscular rheumatism (203102006); Myofascial pain syndrome (726531007); MPS - myofascial pain syndrome (726531007); Myofascial pain dysfunction syndrome (726531007); Myofascial trigger point syndrome (726531007); Fibromyositis (24693007); Fibrositis (56557000)
 
Monarch Initiative: MONDO:0005546
Orphanet: ORPHA41842

Definition

A chronic disorder of unknown etiology characterized by pain, stiffness, and tenderness in the muscles of neck, shoulders, back, hips, arms, and legs. Other signs and symptoms include headaches, fatigue, sleep disturbances, and painful menstruation. [from NCI]

Professional guidelines

PubMed

Siracusa R, Paola RD, Cuzzocrea S, Impellizzeri D
Int J Mol Sci 2021 Apr 9;22(8) doi: 10.3390/ijms22083891. PMID: 33918736Free PMC Article
Lefaucheur JP, Aleman A, Baeken C, Benninger DH, Brunelin J, Di Lazzaro V, Filipović SR, Grefkes C, Hasan A, Hummel FC, Jääskeläinen SK, Langguth B, Leocani L, Londero A, Nardone R, Nguyen JP, Nyffeler T, Oliveira-Maia AJ, Oliviero A, Padberg F, Palm U, Paulus W, Poulet E, Quartarone A, Rachid F, Rektorová I, Rossi S, Sahlsten H, Schecklmann M, Szekely D, Ziemann U
Clin Neurophysiol 2020 Feb;131(2):474-528. Epub 2020 Jan 1 doi: 10.1016/j.clinph.2019.11.002. PMID: 31901449
Macfarlane GJ, Kronisch C, Dean LE, Atzeni F, Häuser W, Fluß E, Choy E, Kosek E, Amris K, Branco J, Dincer F, Leino-Arjas P, Longley K, McCarthy GM, Makri S, Perrot S, Sarzi-Puttini P, Taylor A, Jones GT
Ann Rheum Dis 2017 Feb;76(2):318-328. Epub 2016 Jul 4 doi: 10.1136/annrheumdis-2016-209724. PMID: 27377815

Curated

UK NICE Guideline NG193, Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain, 2021

Recent clinical studies

Etiology

Berwick R, Barker C, Goebel A; guideline development group
Clin Med (Lond) 2022 Nov;22(6):570-574. doi: 10.7861/clinmed.2022-0402. PMID: 36427885Free PMC Article
Bair MJ, Krebs EE
Ann Intern Med 2020 Mar 3;172(5):ITC33-ITC48. doi: 10.7326/AITC202003030. PMID: 32120395
Marques AP, Santo ASDE, Berssaneti AA, Matsutani LA, Yuan SLK
Rev Bras Reumatol Engl Ed 2017 Jul-Aug;57(4):356-363. Epub 2017 Feb 8 doi: 10.1016/j.rbre.2017.01.005. PMID: 28743363
Chinn S, Caldwell W, Gritsenko K
Curr Pain Headache Rep 2016 Apr;20(4):25. doi: 10.1007/s11916-016-0556-x. PMID: 26922414
Queiroz LP
Curr Pain Headache Rep 2013 Aug;17(8):356. doi: 10.1007/s11916-013-0356-5. PMID: 23801009

Diagnosis

Winslow BT, Vandal C, Dang L
Am Fam Physician 2023 Feb;107(2):137-144. PMID: 36791450
Giorgi V, Sirotti S, Romano ME, Marotto D, Ablin JN, Salaffi F, Sarzi-Puttini P
Clin Exp Rheumatol 2022 Jun;40(6):1065-1072. Epub 2022 Jun 22 doi: 10.55563/clinexprheumatol/if9gk2. PMID: 35748720
Maffei ME
Int J Mol Sci 2020 Oct 23;21(21) doi: 10.3390/ijms21217877. PMID: 33114203Free PMC Article
Bair MJ, Krebs EE
Ann Intern Med 2020 Mar 3;172(5):ITC33-ITC48. doi: 10.7326/AITC202003030. PMID: 32120395
Clauw DJ
JAMA 2014 Apr 16;311(15):1547-55. doi: 10.1001/jama.2014.3266. PMID: 24737367

