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Pancreatic neuroendocrine tumor G1

MedGen UID:
459467
Concept ID:
C2987241
Neoplastic Process
Synonyms: grade 1 neuroendocrine neoplasm of pancreas; pancreas carcinoid tumor; pancreas carcinoid tumour; pancreas NET G1; pancreas neuroendocrine neoplasm G1; pancreas neuroendocrine tumor, well differentiated, low grade; Pancreatic NET G1; pancreatic NET G1; Pancreatic Neuroendocrine Tumor G1; pancreatic neuroendocrine tumor G1; Serotonin-Producing Tumors With and Without Carcinoid Syndrome
 
Monarch Initiative: MONDO:0021535

Definition

A low grade well differentiated neoplasm with neuroendocrine differentiation that arises from the pancreas. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal or less than 2%. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Del Rivero J, Perez K, Kennedy EB, Mittra ES, Vijayvergia N, Arshad J, Basu S, Chauhan A, Dasari AN, Bellizzi AM, Gangi A, Grady E, Howe JR, Ivanidze J, Lewis M, Mailman J, Raj N, Soares HP, Soulen MC, White SB, Chan JA, Kunz PL, Singh S, Halfdanarson TR, Strosberg JR, Bergsland EK
J Clin Oncol 2023 Nov 10;41(32):5049-5067. Epub 2023 Sep 29 doi: 10.1200/JCO.23.01529. PMID: 37774329
Harris PE, Zhernosekov K
Front Endocrinol (Lausanne) 2022;13:941832. Epub 2022 Oct 31 doi: 10.3389/fendo.2022.941832. PMID: 36387893Free PMC Article
Pulvirenti A, Raj N, Cingarlini S, Pea A, Tang LH, Luchini C, Chou JF, Grego E, Marinova I, Capanu M, Landoni L, Scarpa A, Allen PJ, Klimstra DS, Reidy-Lagunes DL
Pancreas 2021 Feb 1;50(2):138-146. doi: 10.1097/MPA.0000000000001740. PMID: 33565789Free PMC Article

Recent clinical studies

Etiology

Andrini E, Lamberti G, Alberici L, Ricci C, Campana D
Curr Treat Options Oncol 2023 Jul;24(7):742-756. Epub 2023 May 4 doi: 10.1007/s11864-023-01093-0. PMID: 37140773Free PMC Article
Zhou Y, Liu S, Liu C, Yang J, Lin Q, Zheng S, Chen C, Zhou Q, Chen R
Int J Biol Sci 2021;17(14):3760-3775. Epub 2021 Aug 28 doi: 10.7150/ijbs.61717. PMID: 34671197Free PMC Article
Xu Z, Wang L, Dai S, Chen M, Li F, Sun J, Luo F
JAMA Netw Open 2021 Sep 1;4(9):e2124750. doi: 10.1001/jamanetworkopen.2021.24750. PMID: 34554237Free PMC Article
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
Genç CG, Falconi M, Partelli S, Muffatti F, van Eeden S, Doglioni C, Klümpen HJ, van Eijck CHJ, Nieveen van Dijkum EJM
Ann Surg Oncol 2018 Aug;25(8):2467-2474. Epub 2018 May 22 doi: 10.1245/s10434-018-6518-2. PMID: 29789972Free PMC Article

Diagnosis

Panzuto F, Ramage J, Pritchard DM, van Velthuysen MF, Schrader J, Begum N, Sundin A, Falconi M, O'Toole D
J Neuroendocrinol 2023 Aug;35(8):e13306. Epub 2023 Jul 4 doi: 10.1111/jne.13306. PMID: 37401795
Rindi G, Mete O, Uccella S, Basturk O, La Rosa S, Brosens LAA, Ezzat S, de Herder WW, Klimstra DS, Papotti M, Asa SL
Endocr Pathol 2022 Mar;33(1):115-154. Epub 2022 Mar 16 doi: 10.1007/s12022-022-09708-2. PMID: 35294740
Xu Z, Wang L, Dai S, Chen M, Li F, Sun J, Luo F
JAMA Netw Open 2021 Sep 1;4(9):e2124750. doi: 10.1001/jamanetworkopen.2021.24750. PMID: 34554237Free PMC Article
Ambrosini V, Kunikowska J, Baudin E, Bodei L, Bouvier C, Capdevila J, Cremonesi M, de Herder WW, Dromain C, Falconi M, Fani M, Fanti S, Hicks RJ, Kabasakal L, Kaltsas G, Lewington V, Minozzi S, Cinquini M, Öberg K, Oyen WJG, O'Toole D, Pavel M, Ruszniewski P, Scarpa A, Strosberg J, Sundin A, Taïeb D, Virgolini I, Wild D, Herrmann K, Yao J
Eur J Cancer 2021 Mar;146:56-73. Epub 2021 Feb 12 doi: 10.1016/j.ejca.2021.01.008. PMID: 33588146Free PMC Article
Blank A, Schmitt A, Perren A
Front Horm Res 2015;44:104-14. Epub 2015 Aug 14 doi: 10.1159/000382135. PMID: 26303707

