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Spinal cord glioma

MedGen UID:
423646
•Concept ID:
C2937245
•
Neoplastic Process
Synonyms: Glial Neoplasm Spinal Cord; glial neoplasm spinal cord; Glial tumor of spinal cord; Glial Tumor of Spinal Cord; glial tumor of spinal cord; glial tumour of spinal cord; Glioma of spinal cord; glioma of spinal cord; malignant glioma of spinal cord; Spinal Cord Glial Neoplasm; spinal cord glial neoplasm; Spinal Cord Glial Tumor; spinal cord glial tumor; spinal cord glial tumour; Spinal Cord Glioma; spinal cord glioma; spinal cord malignant glioma
SNOMED CT: Glial tumor of spinal cord (254946004); Glioma of spinal cord (254947008)
 
Monarch Initiative: MONDO:0002542

Definition

A neoplasm that arises from glial cells in the spinal cord. Representative examples include astrocytoma, oligodendroglioma, and ependymoma. [from NCI]

Professional guidelines

PubMed

Challenges in diagnosis and management of adult spinal cord gliomas.
Campello C, Tabouret E, Chinot O
Rev Neurol (Paris) 2021 May;177(5):515-523. Epub 2021 Apr 23 doi: 10.1016/j.neurol.2021.02.384. PMID: 33896651
Treatment outcomes of radiotherapy for primary spinal cord glioma.
Choi SH, Yoon HI, Yi S, Park JW, Cho J, Shin DA, Ha Y, Kim DS, Kim SH, Lee SK, Chang JH, Suh CO
Strahlenther Onkol 2019 Feb;195(2):164-174. Epub 2018 Sep 10 doi: 10.1007/s00066-018-1366-3. PMID: 30203111
Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem Cells.
Ropper AE, Zeng X, Haragopal H, Anderson JE, Aljuboori Z, Han I, Abd-El-Barr M, Lee HJ, Sidman RL, Snyder EY, Viapiano MS, Kim SU, Chi JH, Teng YD
Neurosurgery 2016 Sep;79(3):481-91. doi: 10.1227/NEU.0000000000001174. PMID: 26671631

Recent clinical studies

Etiology

Development and internal validation of machine learning models for personalized survival predictions in spinal cord glioma patients.
Karabacak M, Schupper AJ, Carr MT, Bhimani AD, Steinberger J, Margetis K
Spine J 2024 Jun;24(6):1065-1076. Epub 2024 Feb 15 doi: 10.1016/j.spinee.2024.02.002. PMID: 38365005
Tumor microenvironment in a minipig model of spinal cord glioma.
Tora MS, Neill SG, Lakhina Y, Assed H, Zhang M, Nagarajan PP, Federici T, Gutierrez J, Hoang KB, Du Y, Lei K, Boulis NM
J Transl Med 2023 Sep 27;21(1):667. doi: 10.1186/s12967-023-04531-7. PMID: 37752585Free PMC Article
Contrast-Enhanced Ultrasound in Resection of Spinal Cord Gliomas.
Han B, Zhang L, Jia W
World Neurosurg 2023 Mar;171:e83-e92. Epub 2022 Nov 24 doi: 10.1016/j.wneu.2022.11.087. PMID: 36427693
Challenges in diagnosis and management of adult spinal cord gliomas.
Campello C, Tabouret E, Chinot O
Rev Neurol (Paris) 2021 May;177(5):515-523. Epub 2021 Apr 23 doi: 10.1016/j.neurol.2021.02.384. PMID: 33896651
MRI characteristics and resectability in spinal cord glioma.
Seaman SC, Bathla G, Park BJ, Woodroffe RW, Smith M, Menezes AH, Noeller J, Yamaguchi S, Hitchon PW
Clin Neurol Neurosurg 2021 Jan;200:106321. Epub 2020 Oct 19 doi: 10.1016/j.clineuro.2020.106321. PMID: 33268194

