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Meningeal Leukemia

MedGen UID:
452807
•Concept ID:
C0948840
•
Neoplastic Process
Synonyms: Leukemic Leptomeningitis; Leukemic leptomeningitis; Leukemic Meningitis; Leukemic meningitis; Meningeal leukemia
SNOMED CT: Meningeal leukemia (722795004); Leukemic leptomeningitis (722795004); Leukemic meningitis (722795004)

Definition

Infiltration of the meninges by an acute or chronic leukemia. [from NCI]

Professional guidelines

PubMed

Childhood leukemia: central nervous system abnormalities during and after treatment.
Chen CY, Zimmerman RA, Faro S, Bilaniuk LT, Chou TY, Molloy PT
AJNR Am J Neuroradiol 1996 Feb;17(2):295-310. PMID: 8938302Free PMC Article
Pharmacologic strategies for the treatment of meningeal malignancy.
Blaney SM, Poplack DG
Invest New Drugs 1996;14(1):69-85. doi: 10.1007/BF00173684. PMID: 8880395
Prevention and treatment of meningeal leukemia in children.
Pinkel D, Woo S
Blood 1994 Jul 15;84(2):355-66. PMID: 8025264

Recent clinical studies

Etiology

Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review.
Byrd JC, Edenfield WJ, Shields DJ, Dawson NA
J Clin Oncol 1995 Jul;13(7):1800-16. doi: 10.1200/JCO.1995.13.7.1800. PMID: 7602369
Prevention and treatment of meningeal leukemia in children.
Pinkel D, Woo S
Blood 1994 Jul 15;84(2):355-66. PMID: 8025264
Prevention of meningeal leukemia. Review of 20 years of research and current recommendations.
Pochedly C
Hematol Oncol Clin North Am 1990 Oct;4(5):951-69. PMID: 2262487
Neurotoxicity due to central nervous system therapy for childhood leukemia.
Ochs JJ
Am J Pediatr Hematol Oncol 1989 Spring;11(1):93-105. doi: 10.1097/00043426-198921000-00019. PMID: 2653080
Histopathology of CNS leukemia and complications of therapy.
Price RA
Am J Pediatr Hematol Oncol 1979 Spring;1(1):21-30. PMID: 396790

Diagnosis

Intracerebral granulocytic sarcoma.
Alvarez M
J Neurosci Nurs 2007 Oct;39(5):297-304. doi: 10.1097/01376517-200710000-00007. PMID: 17966297
Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review.
Byrd JC, Edenfield WJ, Shields DJ, Dawson NA
J Clin Oncol 1995 Jul;13(7):1800-16. doi: 10.1200/JCO.1995.13.7.1800. PMID: 7602369
Prevention and treatment of meningeal leukemia in children.
Pinkel D, Woo S
Blood 1994 Jul 15;84(2):355-66. PMID: 8025264
Acute myelogenous leukemia with leukemia cutis. Eighteen cases seen between 1969 and 1986.
Baer MR, Barcos M, Farrell H, Raza A, Preisler HD
Cancer 1989 Jun 1;63(11):2192-200. doi: 10.1002/1097-0142(19890601)63:11<2192::aid-cncr2820631122>3.0.co;2-r. PMID: 2785843
Meningeal leukemia complicating chronic lymphocytic leukemia.
Liepman MK, Votaw ML
Cancer 1981 May 15;47(10):2482-4. doi: 10.1002/1097-0142(19810515)47:10<2482::aid-cncr2820471028>3.0.co;2-o. PMID: 6895047

Therapy

Intracerebral granulocytic sarcoma.
Alvarez M
J Neurosci Nurs 2007 Oct;39(5):297-304. doi: 10.1097/01376517-200710000-00007. PMID: 17966297
Prevention of meningeal leukemia. Review of 20 years of research and current recommendations.
Pochedly C
Hematol Oncol Clin North Am 1990 Oct;4(5):951-69. PMID: 2262487
Neurotoxicity due to central nervous system therapy for childhood leukemia.
Ochs JJ
Am J Pediatr Hematol Oncol 1989 Spring;11(1):93-105. doi: 10.1097/00043426-198921000-00019. PMID: 2653080
Central nervous system pharmacology of antileukemic drugs.
Balis FM, Poplack DG
Am J Pediatr Hematol Oncol 1989 Spring;11(1):74-86. doi: 10.1097/00043426-198921000-00017. PMID: 2496615
Histopathology of CNS leukemia and complications of therapy.
Price RA
Am J Pediatr Hematol Oncol 1979 Spring;1(1):21-30. PMID: 396790

Prognosis

Intracerebral granulocytic sarcoma.
Alvarez M
J Neurosci Nurs 2007 Oct;39(5):297-304. doi: 10.1097/01376517-200710000-00007. PMID: 17966297
Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review.
Byrd JC, Edenfield WJ, Shields DJ, Dawson NA
J Clin Oncol 1995 Jul;13(7):1800-16. doi: 10.1200/JCO.1995.13.7.1800. PMID: 7602369
Prevention and treatment of meningeal leukemia in children.
Pinkel D, Woo S
Blood 1994 Jul 15;84(2):355-66. PMID: 8025264
High incidence of meningeal leukemia in lymphoid blast crisis of chronic myelogenous leukemia.
Saikia TK, Dhabhar B, Iyer RS, Nanjangud G, Gopal R, Nair CN, Nadkarni KS, Ashokkumar MS, Dhond SR, Advani SH
Am J Hematol 1993 May;43(1):10-3. doi: 10.1002/ajh.2830430104. PMID: 8317457
Neurotoxicity due to central nervous system therapy for childhood leukemia.
Ochs JJ
Am J Pediatr Hematol Oncol 1989 Spring;11(1):93-105. doi: 10.1097/00043426-198921000-00019. PMID: 2653080

Clinical prediction guides

An experimental model of human leukemic meningitis in the nude rat.
Barone TA, Plunkett RJ, Hohmann P, Lis A, Glenister N, Barcos M, Ostrow PT, Spence PM, Greenberg SJ
Blood 1997 Jul 1;90(1):298-305. PMID: 9207465
Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review.
Byrd JC, Edenfield WJ, Shields DJ, Dawson NA
J Clin Oncol 1995 Jul;13(7):1800-16. doi: 10.1200/JCO.1995.13.7.1800. PMID: 7602369
Clinical utility of terminal deoxynucleotidyl transferase and adenosine deaminase determinations in adult leukemia with a lymphoid phenotype.
Brusamolino E, Isernia P, Lazzarino M, Scovassi I, Bertazzoni U, Bernasconi C
J Clin Oncol 1984 Aug;2(8):871-80. doi: 10.1200/JCO.1984.2.8.871. PMID: 6589363
Histopathology of CNS leukemia and complications of therapy.
Price RA
Am J Pediatr Hematol Oncol 1979 Spring;1(1):21-30. PMID: 396790
Leukemic ophthalmopathy in children.
Ridgway EW, Jaffe N, Walton DS
Cancer 1976 Oct;38(4):1744-9. doi: 10.1002/1097-0142(197610)38:4<1744::aid-cncr2820380449>3.0.co;2-3. PMID: 1068743

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