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Inflammatory Hepatocellular Adenoma

MedGen UID:
474643
•Concept ID:
C3273010
•
Neoplastic Process
Synonyms: Telangiectatic Adenoma; Telangiectatic Hepatocellular Adenoma

Definition

A hepatocellular adenoma that occurs more often in women. It is characterized by increased levels of inflammation-associated proteins. It is usually associated with steatosis and obesity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInflammatory Hepatocellular Adenoma

Professional guidelines

PubMed

Hepatic adenoma: evolution of a more individualized treatment approach.
Aziz H, Underwood PW, Gosse MD, Afyouni S, Kamel I, Pawlik TM
J Gastrointest Surg 2024 Jun;28(6):975-982. Epub 2024 Mar 16 doi: 10.1016/j.gassur.2024.03.010. PMID: 38521190
Fat in mass in primary liver lesions: are usual MRI diagnostic criteria of both malignant and benign liver lesions still applicable?
Reizine E, Meurgey A, Amaddeo G, Laurent A, Calderaro J, Mule S, Luciani A
Abdom Radiol (NY) 2022 Jul;47(7):2347-2355. Epub 2022 Jun 7 doi: 10.1007/s00261-022-03561-x. PMID: 35672475

Recent clinical studies

Etiology

Hepatic adenoma: evolution of a more individualized treatment approach.
Aziz H, Underwood PW, Gosse MD, Afyouni S, Kamel I, Pawlik TM
J Gastrointest Surg 2024 Jun;28(6):975-982. Epub 2024 Mar 16 doi: 10.1016/j.gassur.2024.03.010. PMID: 38521190
The Human GP130 Cytokine Receptor and Its Expression-an Atlas and Functional Taxonomy of Genetic Variants.
Chen YH, van Zon S, Adams A, Schmidt-Arras D, Laurence ADJ, Uhlig HH
J Clin Immunol 2023 Dec 22;44(1):30. doi: 10.1007/s10875-023-01603-7. PMID: 38133879Free PMC Article
Hepatocellular adenomas: review of pathological and molecular features.
Beaufrère A, Paradis V
Hum Pathol 2021 Jun;112:128-137. Epub 2020 Dec 9 doi: 10.1016/j.humpath.2020.11.016. PMID: 33307077
Hepatocellular adenoma in Taiwan: Distinct ensemble of male predominance, overweight/obesity, and inflammatory subtype.
Huang WC, Liau JY, Jeng YM, Liu KL, Lin CN, Song HL, Tsai JH
J Gastroenterol Hepatol 2020 Apr;35(4):680-688. Epub 2019 Nov 7 doi: 10.1111/jgh.14903. PMID: 31698521
Hepatocellular adenoma: Classification, variants and clinical relevance.
Bioulac-Sage P, Sempoux C, Balabaud C
Semin Diagn Pathol 2017 Mar;34(2):112-125. Epub 2016 Dec 20 doi: 10.1053/j.semdp.2016.12.007. PMID: 28131467

Diagnosis

Hepatic adenoma: evolution of a more individualized treatment approach.
Aziz H, Underwood PW, Gosse MD, Afyouni S, Kamel I, Pawlik TM
J Gastrointest Surg 2024 Jun;28(6):975-982. Epub 2024 Mar 16 doi: 10.1016/j.gassur.2024.03.010. PMID: 38521190
β-Catenin-activated inflammatory hepatocellular adenoma with pigmentation and atypical features: a case report.
Wakasa Y, Toyoki Y, Kusumi T, Kameyama Y, Odagiri T, Jin H, Nakai M, Aoki K, Kawashima H, Endo M
Clin J Gastroenterol 2023 Apr;16(2):237-243. Epub 2023 Jan 14 doi: 10.1007/s12328-023-01757-2. PMID: 36640247
Hepatocellular adenomas: review of pathological and molecular features.
Beaufrère A, Paradis V
Hum Pathol 2021 Jun;112:128-137. Epub 2020 Dec 9 doi: 10.1016/j.humpath.2020.11.016. PMID: 33307077
Liver atoll sign: Inflammatory hepatocellular adenoma.
Xiang H, Han J, Ridley WE, Ridley LJ
J Med Imaging Radiat Oncol 2018 Oct;62 Suppl 1:89. doi: 10.1111/1754-9485.36_12784. PMID: 30309147
Distinction between inflammatory hepatocellular adenoma and mass effect on liver sampling.
Agostini-Vulaj D, Sharma AK, Findeis-Hosey JJ, McMahon LA, Gonzalez RS
Hum Pathol 2017 Mar;61:105-110. Epub 2016 Dec 15 doi: 10.1016/j.humpath.2016.12.001. PMID: 27989788

