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Foveolar-Type Adenoma

MedGen UID:
459645
•Concept ID:
C2987419
•
Neoplastic Process

Definition

A rare neoplastic polyp that arises from the stomach. It is characterized by the presence of foveolar-type epithelium. It may be seen in patients with familial adenomatous polyposis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFoveolar-Type Adenoma

Professional guidelines

PubMed

Endoscopic differential diagnosis between foveolar-type gastric adenoma and gastric hyperplastic polyps in Helicobacter pylori-naïve patients.
Shibagaki K, Ishimura N, Kotani S, Fukuyama C, Takahashi Y, Kishimoto K, Yazaki T, Kataoka M, Omachi T, Kinoshita Y, Hasegawa N, Oka A, Mishima Y, Mishiro T, Oshima N, Kawashima K, Nagase M, Araki A, Kadota K, Ishihara S
Gastric Cancer 2023 Nov;26(6):1002-1011. Epub 2023 Aug 6 doi: 10.1007/s10120-023-01420-2. PMID: 37543537

Recent clinical studies

Etiology

Sporadic foveolar-type gastric adenoma with a raspberry-like appearance in Helicobacter pylori-naïve patients.
Shibagaki K, Mishiro T, Fukuyama C, Takahashi Y, Itawaki A, Nonomura S, Yamashita N, Kotani S, Mikami H, Izumi D, Kawashima K, Ishimura N, Nagase M, Araki A, Ishikawa N, Maruyama R, Kushima R, Ishihara S
Virchows Arch 2021 Oct;479(4):687-695. Epub 2021 May 27 doi: 10.1007/s00428-021-03124-3. PMID: 34043063

Diagnosis

Pachydermoperiostosis combined with pyloric gland adenoma with foveolar-type adenoma.
Long B, Jiang C, Zheng Q, Wan P
United European Gastroenterol J 2024 Feb;12(1):152-154. Epub 2023 Nov 22 doi: 10.1002/ueg2.12484. PMID: 37991153Free PMC Article
The updated WHO classification of digestive system tumours-gastric adenocarcinoma and dysplasia.
Kushima R
Pathologe 2022 Feb;43(1):8-15. Epub 2021 Nov 22 doi: 10.1007/s00292-021-01023-7. PMID: 34807275
APC mutations are common in adenomas but infrequent in adenocarcinomas of the non-ampullary duodenum.
Ishizu K, Hashimoto T, Naka T, Yatabe Y, Kojima M, Kuwata T, Nonaka S, Oda I, Esaki M, Kudo M, Gotohda N, Yoshida T, Yoshikawa T, Sekine S
J Gastroenterol 2021 Nov;56(11):988-998. Epub 2021 Sep 12 doi: 10.1007/s00535-021-01823-x. PMID: 34514550
Sporadic foveolar-type gastric adenoma with a raspberry-like appearance in Helicobacter pylori-naïve patients.
Shibagaki K, Mishiro T, Fukuyama C, Takahashi Y, Itawaki A, Nonomura S, Yamashita N, Kotani S, Mikami H, Izumi D, Kawashima K, Ishimura N, Nagase M, Araki A, Ishikawa N, Maruyama R, Kushima R, Ishihara S
Virchows Arch 2021 Oct;479(4):687-695. Epub 2021 May 27 doi: 10.1007/s00428-021-03124-3. PMID: 34043063
Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach.
Kushima R, Vieth M, Borchard F, Stolte M, Mukaisho K, Hattori T
Gastric Cancer 2006;9(3):177-84. doi: 10.1007/s10120-006-0381-8. PMID: 16952035

Therapy

Iatrogenic deep epithelial misplacement ("gastritis cystica profunda") in a gastric foveolar-type adenoma after endoscopic manipulation: a diagnostic pitfall.
Greywoode G, Szuts A, Wang LM, Sgromo B, Chetty R
Am J Surg Pathol 2011 Sep;35(9):1419-21. doi: 10.1097/PAS.0b013e3182271917. PMID: 21836475

Prognosis

Iatrogenic deep epithelial misplacement ("gastritis cystica profunda") in a gastric foveolar-type adenoma after endoscopic manipulation: a diagnostic pitfall.
Greywoode G, Szuts A, Wang LM, Sgromo B, Chetty R
Am J Surg Pathol 2011 Sep;35(9):1419-21. doi: 10.1097/PAS.0b013e3182271917. PMID: 21836475

Clinical prediction guides

APC mutations are common in adenomas but infrequent in adenocarcinomas of the non-ampullary duodenum.
Ishizu K, Hashimoto T, Naka T, Yatabe Y, Kojima M, Kuwata T, Nonaka S, Oda I, Esaki M, Kudo M, Gotohda N, Yoshida T, Yoshikawa T, Sekine S
J Gastroenterol 2021 Nov;56(11):988-998. Epub 2021 Sep 12 doi: 10.1007/s00535-021-01823-x. PMID: 34514550
Sporadic foveolar-type gastric adenoma with a raspberry-like appearance in Helicobacter pylori-naïve patients.
Shibagaki K, Mishiro T, Fukuyama C, Takahashi Y, Itawaki A, Nonomura S, Yamashita N, Kotani S, Mikami H, Izumi D, Kawashima K, Ishimura N, Nagase M, Araki A, Ishikawa N, Maruyama R, Kushima R, Ishihara S
Virchows Arch 2021 Oct;479(4):687-695. Epub 2021 May 27 doi: 10.1007/s00428-021-03124-3. PMID: 34043063
Iatrogenic deep epithelial misplacement ("gastritis cystica profunda") in a gastric foveolar-type adenoma after endoscopic manipulation: a diagnostic pitfall.
Greywoode G, Szuts A, Wang LM, Sgromo B, Chetty R
Am J Surg Pathol 2011 Sep;35(9):1419-21. doi: 10.1097/PAS.0b013e3182271917. PMID: 21836475

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