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Inflammatory Hepatocellular Adenoma

MedGen UID:
474643
•Concept ID:
C3273010
•
Neoplastic Process
Synonyms: Telangiectatic Adenoma; Telangiectatic Hepatocellular Adenoma

Definition

A hepatocellular adenoma that occurs more often in women. It is characterized by increased levels of inflammation-associated proteins. It is usually associated with steatosis and obesity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInflammatory Hepatocellular Adenoma

Professional guidelines

PubMed

Fat in mass in primary liver lesions: are usual MRI diagnostic criteria of both malignant and benign liver lesions still applicable?
Reizine E, Meurgey A, Amaddeo G, Laurent A, Calderaro J, Mule S, Luciani A
Abdom Radiol (NY) 2022 Jul;47(7):2347-2355. Epub 2022 Jun 7 doi: 10.1007/s00261-022-03561-x. PMID: 35672475

Recent clinical studies

Etiology

Hepatocellular adenomas: review of pathological and molecular features.
Beaufrère A, Paradis V
Hum Pathol 2021 Jun;112:128-137. Epub 2020 Dec 9 doi: 10.1016/j.humpath.2020.11.016. PMID: 33307077
Liver contrast-enhanced sonography: computer-assisted differentiation between focal nodular hyperplasia and inflammatory hepatocellular adenoma by reference to microbubble transport patterns.
Denis de Senneville B, Frulio N, Laumonier H, Salut C, Lafitte L, Trillaud H
Eur Radiol 2020 May;30(5):2995-3003. Epub 2020 Jan 30 doi: 10.1007/s00330-019-06566-1. PMID: 32002637
Hepatocellular adenoma in Taiwan: Distinct ensemble of male predominance, overweight/obesity, and inflammatory subtype.
Huang WC, Liau JY, Jeng YM, Liu KL, Lin CN, Song HL, Tsai JH
J Gastroenterol Hepatol 2020 Apr;35(4):680-688. Epub 2019 Nov 7 doi: 10.1111/jgh.14903. PMID: 31698521
Hepatocellular adenoma: Classification, variants and clinical relevance.
Bioulac-Sage P, Sempoux C, Balabaud C
Semin Diagn Pathol 2017 Mar;34(2):112-125. Epub 2016 Dec 20 doi: 10.1053/j.semdp.2016.12.007. PMID: 28131467
Diagnosis of well-differentiated hepatocellular lesions: role of immunohistochemistry and other ancillary techniques.
Shafizadeh N, Kakar S
Adv Anat Pathol 2011 Nov;18(6):438-45. doi: 10.1097/PAP.0b013e318234abb4. PMID: 21993269

Diagnosis

Hepatocellular adenomas: review of pathological and molecular features.
Beaufrère A, Paradis V
Hum Pathol 2021 Jun;112:128-137. Epub 2020 Dec 9 doi: 10.1016/j.humpath.2020.11.016. PMID: 33307077
Hepatocellular adenoma in Taiwan: Distinct ensemble of male predominance, overweight/obesity, and inflammatory subtype.
Huang WC, Liau JY, Jeng YM, Liu KL, Lin CN, Song HL, Tsai JH
J Gastroenterol Hepatol 2020 Apr;35(4):680-688. Epub 2019 Nov 7 doi: 10.1111/jgh.14903. PMID: 31698521
Copper deposition in focal nodular hyperplasia and inflammatory hepatocellular adenoma.
Chandan VS, Shah SS, Mounajjed T, Torbenson MS, Wu TT
J Clin Pathol 2018 Jun;71(6):504-507. Epub 2017 Nov 10 doi: 10.1136/jclinpath-2017-204820. PMID: 29127141
Distinction between inflammatory hepatocellular adenoma and mass effect on liver sampling.
Agostini-Vulaj D, Sharma AK, Findeis-Hosey JJ, McMahon LA, Gonzalez RS
Hum Pathol 2017 Mar;61:105-110. Epub 2016 Dec 15 doi: 10.1016/j.humpath.2016.12.001. PMID: 27989788
Diagnosis of well-differentiated hepatocellular lesions: role of immunohistochemistry and other ancillary techniques.
Shafizadeh N, Kakar S
Adv Anat Pathol 2011 Nov;18(6):438-45. doi: 10.1097/PAP.0b013e318234abb4. PMID: 21993269

