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Benign Liver Epithelial Neoplasm

MedGen UID:
474640
Concept ID:
C3273007
Neoplastic Process
Synonym: Benign Liver and Intrahepatic Bile Duct Epithelial Neoplasm

Definition

A neoplasm that arises from the hepatocytes or intrahepatic bile duct epithelial cells and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include hepatocellular adenoma and bile duct adenoma. [from NCI]

Professional guidelines

PubMed

Nault JC, Paradis V, Ronot M, Zucman-Rossi J
Nat Rev Gastroenterol Hepatol 2022 Nov;19(11):703-716. Epub 2022 Jul 14 doi: 10.1038/s41575-022-00643-5. PMID: 35835851
Myers L, Ahn J
Clin Liver Dis 2020 Aug;24(3):389-403. Epub 2020 Jun 3 doi: 10.1016/j.cld.2020.04.013. PMID: 32620279
Marrero JA, Ahn J, Rajender Reddy K; Americal College of Gastroenterology
Am J Gastroenterol 2014 Sep;109(9):1328-47; quiz 1348. Epub 2014 Aug 19 doi: 10.1038/ajg.2014.213. PMID: 25135008

Recent clinical studies

Etiology

Gelders F, Struyve M, van Malenstein H
Acta Gastroenterol Belg 2023 Jul-Sep;86(3):483-485. doi: 10.51821/86.3.11733. PMID: 37814564
Nault JC, Paradis V, Ronot M, Zucman-Rossi J
Nat Rev Gastroenterol Hepatol 2022 Nov;19(11):703-716. Epub 2022 Jul 14 doi: 10.1038/s41575-022-00643-5. PMID: 35835851
Wang X, Zhang X
World J Gastroenterol 2022 Apr 14;28(14):1384-1393. doi: 10.3748/wjg.v28.i14.1384. PMID: 35582672Free PMC Article
Vallianou N, Christodoulatos GS, Karampela I, Tsilingiris D, Magkos F, Stratigou T, Kounatidis D, Dalamaga M
Biomolecules 2021 Dec 31;12(1) doi: 10.3390/biom12010056. PMID: 35053205Free PMC Article
Myers L, Ahn J
Clin Liver Dis 2020 Aug;24(3):389-403. Epub 2020 Jun 3 doi: 10.1016/j.cld.2020.04.013. PMID: 32620279

Diagnosis

Reizine E, Mulé S, Luciani A
Radiol Clin North Am 2022 Sep;60(5):755-773. Epub 2022 Jul 4 doi: 10.1016/j.rcl.2022.05.005. PMID: 35989043
Nault JC, Paradis V, Ronot M, Zucman-Rossi J
Nat Rev Gastroenterol Hepatol 2022 Nov;19(11):703-716. Epub 2022 Jul 14 doi: 10.1038/s41575-022-00643-5. PMID: 35835851
Pittman ME, Yantiss RK
Surg Pathol Clin 2018 Jun;11(2):453-466. Epub 2018 Mar 26 doi: 10.1016/j.path.2018.02.012. PMID: 29751885
Vyas M, Jain D
Indian J Pathol Microbiol 2018 Jan-Mar;61(1):2-17. doi: 10.4103/IJPM.IJPM_578_17. PMID: 29567877
Marrero JA, Ahn J, Rajender Reddy K; Americal College of Gastroenterology
Am J Gastroenterol 2014 Sep;109(9):1328-47; quiz 1348. Epub 2014 Aug 19 doi: 10.1038/ajg.2014.213. PMID: 25135008

Therapy

Li L, Zou X, Zheng W, Li Y, Xu X, Li K, Su Z, Han J, Li Q, Zuo Y, Xie S, Wen H, Wang J, Guo Z, Zou R, Zhou J
Radiology 2023 Aug;308(2):e230150. doi: 10.1148/radiol.230150. PMID: 37642573
Renzulli M, Clemente A, Tovoli F, Cappabianca S, Bolondi L, Golfieri R
World J Gastroenterol 2019 May 28;25(20):2442-2449. doi: 10.3748/wjg.v25.i20.2442. PMID: 31171888Free PMC Article
Cillo U, Fondevila C, Donadon M, Gringeri E, Mocchegiani F, Schlitt HJ, Ijzermans JNM, Vivarelli M, Zieniewicz K, Olde Damink SWM, Groot Koerkamp B
Liver Int 2019 May;39 Suppl 1(Suppl Suppl 1):143-155. doi: 10.1111/liv.14089. PMID: 30843343Free PMC Article
Wang S, Bromley E, Xu L, Chen JC, Keltner L
Expert Opin Pharmacother 2010 Jan;11(1):133-40. doi: 10.1517/14656560903463893. PMID: 20001435
Kirk ME
Int J Gynaecol Obstet 1978-1979;16(6):473-8. doi: 10.1002/j.1879-3479.1979.tb00952.x. PMID: 39811

