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Gallbladder Adenocarcinoma, Biliary Type

MedGen UID:
474746
•Concept ID:
C3273113
•
Neoplastic Process

Definition

A well or moderately differentiated adenocarcinoma that arises from the gallbladder. It is the most common type of gallbladder carcinoma and is characterized by the presence of malignant tubular glands. Intestinal differentiation may be present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder Adenocarcinoma, Biliary Type

Professional guidelines

PubMed

Intraductal tubulopapillary neoplasms of the bile ducts: identity, clinicopathologic characteristics, and differential diagnosis of a distinct entity among intraductal tumors.
Pehlivanoglu B, Adsay V
Hum Pathol 2023 Feb;132:12-19. Epub 2022 Aug 5 doi: 10.1016/j.humpath.2022.07.019. PMID: 35934108
A Systematic Review and Meta-analysis of Intraluminal Brachytherapy Versus Stent Alone in the Treatment of Malignant Obstructive Jaundice.
Xu X, Li J, Wu J, Zhu R, Ji W
Cardiovasc Intervent Radiol 2018 Feb;41(2):206-217. Epub 2017 Oct 26 doi: 10.1007/s00270-017-1827-6. PMID: 29075881
Biliary tract malignancies: a population-based study on incidence, prognosis and management of patients.
Juliusson G, Jonasson JG, Jonsdottir SB, Garcia HG, Olafsdottir E, Möller PH, Björnsson ES
Scand J Gastroenterol 2016 Dec;51(12):1520-1525. Epub 2016 Aug 24 doi: 10.1080/00365521.2016.1218538. PMID: 27553174

Recent clinical studies

Etiology

Comparison of clinicopathological characteristics of mucinous adenocarcinoma and conventional adenocarcinoma of gallbladder.
Zou RQ, Hu HJ, Liu F, Lv TR, Wang JK, Regmi P, Li FY
Asian J Surg 2023 Jan;46(1):283-290. Epub 2022 Apr 11 doi: 10.1016/j.asjsur.2022.03.094. PMID: 35422386
Imaging Features of Premalignant Biliary Lesions and Predisposing Conditions with Pathologic Correlation.
Zulfiqar M, Chatterjee D, Yoneda N, Hoegger MJ, Ronot M, Hecht EM, Bastati N, Ba-Ssalamah A, Bashir MR, Fowler K
Radiographics 2022 Sep-Oct;42(5):1320-1337. Epub 2022 Aug 5 doi: 10.1148/rg.210194. PMID: 35930475
Gallbladder Cancer: A Single-Institution 10-Year Experience-Analysis of Adenocarcinoma Subtypes and Tumors Arising from Intracholecystic Papillary Neoplasms.
Berger Y, Sullivan BJ, Leigh NL, Bekhor EY, Dhorajiya P, Mani M, Magge DR, Cha DE, Sarpel U, Hiotis SP, Labow DM, Ward SC, Golas BJ, Cohen NA
Ann Surg Oncol 2022 Aug;29(8):5167-5175. Epub 2022 Apr 18 doi: 10.1245/s10434-022-11719-6. PMID: 35437668
Menopausal hormone therapy and risk of biliary tract cancers.
Jackson SS, Pfeiffer RM, Gabbi C, Anderson L, Gadalla SM, Koshiol J
Hepatology 2022 Feb;75(2):309-321. doi: 10.1002/hep.32198. PMID: 34766362Free PMC Article
Current controversies in cholangiocarcinoma.
Hoyos S, Navas MC, Restrepo JC, Botero RC
Biochim Biophys Acta Mol Basis Dis 2018 Apr;1864(4 Pt B):1461-1467. Epub 2017 Jul 26 doi: 10.1016/j.bbadis.2017.07.027. PMID: 28756216