Diagnosis

Development and internal validation of machine learning models for personalized survival predictions in spinal cord glioma patients.
Karabacak M, Schupper AJ, Carr MT, Bhimani AD, Steinberger J, Margetis K
Spine J 2024 Jun;24(6):1065-1076. Epub 2024 Feb 15 doi: 10.1016/j.spinee.2024.02.002. PMID: 38365005
Genomic profiling and prognostic factors of H3 K27M-mutant spinal cord diffuse glioma.
Chai RC, Yan H, An SY, Pang B, Chen HY, Mu QH, Zhang KN, Zhang YW, Liu YQ, Liu X, Zhao Z, Jiang T, Wang YZ, Jia WQ
Brain Pathol 2023 Jul;33(4):e13153. Epub 2023 Feb 7 doi: 10.1111/bpa.13153. PMID: 36751054Free PMC Article
Challenges in diagnosis and management of adult spinal cord gliomas.
Campello C, Tabouret E, Chinot O
Rev Neurol (Paris) 2021 May;177(5):515-523. Epub 2021 Apr 23 doi: 10.1016/j.neurol.2021.02.384. PMID: 33896651
MRI characteristics and resectability in spinal cord glioma.
Seaman SC, Bathla G, Park BJ, Woodroffe RW, Smith M, Menezes AH, Noeller J, Yamaguchi S, Hitchon PW
Clin Neurol Neurosurg 2021 Jan;200:106321. Epub 2020 Oct 19 doi: 10.1016/j.clineuro.2020.106321. PMID: 33268194
Treatment outcomes of radiotherapy for primary spinal cord glioma.
Choi SH, Yoon HI, Yi S, Park JW, Cho J, Shin DA, Ha Y, Kim DS, Kim SH, Lee SK, Chang JH, Suh CO
Strahlenther Onkol 2019 Feb;195(2):164-174. Epub 2018 Sep 10 doi: 10.1007/s00066-018-1366-3. PMID: 30203111

Therapy

Development and internal validation of machine learning models for personalized survival predictions in spinal cord glioma patients.
Karabacak M, Schupper AJ, Carr MT, Bhimani AD, Steinberger J, Margetis K
Spine J 2024 Jun;24(6):1065-1076. Epub 2024 Feb 15 doi: 10.1016/j.spinee.2024.02.002. PMID: 38365005
Lentiviral Vector Induced Modeling of High-Grade Spinal Cord Glioma in Minipigs.
Tora MS, Texakalidis P, Neill S, Wetzel J, Rindler RS, Hardcastle N, Nagarajan PP, Krasnopeyev A, Roach C, James R, Bruce JN, Canoll P, Federici T, Oshinski JN, Boulis NM
Sci Rep 2020 Mar 24;10(1):5291. doi: 10.1038/s41598-020-62167-9. PMID: 32210315Free PMC Article
Differentiation between spinal cord diffuse midline glioma with histone H3 K27M mutation and wild type: comparative magnetic resonance imaging.
Jung JS, Choi YS, Ahn SS, Yi S, Kim SH, Lee SK
Neuroradiology 2019 Mar;61(3):313-322. Epub 2019 Jan 20 doi: 10.1007/s00234-019-02154-8. PMID: 30662997
Animal model of intramedullary spinal cord glioma using human glioblastoma multiforme neurospheres.
Hsu W, Siu IM, Pradilla G, Gokaslan ZL, Jallo GI, Gallia GL
J Neurosurg Spine 2012 Mar;16(3):315-9. Epub 2011 Dec 23 doi: 10.3171/2011.11.SPINE11492. PMID: 22195609
Temozolomide for malignant primary spinal cord glioma: an experience of six cases and a literature review.
Kim WH, Yoon SH, Kim CY, Kim KJ, Lee MM, Choe G, Kim IA, Kim JH, Kim YJ, Kim HJ
J Neurooncol 2011 Jan;101(2):247-54. Epub 2010 Jun 5 doi: 10.1007/s11060-010-0249-y. PMID: 20526650

