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Ulcerative Colitis-Associated Colorectal Adenocarcinoma

MedGen UID:
474453
•Concept ID:
C3272820
•
Neoplastic Process
Synonyms: UC-Associated CRC; Ulcerative Colitis-Associated Colorectal Carcinoma

Definition

A colorectal adenocarcinoma that develops in patients with a history of ulcerative colitis. Such carcinomas are usually multiple and flat. Histologically, they are usually mucinous or signet-ring cell type. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUlcerative Colitis-Associated Colorectal Adenocarcinoma

Recent clinical studies

Etiology

Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article
Detection of nonpolypoid colorectal neoplasia using magnifying endoscopy in colonic inflammatory bowel disease.
Oka S, Tanaka S, Chayama K
Gastrointest Endosc Clin N Am 2014 Jul;24(3):405-17. doi: 10.1016/j.giec.2014.03.011. PMID: 24975531
Inflammatory bowel disease and colon cancer.
Jawad N, Direkze N, Leedham SJ
Recent Results Cancer Res 2011;185:99-115. doi: 10.1007/978-3-642-03503-6_6. PMID: 21822822
Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies.
Triantafillidis JK, Nasioulas G, Kosmidis PA
Anticancer Res 2009 Jul;29(7):2727-37. PMID: 19596953
Cancer in inflammatory bowel disease.
Xie J, Itzkowitz SH
World J Gastroenterol 2008 Jan 21;14(3):378-89. doi: 10.3748/wjg.14.378. PMID: 18200660Free PMC Article

Diagnosis

The molecular landscape of colitis-associated carcinogenesis.
Saraggi D, Fassan M, Mescoli C, Scarpa M, Valeri N, Michielan A, D'Incá R, Rugge M
Dig Liver Dis 2017 Apr;49(4):326-330. Epub 2016 Dec 21 doi: 10.1016/j.dld.2016.12.011. PMID: 28089111
Surgical resections of ulcerative colitis associated with dysplasia or carcinoma.
Sameshima S, Koketsu S, Takeshita E, Kubota Y, Okuyama T, Saito K, Ueda Y, Sawada T, Oya M
World J Surg Oncol 2015 Feb 21;13:70. doi: 10.1186/s12957-015-0499-4. PMID: 25884202Free PMC Article
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article
Detection of nonpolypoid colorectal neoplasia using magnifying endoscopy in colonic inflammatory bowel disease.
Oka S, Tanaka S, Chayama K
Gastrointest Endosc Clin N Am 2014 Jul;24(3):405-17. doi: 10.1016/j.giec.2014.03.011. PMID: 24975531
Inflammatory bowel disease and colon cancer.
Jawad N, Direkze N, Leedham SJ
Recent Results Cancer Res 2011;185:99-115. doi: 10.1007/978-3-642-03503-6_6. PMID: 21822822

Therapy

Surgical outcomes of Korean ulcerative colitis patients with and without colitis-associated cancer.
Yoon YS, Cho YB, Park KJ, Baik SH, Yoon SN, Ryoo SB, Lee KY, Kim H, Lee RA, Yu CS; IBD Study Group; Korean Society of Coloproctology
World J Gastroenterol 2015 Mar 28;21(12):3547-53. doi: 10.3748/wjg.v21.i12.3547. PMID: 25834319Free PMC Article
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article
Detection of nonpolypoid colorectal neoplasia using magnifying endoscopy in colonic inflammatory bowel disease.
Oka S, Tanaka S, Chayama K
Gastrointest Endosc Clin N Am 2014 Jul;24(3):405-17. doi: 10.1016/j.giec.2014.03.011. PMID: 24975531
The role of chemoprevention of colorectal cancer with 5-aminosalicylates in ulcerative colitis.
Herfarth H
Dig Dis 2012;30 Suppl 2:55-9. Epub 2012 Nov 23 doi: 10.1159/000341894. PMID: 23207933
Cancer in inflammatory bowel disease.
Xie J, Itzkowitz SH
World J Gastroenterol 2008 Jan 21;14(3):378-89. doi: 10.3748/wjg.14.378. PMID: 18200660Free PMC Article

Prognosis

The molecular landscape of colitis-associated carcinogenesis.
Saraggi D, Fassan M, Mescoli C, Scarpa M, Valeri N, Michielan A, D'Incá R, Rugge M
Dig Liver Dis 2017 Apr;49(4):326-330. Epub 2016 Dec 21 doi: 10.1016/j.dld.2016.12.011. PMID: 28089111
Prognosis of Ulcerative Colitis-Associated Colorectal Carcinoma Compared to Sporadic Colorectal Carcinoma: A Matched Pair Analysis.
Leowardi C, Schneider ML, Hinz U, Harnoss JM, Tarantino I, Lasitschka F, Ulrich A, Büchler MW, Kadmon M
Ann Surg Oncol 2016 Mar;23(3):870-6. Epub 2015 Oct 14 doi: 10.1245/s10434-015-4915-3. PMID: 26467453
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article
Inflammatory bowel disease and colon cancer.
Jawad N, Direkze N, Leedham SJ
Recent Results Cancer Res 2011;185:99-115. doi: 10.1007/978-3-642-03503-6_6. PMID: 21822822
Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies.
Triantafillidis JK, Nasioulas G, Kosmidis PA
Anticancer Res 2009 Jul;29(7):2727-37. PMID: 19596953

Clinical prediction guides

Clinical usefulness of endoscopic ultrasonography for the evaluation of ulcerative colitis-associated tumors.
Kobayashi K, Kawagishi K, Ooka S, Yokoyama K, Sada M, Koizumi W
World J Gastroenterol 2015 Mar 7;21(9):2693-9. doi: 10.3748/wjg.v21.i9.2693. PMID: 25759538Free PMC Article
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article
The role of chemoprevention of colorectal cancer with 5-aminosalicylates in ulcerative colitis.
Herfarth H
Dig Dis 2012;30 Suppl 2:55-9. Epub 2012 Nov 23 doi: 10.1159/000341894. PMID: 23207933
Relative role of methylator and tumor suppressor pathways in ulcerative colitis-associated colon cancer.
Sanchez JA, Dejulius KL, Bronner M, Church JM, Kalady MF
Inflamm Bowel Dis 2011 Sep;17(9):1966-70. Epub 2011 May 25 doi: 10.1002/ibd.21526. PMID: 21618350
Ulcerative colitis-associated colorectal cancer shows a poorer survival than sporadic colorectal cancer: a nationwide Japanese study.
Watanabe T, Konishi T, Kishimoto J, Kotake K, Muto T, Sugihara K; Japanese Society for Cancer of the Colon and Rectum
Inflamm Bowel Dis 2011 Mar;17(3):802-8. doi: 10.1002/ibd.21365. PMID: 20848547

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