Therapy

Del Rivero J, Perez K, Kennedy EB, Mittra ES, Vijayvergia N, Arshad J, Basu S, Chauhan A, Dasari AN, Bellizzi AM, Gangi A, Grady E, Howe JR, Ivanidze J, Lewis M, Mailman J, Raj N, Soares HP, Soulen MC, White SB, Chan JA, Kunz PL, Singh S, Halfdanarson TR, Strosberg JR, Bergsland EK
J Clin Oncol 2023 Nov 10;41(32):5049-5067. Epub 2023 Sep 29 doi: 10.1200/JCO.23.01529. PMID: 37774329
Harris PE, Zhernosekov K
Front Endocrinol (Lausanne) 2022;13:941832. Epub 2022 Oct 31 doi: 10.3389/fendo.2022.941832. PMID: 36387893Free PMC Article
Ambrosini V, Kunikowska J, Baudin E, Bodei L, Bouvier C, Capdevila J, Cremonesi M, de Herder WW, Dromain C, Falconi M, Fani M, Fanti S, Hicks RJ, Kabasakal L, Kaltsas G, Lewington V, Minozzi S, Cinquini M, Öberg K, Oyen WJG, O'Toole D, Pavel M, Ruszniewski P, Scarpa A, Strosberg J, Sundin A, Taïeb D, Virgolini I, Wild D, Herrmann K, Yao J
Eur J Cancer 2021 Mar;146:56-73. Epub 2021 Feb 12 doi: 10.1016/j.ejca.2021.01.008. PMID: 33588146Free PMC Article
Pulvirenti A, Raj N, Cingarlini S, Pea A, Tang LH, Luchini C, Chou JF, Grego E, Marinova I, Capanu M, Landoni L, Scarpa A, Allen PJ, Klimstra DS, Reidy-Lagunes DL
Pancreas 2021 Feb 1;50(2):138-146. doi: 10.1097/MPA.0000000000001740. PMID: 33565789Free PMC Article
Angelousi A, Kaltsas G, Koumarianou A, Weickert MO, Grossman A
Rev Endocr Metab Disord 2017 Dec;18(4):485-497. doi: 10.1007/s11154-017-9432-1. PMID: 28890993

Prognosis

Panzuto F, Ramage J, Pritchard DM, van Velthuysen MF, Schrader J, Begum N, Sundin A, Falconi M, O'Toole D
J Neuroendocrinol 2023 Aug;35(8):e13306. Epub 2023 Jul 4 doi: 10.1111/jne.13306. PMID: 37401795
Zhou Y, Liu S, Liu C, Yang J, Lin Q, Zheng S, Chen C, Zhou Q, Chen R
Int J Biol Sci 2021;17(14):3760-3775. Epub 2021 Aug 28 doi: 10.7150/ijbs.61717. PMID: 34671197Free PMC Article
Xu Z, Wang L, Dai S, Chen M, Li F, Sun J, Luo F
JAMA Netw Open 2021 Sep 1;4(9):e2124750. doi: 10.1001/jamanetworkopen.2021.24750. PMID: 34554237Free PMC Article
Angelousi A, Kaltsas G, Koumarianou A, Weickert MO, Grossman A
Rev Endocr Metab Disord 2017 Dec;18(4):485-497. doi: 10.1007/s11154-017-9432-1. PMID: 28890993
Blank A, Schmitt A, Perren A
Front Horm Res 2015;44:104-14. Epub 2015 Aug 14 doi: 10.1159/000382135. PMID: 26303707

Clinical prediction guides

Del Rivero J, Perez K, Kennedy EB, Mittra ES, Vijayvergia N, Arshad J, Basu S, Chauhan A, Dasari AN, Bellizzi AM, Gangi A, Grady E, Howe JR, Ivanidze J, Lewis M, Mailman J, Raj N, Soares HP, Soulen MC, White SB, Chan JA, Kunz PL, Singh S, Halfdanarson TR, Strosberg JR, Bergsland EK
J Clin Oncol 2023 Nov 10;41(32):5049-5067. Epub 2023 Sep 29 doi: 10.1200/JCO.23.01529. PMID: 37774329
Liu C, Bian Y, Meng Y, Liu F, Cao K, Zhang H, Fang X, Li J, Yu J, Feng X, Ma C, Lu J, Xu J, Shao C
Acad Radiol 2022 Apr;29(4):e49-e60. Epub 2021 Jun 24 doi: 10.1016/j.acra.2021.05.017. PMID: 34175209
Xu Z, Wang L, Dai S, Chen M, Li F, Sun J, Luo F
JAMA Netw Open 2021 Sep 1;4(9):e2124750. doi: 10.1001/jamanetworkopen.2021.24750. PMID: 34554237Free PMC Article
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
Blank A, Schmitt A, Perren A
Front Horm Res 2015;44:104-14. Epub 2015 Aug 14 doi: 10.1159/000382135. PMID: 26303707

Recent systematic reviews

Andersen KØ, Detlefsen S, Brusgaard K, Christesen HT
Front Endocrinol (Lausanne) 2024;15:1351624. Epub 2024 May 29 doi: 10.3389/fendo.2024.1351624. PMID: 38868744Free PMC Article
Tanaka M, Heckler M, Mihaljevic AL, Probst P, Klaiber U, Heger U, Schimmack S, Büchler MW, Hackert T
Ann Surg Oncol 2021 Mar;28(3):1614-1624. Epub 2020 Jul 27 doi: 10.1245/s10434-020-08850-7. PMID: 32720049
Zhu JK, Wu D, Xu JW, Huang X, Jiang YY, Edil BH, Li M, Hu SY, Zhan HX
Pancreatology 2019 Jul;19(5):738-750. Epub 2019 May 27 doi: 10.1016/j.pan.2019.05.462. PMID: 31160191
Zong RL, Geng L, Wang X, Xie D
Pancreas 2019 Feb;48(2):151-160. doi: 10.1097/MPA.0000000000001212. PMID: 30640226
Iwasaki T, Nara S, Kishi Y, Esaki M, Shimada K, Hiraoka N
Langenbecks Arch Surg 2017 Sep;402(6):925-933. Epub 2016 Dec 3 doi: 10.1007/s00423-016-1537-6. PMID: 27915372

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