Prognosis

Retinol dehydrogenase 10 promotes epithelial-mesenchymal transition in spinal cord gliomas via PI3K/AKT pathway.
Zhao Z, Song Z, Wang Z, Zhang F, Ding Z, Zhao Z, Liu L, Fan T
Int J Immunopathol Pharmacol 2024 Jan-Dec;38:3946320241276336. doi: 10.1177/03946320241276336. PMID: 39180753Free PMC Article
Development and internal validation of machine learning models for personalized survival predictions in spinal cord glioma patients.
Karabacak M, Schupper AJ, Carr MT, Bhimani AD, Steinberger J, Margetis K
Spine J 2024 Jun;24(6):1065-1076. Epub 2024 Feb 15 doi: 10.1016/j.spinee.2024.02.002. PMID: 38365005
Genomic profiling and prognostic factors of H3 K27M-mutant spinal cord diffuse glioma.
Chai RC, Yan H, An SY, Pang B, Chen HY, Mu QH, Zhang KN, Zhang YW, Liu YQ, Liu X, Zhao Z, Jiang T, Wang YZ, Jia WQ
Brain Pathol 2023 Jul;33(4):e13153. Epub 2023 Feb 7 doi: 10.1111/bpa.13153. PMID: 36751054Free PMC Article
MRI characteristics and resectability in spinal cord glioma.
Seaman SC, Bathla G, Park BJ, Woodroffe RW, Smith M, Menezes AH, Noeller J, Yamaguchi S, Hitchon PW
Clin Neurol Neurosurg 2021 Jan;200:106321. Epub 2020 Oct 19 doi: 10.1016/j.clineuro.2020.106321. PMID: 33268194
Treatment outcomes of radiotherapy for primary spinal cord glioma.
Choi SH, Yoon HI, Yi S, Park JW, Cho J, Shin DA, Ha Y, Kim DS, Kim SH, Lee SK, Chang JH, Suh CO
Strahlenther Onkol 2019 Feb;195(2):164-174. Epub 2018 Sep 10 doi: 10.1007/s00066-018-1366-3. PMID: 30203111

Clinical prediction guides

Retinol dehydrogenase 10 promotes epithelial-mesenchymal transition in spinal cord gliomas via PI3K/AKT pathway.
Zhao Z, Song Z, Wang Z, Zhang F, Ding Z, Zhao Z, Liu L, Fan T
Int J Immunopathol Pharmacol 2024 Jan-Dec;38:3946320241276336. doi: 10.1177/03946320241276336. PMID: 39180753Free PMC Article
Development and internal validation of machine learning models for personalized survival predictions in spinal cord glioma patients.
Karabacak M, Schupper AJ, Carr MT, Bhimani AD, Steinberger J, Margetis K
Spine J 2024 Jun;24(6):1065-1076. Epub 2024 Feb 15 doi: 10.1016/j.spinee.2024.02.002. PMID: 38365005
Contrast-Enhanced Ultrasound in Resection of Spinal Cord Gliomas.
Han B, Zhang L, Jia W
World Neurosurg 2023 Mar;171:e83-e92. Epub 2022 Nov 24 doi: 10.1016/j.wneu.2022.11.087. PMID: 36427693
MRI characteristics and resectability in spinal cord glioma.
Seaman SC, Bathla G, Park BJ, Woodroffe RW, Smith M, Menezes AH, Noeller J, Yamaguchi S, Hitchon PW
Clin Neurol Neurosurg 2021 Jan;200:106321. Epub 2020 Oct 19 doi: 10.1016/j.clineuro.2020.106321. PMID: 33268194
Animal model of intramedullary spinal cord glioma using human glioblastoma multiforme neurospheres.
Hsu W, Siu IM, Pradilla G, Gokaslan ZL, Jallo GI, Gallia GL
J Neurosurg Spine 2012 Mar;16(3):315-9. Epub 2011 Dec 23 doi: 10.3171/2011.11.SPINE11492. PMID: 22195609

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