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Colorectal Micropapillary Adenocarcinoma

MedGen UID:
474448
•Concept ID:
C3272815
•
Neoplastic Process

Definition

A rare, invasive colorectal adenocarcinoma characterized by the presence of clusters of malignant glandular cells within stromal spaces. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Micropapillary Adenocarcinoma

Professional guidelines

PubMed

The cytokeratin 17 expression in primary ovarian tumors has diagnostic but not prognostic significance.
Dundr P, Bazalová B, Bártů M, Bosse T, Drozenová J, Fabian P, Fadare O, Hausnerová J, Jakša R, Laco J, Lax SF, Matěj R, McCluggage WG, Méhes G, Michálková R, Němejcová K, Singh N, Stolnicu S, Škapa P, Švajdler M, Stružinská I
Virchows Arch 2022 Aug;481(2):201-212. Epub 2022 May 13 doi: 10.1007/s00428-022-03338-z. PMID: 35554675
Morphology Matters: A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases.
Jesinghaus M, Schmitt M, Lang C, Reiser M, Scheiter A, Konukiewitz B, Steiger K, Silva M, Tschurtschenthaler M, Lange S, Foersch S, Becker KF, Saur D, Friess H, Halfter K, Engel J, Boxberg M, Pfarr N, Wilhelm D, Weichert W
Am J Surg Pathol 2021 Jul 1;45(7):969-978. doi: 10.1097/PAS.0000000000001692. PMID: 34105518

Recent clinical studies

Etiology

Colorectal cancer with invasive micropapillary components (IMPCs) shows high lymph node metastasis and a poor prognosis: A retrospective clinical study.
Guo Z, Yang Z, Li D, Tang J, Xu J, Shen H, Yuan Y
Medicine (Baltimore) 2020 May 22;99(21):e20238. doi: 10.1097/MD.0000000000020238. PMID: 32481300Free PMC Article
Putative anoikis-resistant subpopulations in colorectal carcinoma: a marker of adverse prognosis.
Patankar M, Mattila T, Väyrynen JP, Klintrup K, Mäkelä J, Tuomisto A, Nieminen P, Mäkinen MJ, Karttunen TJ
APMIS 2020 May;128(5):390-400. Epub 2020 Apr 27 doi: 10.1111/apm.13041. PMID: 32202676
Colorectal micropapillary carcinomas are associated with poor prognosis and enriched in markers of stem cells.
Lee HJ, Eom DW, Kang GH, Han SH, Cheon GJ, Oh HS, Han KH, Ahn HJ, Jang HJ, Han MS
Mod Pathol 2013 Aug;26(8):1123-31. Epub 2012 Oct 12 doi: 10.1038/modpathol.2012.163. PMID: 23060121
Clinicopathological and molecular characterization of colorectal micropapillary carcinoma.
Verdú M, Román R, Calvo M, Rodón N, García B, González M, Vidal A, Puig X
Mod Pathol 2011 May;24(5):729-38. Epub 2011 Feb 18 doi: 10.1038/modpathol.2011.1. PMID: 21336262
Invasive colorectal micropapillary carcinoma: an aggressive variant of adenocarcinoma.
Kim MJ, Hong SM, Jang SJ, Yu E, Kim JS, Kim KR, Gong G, Ro JY
Hum Pathol 2006 Jul;37(7):809-15. doi: 10.1016/j.humpath.2005.10.018. PMID: 16784979

Diagnosis

The cytokeratin 17 expression in primary ovarian tumors has diagnostic but not prognostic significance.
Dundr P, Bazalová B, Bártů M, Bosse T, Drozenová J, Fabian P, Fadare O, Hausnerová J, Jakša R, Laco J, Lax SF, Matěj R, McCluggage WG, Méhes G, Michálková R, Němejcová K, Singh N, Stolnicu S, Škapa P, Švajdler M, Stružinská I
Virchows Arch 2022 Aug;481(2):201-212. Epub 2022 May 13 doi: 10.1007/s00428-022-03338-z. PMID: 35554675
The clinicopathological significance of micropapillary pattern in colorectal cancers.
Pyo JS, Park MJ, Kang DW
Hum Pathol 2018 Jul;77:159-165. Epub 2018 Apr 7 doi: 10.1016/j.humpath.2018.02.027. PMID: 29634975
Invasive micropapillary carcinoma: a distinct type of adenocarcinomas in the gastrointestinal tract.
Guzińska-Ustymowicz K, Niewiarowska K, Pryczynicz A
World J Gastroenterol 2014 Apr 28;20(16):4597-606. doi: 10.3748/wjg.v20.i16.4597. PMID: 24782612Free PMC Article
Combined morphologic and molecular classification for predicting lymph node metastasis in early-stage colorectal adenocarcinoma.
Ryu HS, Kim WH, Ahn S, Kim DW, Kang SB, Park HJ, Park YS, Lee CH, Lee HS
Ann Surg Oncol 2014 Jun;21(6):1809-16. Epub 2014 Feb 22 doi: 10.1245/s10434-014-3539-3. PMID: 24562932
Invasive micropapillary carcinoma of the ascending colon--a report of a case.
Shibuya H, Matsuda K, Shimada R, Horiuchi A, Iinuma H, Hayama T, Yamada H, Nozawa K, Ishihara S, Watanabe T
Int Surg 2011 Jan-Mar;96(1):82-6. doi: 10.9738/1355.1. PMID: 21675626

