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Hepatocellular adenoma

MedGen UID:
61655
Concept ID:
C0206669
Neoplastic Process
Synonyms: Adenoma, Hepatocellular; Adenoma, Liver Cell; Adenomas, Hepatocellular; Adenomas, Liver Cell; Benign Hepatoma; Benign Hepatomas; Hepatocellular Adenoma; Hepatocellular Adenomas; Hepatoma, Benign; Hepatomas, Benign; Liver Cell Adenoma; Liver Cell Adenomas
SNOMED CT: HCA - Hepatocellular adenoma (78058005); Benign hepatoma (78058005); Liver cell adenoma (78058005); Hepatocellular adenoma (78058005); Hepatoma, benign (78058005); Adenoma of liver (424263008); Hepatocellular adenoma (1156419009)
 
HPO: HP:0012028
Monarch Initiative: MONDO:0018902
Orphanet: ORPHA54272

Definition

A benign tumor of the liver of presumably epithelial origin. [from HPO]

Conditions with this feature

Hepatic adenomas, familial
MedGen UID:
374515
Concept ID:
C1840646
Disease or Syndrome

Professional guidelines

PubMed

Myers L, Ahn J
Clin Liver Dis 2020 Aug;24(3):389-403. Epub 2020 Jun 3 doi: 10.1016/j.cld.2020.04.013. PMID: 32620279
Klompenhouwer AJ, de Man RA, Dioguardi Burgio M, Vilgrain V, Zucman-Rossi J, Ijzermans JNM
Liver Int 2020 Jul;40(7):1529-1537. Epub 2020 Jun 11 doi: 10.1111/liv.14547. PMID: 32464711Free PMC Article
Marrero JA, Ahn J, Rajender Reddy K; Americal College of Gastroenterology
Am J Gastroenterol 2014 Sep;109(9):1328-47; quiz 1348. Epub 2014 Aug 19 doi: 10.1038/ajg.2014.213. PMID: 25135008

Recent clinical studies

Etiology

Wang X, Zhang X
World J Gastroenterol 2022 Apr 14;28(14):1384-1393. doi: 10.3748/wjg.v28.i14.1384. PMID: 35582672Free PMC Article
Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Myers L, Ahn J
Clin Liver Dis 2020 Aug;24(3):389-403. Epub 2020 Jun 3 doi: 10.1016/j.cld.2020.04.013. PMID: 32620279
Rebouissou S, Nault JC
J Hepatol 2020 Feb;72(2):215-229. doi: 10.1016/j.jhep.2019.08.017. PMID: 31954487
Nault JC, Couchy G, Balabaud C, Morcrette G, Caruso S, Blanc JF, Bacq Y, Calderaro J, Paradis V, Ramos J, Scoazec JY, Gnemmi V, Sturm N, Guettier C, Fabre M, Savier E, Chiche L, Labrune P, Selves J, Wendum D, Pilati C, Laurent A, De Muret A, Le Bail B, Rebouissou S, Imbeaud S; GENTHEP Investigators, Bioulac-Sage P, Letouzé E, Zucman-Rossi J
Gastroenterology 2017 Mar;152(4):880-894.e6. Epub 2016 Dec 7 doi: 10.1053/j.gastro.2016.11.042. PMID: 27939373

Diagnosis

Reizine E, Mulé S, Luciani A
Radiol Clin North Am 2022 Sep;60(5):755-773. Epub 2022 Jul 4 doi: 10.1016/j.rcl.2022.05.005. PMID: 35989043
LeGout JD, Bolan CW, Bowman AW, Caserta MP, Chen FK, Cox KL, Sanyal R, Toskich BB, Lewis JT, Alexander LF
Radiographics 2022 Jul-Aug;42(4):1043-1061. Epub 2022 Jun 10 doi: 10.1148/rg.210156. PMID: 35687520
Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Takahashi Y, Dungubat E, Kusano H, Ganbat D, Tomita Y, Odgerel S, Fukusato T
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115780. PMID: 34071338Free PMC Article
Myers L, Ahn J
Clin Liver Dis 2020 Aug;24(3):389-403. Epub 2020 Jun 3 doi: 10.1016/j.cld.2020.04.013. PMID: 32620279

