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Biliary Adenofibroma

MedGen UID:
474699
•Concept ID:
C3273066
•
Neoplastic Process
Synonym: Intrahepatic Bile Duct Adenofibroma

Definition

A rare benign neoplasm that arises from the intrahepatic bile ducts. It is characterized by the presence of biliary epithelial tissue and fibroblastic stroma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBiliary Adenofibroma

Recent clinical studies

Etiology

Intrahepatic cholangiocarcinoma: typical features, uncommon variants, and controversial related entities.
Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170
Imaging features of biliary adenofibroma of the liver with malignant transformation: a case report with literature review.
Hu W, Zhao Y, Liu Y, Hua Z, Liu A
BMC Med Imaging 2022 Mar 17;22(1):47. doi: 10.1186/s12880-022-00775-9. PMID: 35296268Free PMC Article
Robotic enucleation of a biliary adenofibroma.
Blears E, Uemura T, Bunker M
BMJ Case Rep 2021 Aug 10;14(8) doi: 10.1136/bcr-2021-242737. PMID: 34376413Free PMC Article
Reduced mobilisation of hematopoietic stem cells after hepatic resection for malignant liver disease.
Menegazzo M, Bagatella P, Marson P, Donadel C, De Silvestro G, Corsini A
Pathol Oncol Res 2008 Dec;14(4):381-5. Epub 2008 Aug 28 doi: 10.1007/s12253-008-9091-3. PMID: 18752047

Diagnosis

Contrast-enhanced ultrasound characteristics for the diagnosis of biliary adenofibroma.
Gerhardt F, Blank V, Prasse G, Wiegand J, Rademacher S, von Laffert M, Karlas T
Ultraschall Med 2024 Feb;45(1):84-86. Epub 2023 Dec 11 doi: 10.1055/a-2209-5837. PMID: 38081210
Multimodal imaging findings of intrahepatic cholangiocarcinoma arising from a biliary adenofibroma: a case report with radiological-pathological correlation.
Kanemaru N, Nakai Y, Watadani T, Nakao T, Hinata M, Nakazawa A, Akamatsu N, Ushiku T, Hasegawa K, Abe O
Abdom Radiol (NY) 2023 Aug;48(8):2469-2476. Epub 2023 Apr 19 doi: 10.1007/s00261-023-03908-y. PMID: 37074475Free PMC Article
Multiple Biliary Adenofibromas with Adenocarcinoma of Gallbladder: Histopathological Conundrum.
Ahuja N, Mitra S, Bal A, Das A, Tandup C, Krishnaraju VS
J Gastrointest Cancer 2023 Sep;54(3):986-988. Epub 2022 Sep 1 doi: 10.1007/s12029-022-00857-5. PMID: 36048315
Intrahepatic cholangiocarcinoma: typical features, uncommon variants, and controversial related entities.
Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170
Biliary Adenofibroma of Liver: Morphology, Tumor Genetics, and Outcomes in 6 Cases.
Arnason T, Borger DR, Corless C, Hagen C, Iafrate AJ, Makhlouf H, Misdraji J, Sapp H, Tsui WM, Wanless IR, Zuluaga Toro T, Lauwers GY
Am J Surg Pathol 2017 Apr;41(4):499-505. doi: 10.1097/PAS.0000000000000773. PMID: 28266931

Prognosis

Robotic enucleation of a biliary adenofibroma.
Blears E, Uemura T, Bunker M
BMJ Case Rep 2021 Aug 10;14(8) doi: 10.1136/bcr-2021-242737. PMID: 34376413Free PMC Article
A case of unclassified multicystic biliary tumor with biliary adenofibroma features.
Kai K, Yakabe T, Kohya N, Miyoshi A, Iwane S, Mizuta T, Miyazaki K, Tokunaga O
Pathol Int 2012 Jul;62(7):506-10. Epub 2012 May 10 doi: 10.1111/j.1440-1827.2012.02830.x. PMID: 22726072
Biliary adenofibroma. A heretofore unrecognized benign biliary tumor of the liver.
Tsui WM, Loo KT, Chow LT, Tse CC
Am J Surg Pathol 1993 Feb;17(2):186-92. PMID: 8422113

Clinical prediction guides

A Case of Multicystic Biliary Hamartoma with a Marked Peribiliary Gland Component Successfully Treated by Purely Laparoscopic Anatomical Liver Resection.
Kai K, Ide T, Tanaka T, Yukimoto K, Irie H, Noshiro H, Aishima S
J Gastrointest Cancer 2023 Sep;54(3):996-999. Epub 2022 Nov 30 doi: 10.1007/s12029-022-00893-1. PMID: 36449146Free PMC Article
Intrahepatic cholangiocarcinoma: typical features, uncommon variants, and controversial related entities.
Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170
Robotic enucleation of a biliary adenofibroma.
Blears E, Uemura T, Bunker M
BMJ Case Rep 2021 Aug 10;14(8) doi: 10.1136/bcr-2021-242737. PMID: 34376413Free PMC Article
Reduced mobilisation of hematopoietic stem cells after hepatic resection for malignant liver disease.
Menegazzo M, Bagatella P, Marson P, Donadel C, De Silvestro G, Corsini A
Pathol Oncol Res 2008 Dec;14(4):381-5. Epub 2008 Aug 28 doi: 10.1007/s12253-008-9091-3. PMID: 18752047
Biliary adenofibroma: a rare neoplasm of bile duct origin with an indolent behavior.
Varnholt H, Vauthey JN, Dal Cin P, Marsh Rde W, Bhathal PS, Hughes NR, Lauwers GY
Am J Surg Pathol 2003 May;27(5):693-8. doi: 10.1097/00000478-200305000-00014. PMID: 12717255

Recent systematic reviews

Imaging features of biliary adenofibroma of the liver with malignant transformation: a case report with literature review.
Hu W, Zhao Y, Liu Y, Hua Z, Liu A
BMC Med Imaging 2022 Mar 17;22(1):47. doi: 10.1186/s12880-022-00775-9. PMID: 35296268Free PMC Article

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