Diagnosis

Imaging Features of Premalignant Biliary Lesions and Predisposing Conditions with Pathologic Correlation.
Zulfiqar M, Chatterjee D, Yoneda N, Hoegger MJ, Ronot M, Hecht EM, Bastati N, Ba-Ssalamah A, Bashir MR, Fowler K
Radiographics 2022 Sep-Oct;42(5):1320-1337. Epub 2022 Aug 5 doi: 10.1148/rg.210194. PMID: 35930475
Menopausal hormone therapy and risk of biliary tract cancers.
Jackson SS, Pfeiffer RM, Gabbi C, Anderson L, Gadalla SM, Koshiol J
Hepatology 2022 Feb;75(2):309-321. doi: 10.1002/hep.32198. PMID: 34766362Free PMC Article
Luschka Ducts of the Gallbladder in Adults: Case Series Report and Review of the Medical Literature.
Handra-Luca A, Ben Romdhane HM, Hong SM
Int J Surg Pathol 2020 Aug;28(5):482-489. Epub 2020 Jan 26 doi: 10.1177/1066896920901334. PMID: 31983263
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.
Wardell CP, Fujita M, Yamada T, Simbolo M, Fassan M, Karlic R, Polak P, Kim J, Hatanaka Y, Maejima K, Lawlor RT, Nakanishi Y, Mitsuhashi T, Fujimoto A, Furuta M, Ruzzenente A, Conci S, Oosawa A, Sasaki-Oku A, Nakano K, Tanaka H, Yamamoto Y, Michiaki K, Kawakami Y, Aikata H, Ueno M, Hayami S, Gotoh K, Ariizumi SI, Yamamoto M, Yamaue H, Chayama K, Miyano S, Getz G, Scarpa A, Hirano S, Nakamura T, Nakagawa H
J Hepatol 2018 May;68(5):959-969. Epub 2018 Jan 31 doi: 10.1016/j.jhep.2018.01.009. PMID: 29360550
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264

Therapy

Menopausal hormone therapy and risk of biliary tract cancers.
Jackson SS, Pfeiffer RM, Gabbi C, Anderson L, Gadalla SM, Koshiol J
Hepatology 2022 Feb;75(2):309-321. doi: 10.1002/hep.32198. PMID: 34766362Free PMC Article
Molecular Characterization of Biliary Tract Cancer Predicts Chemotherapy and Programmed Death 1/Programmed Death-Ligand 1 Blockade Responses.
Yoon JG, Kim MH, Jang M, Kim H, Hwang HK, Kang CM, Lee WJ, Kang B, Lee CK, Lee MG, Chung HC, Choi HJ, Park YN
Hepatology 2021 Oct;74(4):1914-1931. Epub 2021 Jul 29 doi: 10.1002/hep.31862. PMID: 33884649
Covered and uncovered biliary metal stents provide similar relief of biliary obstruction during neoadjuvant therapy in pancreatic cancer: a randomized trial.
Seo DW, Sherman S, Dua KS, Slivka A, Roy A, Costamagna G, Deviere J, Peetermans J, Rousseau M, Nakai Y, Isayama H, Kozarek R; Biliary SEMS During Neoadjuvant Therapy Study Group
Gastrointest Endosc 2019 Oct;90(4):602-612.e4. Epub 2019 Jul 2 doi: 10.1016/j.gie.2019.06.032. PMID: 31276674
Current controversies in cholangiocarcinoma.
Hoyos S, Navas MC, Restrepo JC, Botero RC
Biochim Biophys Acta Mol Basis Dis 2018 Apr;1864(4 Pt B):1461-1467. Epub 2017 Jul 26 doi: 10.1016/j.bbadis.2017.07.027. PMID: 28756216
Hepatobiliary cancers, version 2.2014.
Benson AB 3rd, D'Angelica MI, Abrams TA, Are C, Bloomston PM, Chang DT, Clary BM, Covey AM, Ensminger WD, Iyer R, Kelley RK, Linehan D, Malafa MP, Meranze SG, Park JO, Pawlik T, Posey JA, Scaife C, Schefter T, Sigurdson ER, Tian GG, Vauthey JN, Venook AP, Yen Y, Zhu AX, Hoffmann KG, McMillian NR, Sundar H
J Natl Compr Canc Netw 2014 Aug;12(8):1152-82. doi: 10.6004/jnccn.2014.0112. PMID: 25099447