Therapy

Fenofibrate-induced massive regression of mutiple inflammatory hepatocellular adenoma.
Poupon R, Cazals-Hatem D, Arrivé L
Clin Res Hepatol Gastroenterol 2016 Feb;40(1):e1-3. Epub 2015 Nov 11 doi: 10.1016/j.clinre.2015.09.009. PMID: 26572747

Prognosis

The Human GP130 Cytokine Receptor and Its Expression-an Atlas and Functional Taxonomy of Genetic Variants.
Chen YH, van Zon S, Adams A, Schmidt-Arras D, Laurence ADJ, Uhlig HH
J Clin Immunol 2023 Dec 22;44(1):30. doi: 10.1007/s10875-023-01603-7. PMID: 38133879Free PMC Article
Liver contrast-enhanced sonography: computer-assisted differentiation between focal nodular hyperplasia and inflammatory hepatocellular adenoma by reference to microbubble transport patterns.
Denis de Senneville B, Frulio N, Laumonier H, Salut C, Lafitte L, Trillaud H
Eur Radiol 2020 May;30(5):2995-3003. Epub 2020 Jan 30 doi: 10.1007/s00330-019-06566-1. PMID: 32002637
Copper deposition in focal nodular hyperplasia and inflammatory hepatocellular adenoma.
Chandan VS, Shah SS, Mounajjed T, Torbenson MS, Wu TT
J Clin Pathol 2018 Jun;71(6):504-507. Epub 2017 Nov 10 doi: 10.1136/jclinpath-2017-204820. PMID: 29127141
Distinction between inflammatory hepatocellular adenoma and mass effect on liver sampling.
Agostini-Vulaj D, Sharma AK, Findeis-Hosey JJ, McMahon LA, Gonzalez RS
Hum Pathol 2017 Mar;61:105-110. Epub 2016 Dec 15 doi: 10.1016/j.humpath.2016.12.001. PMID: 27989788
Hepatic resection for inflammatory hepatocellular adenomas: pathological identification of micronodules expressing inflammatory proteins.
Bioulac-Sage P, Laumonier H, Cubel G, Rossi JZ, Balabaud C
Liver Int 2010 Jan;30(1):149-54. Epub 2009 Oct 20 doi: 10.1111/j.1478-3231.2009.02098.x. PMID: 19845852

Clinical prediction guides

The Human GP130 Cytokine Receptor and Its Expression-an Atlas and Functional Taxonomy of Genetic Variants.
Chen YH, van Zon S, Adams A, Schmidt-Arras D, Laurence ADJ, Uhlig HH
J Clin Immunol 2023 Dec 22;44(1):30. doi: 10.1007/s10875-023-01603-7. PMID: 38133879Free PMC Article
Hepatocellular adenomas: review of pathological and molecular features.
Beaufrère A, Paradis V
Hum Pathol 2021 Jun;112:128-137. Epub 2020 Dec 9 doi: 10.1016/j.humpath.2020.11.016. PMID: 33307077
Synchronous Unicentric Castleman Disease and Inflammatory Hepatocellular Adenoma: a Case Report.
De Vito C, Papathomas G T, Pedica F, Kane P, Amir A, Heaton N, Quaglia A
Ann Hepatol 2019 Jan-Feb;18(1):263-268. doi: 10.5604/01.3001.0012.7936. PMID: 31113603
Copper deposition in focal nodular hyperplasia and inflammatory hepatocellular adenoma.
Chandan VS, Shah SS, Mounajjed T, Torbenson MS, Wu TT
J Clin Pathol 2018 Jun;71(6):504-507. Epub 2017 Nov 10 doi: 10.1136/jclinpath-2017-204820. PMID: 29127141
Distinction between inflammatory hepatocellular adenoma and mass effect on liver sampling.
Agostini-Vulaj D, Sharma AK, Findeis-Hosey JJ, McMahon LA, Gonzalez RS
Hum Pathol 2017 Mar;61:105-110. Epub 2016 Dec 15 doi: 10.1016/j.humpath.2016.12.001. PMID: 27989788

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