Prognosis

Das R, Singhi AD, Slivka A
Gastroenterol Clin North Am 2022 Sep;51(3):519-535. Epub 2022 Aug 30 doi: 10.1016/j.gtc.2022.06.003. PMID: 36153108
Nault JC, Paradis V, Ronot M, Zucman-Rossi J
Nat Rev Gastroenterol Hepatol 2022 Nov;19(11):703-716. Epub 2022 Jul 14 doi: 10.1038/s41575-022-00643-5. PMID: 35835851
Vallianou N, Christodoulatos GS, Karampela I, Tsilingiris D, Magkos F, Stratigou T, Kounatidis D, Dalamaga M
Biomolecules 2021 Dec 31;12(1) doi: 10.3390/biom12010056. PMID: 35053205Free PMC Article
Mar WA, Chan HK, Trivedi SB, Berggruen SM
Semin Ultrasound CT MR 2021 Aug;42(4):366-380. Epub 2021 Apr 20 doi: 10.1053/j.sult.2021.04.001. PMID: 34130849
Zhu C, Tabas I, Schwabe RF, Pajvani UB
Nat Rev Gastroenterol Hepatol 2021 Feb;18(2):131-142. Epub 2020 Oct 13 doi: 10.1038/s41575-020-00365-6. PMID: 33051603Free PMC Article

Clinical prediction guides

Schima W, Kopf H, Eisenhuber E
Rofo 2023 Jun;195(6):486-494. Epub 2023 Feb 1 doi: 10.1055/a-1990-5924. PMID: 36724803
Cao LL, Peng M, Xie X, Chen GQ, Huang SY, Wang JY, Jiang F, Cui XW, Dietrich CF
World J Gastroenterol 2022 Jul 21;28(27):3398-3409. doi: 10.3748/wjg.v28.i27.3398. PMID: 36158262Free PMC Article
Nault JC, Paradis V, Ronot M, Zucman-Rossi J
Nat Rev Gastroenterol Hepatol 2022 Nov;19(11):703-716. Epub 2022 Jul 14 doi: 10.1038/s41575-022-00643-5. PMID: 35835851
Vallianou N, Christodoulatos GS, Karampela I, Tsilingiris D, Magkos F, Stratigou T, Kounatidis D, Dalamaga M
Biomolecules 2021 Dec 31;12(1) doi: 10.3390/biom12010056. PMID: 35053205Free PMC Article
Ballestri S, Tana C, Di Girolamo M, Fontana MC, Capitelli M, Lonardo A, Cioni G
Curr Pharm Des 2020;26(32):3915-3927. doi: 10.2174/1381612826666200417142444. PMID: 32303161

Recent systematic reviews

Ciocan A, Margarit S, Bartos A, Ciobanu L, Iancu I, A Ciocan R, Al Hajjar N
Ann Ital Chir 2023;94:580-586. PMID: 38131361
Lee S, Kim YY, Shin J, Son WJ, Roh YH, Choi JY, Sirlin CB, Chernyak V
Radiology 2023 Apr;307(1):e220646. Epub 2023 Jan 10 doi: 10.1148/radiol.220646. PMID: 36625748
Haring MPD, Spijkerboer CS, Cuperus FJC, Duiker EW, de Jong KP, de Haas RJ, de Meijer VE
HPB (Oxford) 2021 Aug;23(8):1152-1163. Epub 2021 Apr 28 doi: 10.1016/j.hpb.2021.04.019. PMID: 33985906
Nilsson LN, Keane MG, Shamali A, Millastre Bocos J, Marijinissen van Zanten M, Antila A, Verdejo Gil C, Del Chiaro M, Laukkarinen J
Pancreatology 2016 Nov-Dec;16(6):1028-1036. Epub 2016 Sep 20 doi: 10.1016/j.pan.2016.09.011. PMID: 27681503
Colli A, Fraquelli M, Massironi S, Colucci A, Paggi S, Conte D
Cochrane Database Syst Rev 2007 Jan 24;2007(1):CD005164. doi: 10.1002/14651858.CD005164.pub2. PMID: 17253542Free PMC Article

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