Therapy

Fenofibrate-induced massive regression of mutiple inflammatory hepatocellular adenoma.
Poupon R, Cazals-Hatem D, Arrivé L
Clin Res Hepatol Gastroenterol 2016 Feb;40(1):e1-3. Epub 2015 Nov 11 doi: 10.1016/j.clinre.2015.09.009. PMID: 26572747

Prognosis

Liver contrast-enhanced sonography: computer-assisted differentiation between focal nodular hyperplasia and inflammatory hepatocellular adenoma by reference to microbubble transport patterns.
Denis de Senneville B, Frulio N, Laumonier H, Salut C, Lafitte L, Trillaud H
Eur Radiol 2020 May;30(5):2995-3003. Epub 2020 Jan 30 doi: 10.1007/s00330-019-06566-1. PMID: 32002637
Copper deposition in focal nodular hyperplasia and inflammatory hepatocellular adenoma.
Chandan VS, Shah SS, Mounajjed T, Torbenson MS, Wu TT
J Clin Pathol 2018 Jun;71(6):504-507. Epub 2017 Nov 10 doi: 10.1136/jclinpath-2017-204820. PMID: 29127141
Distinction between inflammatory hepatocellular adenoma and mass effect on liver sampling.
Agostini-Vulaj D, Sharma AK, Findeis-Hosey JJ, McMahon LA, Gonzalez RS
Hum Pathol 2017 Mar;61:105-110. Epub 2016 Dec 15 doi: 10.1016/j.humpath.2016.12.001. PMID: 27989788
Hepatocellular carcinoma arising in adenoma: similar immunohistochemical and cytogenetic features in adenoma and hepatocellular carcinoma portions of the tumor.
Kakar S, Grenert JP, Paradis V, Pote N, Jakate S, Ferrell LD
Mod Pathol 2014 Nov;27(11):1499-1509. Epub 2014 Apr 18 doi: 10.1038/modpathol.2014.50. PMID: 24743216Free PMC Article
Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma.
Joseph NM, Ferrell LD, Jain D, Torbenson MS, Wu TT, Yeh MM, Kakar S
Mod Pathol 2014 Jan;27(1):62-72. Epub 2013 Jun 28 doi: 10.1038/modpathol.2013.114. PMID: 23807780

Clinical prediction guides

Hepatocellular adenomas: review of pathological and molecular features.
Beaufrère A, Paradis V
Hum Pathol 2021 Jun;112:128-137. Epub 2020 Dec 9 doi: 10.1016/j.humpath.2020.11.016. PMID: 33307077
Liver contrast-enhanced sonography: computer-assisted differentiation between focal nodular hyperplasia and inflammatory hepatocellular adenoma by reference to microbubble transport patterns.
Denis de Senneville B, Frulio N, Laumonier H, Salut C, Lafitte L, Trillaud H
Eur Radiol 2020 May;30(5):2995-3003. Epub 2020 Jan 30 doi: 10.1007/s00330-019-06566-1. PMID: 32002637
Synchronous Unicentric Castleman Disease and Inflammatory Hepatocellular Adenoma: a Case Report.
De Vito C, Papathomas G T, Pedica F, Kane P, Amir A, Heaton N, Quaglia A
Ann Hepatol 2019 Jan-Feb;18(1):263-268. doi: 10.5604/01.3001.0012.7936. PMID: 31113603
Copper deposition in focal nodular hyperplasia and inflammatory hepatocellular adenoma.
Chandan VS, Shah SS, Mounajjed T, Torbenson MS, Wu TT
J Clin Pathol 2018 Jun;71(6):504-507. Epub 2017 Nov 10 doi: 10.1136/jclinpath-2017-204820. PMID: 29127141
Distinction between inflammatory hepatocellular adenoma and mass effect on liver sampling.
Agostini-Vulaj D, Sharma AK, Findeis-Hosey JJ, McMahon LA, Gonzalez RS
Hum Pathol 2017 Mar;61:105-110. Epub 2016 Dec 15 doi: 10.1016/j.humpath.2016.12.001. PMID: 27989788

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