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Benign neoplasm of stomach

MedGen UID:
57805
•Concept ID:
C0153943
•
Neoplastic Process
Synonyms: Benign Gastric Neoplasm; benign gastric neoplasm; Benign Gastric Tumor; benign gastric tumor; Benign Gastric Tumors; benign gastric tumors; benign gastric tumour; benign gastric tumours; Benign Neoplasm of Stomach; benign neoplasm of stomach; Benign Neoplasm of the Stomach; benign neoplasm of the stomach; Benign Stomach Neoplasms; benign stomach neoplasms; Benign Stomach Tumors; benign stomach tumors; benign stomach tumours; Benign tumor of stomach; Benign Tumor of Stomach; benign tumor of stomach; Benign Tumor of the Stomach; benign tumor of the stomach; Benign Tumors of Stomach; benign tumors of stomach; Benign Tumors of the Stomach; benign tumors of the stomach; benign tumour of stomach; benign tumour of the stomach; benign tumours of stomach; benign tumours of the stomach; Gastric Neoplasms, Benign; gastric neoplasms, benign; Gastric Tumors, Benign; gastric tumors, benign; stomach benign neoplasm; Stomach Neoplasms, Benign; stomach neoplasms, benign; Stomach Tumors, Benign; stomach tumors, benign
SNOMED CT: Benign tumor of stomach (92411005); Benign neoplasm of stomach (92411005)
 
Monarch Initiative: MONDO:0021449

Definition

A neoplasm that arises from the stomach and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

ACG Clinical Guideline: Diagnosis and Management of Gastrointestinal Subepithelial Lesions.
Jacobson BC, Bhatt A, Greer KB, Lee LS, Park WG, Sauer BG, Shami VM
Am J Gastroenterol 2023 Jan 1;118(1):46-58. Epub 2022 Sep 6 doi: 10.14309/ajg.0000000000002100. PMID: 36602835
Gastric cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Lordick F, Carneiro F, Cascinu S, Fleitas T, Haustermans K, Piessen G, Vogel A, Smyth EC; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2022 Oct;33(10):1005-1020. Epub 2022 Jul 29 doi: 10.1016/j.annonc.2022.07.004. PMID: 35914639
Advances in screening and detection of gastric cancer.
Xia JY, Aadam AA
J Surg Oncol 2022 Jun;125(7):1104-1109. doi: 10.1002/jso.26844. PMID: 35481909Free PMC Article

Recent clinical studies

Etiology

KLHL21 suppresses gastric tumourigenesis via maintaining STAT3 signalling equilibrium in stomach homoeostasis.
Huang XB, Huang Q, Jiang MC, Zhong Q, Zheng HL, Wang JB, Huang ZN, Wang HG, Liu ZY, Li YF, Xu KX, Lin M, Li P, Huang ZH, Xie JW, Lin JX, Lu J, Que JW, Zheng CH, Chen QY, Huang CM
Gut 2024 Oct 7;73(11):1785-1798. doi: 10.1136/gutjnl-2023-331111. PMID: 38969490
The interaction between autophagy, Helicobacter pylori, and gut microbiota in gastric carcinogenesis.
Nabavi-Rad A, Yadegar A, Sadeghi A, Aghdaei HA, Zali MR, Klionsky DJ, Yamaoka Y
Trends Microbiol 2023 Oct;31(10):1024-1043. Epub 2023 Apr 27 doi: 10.1016/j.tim.2023.04.001. PMID: 37120362Free PMC Article
Problems Associated with Deprescribing of Proton Pump Inhibitors.
Helgadottir H, Bjornsson ES
Int J Mol Sci 2019 Nov 2;20(21) doi: 10.3390/ijms20215469. PMID: 31684070Free PMC Article
Metaplasia in the Stomach-Precursor of Gastric Cancer?
Kinoshita H, Hayakawa Y, Koike K
Int J Mol Sci 2017 Sep 27;18(10) doi: 10.3390/ijms18102063. PMID: 28953255Free PMC Article
Redefining early gastric cancer.
Barreto SG, Windsor JA
Surg Endosc 2016 Jan;30(1):24-37. Epub 2015 Apr 1 doi: 10.1007/s00464-015-4184-z. PMID: 25829068