Therapy

Zhang Y, Wang C
Curr Rheumatol Rep 2020 Sep 25;22(11):80. doi: 10.1007/s11926-020-00954-z. PMID: 32978666Free PMC Article
Lowry E, Marley J, McVeigh JG, McSorley E, Allsopp P, Kerr D
Nutrients 2020 Aug 31;12(9) doi: 10.3390/nu12092664. PMID: 32878326Free PMC Article
Yeh SW, Hong CH, Shih MC, Tam KW, Huang YH, Kuan YC
Pain Physician 2019 May;22(3):241-254. PMID: 31151332
Sosa-Reina MD, Nunez-Nagy S, Gallego-Izquierdo T, Pecos-Martín D, Monserrat J, Álvarez-Mon M
Biomed Res Int 2017;2017:2356346. Epub 2017 Sep 20 doi: 10.1155/2017/2356346. PMID: 29291206Free PMC Article
Busch AJ, Webber SC, Brachaniec M, Bidonde J, Bello-Haas VD, Danyliw AD, Overend TJ, Richards RS, Sawant A, Schachter CL
Curr Pain Headache Rep 2011 Oct;15(5):358-67. doi: 10.1007/s11916-011-0214-2. PMID: 21725900Free PMC Article

Prognosis

Coles ML, Weissmann R, Uziel Y
Pediatr Rheumatol Online J 2021 Mar 1;19(1):22. doi: 10.1186/s12969-021-00493-6. PMID: 33648522Free PMC Article
Bair MJ, Krebs EE
Ann Intern Med 2020 Mar 3;172(5):ITC33-ITC48. doi: 10.7326/AITC202003030. PMID: 32120395
Arnold LM, Bennett RM, Crofford LJ, Dean LE, Clauw DJ, Goldenberg DL, Fitzcharles MA, Paiva ES, Staud R, Sarzi-Puttini P, Buskila D, Macfarlane GJ
J Pain 2019 Jun;20(6):611-628. Epub 2018 Nov 16 doi: 10.1016/j.jpain.2018.10.008. PMID: 30453109
Andrade CP, Zamunér AR, Forti M, Tamburús NY, Silva E
Eur J Phys Rehabil Med 2019 Feb;55(1):79-88. Epub 2018 Jul 6 doi: 10.23736/S1973-9087.18.05041-4. PMID: 29984564
Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Häuser W, Katz RS, Mease P, Russell AS, Russell IJ, Winfield JB
J Rheumatol 2011 Jun;38(6):1113-22. Epub 2011 Feb 1 doi: 10.3899/jrheum.100594. PMID: 21285161

Clinical prediction guides

Puri BK, Lee GS
P R Health Sci J 2021 Dec;40(4):188-191. PMID: 35077079
Chaves C, Bittencourt PCT, Pelegrini A
Pain Med 2020 Oct 1;21(10):2212-2218. doi: 10.1093/pm/pnaa303. PMID: 33118602Free PMC Article
Vaidya B, Nakarmi S, Bhochhibhoya M, Joshi R
Int J Rheum Dis 2020 Jul;23(7):939-944. Epub 2020 Jun 15 doi: 10.1111/1756-185X.13886. PMID: 32538548
Duarte JM, Crow C, Antik A, Appiani F, Caride A
CNS Spectr 2019 Dec;24(6):605-608. doi: 10.1017/S1092852918001608. PMID: 30894235
Kravitz HM, Katz RS
Rheumatol Int 2015 Jul;35(7):1115-25. Epub 2015 Jan 13 doi: 10.1007/s00296-014-3208-7. PMID: 25583051

Recent systematic reviews

Valera-Calero JA, Fernández-de-Las-Peñas C, Navarro-Santana MJ, Plaza-Manzano G
Int J Environ Res Public Health 2022 Aug 11;19(16) doi: 10.3390/ijerph19169904. PMID: 36011540Free PMC Article
Sarzi-Puttini P, Giorgi V, Marotto D, Atzeni F
Nat Rev Rheumatol 2020 Nov;16(11):645-660. Epub 2020 Oct 6 doi: 10.1038/s41584-020-00506-w. PMID: 33024295
Kim PS, Fishman MA
Curr Pain Headache Rep 2020 Aug 26;24(10):64. doi: 10.1007/s11916-020-00898-0. PMID: 32845365
Sosa-Reina MD, Nunez-Nagy S, Gallego-Izquierdo T, Pecos-Martín D, Monserrat J, Álvarez-Mon M
Biomed Res Int 2017;2017:2356346. Epub 2017 Sep 20 doi: 10.1155/2017/2356346. PMID: 29291206Free PMC Article
Huston P, McFarlane B
Can Fam Physician 2016 Nov;62(11):881-890. PMID: 28661865Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline NG193, Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain, 2021

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...