Therapy

McKay B, Webber L, Manoharan B, Miller G, Clouston A, Bryant R, Cavallucci D, O'Rourke N
ANZ J Surg 2020 Jun;90(6):1099-1103. Epub 2020 Jan 26 doi: 10.1111/ans.15702. PMID: 31983071
Rebouissou S, Nault JC
J Hepatol 2020 Feb;72(2):215-229. doi: 10.1016/j.jhep.2019.08.017. PMID: 31954487
Renzulli M, Clemente A, Tovoli F, Cappabianca S, Bolondi L, Golfieri R
World J Gastroenterol 2019 May 28;25(20):2442-2449. doi: 10.3748/wjg.v25.i20.2442. PMID: 31171888Free PMC Article
Frulio N, Chiche L, Bioulac-Sage P, Balabaud C
Clin Res Hepatol Gastroenterol 2014 Apr;38(2):132-6. Epub 2013 Oct 11 doi: 10.1016/j.clinre.2013.08.004. PMID: 24126236
Lin H, van den Esschert J, Liu C, van Gulik TM
J Gastroenterol Hepatol 2011 Jan;26(1):28-35. doi: 10.1111/j.1440-1746.2010.06502.x. PMID: 21175790

Prognosis

Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Hahn E, Putra J
World J Gastroenterol 2020 May 21;26(19):2294-2304. doi: 10.3748/wjg.v26.i19.2294. PMID: 32476794Free PMC Article
Rebouissou S, Nault JC
J Hepatol 2020 Feb;72(2):215-229. doi: 10.1016/j.jhep.2019.08.017. PMID: 31954487
Sempoux C, Chang C, Gouw A, Chiche L, Zucman-Rossi J, Balabaud C, Bioulac-Sage P
Clin Res Hepatol Gastroenterol 2013 Sep;37(4):322-7. Epub 2013 Jul 19 doi: 10.1016/j.clinre.2013.04.008. PMID: 23876350
Lin H, van den Esschert J, Liu C, van Gulik TM
J Gastroenterol Hepatol 2011 Jan;26(1):28-35. doi: 10.1111/j.1440-1746.2010.06502.x. PMID: 21175790

Clinical prediction guides

Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Haring MPD, Cuperus FJC, Duiker EW, de Haas RJ, de Meijer VE
BMJ Open Gastroenterol 2021 Aug;8(1) doi: 10.1136/bmjgast-2020-000592. PMID: 34362758Free PMC Article
Beaufrère A, Paradis V
Hum Pathol 2021 Jun;112:128-137. Epub 2020 Dec 9 doi: 10.1016/j.humpath.2020.11.016. PMID: 33307077
Rebouissou S, Nault JC
J Hepatol 2020 Feb;72(2):215-229. doi: 10.1016/j.jhep.2019.08.017. PMID: 31954487
Lin H, van den Esschert J, Liu C, van Gulik TM
J Gastroenterol Hepatol 2011 Jan;26(1):28-35. doi: 10.1111/j.1440-1746.2010.06502.x. PMID: 21175790

Recent systematic reviews

Haring MPD, Spijkerboer CS, Cuperus FJC, Duiker EW, de Jong KP, de Haas RJ, de Meijer VE
HPB (Oxford) 2021 Aug;23(8):1152-1163. Epub 2021 Apr 28 doi: 10.1016/j.hpb.2021.04.019. PMID: 33985906
van Rosmalen BV, Coelen RJS, Bieze M, van Delden OM, Verheij J, Dejong CHC, van Gulik TM
Br J Surg 2017 Jun;104(7):823-835. doi: 10.1002/bjs.10547. PMID: 28518415
McInnes MD, Hibbert RM, Inácio JR, Schieda N
Radiology 2015 Nov;277(2):413-23. Epub 2015 May 26 doi: 10.1148/radiol.2015142986. PMID: 26020440
van Aalten SM, de Man RA, IJzermans JN, Terkivatan T
Br J Surg 2012 Jul;99(7):911-6. Epub 2012 May 22 doi: 10.1002/bjs.8762. PMID: 22619025
Lin H, van den Esschert J, Liu C, van Gulik TM
J Gastroenterol Hepatol 2011 Jan;26(1):28-35. doi: 10.1111/j.1440-1746.2010.06502.x. PMID: 21175790

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