Diagnosis

Normal Components and Contaminants.
Dhillon J
Monogr Clin Cytol 2020;26:34-41. Epub 2020 Sep 28 doi: 10.1159/000455733. PMID: 32987395
Recent Advances in the Surgical Treatment of Advanced Gastric Cancer: A Review.
Tan Z
Med Sci Monit 2019 May 13;25:3537-3541. doi: 10.12659/MSM.916475. PMID: 31080234Free PMC Article
Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature.
Kai K, Satake M, Tokunaga O
World J Gastroenterol 2018 Jul 14;24(26):2915-2920. doi: 10.3748/wjg.v24.i26.2915. PMID: 30018486Free PMC Article
Biomarkers of gastric cancer: Current topics and future perspective.
Matsuoka T, Yashiro M
World J Gastroenterol 2018 Jul 14;24(26):2818-2832. doi: 10.3748/wjg.v24.i26.2818. PMID: 30018477Free PMC Article
Gastric Angiolipoma: A Rare Entity.
Liu YJ, Karamchandani DM
Arch Pathol Lab Med 2017 Jun;141(6):862-866. doi: 10.5858/arpa.2016-0239-RS. PMID: 28557598

Therapy

Microbiota in the stomach and application of probiotics to gastroduodenal diseases.
Koga Y
World J Gastroenterol 2022 Dec 21;28(47):6702-6715. doi: 10.3748/wjg.v28.i47.6702. PMID: 36620346Free PMC Article
MATTERHORN: phase III study of durvalumab plus FLOT chemotherapy in resectable gastric/gastroesophageal junction cancer.
Janjigian YY, Van Cutsem E, Muro K, Wainberg Z, Al-Batran SE, Hyung WJ, Molena D, Marcovitz M, Ruscica D, Robbins SH, Negro A, Tabernero J
Future Oncol 2022 Jun;18(20):2465-2473. Epub 2022 May 10 doi: 10.2217/fon-2022-0093. PMID: 35535555
Assessment of Pembrolizumab Therapy for the Treatment of Microsatellite Instability-High Gastric or Gastroesophageal Junction Cancer Among Patients in the KEYNOTE-059, KEYNOTE-061, and KEYNOTE-062 Clinical Trials.
Chao J, Fuchs CS, Shitara K, Tabernero J, Muro K, Van Cutsem E, Bang YJ, De Vita F, Landers G, Yen CJ, Chau I, Elme A, Lee J, Özgüroglu M, Catenacci D, Yoon HH, Chen E, Adelberg D, Shih CS, Shah S, Bhagia P, Wainberg ZA
JAMA Oncol 2021 Jun 1;7(6):895-902. doi: 10.1001/jamaoncol.2021.0275. PMID: 33792646Free PMC Article
Biomarkers of gastric cancer: Current topics and future perspective.
Matsuoka T, Yashiro M
World J Gastroenterol 2018 Jul 14;24(26):2818-2832. doi: 10.3748/wjg.v24.i26.2818. PMID: 30018477Free PMC Article
Current clinical management of gastrointestinal stromal tumor.
Akahoshi K, Oya M, Koga T, Shiratsuchi Y
World J Gastroenterol 2018 Jul 14;24(26):2806-2817. doi: 10.3748/wjg.v24.i26.2806. PMID: 30018476Free PMC Article