Prognosis

Imaging Features of Premalignant Biliary Lesions and Predisposing Conditions with Pathologic Correlation.
Zulfiqar M, Chatterjee D, Yoneda N, Hoegger MJ, Ronot M, Hecht EM, Bastati N, Ba-Ssalamah A, Bashir MR, Fowler K
Radiographics 2022 Sep-Oct;42(5):1320-1337. Epub 2022 Aug 5 doi: 10.1148/rg.210194. PMID: 35930475
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.
Wardell CP, Fujita M, Yamada T, Simbolo M, Fassan M, Karlic R, Polak P, Kim J, Hatanaka Y, Maejima K, Lawlor RT, Nakanishi Y, Mitsuhashi T, Fujimoto A, Furuta M, Ruzzenente A, Conci S, Oosawa A, Sasaki-Oku A, Nakano K, Tanaka H, Yamamoto Y, Michiaki K, Kawakami Y, Aikata H, Ueno M, Hayami S, Gotoh K, Ariizumi SI, Yamamoto M, Yamaue H, Chayama K, Miyano S, Getz G, Scarpa A, Hirano S, Nakamura T, Nakagawa H
J Hepatol 2018 May;68(5):959-969. Epub 2018 Jan 31 doi: 10.1016/j.jhep.2018.01.009. PMID: 29360550
Current controversies in cholangiocarcinoma.
Hoyos S, Navas MC, Restrepo JC, Botero RC
Biochim Biophys Acta Mol Basis Dis 2018 Apr;1864(4 Pt B):1461-1467. Epub 2017 Jul 26 doi: 10.1016/j.bbadis.2017.07.027. PMID: 28756216
Precancerous lesions of the biliary tree.
Klöppel G, Adsay V, Konukiewitz B, Kleeff J, Schlitter AM, Esposito I
Best Pract Res Clin Gastroenterol 2013 Apr;27(2):285-97. doi: 10.1016/j.bpg.2013.04.002. PMID: 23809246
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264

Clinical prediction guides

Neuroendocrine Carcinomas of the Gallbladder: A Clinicopathologic and Immunohistochemical Analysis of 34 Resected Cases.
Lee SM, Sung CO
Am J Surg Pathol 2020 Oct;44(10):1308-1321. doi: 10.1097/PAS.0000000000001536. PMID: 32739935
Luschka Ducts of the Gallbladder in Adults: Case Series Report and Review of the Medical Literature.
Handra-Luca A, Ben Romdhane HM, Hong SM
Int J Surg Pathol 2020 Aug;28(5):482-489. Epub 2020 Jan 26 doi: 10.1177/1066896920901334. PMID: 31983263
Covered and uncovered biliary metal stents provide similar relief of biliary obstruction during neoadjuvant therapy in pancreatic cancer: a randomized trial.
Seo DW, Sherman S, Dua KS, Slivka A, Roy A, Costamagna G, Deviere J, Peetermans J, Rousseau M, Nakai Y, Isayama H, Kozarek R; Biliary SEMS During Neoadjuvant Therapy Study Group
Gastrointest Endosc 2019 Oct;90(4):602-612.e4. Epub 2019 Jul 2 doi: 10.1016/j.gie.2019.06.032. PMID: 31276674
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.
Wardell CP, Fujita M, Yamada T, Simbolo M, Fassan M, Karlic R, Polak P, Kim J, Hatanaka Y, Maejima K, Lawlor RT, Nakanishi Y, Mitsuhashi T, Fujimoto A, Furuta M, Ruzzenente A, Conci S, Oosawa A, Sasaki-Oku A, Nakano K, Tanaka H, Yamamoto Y, Michiaki K, Kawakami Y, Aikata H, Ueno M, Hayami S, Gotoh K, Ariizumi SI, Yamamoto M, Yamaue H, Chayama K, Miyano S, Getz G, Scarpa A, Hirano S, Nakamura T, Nakagawa H
J Hepatol 2018 May;68(5):959-969. Epub 2018 Jan 31 doi: 10.1016/j.jhep.2018.01.009. PMID: 29360550
Mucosal cell proliferation activity of the gallbladder in children with anomalous arrangement of the pancreaticobiliary duct.
Tokiwa K, Ono S, Iwai N
J Hepatobiliary Pancreat Surg 1999;6(3):213-7. doi: 10.1007/s005340050109. PMID: 10526054

Recent systematic reviews

Crossing borders: A systematic review with quantitative analysis of genetic mutations of carcinomas of the biliary tract.
Roos E, Soer EC, Klompmaker S, Meijer LL, Besselink MG, Giovannetti E, Heger M, Kazemier G, Klümpen HJ, Takkenberg RB, Wilmink H, Würdinger T, Dijk F, van Gulik TM, Verheij J, van de Vijver MJ
Crit Rev Oncol Hematol 2019 Aug;140:8-16. Epub 2019 May 24 doi: 10.1016/j.critrevonc.2019.05.011. PMID: 31158800
A Systematic Review and Meta-analysis of Intraluminal Brachytherapy Versus Stent Alone in the Treatment of Malignant Obstructive Jaundice.
Xu X, Li J, Wu J, Zhu R, Ji W
Cardiovasc Intervent Radiol 2018 Feb;41(2):206-217. Epub 2017 Oct 26 doi: 10.1007/s00270-017-1827-6. PMID: 29075881

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