Therapy

Colorectal micropapillary carcinomas are associated with poor prognosis and enriched in markers of stem cells.
Lee HJ, Eom DW, Kang GH, Han SH, Cheon GJ, Oh HS, Han KH, Ahn HJ, Jang HJ, Han MS
Mod Pathol 2013 Aug;26(8):1123-31. Epub 2012 Oct 12 doi: 10.1038/modpathol.2012.163. PMID: 23060121

Prognosis

Colorectal cancer with invasive micropapillary components (IMPCs) shows high lymph node metastasis and a poor prognosis: A retrospective clinical study.
Guo Z, Yang Z, Li D, Tang J, Xu J, Shen H, Yuan Y
Medicine (Baltimore) 2020 May 22;99(21):e20238. doi: 10.1097/MD.0000000000020238. PMID: 32481300Free PMC Article
Micropapillary Structures in Colorectal Cancer: An Anoikis-resistant Subpopulation.
Patankar M, Väyrynen S, Tuomisto A, Mäkinen M, Eskelinen S, Karttunen TJ
Anticancer Res 2018 May;38(5):2915-2921. doi: 10.21873/anticanres.12539. PMID: 29715117
Invasive micropapillary carcinoma: a distinct type of adenocarcinomas in the gastrointestinal tract.
Guzińska-Ustymowicz K, Niewiarowska K, Pryczynicz A
World J Gastroenterol 2014 Apr 28;20(16):4597-606. doi: 10.3748/wjg.v20.i16.4597. PMID: 24782612Free PMC Article
Colorectal micropapillary carcinomas are associated with poor prognosis and enriched in markers of stem cells.
Lee HJ, Eom DW, Kang GH, Han SH, Cheon GJ, Oh HS, Han KH, Ahn HJ, Jang HJ, Han MS
Mod Pathol 2013 Aug;26(8):1123-31. Epub 2012 Oct 12 doi: 10.1038/modpathol.2012.163. PMID: 23060121
Colorectal adenocarcinoma with micropapillary pattern and its association with lymph node metastasis.
Haupt B, Ro JY, Schwartz MR, Shen SS
Mod Pathol 2007 Jul;20(7):729-33. Epub 2007 Apr 27 doi: 10.1038/modpathol.3800790. PMID: 17464318

Clinical prediction guides

Colorectal cancer with invasive micropapillary components (IMPCs) shows high lymph node metastasis and a poor prognosis: A retrospective clinical study.
Guo Z, Yang Z, Li D, Tang J, Xu J, Shen H, Yuan Y
Medicine (Baltimore) 2020 May 22;99(21):e20238. doi: 10.1097/MD.0000000000020238. PMID: 32481300Free PMC Article
Histological grading in colorectal cancer: new insights and perspectives.
Barresi V, Reggiani Bonetti L, Ieni A, Caruso RA, Tuccari G
Histol Histopathol 2015 Sep;30(9):1059-67. Epub 2015 May 25 doi: 10.14670/HH-11-633. PMID: 26004398
Invasive micropapillary carcinoma: a distinct type of adenocarcinomas in the gastrointestinal tract.
Guzińska-Ustymowicz K, Niewiarowska K, Pryczynicz A
World J Gastroenterol 2014 Apr 28;20(16):4597-606. doi: 10.3748/wjg.v20.i16.4597. PMID: 24782612Free PMC Article
Colorectal adenocarcinoma with micropapillary pattern and its association with lymph node metastasis.
Haupt B, Ro JY, Schwartz MR, Shen SS
Mod Pathol 2007 Jul;20(7):729-33. Epub 2007 Apr 27 doi: 10.1038/modpathol.3800790. PMID: 17464318
Invasive colorectal micropapillary carcinoma: an aggressive variant of adenocarcinoma.
Kim MJ, Hong SM, Jang SJ, Yu E, Kim JS, Kim KR, Gong G, Ro JY
Hum Pathol 2006 Jul;37(7):809-15. doi: 10.1016/j.humpath.2005.10.018. PMID: 16784979

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