Prognosis

Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes.
Gullo I, Grillo F, Mastracci L, Vanoli A, Carneiro F, Saragoni L, Limarzi F, Ferro J, Parente P, Fassan M
Pathologica 2020 Sep;112(3):166-185. doi: 10.32074/1591-951X-166. PMID: 33179620Free PMC Article
Progress in cancer mortality, incidence, and survival: a global overview.
Santucci C, Carioli G, Bertuccio P, Malvezzi M, Pastorino U, Boffetta P, Negri E, Bosetti C, La Vecchia C
Eur J Cancer Prev 2020 Sep;29(5):367-381. doi: 10.1097/CEJ.0000000000000594. PMID: 32740162
Recent Advances in the Surgical Treatment of Advanced Gastric Cancer: A Review.
Tan Z
Med Sci Monit 2019 May 13;25:3537-3541. doi: 10.12659/MSM.916475. PMID: 31080234Free PMC Article
Global Cancer Incidence and Mortality Rates and Trends--An Update.
Torre LA, Siegel RL, Ward EM, Jemal A
Cancer Epidemiol Biomarkers Prev 2016 Jan;25(1):16-27. Epub 2015 Dec 14 doi: 10.1158/1055-9965.EPI-15-0578. PMID: 26667886
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F
Int J Cancer 2015 Mar 1;136(5):E359-86. Epub 2014 Oct 9 doi: 10.1002/ijc.29210. PMID: 25220842

Clinical prediction guides

Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing.
Zhang M, Hu S, Min M, Ni Y, Lu Z, Sun X, Wu J, Liu B, Ying X, Liu Y
Gut 2021 Mar;70(3):464-475. Epub 2020 Jun 12 doi: 10.1136/gutjnl-2019-320368. PMID: 32532891Free PMC Article
Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature.
Kai K, Satake M, Tokunaga O
World J Gastroenterol 2018 Jul 14;24(26):2915-2920. doi: 10.3748/wjg.v24.i26.2915. PMID: 30018486Free PMC Article
Biomarkers of gastric cancer: Current topics and future perspective.
Matsuoka T, Yashiro M
World J Gastroenterol 2018 Jul 14;24(26):2818-2832. doi: 10.3748/wjg.v24.i26.2818. PMID: 30018477Free PMC Article
Mucosal microbiome dysbiosis in gastric carcinogenesis.
Coker OO, Dai Z, Nie Y, Zhao G, Cao L, Nakatsu G, Wu WK, Wong SH, Chen Z, Sung JJY, Yu J
Gut 2018 Jun;67(6):1024-1032. Epub 2017 Aug 1 doi: 10.1136/gutjnl-2017-314281. PMID: 28765474Free PMC Article
MDCT imaging of the stomach: advances and applications.
Nagpal P, Prakash A, Pradhan G, Vidholia A, Nagpal N, Saboo SS, Kuehn DM, Khandelwal A
Br J Radiol 2017 Jan;90(1069):20160412. Epub 2016 Dec 8 doi: 10.1259/bjr.20160412. PMID: 27785936Free PMC Article

Recent systematic reviews

Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline.
Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Effect of Dietary Salt Intake on Risk of Gastric Cancer: A Systematic Review and Meta-Analysis of Case-Control Studies.
Wu X, Chen L, Cheng J, Qian J, Fang Z, Wu J
Nutrients 2022 Oct 12;14(20) doi: 10.3390/nu14204260. PMID: 36296944Free PMC Article
Risk factors for stomach cancer: a systematic review and meta-analysis.
Poorolajal J, Moradi L, Mohammadi Y, Cheraghi Z, Gohari-Ensaf F
Epidemiol Health 2020;42:e2020004. Epub 2020 Feb 2 doi: 10.4178/epih.e2020004. PMID: 32023777Free PMC Article
Risk Factors for Gastric Cancer: A Systematic Review.
Yusefi AR, Bagheri Lankarani K, Bastani P, Radinmanesh M, Kavosi Z
Asian Pac J Cancer Prev 2018 Mar 27;19(3):591-603. doi: 10.22034/APJCP.2018.19.3.591. PMID: 29579788Free PMC Article
Stomach cancer.
Bailey C
BMJ Clin Evid 2011 Mar 28;2011 PMID: 21439098Free PMC Article

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